A case-study investigating the physicochemical characteristics that dictate the function of a liposomal adjuvant

The Mincle-Activating Adjuvant TDB Induces MyD88-Dependent Th1 and Th17 Responses through IL-1R Signaling

(2013) Christiane Desel et al.   PLoS One

Manipulation of the surface pegylation in combination with reduced vesicle size of cationic liposomal adjuvants modifies their clearance kinetics from the injection site, and the rate and type of T cell response

(2012) Randip Kaur et al.   JOURNAL OF CONTROLLED RELEASE

A cationic vaccine adjuvant based on a saturated quaternary ammonium lipid have different in vivo distribution kinetics and display a distinct CD4 T cell-inducing capacity compared to its unsaturated analog

(2012) Dennis Christensen et al.   JOURNAL OF CONTROLLED RELEASE

Antigen depot is not required for alum adjuvanticity

(2011) Sharon Hutchison et al.   FASEB JOURNAL

Targeting Syk-Card9-activating C-type lectin receptors by vaccine adjuvants: Findings, implications and open questions

(2011) Roland Lang et al.   IMMUNOBIOLOGY

The vesicle size of DDA:TDB liposomal adjuvants plays a role in the cell-mediated immune response but has no significant effect on antibody production

(2011) Malou Henriksen-Lacey et al.   JOURNAL OF CONTROLLED RELEASE

Pegylation of DDA:TDB liposomal adjuvants reduces the vaccine depot effect and alters the Th1/Th2 immune responses

(2011) Randip Kaur et al.   JOURNAL OF CONTROLLED RELEASE

Effect of vesicle size on tissue localization and immunogenicity of liposomal DNA vaccines

(2011) Myrra G. Carstens et al.   VACCINE

Increased potential of a cationic liposome-based delivery system: Enhancing stability and sustained immunological activity in pre-clinical development

(2010) Afzal R. Mohammed et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Administration routes affect the quality of immune responses: A cross-sectional evaluation of particulate antigen-delivery systems

(2010) Deepa Mohanan et al.   JOURNAL OF CONTROLLED RELEASE

Liposomal cationic charge and antigen adsorption are important properties for the efficient deposition of antigen at the injection site and ability of the vaccine to induce a CMI response

(2010) Malou Henriksen-Lacey et al.   JOURNAL OF CONTROLLED RELEASE

Cutting Edge: Mincle Is Essential for Recognition and Adjuvanticity of the Mycobacterial Cord Factor and its Synthetic Analog Trehalose-Dibehenate

(2010) H. Schoenen et al.   JOURNAL OF IMMUNOLOGY

Subunit Vaccines: Distearoylphosphatidylcholine-Based Liposomes Entrapping Antigen Offer a Neutral Alternative to Dimethyldioctadecylammonium-Based Cationic Liposomes as an Adjuvant Delivery System

(2010) Sarah E. McNeil et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Comparison of the Depot Effect and Immunogenicity of Liposomes Based on Dimethyldioctadecylammonium (DDA), 3β-[N-(N′,N′-Dimethylaminoethane)carbomyl] Cholesterol (DC-Chol), and 1,2-Dioleoyl-3-trimethylammonium Propane (DOTAP): Prolonged Liposome Retention Mediates Stronger Th1 Responses

(2010) Malou Henriksen-Lacey et al.   MOLECULAR PHARMACEUTICS

Mechanism of immunopotentiation by aluminum-containing adjuvants elucidated by the relationship between antigen retention at the inoculation site and the immune response

(2010) Stephanie M. Noe et al.   VACCINE

Radiolabelling of Antigen and Liposomes for Vaccine Biodistribution Studies

(2010) Malou Henriksen-Lacey et al.   Pharmaceutics

Liposomes based on dimethyldioctadecylammonium promote a depot effect and enhance immunogenicity of soluble antigen

(2009) Malou Henriksen-Lacey et al.   JOURNAL OF CONTROLLED RELEASE

Adjuvanticity of a synthetic cord factor analogue for subunitMycobacterium tuberculosisvaccination requires FcRγ–Syk–Card9–dependent innate immune activation

(2009) Kerstin Werninghaus et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tuberculosis Subunit Vaccination Provides Long-Term Protective Immunity Characterized by Multifunctional CD4 Memory T Cells

(2009) T. Lindenstrom et al.   JOURNAL OF IMMUNOLOGY

Liposome-based cationic adjuvant formulations (CAF): Past, present, and future

(2009) Dennis Christensen et al.   JOURNAL OF LIPOSOME RESEARCH

α,α′-trehalose 6,6′-dibehenate in non-phospholipid-based liposomes enables direct interaction with trehalose, offering stability during freeze-drying

(2008) Dennis Christensen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Liposomes act as stronger sub-unit vaccine adjuvants when compared to microspheres

(2008) Daniel J. Kirby et al.   JOURNAL OF DRUG TARGETING

PLGA microspheres for the delivery of a novel subunit TB vaccine

(2008) Daniel J. Kirby et al.   JOURNAL OF DRUG TARGETING

Cationic Liposomes Formulated with Synthetic Mycobacterial Cordfactor (CAF01): A Versatile Adjuvant for Vaccines with Different Immunological Requirements

(2008) Else Marie Agger et al.   PLoS One