Article
Chemistry, Multidisciplinary
Razie Amraei, Wenqing Yin, Marc A. Napoleon, Ellen L. Suder, Jacob Berrigan, Qing Zhao, Judith Olejnik, Kevin Brown Chandler, Chaoshuang Xia, Jared Feldman, Blake M. Hauser, Timothy M. Caradonna, Aaron G. Schmidt, Suryaram Gummuluru, Elke Muehlberger, Vipul Chitalia, Catherine E. Costello, Nader Rahimi
Summary: The study identified CD209L and CD209 as receptors for SARS-CoV-2 entry into human cells. CD209L is prominently expressed in lung and kidney tissues and interacts with ACE2, potentially playing a role in SARS-CoV-2 infection. This finding may have implications for antiviral drug development in tissues where ACE2 expression is low or absent.
ACS CENTRAL SCIENCE
(2021)
Article
Multidisciplinary Sciences
Lei Guo, Yan Liang, Heng Li, Huiwen Zheng, Zening Yang, Yanli Chen, Xin Zhao, Jing Li, Binxiang Li, Haijing Shi, Ming Sun, Longding Liu
Summary: Glycosylation of the SARS-CoV-2 spike glycoprotein is crucial for viral entry and immune evasion, with different glycan patterns affecting binding affinities to C-type lectin receptors. Although C-type lectin receptors do not support productive viral infection, they play a significant role in viral trans and cis-infection, especially with virions containing a high-mannose structure at specific glycan sites. This highlights the importance of viral epigenetic glycosylation in authentic viral infection and the co-receptor role of DC&L-SIGN in SARS-CoV-2 infection and prevention.
Article
Immunology
Hyeongjwa Choi, Seung-Woo Yang, Jin-Soo Joo, Min Park, Yihua Jin, Ji-Woon Kim, Seon-Yeong Lee, Sung-Vin Lee, Tae-Jin Yun, Mi-La Cho, Han-Sung Hwang, Young-Sun Kang
Summary: Although the exact action mechanisms of IVIg are not fully understood, the interaction between DC-SIGN and sIVIg in HBCs promotes IL-10 secretion and enhances immune tolerance. This suggests the therapeutic application of sIVIg to prevent preeclampsia, a major complication in pregnancy.
CLINICAL IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Li Xiaocui, Hong Wei, Cai Yunlang, Zheng Zhenzhen, An Min
Summary: This study investigated the role of DC-SIGN(+) macrophages in the immune microenvironment of endometriosis and found that CSF-1 can induce the polarization of macrophages into cells with a DC-SIGN(+) phenotype. Further investigation of the mechanism and biological activities of CSF-1-induced DC-SIGN(+) macrophages is important for enhancing our understanding of the physiology of endometriosis.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Biology
Rohan P. Choraghe, Aaron K. Neumann
Summary: Dectin-1 and DC-SIGN collaborate to enhance the capture and retention of Candida albicans, with Dectin-1 playing a crucial role in promoting the recruitment of DC-SIGN to the contact site.
Article
Multidisciplinary Sciences
Wenjing Dong, Erqun Song, Yang Song
Summary: The study found that co-treatment of LPS/D-GalN exhibited genotoxic effects on liver and brain cells in mice, but not on sperm and bone marrow cells. This indicates the potential genotoxicity of LPS/D-GalN administered together, suggesting it as an in vivo experimental model for genotoxic studies.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Jorge Postigo-Fernandez, Rebuma Firdessa-Fite, Remi J. Creusota
Summary: Antigen-specific immunotherapy using tailored epitopes delivered through proteins, peptides, or nucleic acids can reestablish tolerance and potentially provide precision medicine approach for treating tissue-specific autoimmune diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Aleksandra Kopacz, Damian Kloska, Dominik Cysewski, Izabela Kraszewska, Karolina Przepiorska, Malgorzata Lenartowicz, Agnieszka Loboda, Anna Grochot-Przecezek, Witold Nowak, Alicja Jozkowicz, Aleksandra Piechota-Polanczyk
Summary: The study found that hemolysis and statin treatment in patients with hypertension may lead to heme degradation and iron accumulation in the kidneys, resulting in kidney failure. The study also identified mucin-1 as a protective factor against oxidative stress caused by heme and iron. Overall, the results suggest that hypertensive patients with less active HMOX1 alleles may have a higher risk of kidney injury after statin treatment.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Immunology
Rafael Tiburcio, Leon Dimitri Melo, Sara Nunes, Ana Luisa Augusto Barbosa, Elaine Carvalho de Oliveira, Martha Suarez, Valeria M. Borges, Natalia Tavares, Claudia Ida Brodskyn
Summary: This study focused on the interaction between PMNs and infected DCs in an in vitro model of Leishmania amazonensis infection. It was found that infected DCs showed lower infection rates when co-cultured with resting or activated PMNs. The release of neutrophil enzymes was not involved in parasite killing, and the interaction between PMNs and infected DCs was mediated by DC-SIGN. This study highlights the importance of direct contact between PMNs and infected DCs via DC-SIGN for the production of inflammatory mediators and subsequent parasite elimination.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Environmental Sciences
Fengming Yang, Yongfeng Gao, Jikai Liu, Zihao Chen, Victor Resco de Dios, Qian Gao, Meng Zhang, Zhuoxi Peng, Yinan Yao
Summary: With the increasing demand in the electric vehicle industry, the distribution of Mn and Co in plants has become more significant. Research shows that PtrMTP6 plays a crucial role in the transportation of Mn and Co in poplar. Overexpression of PtrMTP6 led to more severe damage under high Co concentrations, while there was little change in tolerance to excess Mn. Further studies on the regulation of PtrMTP6 could enhance bioremediation in ecosystems contaminated with Mn and Co.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Immunology
Mei Yin, Joungmin Kim, Jeong-Il Choi, Joon-Suk Bom, Hong-Beom Bae, Seongtae Jeong
Summary: Adenosine monophosphate-activated protein kinase (AMPK) activator metformin inhibits the development of endotoxin tolerance by suppressing the production and signaling pathway of TGF-beta 1 induced by LPS stimulation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Plant Sciences
Tao Zou, Ruoyi Lin, Lin Pu, Qiming Mei, Zhengfeng Wang, Shuguang Jian, Mei Zhang
Summary: Plant metal tolerance proteins (MTPs) play crucial roles in heavy metal uptake and homeostasis in plants. The origin and diversification of MTPs from red canavalia were explored using genome-wide and phylogenetic methods. Different promoter regions of CrMTPs contain a variety of heavy metal regulated elements and stress-responsive elements, influencing heavy metal stress responses and adaptation in C. rosea plants. Functions and molecular mechanisms of heavy metal absorption, translocation, and accumulation in C. rosea plants were investigated through transcriptome data analysis and yeast experiments.
Article
Chemistry, Multidisciplinary
Vanessa Porkolab, Martin Lepsik, Stefania Ordanini, Alexander St John, Aline Le Roy, Michel Thepaut, Emanuele Paci, Christine Ebel, Anna Bernardi, Franck Fieschi
Summary: DC-SIGN functions as the coreceptor for SARSCoV-2 virus, and a glycomimetic ligand called Polyman26 inhibits DC-SIGN-dependent trans-infection. By designing dendrimer constructs that can engage two binding sites of the tetrameric DC-SIGN simultaneously, the researchers were able to achieve nanomolar affinity. This study opens up possibilities for developing new virus attachment blockers for different C-type lectin receptors.
ACS CENTRAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Grzegorz Dyduch, Apolonia Miazek, Lukasz Laskowicz, Joanna Szpor
Summary: Treatment options for endometrial cancer are not satisfactory for advanced cases, leading to interest in novel immunological therapies. This study investigated the role of dendritic cells (DCs) in endometrial cancer and found that the distribution of different DC subtypes was associated with the grade and stage of the cancer. The study highlights the potential of targeting specific DC subsets for future treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Natalia Alvarez, Sandra M. Gonzalez, Juan C. Hernandez, Maria T. Rugeles, Wbeimar Aguilar-Jimenez
Summary: The study suggests that vitamin D may reduce HIV-1 transmission by regulating the gene expression of dendritic cells (DCs). DCs treated with vitamin D exhibit decreased expression of molecules associated with viral transfer, leading to a reduced transfer of viral particles.