Article
Clinical Neurology
Luis R. Patino, Maxwell J. Tallman, Hongbo Wen, Caleb M. Adler, Jeffrey A. Welge, Melissa P. DelBello
Summary: The objective of this study was to evaluate differences in sustained attention and associated neurofunctional profiles between bipolar disorder type I, attention-deficit/hyperactivity disorder, and healthy comparison youth. Adolescent participants underwent MRI while completing a modified Continuous Performance Task. BD participants displayed deficits in sustained attention and lower activation in brain regions associated with performance and neural integration. These differences were distinct to the BD group and not attributable to ADHD comorbidity.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Tong Guo, Yuan Yang, Qian Zhao, Lei Zhang, Chee H. Ng, Teris Cheung, Yang Li, Xue-Quan Zhu, Xiao-Hong Li, Yu-Tao Xiang
Summary: The study aimed to assess the clinical phenomenology and characteristics of prodromal symptoms in Chinese patients with bipolar disorder prior to their index mood episode. The findings indicated that identifying prodromal symptoms of BPD may be beneficial for early diagnosis and intervention before the development of full episodes.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Jane E. Persons, Paul Lodder, William H. Coryell, John Nurnberger, Jess G. Fiedorowicz
Summary: This study found that manic and anxiety symptoms did not significantly contribute to suicidal ideation and behavior in individuals with bipolar disorder during a depressive state, with the main risk factor being severe depressive symptoms. The limitations of small sample size and measurement tools may have influenced these findings, suggesting future studies would benefit from larger samples and more rigorous assessments.
PSYCHIATRY RESEARCH
(2022)
Article
Psychiatry
F. Pacchioni, F. Casoni, A. Sarzetto, F. Attanasio, B. Barbini, M. Locatelli, C. Colombo, M. C. Cavallini, L. Fregna
Summary: Sleep plays a crucial role in the development and manifestation of mood disorders, but few studies have examined sleep architecture during manic episodes of Bipolar Disorder (BD) and changes in sleep parameters. This study investigated 21 BD patients in the manic phase and found that their sleep quantity and quality improved during hospitalization, accompanied by clinical improvement. The study also revealed an increase in REM sleep. These findings suggest that changes in sleep architecture can serve as sensitive markers for clinical variations during manic phases of Bipolar Disorder.
PSYCHIATRY RESEARCH
(2023)
Article
Behavioral Sciences
Nicole M. Sekula, Anastasia K. Yocum, Steven Anderau, Melvin G. McInnis, David F. Marshall
Summary: This study reveals that comorbid migraine in patients with BD is associated with worse clinical outcomes, and the use of lithium may exacerbate manic symptoms in BD patients with a history of migraines.
BRAIN AND BEHAVIOR
(2022)
Review
Clinical Neurology
Guido Cereda, Paolo Enrico, Valentina Ciappolino, Giuseppe Delvecchio, Paolo Brambilla
Summary: Most studies found no significant differences in vitamin D levels between bipolar disorder patients and other psychiatric disorders, with the average values in the bipolar population being sub-threshold for deficiency. Although an association between vitamin D levels and clinical symptoms was observed, it is not a specific marker for bipolar disorder but a common characteristic shared with other psychiatric disorders. Additionally, vitamin D supplementation was linked to a reduction in depressive and manic symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Catarina Rodrigues Cordeiro, Beatriz Romao Corte-Real, Rodrigo Saraiva, Benicio N. Frey, Flavio Kapczinski, Taiane de Azevedo Cardoso
Summary: This systematic review aimed to identify triggers of acute mood episodes in bipolar disorder (BD). The review found that pharmacotherapy, particularly the use of antidepressants, was the trigger with the strongest evidence for manic/hypomanic relapse. Other identified triggers for mania included brain stimulation, energy drinks, acetyl-lcarnitine, St. John's wort, seasonal changes, hormonal changes, and viral infections. However, there is a lack of evidence regarding triggers for depressive relapses in BD, highlighting the need for further research in this area.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychiatry
Mahdieh Saeidi, Tara Rezvankhah, Victor Pereira-Sanchez, Maryam Rafieian, Behnam Shariati, Soode Tajik Esmaeeli, Maziar Emamikhah, Kaveh Alavi, Amir Shabani, Shiva Soraya, Fatemeh Kashaninasab, Fatemeh Sadat Mirfazeli
Summary: A case series study was conducted to document the clinical presentations, family aggregation patterns, and brain imaging correlates of patients with manic episodes shortly after COVID-19 infections. The study found that a family history of bipolar disorder and the use of corticosteroids may be factors to focus on in further research.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Endocrinology & Metabolism
Vania Machado Recart, Luiza Spohr, Mayara Sandrielly Pereira Soares, Karina Pereira Luduvico, Francieli Moro Stefanello, Roselia Maria Spanevello
Summary: Bipolar disorder is characterized by mood swings and remains poorly understood with limited treatment options. Recent studies suggest that natural compounds may hold therapeutic potential in alleviating symptoms of BD.
METABOLIC BRAIN DISEASE
(2021)
Article
Behavioral Sciences
Samira S. Valvassori, Jorge M. Aguiar-Geraldo, Taise Possamai-Della, Dayane D. da-Rosa, Jefte Peper-Nascimento, Jose H. Cararo, Joao Quevedo
Summary: The study suggests that long-term Na+K+ATPase inhibition induces depressive-like behavior in rats, accompanied by increased inflammation. Lithium treatment partially reverses these detrimental behaviors.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Article
Psychiatry
Rebecca E. Easter, Kelly A. Ryan, Ryne Estabrook, David F. Marshall, Melvin G. McInnis, Scott A. Langenecker
Summary: This study found that cognitive performance is largely unrelated to depressive and manic symptoms in patients with bipolar disorder. The results suggest that cognitive dysfunction is stable in BD and is not dependent on mood state. Future research could investigate how treatment affects the relationship between cognition and mood.
ACTA PSYCHIATRICA SCANDINAVICA
(2022)
Article
Psychiatry
Marta Migo, Kendra Simpson, Amy Peters, Kristen K. Ellard, Tina Chou, Andrew A. Nierenberg, Darin D. Dougherty, Thilo Deckersbach
Summary: By dimensionally analyzing symptom severity in patients with bipolar disorder, more accurate differences in neural responses to emotional stimuli can be captured. There is a correlation between symptom severity and brain activation, with depression severity associated with increased activation in various brain regions and mania severity associated with both increased and decreased activation.
PSYCHIATRY RESEARCH
(2022)
Article
Psychiatry
Norio Sugawara, Naoto Adachi, Yukihisa Kubota, Yoichiro Watanabe, Kazuhira Miki, Takaharu Azekawa, Koji Edagawa, Eiichi Katsumoto, Seiji Hongo, Eiichiro Goto, Hitoshi Ueda, Masaki Kato, Reiji Yoshimura, Atsuo Nakagawa, Toshiaki Kikuchi, Takashi Tsuboi, Koichiro Watanabe, Kazutaka Shimoda, Norio Yasui-Furukori
Summary: This study investigated the long-term clinical outcomes of patients with bipolar disorder (BD) and identified several predictors of these outcomes. The findings can assist clinicians in predicting the course of the illness based on demographic and clinical characteristics.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Review
Clinical Neurology
Beatriz Corte-Real, Rodrigo Saraiva, Catarina Rodrigues Cordeiro, Benicio N. Frey, Flavio Kapczinski, Taiane de Azevedo Cardoso
Summary: The study aimed to investigate whether atypical antipsychotics (AA) can induce mania in mood disorders. A systematic review and meta-analysis showed that AA-induced mania is rare and the use of AA is more effective in preventing the development of mania compared to placebo.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Pharmacology & Pharmacy
Cuirong Zeng, Yan Qiu, Sujuan Li, Ziwei Teng, Hui Xiang, Jindong Chen, Xiangxin Wu, Ting Cao, Shuangyang Zhang, Qian Chen, Haishan Wu, HuaLin Cai
Summary: This study aimed to investigate the effects of probiotic supplementation on oxidative stress biomarkers and clinical symptoms in patients with bipolar disorder. The results showed that probiotics had advantageous effects on specific clinical symptoms, especially manic symptoms, in these patients. The changes in plasma oxidative stress biomarkers may serve as prognostic indexes for bipolar patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biology
Carmel Bilu, Paul Zimmet, Vicktoria Vishnevskia-Dai, Haim Einat, Galila Agam, Ehud Grossman, Noga Kronfeld-Schor
JOURNAL OF BIOLOGICAL RHYTHMS
(2019)
Article
Pharmacology & Pharmacy
Lydmila Kazavchinsky, Anat Dafna, Haim Einat
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
(2019)
Editorial Material
Behavioral Sciences
Jared W. Young, Haim Einat
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2019)
Article
Behavioral Sciences
Anat Lan, Haim Einat
BEHAVIOURAL BRAIN RESEARCH
(2019)
Article
Biology
Carmel Bilu, Haim Einat, Katy Tal-Krivisky, Joseph Mizrahi, Vicktoria Vishnevskia-Dai, Galila Agam, Noga Kronfeld-Schor
CHRONOBIOLOGY INTERNATIONAL
(2019)
Review
Medicine, General & Internal
P. Zimmet, K. G. M. M. Alberti, N. Stern, C. Bilu, A. El-Osta, H. Einat, N. Kronfeld-Schor
JOURNAL OF INTERNAL MEDICINE
(2019)
Article
Neurosciences
Jia Wang, Qi Yun, Jin-Jun Qian, Hua-Rong Song, Lei Wang, Samuel Eguasi Inkabi, Ru-Jing Xu, Yan-Mei Hu, Wei-Ning Zhang, Haim Einat
NEUROPSYCHOBIOLOGY
(2019)
Article
Multidisciplinary Sciences
Carmel Bilu, Haim Einat, Orly Barak, Paul Zimmet, Vicktoria Vishnevskia-Dai, Amanda Govrin, Galila Agam, Noga Kronfeld-Schor
SCIENTIFIC REPORTS
(2019)
Meeting Abstract
Clinical Neurology
C. Bilu, P. Zimmet, N. Kronfeld-Schor, H. Einat
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2019)
Review
Clinical Neurology
Erez Langer, Haim Einat, Yelena Stukalin
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2020)
Review
Behavioral Sciences
Yelena Stukalin, Anat Lan, Haim Einat
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2020)
Meeting Abstract
Clinical Neurology
Y. Stukalin, A. Lan, H. Einat
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2019)
Meeting Abstract
Clinical Neurology
Y. Stukalin, H. Einat
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2019)
Meeting Abstract
Clinical Neurology
M. Kazavchinsky, A. Lan, A. Dafna, H. Einat
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2019)
Meeting Abstract
Clinical Neurology
A. Lan, M. Alfie, M. Kazavchinsky, H. Einat
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2019)