Article
Cell Biology
Heng Lee, Rong-Nan Chien, Li-Heng Pao, Chia-Jung Kuo, Po-Han Huang, Ming-Ling Chang
Summary: In chronic HCV-infected patients receiving direct-acting antivirals (DAAs), recovery of altered lipid and glucose metabolism in SVR patients was not coupled until 72 weeks post-therapy, when HOMA-IR reached its nadir. SVR patients with baseline IR recovered from HCV-associated metabolic alterations earlier than those without baseline IR.
Article
Medicine, Research & Experimental
Aku Enam Motto, Povi Lawson-Evi, Kwashie Eklu-Gadegbeku
Summary: This study evaluated the antidiabetic properties of hydro alcoholic extract and supernatant fraction of Anogeissus leiocarpus roots. The extract and supernatant showed significant decrease in blood glucose level, improvement in lipid profile, and increased antioxidant potential in diabetic rats. The supernatant fraction exerted stronger antidiabetic and antioxidant effects than the total extract.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pediatrics
A. P. C. Candido, B. Geloneze, A. Calixto, A. C. J. Vasques, R. N. Freitas, S. N. Freitas, G. L. L. Machado-Coelho
Summary: In children and adolescents, HOMA-AD and HOMA-IR are associated with metabolic risk and are the most suitable methods for screening metabolic syndrome, while adiponectin levels are not as indicative of metabolic risk.
INDIAN JOURNAL OF PEDIATRICS
(2021)
Article
Nutrition & Dietetics
Samar R. Saleh, Rania Zaki, Radwa Hassan, Mohamed A. El-Kersh, Mohamed M. El-Sayed, Alshimaa A. Abd Elmoneam
Summary: High doses of vitamin A supplementation increase the risk of hypothyroidism, modulate insulin sensitivity, and over a long period, increase the incidence of type 2 diabetes mellitus associated with oxidative stress and hepatitis.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Pediatrics
Shin-Hee Kim, Yun Jung Choi, Moon Bae Ahn, Won Kyoung Cho, Kyoung Soon Cho, Min Ho Jung, Byung-Kyu Suh
Summary: Among children and adolescents with obesity, serum sclerostin was negatively correlated with HOMA-IR. Further studies are needed to clarify the mechanisms involved to understand how sclerostin affects the glucose metabolism.
Review
Food Science & Technology
Shixiang Li, Aizhen Zong, Ran An, Haiou Wang, Lina Liu, Jie Liu, Xiaofei Guo, Zhixiang Xu, Jing Wang, Duo Li, Fangling Du, Tongcheng Xu
Summary: Whole grain consumption can lower fasting glucose, fasting insulin, HbA1c, and insulin resistance. Oats have a significant effect in reducing glycemic markers, and multiple interventions per day can consolidate the effectiveness of whole grains.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Mona F. Mahmoud, Noura Ali, Islam Mostafa, Rehab A. Hasan, Mansour Sobeh
Summary: The present study aimed to investigate the effect of coriander oil on dexamethasone-induced insulin resistance in rats and characterized its chemical composition using GC-MS. The results showed that coriander oil could be used as an adjuvant antihyperglycemic agent in type 2 diabetes and reversed the abnormal changes caused by insulin resistance.
Article
Environmental Sciences
Maha M. Al-Bazi, Taha A. Kumosani, Abdulrahman L. Al-Malki, Kurunthachalam Kannan, Said S. Moselhy
Summary: This study investigated the incidence of type 2 diabetes mellitus in Saudi subjects and found significant concentrations of urinary phthalate metabolites in diabetic patients. Additionally, the study suggests that phthalate toxicity may contribute to insulin resistance and the development of type 2 diabetes mellitus.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Endocrinology & Metabolism
Xin Chen, Chang Chu, Cornelia Doebis, Volker von Baehr, Berthold Hocher
Summary: The study examined the sex-dependent association between insulin resistance and 25-hydroxyvitamin D [25(OH)D] in a large Caucasian population. Results showed an inverse and independent association between vitamin D and insulin resistance only in women with vitamin D deficiency, suggesting potential benefits of vitamin D supplementation for improving insulin resistance in this group.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Xin Chen, Chang Chu, Cornelia Doebis, Volker von Baehr, Berthold Hocher
Summary: The study found that vitamin D was inversely and independently associated with insulin resistance only in women with vitamin D deficiency. This association was not observed in men or in the vitamin D sufficient group.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Food Science & Technology
Lili Hu, Xinyi Xia, Yue Zong, Yunjie Gu, Li Wei, Jun Yin
Summary: This study investigates the effects of 40% calorie restriction (CR) on the metabolic phenotype and mechanism in mice. The results suggest that CR induces global physiological insulin resistance except in muscle, and enhances glycogen metabolism, leading to the stability of blood glucose levels. CR also results in lipid insufficiency and stress, which contributes to the stable blood glucose levels observed.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Aditya Saxena, Nitish Mathur, Pooja Pathak, Pradeep Tiwari, Sandeep Kumar Mathur
Summary: Insulin resistance (IR) is the precursor and key mechanism of type 2 diabetes (T2D) and metabolic syndrome (MetS), but the pathways shared by IR and T2D are not well understood. This study identified a set of key metagenes shared by IR and T2D using a feature selection method and found that artificial neural network (ANN) performed well in differentiating diabetics from normal glucose tolerant (NGT) persons with 73% accuracy. These key metagenes were also validated in diabetes-associated genetic studies, indicating their potential importance in the molecular pathology of both IR and T2D.
Article
Psychology, Developmental
Peiyu Chen, Ana Baylin, Joyce Lee, Galit Levi Dunietz, Alejandra Cantoral, Martha Maria Tellez Rojo, Karen E. Peterson, Erica C. Jansen
Summary: The study examined the relationship between sleep duration, timing, and insulin resistance in Mexican adolescents. Shorter sleep duration and later sleep timing were both independently associated with higher insulin resistance, particularly among girls.
JOURNAL OF ADOLESCENT HEALTH
(2021)
Article
Endocrinology & Metabolism
Honglin Sun, Xiaona Chang, Nannan Bian, Yu An, Jia Liu, Song Leng, Guang Wang
Summary: Adipose tissue insulin resistance was strongly associated with serum uric acid levels and hyperuricemia regardless of BMI classification. In men with normal BMI, Adipo-IR, rather than HOMA-IR, was closely associated with hyperuricemia. These findings emphasize the critical role of adipose tissue insulin resistance in serum uric acid metabolism and hyperuricemia.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Qu Tian, Brendan A. Mitchell, Ruin Moaddel, Carmine Zoccali, Stefania Bandinelli, Luigi Ferrucci
Summary: This study used metabolomics analysis to identify a specific set of metabolites mediating anisocytosis with aging, including SDMA, ADMA, and 1-methylhistidine.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yupeng He, Marlien van Mever, Wei Yang, Luojiao Huang, Rawi Ramautar, Yvonne Rijksen, Wilbert P. Vermeij, Jan H. J. Hoeijmakers, Amy C. Harms, Peter W. Lindenburg, Thomas Hankemeier
Summary: In this study, the authors focused on the metabolic profiling of muscle tissue in order to understand sarcopenia. They evaluated and compared different sample preparation methods and found that the BMMW method had the highest extraction recovery and matrix effect. They successfully applied this method to small muscle tissue samples and detected a variety of lipids and metabolites. The authors also emphasized the importance of fast sample isolation for more oxidative muscles in sarcopenia studies.
Article
Biochemistry & Molecular Biology
Naama Karu, Alida Kindt, Adriaan J. van Gammeren, Anton A. M. Ermens, Amy C. Harms, Lutzen Portengen, Roel C. H. Vermeulen, Willem A. Dik, Anton W. Langerak, Vincent H. J. van der Velden, Thomas Hankemeier
Summary: This article is significant in characterizing the biochemical response of COVID-19 patients and identifying therapeutic targets. Through LC-MS platform analysis of plasma samples, the study found certain amino acids and derivatives associated with inflammatory responses, contributing to understanding the metabolic status of severe cases.
Article
Chemistry, Analytical
Thomas Hankemeier, Luojiao Huang, Nicolas Drouin, Jason Causon, Agnieszka Wegrzyn, Jose Castro-Perez, Ronan Fleming, Amy Harms
Summary: Accurate reconstruction of metabolic pathways is crucial for understanding metabolomics changes and biological processes in diseases. A tracer-based metabolomics strategy using stable isotope labeled precursors can trace pathways by measuring the transformation of metabolites. By quantifying labeled metabolite substructures, a new method achieves simultaneous isotopic labeling information at the intact metabolite and moiety level. This method was applied to trace the fate of labeled atoms in human-induced pluripotent stem cell-derived neurons, revealing the pathway reconstruction of de novo glutathione synthesis and its alteration under oxidative stress and neurodegeneration.
ANALYTICAL CHEMISTRY
(2023)
Article
Behavioral Sciences
Fiona A. Hagenbeek, Jenny van Dongen, Rene Pool, Peter J. Roetman, Amy C. Harms, Jouke Jan Hottenga, Cornelis Kluft, Olivier F. Colins, Catharina E. M. van Beijsterveldt, Vassilios Fanos, Erik A. Ehli, Thomas Hankemeier, Robert R. J. M. Vermeiren, Meike Bartels, Sebastien Dejean, Dorret Boomsma
Summary: This study introduces and demonstrates the potential of an integrated multi-omics approach in investigating the biology of childhood aggressive behavior. By using single- and integrative multi-omics models, the researchers identified biomarkers for subclinical aggression and studied the connections among these biomarkers. The study found strong associations between DNA methylation, amino acids, and parental non-transmitted polygenic scores with traits like ADHD, Autism Spectrum Disorder, intelligence, smoking initiation, and self-reported health. Aggression-related omics traits were also linked to known and novel risk factors such as inflammation, carcinogens, and smoking.
Review
Biochemistry & Molecular Biology
Chunyuan Yin, Amy C. C. Harms, Thomas Hankemeier, Alida Kindt, Elizabeth C. M. de Lange
Summary: Alzheimer's disease is an aging-related neurodegenerative disease that leads to progressive memory loss and cognitive decline. Understanding the pathogenesis and etiology of the disease is still limited, and there are no effective treatments available. Metabolomics offers a valuable approach to studying biochemical changes and discovering potential therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Plant Sciences
Kanchana Pandian, Minami Matsui, Thomas Hankemeier, Ahmed Ali, Emiko Okubo-Kurihara
Summary: Single-cell metabolomics is a powerful tool for understanding cellular heterogeneity and unraveling the mechanisms of biological phenomena. It holds great promise in plant research, especially when cellular heterogeneity affects different biological processes. Metabolomics, as a detailed phenotypic analysis, is expected to provide answers to previously unaddressed questions, leading to improved crop production, better understanding of disease resistance, and other applications.
Article
Biochemical Research Methods
Balazs Erdos, Johan A. Westerhuis, Michiel E. Adriaens, Shauna D. O'Donovan, Ren Xie, Cecile M. Singh-Povel, Age K. Smilde, Ilja C. W. Arts
Summary: In this study, a novel methodology is introduced to analyze high-dimensional, frequently sampled time-series data from longitudinal intervention studies. The proposed method can quantify the temporal dependency and subject-to-subject variability while considering the study design and temporal dependency. The effectiveness of the method is demonstrated through simulation and metabolomics dataset experiments.
PLOS COMPUTATIONAL BIOLOGY
(2023)
Article
Allergy
Sarah Kristine Norgaard, Nilo Folsgaard, Nadja Hawwa Vissing, Julie Nyholm Kyvsgaard, Bo Chawes, Jakob Stokholm, Age K. Smilde, Klaus Bonnelykke, Hans Bisgaard, Morten Arendt Rasmussen
Summary: This study investigates the disease burden of common childhood diseases and finds a connection between symptom patterns and various factors. The research shows that children experience multiple episodes of illness during the first three years of life, with respiratory infections being the most common. Additionally, certain factors such as prematurity and maternal asthma have a significant impact on symptom burden.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Environmental Sciences
Sophie Sakkaki, Noemie Cresto, Raphael Chancel, Emma Zub, Pierre Sicard, Tangui Maurice, Sandrine Ellero-Simatos, Laurence Gamet-Payrastre, Nicola Marchi, Julie Perroy
Summary: This study investigates the risk of continuous exposure to glyphosate from prenatal to adulthood and the impact of Shank3 synaptic gene mutation on neurological adaptations. The results show that prenatal exposure to glyphosate increases embryonic mortality rate and leads to neuroinflammation and behavioral adaptations in progenies of Shank3(Delta C/+) mice.
ENVIRONMENT INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
Laura Ann Hetzel, Ahmed Ali, Vincenzo Corbo, Thomas Hankemeier
Summary: Organoids are a valuable cell model used to study organ development, disease progression, and treatment effectiveness. The use of microfluidic devices is emerging as a solution to overcome challenges and optimize organoid assays. However, the specific features and materials of these devices must be carefully considered based on the intended application and organoid development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Zhengzheng Zhang, Madhulika Singh, Alida Kindt, Agnieszka B. Wegrzyn, Mackenzie J. Pearson, Ahmed Ali, Amy C. Harms, Paul Baker, Thomas Hankemeier
Summary: The importance of lipidomics research in understanding various diseases, including metabolism, cancer, and the recent COVID-19 pandemic, has led to the development of a targeted HILIC-MS/MS method that allows for comprehensive analysis of lipid species. This method overcomes the challenges posed by the diverse structures and properties of lipids in biological systems, and provides accurate quantitation of lipid concentrations at the fatty acyl chain level. The applicability of this method has been demonstrated through the discovery of differential lipid features related to COVID-19 severity, highlighting its potential for future investigations of the lipidome in different disease contexts.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Multidisciplinary Sciences
Marc Schoeler, Sandrine Ellero-Simatos, Till Birkner, Jordi Mayneris-Perxachs, Lisa Olsson, Harald Brolin, Ulrike Loeber, Jamie D. Kraft, Arnaud Polizzi, Marian Marti-Navas, Josep Puig, Antonio Moschetta, Alexandra Montagner, Pierre Gourdy, Christophe Heymes, Herve Guillou, Valentina Tremaroli, Jose Manuel Fernandez-Real, Sofia K. Forslund, Remy Burcelin, Robert Caesar
Summary: The relationship between dietary lipids and gut microbiota has an impact on the development of liver steatosis. Low intake of saturated fatty acids is associated with increased microbial diversity in humans, while poorly absorbed dietary long-chain saturated fatty acids improve metabolism and steatosis in mice through a shift in bile acid profile.
NATURE COMMUNICATIONS
(2023)
Article
Biochemical Research Methods
Ronan M. T. Fleming, Hulda S. Haraldsdottir, Le Hoai Minh, Phan Tu Vuong, Thomas Hankemeier, Ines Thiele
Summary: Several applications in constraint-based modelling can be formulated as cardinality optimization problems involving the minimization or maximization of the number of nonzeros in a vector. By approximating the zero-norm with nonconvex continuous functions, a set of cardinality optimization problems in constraint-based modelling is reformulated into a difference of convex functions. Novel algorithms are implemented and numerically tested, demonstrating their efficiency and practical utility in various biochemical networks.
Article
Endocrinology & Metabolism
Xinyu Di, Borja Martinez-Tellez, Elke H. J. Krekels, Lucas Jurado-Fasoli, Francisco J. Osuna-Prieto, Lourdes Ortiz-Alvarez, Thomas Hankemeier, Patrick C. N. Rensen, Jonatan R. Ruiz, Isabelle Kohler
Summary: The plasma levels of eCBs and their analogues are associated with higher adiposity and worse cardiometabolic profile.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Yi Ding, Marielle C. Haks, Susan J. F. van den Eeden, Tom H. M. Ottenhoff, Amy C. Harms, Thomas Hankemeier, Muhamed N. H. Eeza, Jorg Matysik, A. Alia, Herman P. Spaink
Summary: The leptin signaling pathway plays an important role in regulating glucose homeostasis, metabolism, and systemic inflammatory responses. However, its metabolic effects on infectious diseases like tuberculosis are not well understood. In this study, the researchers investigated the role of leptin in metabolism in zebrafish larvae and mice in the absence and presence of mycobacterial infection. They found that leptin mutation and mycobacterial infection lead to a similar metabolic syndrome characterized by a decrease in 11 amine metabolites. The researchers concluded that leptin and mycobacterial infection impact metabolism independently, without a synergistic effect. They also observed distinct transcriptomic responses in the leptin mutant zebrafish larvae and mycobacterial infection, which can lead to similar metabolic end states.