Review
Cardiac & Cardiovascular Systems
Paul Human, Deon Bezuidenhout, Elena Aikawa, Peter Zilla
Summary: The article questions the effectiveness of focusing on decellularization and highlights the importance of studying the host response to the extracellular matrix.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Engineering, Biomedical
Yuriy Snyder, Soumen Jana
Summary: Valvular heart diseases are commonly treated using mechanical or bioprosthetic heart valves, but these valves have limitations. Heart valve tissue engineering offers a potential solution by using scaffolds that can grow with patients and function without the need for lifelong anticoagulation medication.
Article
Engineering, Biomedical
Yu Luo, Shenyu Huang, Lie Ma
Summary: The study suggested that using SLS-based decellularization combined with EDC/NHS crosslink can produce BHVs with excellent extracellular matrix stability and biocompatibility, showing reduced immune response and calcification compared to GA treatment after implantation.
BIOMEDICAL MATERIALS
(2021)
Review
Engineering, Biomedical
Marcus Ground, Steve Waqanivavalagi, Robert Walker, Paget Milsom, Jillian Cornish
Summary: Tissue engineered heart valves offer a potential alternative to traditional valve prostheses, but predicting their in vivo performance is challenging. Understanding the short and long term immune reactions is crucial for bringing these prostheses to market, and researchers need to utilize a variety of models to fully elucidate the host's impact on the graft.
ACTA BIOMATERIALIA
(2021)
Review
Biotechnology & Applied Microbiology
F. Naso, A. Gandaglia
Summary: The extracellular matrix (ECM) plays a critical role in tissue and organ functionality. Decellularization is a promising technique to generate tissue-specific ECM-derived products. This paper reviews the latest decellularization approaches in cardiovascular tissue engineering and discusses parameters for evaluating efficacy and tissue biocompatibility.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Zhen Meng, Zhe Li, Erli Zhang, Li Zhang, Qingrong Liu, Yongjian Wu
Summary: The study demonstrates that sevelamer treatment can alleviate calcification of bioprosthetic heart valves and has anti-inflammatory effects. These effects are independent of serum calcium and phosphate regulation and may help prolong the longevity of bioprosthetic heart valves.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Agriculture, Dairy & Animal Science
M. J. O'Brien, N. J. Beijerink, C. M. Wade
Summary: Myxomatous mitral valve disease (MMVD) is the most common heart disease in domestic dogs, characterized by a slow progressive degeneration that can lead to congestive heart failure in severe cases. Genetic factors play a role in the progression of the disease, and advanced genomic technologies offer potential for identifying genetic risk factors within breeds, particularly in breeds like the Cavalier King Charles Spaniel.
Article
Immunology
Filippo Naso, Andrea Colli, Peter Zilla, Antonio Maria Calafiore, Chaim Lotan, Massimo A. Padalino, Giulio Sturaro, Alessandro Gandaglia, Michele Spina
Summary: This study evaluates the calcium deposition on commercial bioprosthetic heart valves using a new humanized murine aGal knockout (KO) animal model. The polyphenol-based treatment effectively prevents calcium deposition by masking the aGal antigen.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Hellmuth Weich, Lezelle Botes, Anton Doubell, Johan Jordaan, Angelique Lewies, Prennie Marimuthu, Johannes van den Heever, Francis Smit
Summary: In a juvenile sheep model, transcatheter heart valves utilizing two new types of decellularized bovine pericardial leaflets showed better performance compared to traditional industry standards. The low dose of monomeric glutaraldehyde fixation resulted in reduced pannus formation, calcification, and improved hemodynamic function, suggesting potential for use in younger patients needing heart valve surgery.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Dmitry Bobylev, Alexander Horke, Dietmar Boethig, Mark Hazekamp, Bart Meyns, Filip Rega, Hitendu Dave, Martin Schmiady, Anatol Ciubotaru, Eduard Cheptanaru, Vladimiro Vida, Massimo Padalino, Victor Tsang, Ramadan Jashari, Gunther Laufer, Martin Andreas, Alexandra Andreeva, Igor Tudorache, Serghei Cebotari, Axel Haverich, Samir Sarikouch
Summary: Early results from the ESPOIR Trial suggest that decellularized pulmonary homografts (DPH) have excellent performance in pulmonary valve replacement. A 5-year analysis of ESPOIR Trial patients showed low rates of adverse events and better freedom from explantation compared to cryopreserved homografts (CH) patients.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Adrian H. Chester, Padmini Sarathchandra, Ann McCormack, Magdi H. Yacoub
Summary: A model of calcification using intact porcine valve leaflets has been developed, showing the formation of calcified nodules in response to biological stimuli. The presence of calcium and phosphorus-containing nodules was confirmed through electron microscope images and immunohistochemical staining. The formation of calcified nodules and expression of bone markers were inhibited by adenosine in a concentration-dependent manner, demonstrating the potential for pharmacological manipulation in this model.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Michael J. Jarrett, Qingzhou Yao, Neil Venardos, Michael J. Weyant, T. Brett Reece, Xianzhong Meng, David A. Fullerton
Summary: The study found that simvastatin has anti-inflammatory effects and can prevent osteogenic activity in aortic valve interstitial cells by reducing TLR4 levels and inhibiting NF-kB signaling.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Materials Science, Multidisciplinary
Yuriy Snyder, Soumen Jana
Summary: Creating leaflet substrates that mimic the trilayered structure, anisotropic tensile characteristics, and elastomeric features of human heart valve leaflets is crucial to successful heart valve tissue engineering. In this study, elastomeric trilayer substrates made of a combination of polymers were developed to resemble native tissue. These substrates exhibited better cell adhesion, proliferation, extracellular matrix production, and resistance to calcification compared to non-elastomeric substrates.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Chemistry, Medicinal
Yi-Fen Chiang, Chih-Hung Tsai, Hsin-Yuan Chen, Kai-Lee Wang, Hsin-Yi Chang, Yun-Ju Huang, Yong-Han Hong, Mohamed Ali, Tzong-Ming Shieh, Tsui-Chin Huang, Ching- Lin, Shih-Min Hsia
Summary: Cardiovascular diseases like atherosclerosis and aortic valve sclerosis involve inflammatory reactions due to various stimuli, causing increased oxidative stress which damages heart cells. Recent research has explored the protective effects of fucoxanthin (Fx), a marine carotenoid, on heart valve cells under high oxidative stress. Results show that Fx can improve cell survival, reduce oxidative stress-induced DNA damage, and protect against calcification, indicating its potential in treating heart valve diseases.
Review
Pharmacology & Pharmacy
Shuyu Wen, Ying Zhou, Wai Yen Yim, Shijie Wang, Li Xu, Jiawei Shi, Weihua Qiao, Nianguo Dong
Summary: Valve replacement is the main therapy for valvular heart disease, with bioprosthetic heart valves (BHV) surpassing mechanical heart valves (MHV) as the leading option due to their excellent properties. However, BHV is prone to structural valve degeneration (SVD) primarily caused by calcification. Understanding the basic mechanisms of calcification is essential for addressing the limited durability of BHV.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Astronomy & Astrophysics
Nadezhda M. Zakharova, Yury S. Tarahovsky, Natalia P. Komelina, Irina S. Fadeeva, Anatoly L. Kovtun
Summary: The experiment successfully demonstrated the maintenance of pharmacological torpor and hypothermia in rats for a week, with the potential application in medicine and for protecting astronauts during long missions in space.
LIFE SCIENCES IN SPACE RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yulia Baburina, Irina Odinokova, Olga Krestinina
Summary: Carbenoxolone significantly increased its effect in the liver mitochondria of rats with chronic intoxication, showing a reduction in lag phase, a decrease in threshold calcium concentration, acceleration of mitochondria swelling, and an increase in the level of membrane-bound proteins affected by carbenoxolone. This suggests that carbenoxolone is involved in the development/modulation of alcohol tolerance and dependence in rats.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Anastasia Yu. Teterina, Igor V. Smirnov, Irina S. Fadeeva, Roman S. Fadeev, Polina V. Smirnova, Vladislav V. Minaychev, Margarita I. Kobyakova, Aleksandr Yu. Fedotov, Sergey M. Barinov, Vladimir S. Komlev
Summary: The study presented the synthesis of low-temperature calcium phosphate compounds with strontium substitution to improve bioactive properties, indicating the effectiveness of using strontium in OCP for enhancing biocompatibility in composite materials intended for bone repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yana Vladimirovna Lomovskaya, Margarita Igorevna Kobyakova, Anatoly Sergeevich Senotov, Alexey Igorevich Lomovsky, Vladislav Valentinovich Minaychev, Irina Sergeevna Fadeeva, Daria Yuryevna Shtatnova, Kirill Sergeevich Krasnov, Alena Igorevna Zvyagina, Vladimir Semenovich Akatov, Roman Sergeevich Fadeev
Summary: The resistance of leukemic cells to TRAIL-induced apoptosis is a major challenge in the treatment of leukemia. In this study, researchers discovered that human acute myeloid leukemia cells, when subjected to high-density culture conditions, displayed a macrophage-like phenotype and increased resistance to TRAIL-induced cell death. This resistance can be attributed to a decrease in the expression of death receptors DR4 and DR5 on the leukemic cells. The findings suggest that stress conditions in high-density cell cultures may contribute to tumor progression by promoting TRAIL resistance.
Article
Biochemistry & Molecular Biology
Yulia Baburina, Roman Krestinin, Irina Odinokova, Irina Fadeeva, Linda Sotnikova, Olga Krestinina
Summary: The study identified a decrease in the level of PHB in rat heart mitochondria with heart failure, and found that astaxanthin increased PHB content, suggesting a potential protective role. The interaction between PHB and other mitochondrial proteins in respiratory chain complexes was investigated under experimental conditions to understand this protective action.
Article
Biochemistry & Molecular Biology
Margarita Kobyakova, Yana Lomovskaya, Anatoly Senotov, Alexey Lomovsky, Vladislav Minaychev, Irina Fadeeva, Daria Shtatnova, Kirill Krasnov, Alena Zvyagina, Irina Odinokova, Vladimir Akatov, Roman Fadeev
Summary: It is known that cell culture density can modulate the drug resistance of acute myeloid leukemia (AML) cells. In this study, the drug sensitivity of AML cells in high-density cell cultures was investigated. The results showed that AML cells in high-density cell cultures were significantly more resistant to DNA-damaging drugs and recombinant ligand izTRAIL compared to those in low-density cell cultures. Further analysis revealed that the increased drug resistance of AML cells in high-density cultures was associated with the accumulation of inflammatory cytokines and the activation of NF-kB-dependent inflammatory-like cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Olga Krestinina, Irina Odinokova, Linda Sotnikova, Roman Krestinin, Alena Zvyagina, Yulia Baburina
Summary: The search for new targets for the pathological action of ethanol remains an urgent task of biomedicine. In this study, it was found that astaxanthin can protect liver mitochondria from degenerative changes caused by ethanol and improve mitochondrial functions. Astaxanthin positively influences the activity and expression of proteins of the mitochondrial respiratory chain complexes and ATPase, and has a protective effect on mitochondrial respiration rate and activity.
Article
Biochemistry & Molecular Biology
Marina Solovieva, Yuri Shatalin, Irina Odinokova, Olga Krestinina, Yulia Baburina, Yana Lomovskaya, Anton Pankratov, Natalia Pankratova, Olga Buneeva, Arthur Kopylov, Alexei Medvedev, Vladimir Akatov
Summary: DSF and its oxy-derivatives enhance the oxidation and ubiquitination of proteins, leading to inhibition of protein retrotranslocation and initiation of paraptosis-like cell death. This provides new insight into the role of protein ubiquitination/deubiquitination in regulating protein retrotranslocation and cell death.
Article
Biochemistry & Molecular Biology
Artem Mishukov, Irina Odinokova, Ekaterina Mndlyan, Margarita Kobyakova, Serazhutdin Abdullaev, Vitaly Zhalimov, Xenia Glukhova, Vasiliy Galat, Yekaterina Galat, Anatoly Senotov, Roman Fadeev, Artem Artykov, Marine E. Gasparian, Marina Solovieva, Igor Beletsky, Ekhson Holmuhamedov
Summary: ONC201 targets mitochondrial ATP-dependent caseinolytic peptidase P (ClpP) and has reversible and irreversible effects on cancer cells. When used in combination with NK cells, it enhances the anti-cancer effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Mathematics
Eugene Talygin, Alexander Gorodkov, Teona Tibua, Leo Bockeria
Summary: By studying the geometric shape and hydrodynamics of the aortic flow channel, new quantitative parameters were obtained to assess the degree of shape deviations in the aorta.
Article
Engineering, Multidisciplinary
Irina S. Fadeeva, Anastasia Yu. Teterina, Vladislav V. Minaychev, Anatoliy S. Senotov, Igor V. Smirnov, Roman S. Fadeev, Polina V. Smirnova, Vladislav O. Menukhov, Yana V. Lomovskaya, Vladimir S. Akatov, Sergey M. Barinov, Vladimir S. Komlev
Summary: This study proposes a method to develop composite biomimetic bone material for reconstructive surgery through deposition (remineralization) of calcium phosphate layers on high-purity, demineralized bone collagen matrix. The results show reproduction of bone tissue matrix architectonics and high-purity collagen scaffolds, as well as high biocompatibility of the materials obtained. Various analysis techniques confirm the efficiency of calcium phosphate deposition on the surface of bone collagen scaffolds. Heterotopic implantation experiments in rats demonstrate that remineralized bone collagen matrices have a higher osteostimulating ability compared to demineralized ones, indicating the potential for creating effective osteoplastic materials for bone tissue regeneration and augmentation.
Article
Medicine, General & Internal
Gregory P. Arutyunov, Alexander G. Arutyunov, Yuri N. Belenkov, Alexandra O. Konradi, Yury M. Lopatin, Andrey P. Rebrov, Sergey N. Tereshchenko, Anna Chesnikova, Hamlet G. Hayrapetyan, Aleksandr P. Babin, Igor G. Bakulin, Natalia Bakulina, Larisa A. Balykova, Anna S. Blagonravova, Marina Boldina, Alexandra R. Vaisberg, Albert S. Galyavich, Veronika V. Gomonova, Natalia Iu Grigor'eva, Irina Gubareva, Irina Demko, Angelika Evzerikhina, Aleksandr Zharkov, Umida K. Kamilova, Zulfia F. Kim, Tatiana Yu Kuznetsova, Natalia Lareva, Ekaterina Makarova, Svetlana Malchikova, Sergey Nedogoda, Marina M. Petrova, Ilya G. Pochinka, Konstantin Protasov, Denis N. Protsenko, Dmitry Yu Ruzanau, Sergey A. Sayganov, Akpay Sh Sarybaev, Natalia M. Selezneva, Akhmetzhan B. Sugraliev, Igor Fomin, Olga Khlynova, Olga Yu Chizhova, Igor I. Shaposhnik, Dmitry A. Shchukarev, Aygul K. Abdrahmanova, Susanna A. Avetisian, Hovhannes G. Avoyan, Karine K. Azarian, Galiya T. Aimakhanova, Dinara A. Ayipova, Almazbek Ch Akunov, Marianna K. Alieva, Aliona Aparkina, Olga R. Aruslanova, Ekaterina Yu Ashina, Olga Yu Badina, Olga Yu Barisheva, Alina S. Batchayeva, Anna M. Bitieva, Ismail U. Bikhteyev, Nataliya A. Borodulina, Maksim Bragin, Angela M. Budu, Galina A. Bykova, Kristina R. Vagapova, Darina D. Varlamova, Natalia N. Vezikova, Elena A. Verbitskaya, Olga E. Vilkova, Elena A. Vinnikova, Vera V. Vustina, Elena A. Galova, Vadim V. Genkel, Elena Gorshenina, Roman Gostishchev, Elena Grigorieva, Ekaterina Yu Gubareva, GaukharM Dabylova, Anastasiya Demchenko, Oleg Yu Dolgikh, Melis Y. Duyshobayev, Dmitrii S. Evdokimov, Ksenia E. Egorova, Anastasiia N. Ermilova, Aliya E. Zheldybayeva, Nataliya Zarechnova, Yuliia D. Zimina, Svetlana Yu Ivanova, Elena Yu Ivanchenko, Mariya Ilina, Maria Kazakovtseva, Elena Kazymova, Yuliya S. Kalinina, Nadezhda A. Kamardina, Anastasiya M. Karachenova, Igor A. Karetnikov, Nina A. Karoli, Magomed Kh Karsiev, Karina F. Kasymova, Zhainagul B. Kerimbekova, Ailar Sh Kerimova, Eugeni S. Kim, Nina Kiseleva, Darya A. Klimenko, Anastasiia Klimova, Olga Kovalishena, Elena Kolmakova, Tatyana P. Kolchinskaya, Maria Kolyadich, Olga Kondriakova, Marina P. Konoval, Dmitryi Yu Konstantinov, Elena A. Konstantinova, Vera A. Kordukova, Ekaterina Koroleva, Angelina Yu Kraposhina, Tamara Kriukova, Alla S. Kuznetsova, TatyanaYu Kuzmina, Kirill Kuzmichev, Cholpon K. Kulchoroeva, Tatiana Kuprina, Irina M. Kouranova, Liliya Kurenkova, Natalia Yu Kurchugina, Nadira A. Kushubakova, Valeriia Levankova, Natalia A. Lyubavina, Nadezhda A. Magdeyeva, Konstantin Mazalov, Viktoryia Maiseenka, Aleksandra S. Makarova, Abdirashit M. Maripov, Anastasiia A. Marusina, Evgenii S. Melnikov, Nikita B. Moiseenko, Fazliniso N. Muradova, Rimma G. Muradyan, Shahane N. Musaelian, Anton O. Myshak, Ekaterina S. Nekaeva, Nataliia M. Nikitina, Bela B. Ogurlieva, Alla A. Odegova, Yuliia M. Omarova, Nazgul A. Omurzakova, Shynar O. Ospanova, Ekaterina Pahomova, Liviu D. Petrov, Svetlana S. Plastinina, Vera A. Pogrebetskaya, Dmitry S. Polyakov, Ekaterina Ponomarenko, Larisa L. Popova, Natalya A. Prokofeva, Inna A. Pudova, Nikita A. Rakov, Abdurakhmon N. Rakhimov, Nadezhda A. Rozanova, Saltanat Serikbolkyzy, Andrei A. Simonov, Valeriya V. Skachkova, Daria Soloveva, Irina A. Soloveva, Alexander K. Subbotin, Irina M. Sukhomlinova, Anastasiia G. Sushilova, Dilnoza R. Tagayeva, Yuliia Titojkina, Elena P. Tikhonova, Danil S. Tokmin, Anastasiia A. Tolmacheva, Mariya S. Torgunakova, Ksenia Trenogina, Natalia A. Trostianetckaia, Dmitriy A. Trofimov, Alexander A. Tulichev, Assiya T. Tursunova, Nina D. Ulanova, Oleg Fatenkov, Olga Fedorishina, Tatiana S. Fil, Irina Yu Fomina, Irina S. Fominova, Irina A. Frolova, Svetlana M. Tsvinger, Vera V. Tsoma, Meerim B. Cholponbaeva, Tatiana Chudinovskikh, Olga A. Shevchenko, Tatyana Sheshina, Ekaterina A. Shishkina, Konstantin Yu Shishkov, Stanislav Yu Sherbakov, Ekaterina A. Yausheva
Summary: This study aimed to investigate the impact of various combinations of comorbid original diseases on the disease progression and outcomes of COVID-19. The results showed that cardiovascular diseases, diabetes mellitus, and obesity are the most common comorbidities in COVID-19 patients, and these combinations increase the risk of lethal outcomes.
TERAPEVTICHESKII ARKHIV
(2022)
Meeting Abstract
Oncology
Margarita I. Kobyakova, Serazhutdin Abdullaev, Yana V. Evstratova, Artem Mishukov, Irina Odinokova, Lee M. Graves, Ekhson Holmuhamedov
Meeting Abstract
Oncology
Yana Evstratova, Margarita Kobyakova, Irina Odinokova, Alexander Stolyarov, Artyom Mishukov, Lee M. Graves, Ekhson Holmuhamedov
Article
Cell Biology
M. Kobyakova, Ya Evstratova, A. S. Senotov, A. Lomovsky, V. V. Minaichev, A. Zvyagina, M. E. Solovieva, I. S. Fadeeva, V. S. Akatov, R. S. Fadeev
Summary: The study showed that the increase in TRAIL resistance of AML THP-1 cells in multicellular aggregates is associated with the appearance of signs characteristic of monocyte-like differentiation and a pro-inflammatory phenotype.
BIOLOGICHESKIE MEMBRANY
(2021)