Article
Chemistry, Physical
Yongbo Qiao, YaXin Zhang, Jie Chen, Shenghui Jin, Yaming Shan
Summary: This study reports a biepitope nanovaccine for universal influenza vaccine development by incorporating multiple epitopes. The vaccine provides complete protection against H3N2 virus and partial protection against H1N1 virus. Subcutaneous immunization with the vaccine induces robust immune responses.
Article
Biology
Isil Kutluturk Karagoz, Mucahit Kaya, Rene Ruckert, Nazli Bozman, Vildan Kaya, Halim Bayram, Mustafa Yildirim
Summary: A study found that pre-existing virus-reactive T-cells in COVID-19 patients may be due to similarity with certain allergens. The presence of these cells may affect the course of the disease, but further research is needed to determine their specific role.
COMPUTATIONAL BIOLOGY AND CHEMISTRY
(2023)
Article
Immunology
Kunal Bhattacharya, Israa M. Shamkh, Mohammad Shahbaz Khan, Marwa M. Lotfy, Jean Bosco Nzeyimana, Reem Fawaz Abutayeh, Nadia M. Hamdy, Dalia Hamza, Nongmaithem Randhoni Chanu, Pukar Khanal, Atanu Bhattacharjee, Emad B. Basalious
Summary: A potential vaccine against the monkeypox virus was developed using bioinformatics and immunoinformatics. The constructed multiepitope vaccine showed good antigenicity, non-allergenicity, and non-toxicity. In silico expression studies and cloning in E. coli were successful, making the vaccine construct suitable for mass production in the pharmaceutical industry.
Article
Chemistry, Multidisciplinary
Fengyun Shen, Zijian Xiong, Yumin Wu, Rui Peng, Yue Wang, Lele Sun, Chunhai Fan, Zhuang Liu
Summary: Researchers constructed framework nucleic acids (FNAs) with regulated rigidity and size to organize epitopes and investigated their influence on peptide vaccine efficiency. They found that assembling epitopes on rigid tetrahedral FNAs could enhance their immunogenicity. By integrating epitopes from SARS-CoV-2 on preferred tFNAs, a COVID-19 peptide vaccine was developed, inducing high antibody titers and increasing memory B and T cell ratio in mice. This research provides a new idea for developing efficient peptide vaccines.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Immunology
Jonas Birkelund Nilsson, Alba Grifoni, Alison Tarke, Alessandro Sette, Morten Nielsen
Summary: PopCover-2.0 is an effective method for rational selection of peptide subsets with broad HLA and pathogen coverage, its effectiveness has been demonstrated through historical data and experimental validation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Peripheral Vascular Disease
Ryo Nakamaru, Hironori Nakagami, Hiroki Hayashi, Jiao Sun, Akiko Tenma, Koichi Yamamoto, Munehisa Shimamura, Ryuichi Morishita, Hiromi Rakugi
Summary: The peptide vaccine AJ-Ang II, which combines AJP001 with Ang II, can increase the anti-Ang II antibody titer in mice and induce a Th2 response. In addition, immunized mice showed significantly lower blood pressure and attenuated perivascular fibrosis induced by Ang II in the heart.
JOURNAL OF HYPERTENSION
(2021)
Article
Biochemistry & Molecular Biology
Ali Forouharmehr, Narges Nazifi, Seyyed Mojtaba Mousavi, Amin Jaydari
Summary: The current study aimed to design an epitope-based vaccine against bovine babesiosis. Four immunogenic proteins were selected and used for epitope prediction. The designed vaccine showed antigenicity, non-allergenicity, and stability. It could stably bind to TLR/MD-2. The DNA sequence of the vaccine was suitable for cloning in a vector. This vaccine can be considered as a potential candidate for preventing bovine babesiosis.
PROCESS BIOCHEMISTRY
(2022)
Article
Computer Science, Artificial Intelligence
Yanyi Chu, Yan Zhang, Qiankun Wang, Lingfeng Zhang, Xuhong Wang, Yanjing Wang, Dennis Russell Salahub, Qin Xu, Jianmin Wang, Xue Jiang, Yi Xiong, Dong-Qing Wei
Summary: The study presents the TransMut framework, which automatically optimizes mutated peptides with higher affinity to the target HLA allele. This framework provides an automated approach for screening immunogenic peptides and vaccine design.
NATURE MACHINE INTELLIGENCE
(2022)
Article
Immunology
Fang-Fang Zhang, Yaru Qiao, Yu Xie, Chenlu Liu, Hui Wu, Jia-Xin Wu, Xiang-Hui Yu, Wei Kong, Hai-Hong Zhang
Summary: This study demonstrates for the first time that the FAP.291 minigene vaccine can induce mouse CTLs and function as a tumor regression antigen. However, the analogue epitope FAP.291I9 did not enhance the anti-tumor immune response, possibly due to increased levels of immunosuppressive factors.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Elham Jafari, Shirin Mahmoodi
Summary: The study designed a potential vaccine against Helicobacter Pylori using immunoinformatics, incorporating selected epitopes and honey bee venom protein as an adjuvant. Experimental results showed high antigenicity and non-allergenic potential of the vaccine.
MICROBIAL PATHOGENESIS
(2021)
Article
Immunology
Kush Savsani, Gabriel Jabbour, Sivanesan Dakshanamurthy
Summary: The study developed an epitope selection method for MHC targeting peptide vaccines, which was validated through experimental data. Applying clinical checkpoint filters to epitope selection proved to be an effective method for identifying top epitopes for vaccine design.
Article
Immunology
Sadhana Suri, Sivanesan Dakshanamurthy
Summary: In this study, a comprehensive machine learning method called IntegralVac was developed to predict peptide binding affinity and immunogenicity for vaccine design in COVID-19 and cancer research. IntegralVac integrated three existing deep learning tools and showed improved prediction accuracy compared to control servers. The method was validated using multiple datasets and additional clinical checkpoint filters were implemented to further enhance prediction accuracy.
Article
Biochemistry & Molecular Biology
Fei Zhu, Shiyang Ma, Haicheng Wen, Mingjun Rao, Peipei Zhang, Wenzhong Peng, Yanhui Cui, Hang Yang, Caixia Tan, Jie Chen, Pinhua Pan
Summary: This study developed a potential effective vaccine against Staphylococcus aureus by mapping epitopes and using bioinformatics and molecular dynamic simulation to predict and validate its stability and immunological effects. The vaccine may aid in controlling the spread of S. aureus infection.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Cell Biology
Audrey Kassardjian, Eric Sun, Jamie Sookhoo, Krithika Muthuraman, Kayluz Frias Boligan, Iga Kucharska, Edurne Rujas, Arif Jetha, Donald R. Branch, Shawn Babiuk, Brian Barber, Jean-Philippe Julien
Summary: To avoid the need for adjuvants, we developed a stable immunotargeting vaccine (ITV) that utilized the pan-HLA-DR monoclonal antibody 44H10 to deliver the viral spike protein receptor-binding domain (RBD) to antigen-presenting cells. Adjuvant-free ITV immunization induced strong antibody responses against RBD and provided protection against SARS-CoV-2 variants in animal models.
Article
Biology
Julia Bauza-Martinez, Albert J. R. Heck, Wei Wu
Summary: Bauza-Martinez et al. analyzed the HLA-I peptide ligandome in extracellular vesicles (EVs) from an EBV-immortalized B cell line, JY, and compare HLA-I-binding peptides recovered from EVs to those recovered from whole-cells. The authors report an enrichment for HLA-B-binding peptides and for post-translationally modified cysteinylated peptides in EVs as compared to whole-cells.
COMMUNICATIONS BIOLOGY
(2021)