Article
Genetics & Heredity
Lin Yang, Hong-Gang Sui, Meng-Meng Wang, Jia-Yin Li, Xiao-Feng He, Jing-Yuan Li, Xiao-Zeng Wang
Summary: Plasma levels of miR-30c-1-3p and MMP-9 may serve as candidate biomarkers for AAA progression.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Cardiac & Cardiovascular Systems
Dunpeng Cai, Chenming Sun, Gui Zhang, Xingyi Que, Ken Fujise, Neal L. Weintraub, Shi-You Chen
Summary: The study identified ADAR1 as a novel regulator of AAA development, showing its interaction with HuR to regulate the stability of MMP2 and MMP9 mRNA, leading to increased MMP levels and activities that may represent a potential new therapeutic target to hinder AAA growth and rupture.
CIRCULATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Jen-Chun Wang, Shih-Hung Tsai, Hsiao-Ya Tsai, Shing-Jong Lin, Po-Hsun Huang
Summary: This study aimed to elucidate the relationship between hyperuricemia and abdominal aortic aneurysm (AAA). Retrospective study and mouse model revealed that hyperuricemia exacerbates AAA formation and activates the URAT1/ERK1/2/ROS/MMP-9 pathway in human aortic smooth muscle cells (HASMCs).
BMC CARDIOVASCULAR DISORDERS
(2023)
Review
Medicine, General & Internal
Petroula Nana, Konstantinos Dakis, Alexandros Brodis, Konstantinos Spanos, George Kouvelos
Summary: A systematic review examined the correlation of abdominal aortic aneurysm expansion rates with serum circulating biomarkers, identifying specific biomarkers potentially useful for individualized surveillance of patients with increased AAA growth rates. Various biomarkers, including D-dimers, LDL-C, HDL-C, and genetic factors, were found to be significantly associated with AAA growth rates, suggesting a potential role for serum biomarkers in patient monitoring.
JOURNAL OF CLINICAL MEDICINE
(2021)
Editorial Material
Biochemistry & Molecular Biology
Naofumi Amioka, Toru Miyoshi
Summary: Abdominal aortic aneurysm (AAA) is a life-threatening disease without established treatment. Fibrates, such as fenofibrate, can regulate the pathogenesis of AAA through anti-inflammatory and anti-oxidative effects. This paper summarizes the studies on the effects of fenofibrate on AAA and discusses the issues associated with its use as a therapeutic agent.
Article
Medicine, Research & Experimental
Yi-Chen Lin, Qin-Ye Chen, Jie Xiao, Li-Chuan Shen, Xian-Tao Li, Yu-Ze Yang, Ping-Fan Guo, Mo-Jun Lin, Da -Cen Lin
Summary: This study successfully developed a mouse model that mimics human abdominal aortic aneurysms (AAAs) by periarterial incubation with papain. The model offers advantages such as simplicity, convenience, and high efficiency, making it suitable for investigating the pathophysiologic mechanisms and potential treatments for human AAAs.
LABORATORY INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Tingting Chen, Hongliang Zhang, Yang Zhang, Mengqi Yang, Juntao Wu, Minjun Yang, Jiangbo Lin, Weixu Gao, Lijiang Tang, Baohui Xu, Jianjun Jiang, Xiaofeng Chen
Summary: The meta-analysis found that circulating zinc and Zn/Cu ratio were significantly lower in AAA patients, and aneurysmal aorta associated with AAA also had significantly lower zinc levels and Zn/Cu ratio. However, there was no significant difference in circulating or aortic copper levels between AAA patients and the control group.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Hematology
Michele Silvestro, Cristobal F. Rivera, Dornazsadat Alebrahim, John Vlahos, Muhammad Yogi Pratama, Cuijie Lu, Claudia Tang, Zander Harpel, Rayan Sleiman Tellaoui, Ariadne L. Zias, Delphina J. Maldonado, Devon Byrd, Mukundan Attur, Paolo Mignatti, Bhama Ramkhelawon
Summary: The cytoplasmic domain of MT1-MMP protects against the development of AAA and atherosclerotic plaques through a nonproteolytic signaling mechanism. This finding reveals a novel mechanism of synchronous onset of AAA and atherogenesis and highlights the importance of MT1-MMP in the control of vascular wall homeostasis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Immunology
Yu Fu, Haole Liu, Kexin Li, Panpan Wei, Naqash Alam, Jie Deng, Meng Li, Haibin Wu, Xue He, Haiwen Hou, Congcong Xia, Rong Wang, Weirong Wang, Liang Bai, Baohui Xu, Yankui Li, Yi Wu, Enqi Liu, Sihai Zhao
Summary: CRP deficiency suppresses AAA by reducing aneurysmal elastin destruction, macrophage accumulation, and matrix metalloproteinase 2 expression
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Chung-Huang Chen, Hua-Hui Ho, Wei-Cheng Jiang, Wai-Sam Ao-Ieong, Jane Wang, Alexander N. Orekhov, Igor A. Sobenin, Matthew D. Layne, Shaw-Fang Yet
Summary: This study found that the lack of Cysteine-rich protein 2 (CRP2) can alleviate the occurrence and severity of abdominal aortic aneurysm (AAA) induced by angiotensin II (Ang II), by maintaining the density of aortic vascular smooth muscle cells (VSMCs), extracellular matrix protein homeostasis, and structural integrity of the aorta. In addition, CRP2 deficiency can also reduce elastin degradation, collagen deposition, and abnormal blood pressure, and exert its effects through the Erk1/2-Col III and MMP2 signaling pathways.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Review
Endocrinology & Metabolism
Zhen Yuan, Zhijian Heng, Yi Lu, Jia Wei, Zhejun Cai
Summary: The study found that metformin can reduce the growth rate and rupture risk of abdominal aortic aneurysm in type 2 diabetes patients, providing research evidence for related treatment strategies.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Multidisciplinary Sciences
Ian Wee, Brian Chin, Nicholas Syn, Keng Siang Lee, Jun Jie Ng, Andrew M. T. L. Choong
Summary: Previous studies have shown a causal association between fluoroquinolone use and collagen pathologies, while this meta-analysis found a statistically significant risk of aortic dissection or aneurysm associated with current fluoroquinolone use. Further research is needed to understand the mechanistic plausibility of this association, but caution should be exercised in prescribing fluoroquinolones, especially when clinically necessary.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Benjamin T. Ledford, Adam W. Akerman, Kui Sun, David C. Gillis, Jenna M. Weiss, Johnny Vang, Smaranda Willcox, Tristan D. Clemons, Hiroaki Sai, Ruomeng Qiu, Mark R. Karver, Jack D. Griffith, Nick D. Tsihlis, Samuel Stupp, John S. Ikonomidis, Melina R. Kibbe
Summary: This study reports the development of injectable supramolecular nanofibers that target fragmented elastin, matrix metalloproteinase 2, and membrane type 1 matrix metalloproteinase to reduce the risks associated with a ruptured abdominal aortic aneurysm. The results show that one of the nanofibers was able to better localize to the aneurysm tissue and had an optimal dose.
Article
Hematology
Xia Guo, Dunpeng Cai, Kun Dong, Chenxiao Li, Zaiyan Xu, Shi-You Chen
Summary: DOCK2 is identified as a novel regulator for AAA formation, playing a role in promoting vascular inflammation and elastin degradation by upregulating MCP-1 and MMP2 expression.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Review
Medicine, General & Internal
Smit Paghdar, Taheseen M. Khan, Nishant P. Patel, Savitri Chandrasekaran, Joaquim Francisco Maria De Sousa, Nicholas Tsouklidis
Summary: The study found that doxycycline can slow the growth of small AAAs by inhibiting MMP, thus reducing the need for invasive treatments.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
