Article
Cell Biology
Young-Ae Choi, Hima Dhakal, Soyoung Lee, Namkyung Kim, Byungheon Lee, Taeg Kyu Kwon, Dongwoo Khang, Sang-Hyun Kim
Summary: This study elucidated the non-transcriptional role of IRF3 in mast cell activation and allergic inflammation. In vitro and in vivo experiments showed that IRF3 played a significant role in mast cell-mediated allergic inflammation. The activation of IRF3 was observed during mast cell activation process, and it affected the production of granule contents and the anaphylaxis responses. Overall, IRF3 is an important factor inducing mast cell activation and regulating HDC activity.
Article
Allergy
Ying Wang, Mang Yu, Kazufumi Matsushita, Chen Liu, Naotada Ishihara, Masatoshi Nomura, Mindy Tsai, Stephen J. Galli
Summary: This study reveals that the protein Drp1 can differentially regulate the activation of mast cells by different stimuli. Promoting or inhibiting Drp1 activation might represent novel approaches for treating IgE-dependent mast cell activation or mitigating other substance P-induced mast cell-dependent responses.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Gabriella Chieffi Baccari, Sara Falvo, Antonia Lanni, Maria Maddalena Di Fiore, Federica Cioffi, Alessandra Santillo
Summary: This study found that hypothyroidism significantly increased the number of mast cells and histamine content in the skin and exorbital lacrimal gland of Wistar rats. It also showed an increase in the percentage of degranulating mast cells, suggesting that thyroid status influences the activation state of these cells.
Article
Veterinary Sciences
Susanne Gamperl, Gabriele Stefanzl, Michael Willmann, Peter Valent, Emir Hadzijusufovic
Summary: This study found that certain HR1 antagonists have inhibitory effects on proliferation and apoptosis of canine neoplastic mast cells, with desloratadine, rupatadine, and cyproheptadine showing stronger effects. Additionally, some HR1 antagonists were able to suppress histamine release. The concentrations needed for significant effects were relatively high, suggesting potential limitations in using these drugs for growth or activation suppression in vivo.
VETERINARY MEDICINE AND SCIENCE
(2021)
Review
Cell Biology
Rachel Bleach, Mark Sherlock, Michael W. O'Reilly, Marie McIlroy
Summary: IGF signaling plays a crucial role in tumor growth, with complex interactions with sex hormones and endocrine-driven cancers. IGF-1 plays a compensatory role in ER and AR by enhancing hormonal responses, and dysregulated IGF signaling is associated with breast and prostate cancers.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
N. N. Gancz, J. A. Levinson, B. L. Callaghan
Summary: A large body of research from animal models has shown bidirectional relationships between the brain-gut-microbiome axis and sex. However, these findings have not translated well to human models. The oversimplified approach to sex and the lack of consideration for gender may be contributing factors. Research practices that consider the complexity of sex and gender will enhance our understanding of the system and improve the development of treatments for related health outcomes.
BRAIN RESEARCH BULLETIN
(2023)
Article
Psychology, Multidisciplinary
Elizabeth R. R. Brown, Jessi L. L. Smith, Doralyn Rossmann
Summary: Men are perceived as default in academia due to their overrepresentation in positions of power, leading to androcentrism. Research in the field of bias (psychology) found that men-related journals are favored over sex/gender-related journals. Male undergraduate students and those with low feminist ideology showed less support for sex/gender-related journals, leading to decreased subscription recommendations. Furthermore, there may be a bias towards androcentric interests in the public sphere, with articles in sex/gender-related journals having greater public reach compared to other-specialty journals.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Behavioral Sciences
Liat Helpman
Summary: Stress-related disorders (SRD) have a greater impact on women, and cortisol blunting, a failure in cortisol response to stress, is more pronounced among women with SRDs. Cortisol blunting is influenced by both biological factors, such as estrogen and its fluctuations, and psychosocial factors, such as discrimination, harassment, and gender roles. A theoretical model is proposed to link experience, sex- and gender-related factors, and neuroendocrine substrates to explain the heightened risk of SRDs among women, providing a comprehensive framework for understanding the stress experienced by women. Utilizing this framework in research can help identify targeted risk factors specific to sex and gender, informing interventions, medical advice, education, community programming, and policies.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Cardiac & Cardiovascular Systems
Mattia Zampieri, Alessia Argiro, Marco Allinovi, Luigi Tassetti, Chiara Zocchi, Martina Gabriele, Valentina Andrei, Carlo Fumagalli, Carlo Di Mario, Alessia Tomberli, Iacopo Olivotto, Federico Perfetto, Francesco Cappelli
Summary: This study aimed to investigate whether sex-related differences are relevant to the clinical presentation, cardiac phenotype, and all-cause mortality in different types of cardiac amyloidosis. The study found that there were no major differences in clinical expression related to sex in different types of cardiac amyloidosis. However, women with wild type transthyretin amyloidosis showed signs of more advanced disease and higher NAC score at diagnosis, indicating a possible later recognition of the disease compared to men.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Agronomy
Marzia Pezzolato, Elena Biasibetti, Marilena Gili, Cristiana Maurella, Alessandro Benedetto, Marianna Marturella, Federica Ostorero, Giancarlo Bozzo, Claudio Bellino, Antonio D'angelo, Flaminia Valentini, Francesca Roberti, Maurizio Fiori, Paolo Stacchini, Elena Bozzetta
Summary: The aim of this study was to verify if veal calves housed under controlled conditions still have physiological levels of natural steroid hormones and if this affects the normal histological pattern of growth promoters in target organs.
Review
Biochemistry & Molecular Biology
Onella Athnaiel, Santiago Cantillo, Stephania Paredes, Nebojsa Nick Knezevic
Summary: This article examines the impact of hormone replacement therapy on pain perception in the transgender community, particularly in relation to other pain-related conditions such as headaches, fibromyalgia, temporomandibular myalgia, and visceral pain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Paulina Zelechowska, Ewa Brzezinska-Blaszczyk, Justyna Agier, Elzbieta Kozlowska
Summary: This study compares the effects of different fungal cell wall components on the activity of mast cells. The results show that inner layer fungal cell wall components, specifically β-glucans, have a stronger ability to activate mast cells.
IMMUNOLOGY LETTERS
(2022)
Article
Medicine, General & Internal
Francesco Angeli, Luca Bergamaschi, Andrea Rinaldi, Pasquale Paolisso, Matteo Armillotta, Andrea Stefanizzi, Angelo Sansonetti, Sara Amicone, Andrea Impellizzeri, Francesca Bodega, Lisa Canton, Nicole Suma, Damiano Fedele, Davide Bertolini, Francesco Pio Tattilo, Daniele Cavallo, Ornella Di Iuorio, Khrystyna Ryabenko, Marcello Casuso Alvarez, Nazzareno Galie, Alberto Foa, Carmine Pizzi
Summary: This study evaluated the sex-related disparities in clinical presentation and outcomes of cardiac masses in a cohort of 321 patients. The results showed that females were more likely to have benign masses, while males were more likely to have malignant masses. Despite better overall survival in women, sex did not influence the prognosis of benign and malignant masses.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Muhammad N. A. Sahid, Shuang Liu, Takeshi Kiyoi, Kazutaka Maeyama, Masaki Mogi
Summary: The study investigated the effect of zoledronate on histamine release from RBL-2H3 cells, with a focus on its impact on Rab27a/Doc2a interaction. Zoledronate was found to inhibit histamine release without affecting intracellular Ca2+ levels or Rab27a/Doc2a interaction.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2021)
Review
Oncology
Paola Matarrese, Gianfranco Mattia, Maria Teresa Pagano, Giada Pontecorvi, Elena Ortona, Walter Malorni, Alessandra Care
Summary: The study highlights the significant role of autophagy in the interaction between the tumor microenvironment and cancer cells, emphasizing the impact of gender on TME-cancer interaction and tumor growth.
Article
Parasitology
Jorge Morales-Montor, Alvaro Colin-Oviedo, Gloria M. Gonzalez, Jose Prisco Palma-Nicolas, Alejandro Sanchez-Gonzalez, Karen Elizabeth Nava-Castro, Lenin Dominguez-Ramirez, Martin Garcia-Varela, Victor Hugo Del Rio-Araiza, Romel Hernandez-Bello
Summary: This study reveals that progesterone may act on Trichinella spiralis eggs by binding to the parasite protein PGRMC2-Ts. The findings have implications in the co-evolution between parasites and hosts, as well as the susceptibility to this infection based on gender. Additionally, these results may contribute to the development of new anti-parasite drugs.
VETERINARY PARASITOLOGY
(2022)
Article
Environmental Sciences
Mariana Segovia-Mendoza, Margarita Isabel Palacios-Arreola, Lenin Pavon, Luis Enrique Becerril, Karen Elizabeth Nava-Castro, Omar Amador-Munoz, Jorge Morales-Montor
Summary: Public concern has emerged about the effects of endocrine-disrupting compounds (EDCs) on neuropsychiatric disorders. Preclinical evidence suggests that exposure to EDCs is associated with the development of major depressive disorder (MDD) and could result in neural degeneration. Studies in Mexico show an increasing incidence of MDD, but no clinical associations have been found between blood levels of EDCs and MDD.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Margarita Isabel Palacios-Arreola, Norma Angelica Moreno-Mendoza, Karen Elizabeth Nava-Castro, Mariana Segovia-Mendoza, Armando Perez-Torres, Claudia Angelica Garay-Canales, Jorge Morales-Montor
Summary: This study demonstrates for the first time that BPA injection during a specific developmental stage in mice leads to an increase in lung metastasis in adulthood. The analysis of the tumor microenvironment suggests that BPA induces an increase in pro-metastatic cytokines. These findings highlight the potential role of BPA as an inducer of breast cancer metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Karen Elizabeth Nava-Castro, Lenin Pavon, Luis Enrique Becerril-Villanueva, Maria Dolores Ponce-Regalado, Hugo Aguilar-Diaz, Mariana Segovia-Mendoza, Jorge Morales-Montor
Summary: The interaction among the nervous, immune, and endocrine systems is crucial for maintaining homeostasis in vertebrates. This study used the Taenia crassiceps mouse system to investigate the impact of infection on neurotransmitters, cytokines, sex steroids, and sex-steroid receptors in the spleen. The results showed that females had a higher parasite load, while infected males had significantly decreased levels of epinephrine. The expression of IL-2 and IL-4 increased in the spleen of infected mice, but the expression of IL-10 and IFN-gamma decreased. Additionally, differences were observed between the non-infected and infected mice, including increased estradiol levels in infected males and decreased levels in females.
Article
Microbiology
Laura Sanchez-Garcia, Armando Perez-Torres, Samira Munoz-Cruz, Norma Salaiza-Suazo, Jorge Morales-Montor, Ingeborg Becker
Summary: The presence of male sex hormones modulates the mast-cell response to Leishmania infections and salivary proteins of the sand fly vector, inducing an intense inflammatory response. Their absence in orchiectomized mice results in a delayed inflammatory response, enabling better control of the infection and slower disease progression.
Article
Environmental Sciences
Mariana Segovia-Mendoza, Margarita Isabel Palacios-Arreola, Luz Maria Monroy-Escamilla, Alexandra Estela Soto-Pina, Karen Elizabeth Nava-Castro, Yizel Becerril-Alarcon, Roberto Camacho-Beiza, David Eduardo Aguirre-Quezada, Elias Cardoso-Pena, Omar Amador-Munoz, Jose de Jesus Garduno-Garcia, Jorge Morales-Montor
Summary: The results of the study support the hypothesis of a positive association between exposure to phthalates and the incidence of breast cancer.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Editorial Material
Microbiology
Jorge Morales-Montor, Derek M. McKay, Luis Terrazas
Article
Biochemistry & Molecular Biology
Rocio Alejandra Ruiz Manzano, Karen Elizabeth Nava-Castro, Margarita Isabel Palacios-Arreola, Rosalia Hernandez-Cervantes, Victor Hugo Del Rio-Araiza, Mariana Segovia-Mendoza, Armando Perez-Torres, Manuel Ivan Giron-Perez, Jorge Morales-Montor
Summary: Breast cancer treatment failure is related to low response rates, high costs, and long-term toxicities. The study found that the androstene-3 beta, 17 alpha-diol (alpha-AED) has potential as a less toxic and effective treatment for triple-negative mammary tumors. In vitro experiments showed that higher doses of alpha-AED have an antiproliferative effect on tumor cells. In vivo experiments demonstrated that intratumoral administration of alpha-AED reduced tumor weight and increased the percentage of natural killer cells in mice tumors. These findings suggest that alpha-AED may be a promising alternative or adjunct therapy for breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Oncology
Karen Elizabeth Nava-Castro, Mariana Segovia-Mendoza, Jorge Morales-Montor
FRONTIERS IN ONCOLOGY
(2022)
Letter
Toxicology
Gregory J. Garvey, Janet K. Anderson, Philip P. Goodrum, Kirby H. Tyndall, L. Anthony Cox, Mahin Khatami, Jorge Morales-Montor, Rita S. Schoeny, Jennifer G. Seed, Rajeev K. Tyagi, Christopher R. Kirman, Sean M. Hays
CRITICAL REVIEWS IN TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Moises Rubio-Osornio, Carmen T. Gomez-De Leon, Sergio Montes, Carmen Rubio, Camilo Rios, Antonio Monroy, Jorge Morales-Montor
Summary: Parkinson's disease is characterized by oxidative stress and immune activation. Simvastatin, a cholesterol-regulating drug, can protect against atherosclerosis disease. Pretreatment with simvastatin reduced MPP+-induced damage in rats and decreased inflammation response proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Toxicology
Gregory J. Garvey, Janet K. Anderson, Philip E. Goodrum, Kirby H. Tyndall, L. Anthony Cox, Mahin Khatami, Jorge Morales-Montor, Rita S. Schoeny, Jennifer G. Seed, Rajeev K. Tyagi, Christopher R. Kirman, Sean M. Hays
Summary: An independent international expert panel found moderate evidence that PFOS and PFOA are immunotoxic based on animal data. However, limitations in data make it difficult to establish species concordance and human relevance. The panel recommends further testing and research to overcome these limitations and better understand the immunotoxicity of PFAS.
CRITICAL REVIEWS IN TOXICOLOGY
(2023)
