Article
Oncology
Giorgio Lo Iacono, Antonio Mazzella, Shehab Mohamed, Francesco Petrella, Giulia Sedda, Monica Casiraghi, Lara Girelli, Luca Bertolaccini, Lorenzo Spaggiari
Summary: Primary chest wall tumors are rare and the best treatment method is still undetermined. Surgeons play an essential role in approaching these tumors among other oncological considerations. Radical oncological surgery is crucial in a multidisciplinary approach.
Article
Cardiac & Cardiovascular Systems
Yochun Jung, Kyo Seon Lee, Sang Gi Oh, Yangseung Jeong
Summary: This study aimed to evaluate the utility of mediastinal drainage fluid culture (MDFC) in early diagnosis of poststernotomy mediastinitis (PSM). The results showed that routine MDFC can facilitate early diagnosis of PSM, and early treatment for PSM may be indicated in patients in whom Staphylococci are identified in the MDFC.
THORACIC AND CARDIOVASCULAR SURGEON
(2023)
Article
Medicine, General & Internal
Christian Braun, Filip Schroeter, Magdalena Lydia Laux, Ralf-Uwe Kuehnel, Roya Ostovar, Martin Hartrumpf, Anna-Maria Necaev, Viyan Sido, Johannes Maximilian Albes
Summary: The study investigated the relationship between age and sex in regards to the development of deep sternal wound infections and sternal instability following median sternotomy. The results showed that older patients and men had a higher incidence of postoperative delirium, while the frequency of sternum instability and deep-wound-healing problems were equal between different age groups and sexes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Thambirajoo Maheswary, Asma Abdullah Nurul, Mh Busra Fauzi
Summary: The diversity of normal flora on human skin varies between individuals and parts of the skin. A symbiotic relationship has been formed over time between humans and normal flora. In chronic wounds, particularly in patients with diabetes, the conditions become favorable for microbes to colonize and establish infections within the skin. Antibiotics and wound dressings are the targeted therapy to treat chronic wounds, although prolonged usage may lead to ineffectiveness or resistance. Further studies are needed to comprehensively understand the role of human skin normal flora in chronic injuries at the cellular and molecular level.
Review
Medicine, Research & Experimental
Bharat Kumar Reddy Sanapalli, Vidyasrilekha Yele, Mantosh Kumar Singh, Praveen Thaggikuppe Krishnamurthy, Veera Venkata Satyanarayana Reddy Karri
Summary: The treatment of diabetic wounds presents complex challenges due to multifaceted pathophysiology, requiring appropriate animal models for study. While various animal models have been developed to examine wound healing processes, many lack the ability to properly replicate human diabetic wounds. Therefore, the major future challenge lies in developing a model that closely resembles the human diabetic wound environment in order to advance translational research in wound care.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Nanoscience & Nanotechnology
Li Mei, Dongjie Zhang, Huarong Shao, Yuanping Hao, Ting Zhang, Weiping Zheng, Yanjing Ji, Peixue Ling, Yun Lu, Qihui Zhou
Summary: Superbacteria-induced skin wound infections are significant health challenges. Probiotic therapy combined with biomimicking hydrogels shows great potential in treating infections and promoting wound repair.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Surgery
Minna K. Laitinen, Gilber Kask, Katariina Laurila, Erkki J. Tukiainen, Mikko Ronty, Ville Haapamaki, Juho T. K. Salo
Summary: This study reported the outcomes of surgical procedures and factors predicting survival of patients with chest wall chondrosarcoma treated in a single sarcoma center. The results showed that clear margins could effectively reduce local recurrence and improve disease-specific survival. Increasing tumor volume was found to significantly reduce the survival rate of patients.
ANNALS OF PLASTIC SURGERY
(2023)
Article
Dermatology
Kohei Aoki, Yukiko Ida, Noritoshi Fukushima, Hajime Matsumura
Summary: The study investigated the usefulness of oxygen nano-bubble water as an oxygen-rich liquid for wound healing and found that it enhances the healing process of ischemic wounds.
INTERNATIONAL WOUND JOURNAL
(2022)
Review
Pharmacology & Pharmacy
Suvash Ghimire, Pritha Sarkar, Kasey Rigby, Aditya Maan, Santanu Mukherjee, Kaitlyn E. Crawford, Kausik Mukhopadhyay
Summary: Hemorrhage poses a significant threat to life on the battlefield, with a high percentage of combat deaths occurring within 30 minutes of injury. There is a pressing need for a unique and easy-to-use hemostatic treatment that can be applied by first responders to stop bleeding within 1 to 2 minutes at the point of injury.
Review
Pharmacology & Pharmacy
Anna Herman, Andrzej Przemyslaw Herman
Summary: The purpose of this review is to provide verified data on the current knowledge acquired in preclinical and clinical studies regarding topically used herbal products and their active constituents with diabetic wound healing activity. The selected articles compared the effects of topically used herbal products in diabetic wound healing treatment versus control treatments. Herbal products can serve as an important support during conventional therapy or even as a substitute for synthetic drugs used for diabetic wound treatment, as they have various mechanisms of action.
Article
Biochemistry & Molecular Biology
Camila dos Santos Leite, Gabriel Alves Bonafe, Oscar Cesar Pires, Tanila Wood dos Santos, Geovanna Pacciulli Pereira, Jose Aires Pereira, Thalita Rocha, Carlos Augusto Real Martinez, Manoela Marques Ortega, Marcelo Lima Ribeiro
Summary: The study aimed to evaluate the anti-inflammatory effect of topical Dipotassium Glycyrrhizinate (DPG) on wound healing. Results showed that DPG treatment reduced inflammatory exudate, eliminated active hyperemia, increased granulation tissue, promoted tissue reepithelialization, and enhanced total collagen. In addition, DPG treatment decreased the expression of pro-inflammatory cytokines while increasing the expression of anti-inflammatory cytokine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nanoscience & Nanotechnology
Jia-Ying Ji, Dan-Yang Ren, Ying-Zheng Weng
Summary: This review article discusses the recent developments and innovations of antibacterial hydrogels for diabetic chronic wound healing.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Jiaojiao Zhu, Tiao Wen, Shuangquan Qu, Qingnian Li, Biwu Liu, Wenhu Zhou
Summary: This study developed a multifunctional silver nanoclusters-based hydrogel dressing for the treatment of infected wounds. The dressing has the capability to simultaneously fight infection and promote wound healing, showing excellent therapeutic efficacy in a mouse model of infected wounds.
Article
Nanoscience & Nanotechnology
Kunbao Zhang, Chao Yang, Chuanxu Cheng, Chengxin Shi, Madi Sun, Hanze Hu, Tongfei Shi, Xuenian Chen, Xuan He, Xiao Zheng, Mingqiang Li, Dan Shao
Summary: A bioactive hydrogel is developed for efficient and safe bacteria-infected diabetic wound healing by targeting inflammation and infection. The hydrogel can capture danger molecules and deliver antibiotics, resulting in improved wound closure rate and anti-inflammatory and antibacterial effects.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Kunbao Zhang, Chao Yang, Chuanxu Cheng, Chengxin Shi, Madi Sun, Hanze Hu, Tongfei Shi, Xuenian Chen, Xuan He, Xiao Zheng, Mingqiang Li, Dan Shao
Summary: This study introduces a bioactive hydrogel, named OCMC-Tob/PEI hydrogel, for the treatment of infected wounds in patients with chronic diabetes. The hydrogel achieves dual effects of anti-inflammation and anti-infection by scavenging danger molecules and releasing antibiotics.
ACS APPLIED MATERIALS & INTERFACES
(2022)