Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 284, Issue -, Pages 94-102Publisher
ELSEVIER
DOI: 10.1016/j.bbr.2015.02.017
Keywords
Taste; Neophobia; Perirhinal cortex; Hippocampus; Learning; Memory
Categories
Funding
- Spanish Subdireccion General de Proyectos de Investigacion
- Ministerio de Economia y Competitividad (Madrid, Spain)
- European Regional Development Fund-ERDF [PSI2013-41098-P]
Ask authors/readers for more resources
Although the perirhinal cortex (Prh) has been extensively related to recognition memory, little is known about its specific role in taste memories. The main aim of the present series was therefore to examine the effect of neurotoxic lesions of the Prh on taste neophobia, a phenomenon consisting of a low intake of a novel food until its postingestive consequences are determined. The results showed that Prh-lesioned rats consumed significantly more novel saccharin in trial 1 than control subjects when a saccharin solution of 0.3% (expt la) and 0.5%'(expt. 1 b) was presented. However, when the saccharin concentration was high and qualitatively more aversive, Prh lesions did not affect the neophobic response (0.7%, expt. 1c) and the lesioned and control animals consumed a similar amount of the fluid during the first and subsequent test trials. In all three experiments, Prh-lesioned and control rats showed a comparable intake at asymptote. Experiment 2 and 3 showed that neurotoxic lesions to the dorsal hippocampus prior to or 24 h after the intake of the novel taste (0.3% saccharin) had no effect on the initial occurrence of the neophobic response or on the consolidation of safe taste memory, respectively. These findings support a dissociation of functions between the Prh and the hippocampus in taste neophobia. Also, the data suggests that the Prh plays an essential role in detecting the novelty of the new tastant. (C) 2015 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available