Article
Cell Biology
Lobna A. Abdelzaher, Ola A. Hussein, I. E. M. Ashry
Summary: Thimerosal has been accused of being a potential factor in neurodevelopmental disorders, and this study examined the therapeutic effect of montelukast on THIM-induced social deficits in mice. Montelukast was found to alleviate social deficits by upregulating alpha 7nAChRs and downregulating NF-kappa B activation, thereby reducing neuronal toxicity and inflammation.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Article
Environmental Sciences
Sarah A. Carter, Md Mostafijur Rahman, Jane C. Lin, Ting Chow, Xin Yu, Mayra P. Martinez, Pat Levitt, Zhanghua Chen, Jiu-Chiuan Chen, Sandrah P. Eckel, Joel Schwartz, Frederick W. Lurmann, Michael J. Kleeman, Rob McConnell, Anny H. Xiang
Summary: This study found that maternal exposure to aircraft-emitted ultrafine particles (PM0.1) was associated with the diagnosis of autism spectrum disorder (ASD) in children. It is the first study to examine the neurodevelopmental outcomes of aircraft emissions. The results reinforce the evidence that maternal particulate matter exposure during pregnancy poses health risks and identify PM0.1 from aircraft as a novel area for further research and potential regulation.
ENVIRONMENT INTERNATIONAL
(2023)
Review
Endocrinology & Metabolism
Yandra Giovanna de Oliveira Cunha, Giovanna Cavalcanti Brito do Amaral, Alana Almeida Felix, Bruce Blumberg, Angelica Amorim Amato
Summary: This systematic review examined the association between maternal exposure to endocrine-disrupting chemicals (EDCs) during pregnancy and the risk of autism spectrum disorder (ASD) in the offspring. The findings suggest that there is no association between prenatal exposure to specific ECDs and the occurrence of autistic traits in offspring.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Environmental Sciences
Julie Bang Hansen, Niels Bilenberg, Clara Amalie Gade Timmermann, Richard Christian Jensen, Hanne Frederiksen, Anna-Maria Andersson, Henriette Boye Kyhl, Tina Kold Jensen
Summary: This study aimed to assess the association between in utero exposure to BPA and symptoms of ADHD and ASD in 2 and 5-year old Danish children. The results showed that there were no associations between maternal BPA exposure and ASD at age 2 years or ADHD at age 5 years, but a potential link between BPA exposure and ASD symptoms in 5-year old children, especially girls, was found.
ENVIRONMENTAL HEALTH
(2021)
Article
Neurosciences
Asma Oummadi, Arnaud Menuet, Sarah Meresse, Anthony Laugeray, Gilles Guillemin, Stephane Mortaud
Summary: Prenatal maternal immune activation (MIA) and perinatal exposure to xenobiotics have been identified as risk factors for neurological disorders. This study demonstrated that early multi-exposure to insults can lead to neuropathologies, and prenatal immune sensitization can increase susceptibility to subsequent exposure to neurotoxins.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Yuda Huo, Wen Lu, Yuan Tian, Qingming Hou, Heng-Ye Man
Summary: This study found that Prkn knockout mice exhibit autistic-like behaviors and abnormalities in neuronal activity, cell morphology, and synapse density. This suggests the importance of the Prkn gene in brain development and the potential use of Prkn KO mice as a model for autism research.
Article
Environmental Sciences
Yang Zhang, Yao Dang, Fucheng Pei, Yongchao Yuan, Junfa Yuan, Zemao Gu, Jianghua Wang
Summary: This study investigated the subacute toxicity of the agricultural herbicide glufosinateammonium (GLA) on crayfish. The results showed that GLA exposure caused structural damage to the hepatopancreatic tissue, decreased antioxidant capacity, and non-specific immunity in crayfish. These findings provide important insights into the toxicity of herbicides on non-target organisms.
ENVIRONMENTAL POLLUTION
(2023)
Article
Multidisciplinary Sciences
Noi Suzuki, Masahiro Hirai
Summary: A recent study explored the relationship between autism traits, intolerance of uncertainty, and dichotomous thinking. The study found that autistic traits indirectly influenced dichotomous thinking through intolerance of uncertainty. Additionally, it was observed that intolerance of uncertainty was positively associated with autism traits and dichotomous thinking, while there was a negative direct association between autism traits and dichotomous thinking. These findings provide valuable insights into the cognitive patterns of autistic individuals.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
I. S. Plank, L. S. Traiger, A. M. Nelson, J. C. Koehler, S. F. Lang, R. Tepest, K. Vogeley, A. L. Georgescu, C. M. Falter-Wagner
Summary: When people meet, they quickly form impressions of each other. A study found that first impressions of individuals with autism spectrum condition (ASC) are less favorable compared to non-autistic individuals. The study investigated the influence of interpersonal synchrony on impression formation and found that synchrony of motion energy is one driver of these less favorable impressions of autistic people.
SCIENTIFIC REPORTS
(2023)
Review
Behavioral Sciences
Katharina Otten, Lara Keller, Andrei A. Puiu, Beate Herpertz-Dahlmann, Jochen Seitz, Nils Kohn, J. Christopher Edgar, Lisa Wagels, Kerstin Konrad
Summary: This study examined the effects of early antibiotic exposure on ADHD risk and found that prenatal antibiotic exposure may be a potential risk factor for ADHD, possibly due to disruption of the gut microbiome and interference with neurodevelopment.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Environmental Sciences
Jian-Hui Yang, Esben Strodl, Chuan-An Wu, Xiang-Yu Hou, Xiao-Na Yin, Guo-Min Wen, Deng-Li Sun, Dan-Xia Xian, Jing-Yi Chen, Ying-Jie Chen, Jing Chen, Wei-Qing Chen
Summary: There is growing evidence that maternal exposure to cooking oil fumes (COFs) during pregnancy in China may increase the risk of children's autistic-like behaviors. This study analyzed data from the Longhua Child Cohort Study and found that higher levels of COF exposure and more frequent cooking during pregnancy were associated with a higher risk of autistic-like behaviors in children. The use of natural gas as cooking fuels and ventilation measures during cooking were found to decrease the likelihood of autistic-like behaviors in offspring.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Johanna Inhyang Kim, Jung Lee, Kyung-Shin Lee, Young Ah Lee, Choong Ho Shin, Yun-Chul Hong, Bung-Nyun Kim, Youn-Hee Lim
Summary: This study found that exposure to certain phthalate metabolites during pregnancy can lead to increased autistic traits in young children, while exposure to other metabolites during early childhood may result in autistic traits in older school-aged children, especially boys.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Hanjin Wang, Hongling Zhang, Juxiao Li, Jiaqiang Liao, Jiangtao Liu, Chen Hu, Xiaojie Sun, Tongzhang Zheng, Wei Xia, Shunqing Xu, Shiqiong Wang, Yuanyuan Li
Summary: This study found that both prenatal and early postnatal exposure to ambient particulate matter are associated with impaired offspring neurodevelopment, with the effects of early postnatal exposure being stronger.
ENVIRONMENTAL RESEARCH
(2022)
Article
Psychology, Clinical
Katie N. Sampson, Rachel Upthegrove, Ahmad Abu-Akel, Sayeed Haque, Stephen J. Wood, Renate Reniers
Summary: The study found a positive correlation between sub-clinical autistic and positive psychotic traits. Autistic traits and psychotic traits independently predict depression, self-harm, and suicidality. Interestingly, a negative interaction between the autistic trait of attention to detail and psychotic traits was associated with depression.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Psychology, Developmental
Haoyan Ge, Albert Kwing Lok Lee, Hoi Kwan Yuen, Fang Liu, Virginia Yip
Summary: This study found that bilingual autistic children performed similarly to monolingual autistic children in the production of focus, but outperformed their monolingual peers in the production of object focus. Bilingual exposure did not have a detrimental effect on the language skills of autistic children and might enhance their production of focus in their first language, Cantonese.
Article
Obstetrics & Gynecology
Estelle Lecluze, Antoine D. Rolland, Panagiotis Filis, Bertrand Evrard, Sabrina Leverrier-Penna, Millissia Ben Maamar, Isabelle Coiffec, Vincent Lavoue, Paul A. Fowler, Severine Mazaud-Guittot, Bernard Jegou, Frederic Chalmel
HUMAN REPRODUCTION
(2020)
Article
Biochemistry & Molecular Biology
Majorie B. M. van Duursen, Julie Boberg, Sofie Christiansen, Lisa Connolly, Pauliina Damdimopoulou, Panagiotis Filis, Paul A. Fowler, Bart M. Gadella, Jan Holte, Kersti Jaager, Hanna K. L. Johansson, Tianyi Li, Severine Mazaud-Guittot, Anne-Simone Parent, Andres Salumets, Ana M. Soto, Terje Svingen, Agne Velthut-Meikas, Eva Bay Wedebye, Yuling Xie, Martin van den Berg
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Pauline Rontani, Olivier Perche, Louise Greetham, Nicolas Jullien, Bruno Gepner, Francois Feron, Emmanuel Nivet, Madeleine Erard-Garcia
Summary: Researchers isolated stem cells from the nasal cavity of ASD patients and found under-expression of the MOCOS gene in these patients' stem cells, as well as a new noncoding RNA called COSMOC associated with ASD patients' MOCOS expression.
MOLECULAR PSYCHIATRY
(2021)
Review
Urology & Nephrology
Hugoline Boulay, Severine Mazaud-Guittot, Jeanne Supervielle, Jonathan M. Chemouny, Virginie Dardier, Agnes Lacroix, Ludivine Dion, Cecile Vigneau
Summary: This review summarizes existing data on maternal and foetal complications of pregnancies in women after renal transplant, focusing on the management of immunosuppression. Additionally, it describes the limited available data on the middle- and long-term outcomes of children exposed in utero to immunosuppressive drugs.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Sabrina Leverrier-Penna, Alain Michel, Laetitia L. Lecante, Nathalie Costet, Antonio Suglia, Christele Desdoits-Lethimonier, Hugoline Boulay, Roselyne Viel, Jonathan M. Chemouny, Emmanuelle Becker, Vincent Lavoue, Antoine D. Rolland, Nathalie Dejucq-Rainsford, Cecile Vigneau, Severine Mazaud-Guittot
Summary: This study investigated the effects of analgesics on human fetal kidneys during early pregnancy, revealing a spectrum of abnormalities induced by these drugs, ranging from cell death to a decline in differentiating glomeruli density. Caution is warranted for the use of these medications during the first trimester of pregnancy.
Review
Biochemistry & Molecular Biology
Stephane Connan-Perrot, Thibaut Leger, Pauline Lelandais, Christele Desdoits-Lethimonier, Arthur David, Paul A. Fowler, Severine Mazaud-Guittot
Summary: Human fetal gonads acquire steroidogenic capabilities early in their differentiation, which play a central role in sexually dimorphic development of external genitalia. Technological advances have improved understanding of steroidogenesis, with various techniques providing complementary information for generating robust data on steroid hormones and their roles in fetal development and functions. The debate on choosing between available technologies should focus on maximizing reproducibility and sensitivity while implementing quality controls.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Muzlifah Haniffa, Deanne Taylor, Sten Linnarsson, Bruce J. Aronow, Gary D. Bader, Roger A. Barker, Pablo G. Camara, J. Gray Camp, Alain Chedotal, Andrew Copp, Heather C. Etchevers, Paolo Giacobini, Berthold Gottgens, Guoji Guo, Ania Hupalowska, Kylie R. James, Emily Kirby, Arnold Kriegstein, Joakim Lundeberg, John C. Marioni, Kerstin B. Meyer, Kathy K. Niakan, Mats Nilsson, Bayanne Olabi, Dana Pe'er, Aviv Regev, Jennifer Rood, Orit Rozenblatt-Rosen, Rahul Satija, Sarah A. Teichmann, Barbara Treutlein, Roser Vento-Tormo, Simone Webb
Summary: The Human Developmental Cell Atlas initiative aims to create a comprehensive reference map of cells during development to understand the basis of human development, congenital and childhood disorders, as well as aging, cancer, and regenerative medicine. The initiative integrates scientists’ data on human development and uses state-of-the-art technologies to create a reference atlas across gestation.
Article
Endocrinology & Metabolism
Laetitia L. Lecante, Sabrina Leverrier-Penna, Thomas Gicquel, Frank Giton, Nathalie Costet, Christele Desdoits-Lethimonier, Laurianne Lesne, Bernard Fromenty, Vincent Lavoue, Antoine D. Rolland, Severine Mazaud-Guittot
Summary: The study found that APAP can impact the development of fetal human ovaries, especially during the 10-12 week window of heightened sensitivity. APAP reduced the total cell number in ovaries, induced cell death, and decreased KI67-positive cell density independently of fetal age.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Environmental Sciences
Pascal Vaudin, Corinne Auge, Nathalie Just, Sakina Mhaouty-Kodja, Stephane Mortaud, Delphine Pillon
Summary: Pharmaceutical drugs have become consumer products and environmental pollutants due to their volume of production and consumption. This article discusses the potential effects of antibiotics, antidepressants, and non-steroidal anti-inflammatory drugs on neurodevelopment, along with experimental studies and brain imaging in assessing their adverse effects.
ENVIRONMENTAL RESEARCH
(2022)
Article
Obstetrics & Gynecology
Marion Pinsard, Nicolas Mouchet, Ludivine Dion, Thomas Bessede, Martin Bertrand, Emile Darai, Pascale Bellaud, Philippe Loget, Severine Mazaud-Guittot, Xavier Morandi, Jean Leveque, Vincent Lavoue, Martha Duraes, Krystel Nyangoh Timoh
Summary: We have successfully constructed a three-dimensional model of uterine innervation in humans through anatomical and functional mapping of the pelvises of human female fetuses. This model provides a foundation for studying uterine innervation in pathological conditions and discovering new therapeutic approaches.
FERTILITY AND STERILITY
(2022)
Article
Toxicology
Indusha Kugathas, Hanna K. L. Johansson, Edith Chan Sock Peng, Maryne Toupin, Bertrand Evrard, Thomas A. A. Darde, Julie Boberg, Monica K. K. Draskau, Antoine D. D. Rolland, Severine Mazaud-Guittot, Frederic Chalmel, Terje Svingen
Summary: Exposure to endocrine-disrupting chemicals during development may cause reproductive disorders in women. This study characterized the transcriptional landscape of rat ovaries exposed to two well-known EDCs, diethylstilbestrol (DES) and ketoconazole (KTZ), and identified new candidate biomarkers for female reproductive toxicity induced by EDC.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Sarah Meresse, Vanessa Larrigaldie, Asma Oummadi, Vidian de Concini, Severine Morisset-Lopez, Flora Reverchon, Arnaud Menuet, Celine Montecot-Dubourg, Stephane Mortaud
Summary: This study reveals that BMAA disrupts neurogenesis from SVZ cells in mice and induces neuroinflammation. It affects the population of undifferentiated cells and the organization of neuroblasts, potentially impairing the SVZ function. Additionally, BMAA increases the release of proinflammatory cytokines, suggesting its role in neuroinflammatory processes.
Article
Genetics & Heredity
Laura Mary, Delphine Leclerc, Audrey Labalme, Pascale Bellaud, Severine Mazaud-Guittot, Stephane Dreano, Bertrand Evrard, Antoine Bigand, Aurelie Cauchoix, Philippe Loget, Anna Lokchine, Laurence Cluzeau, David Gilot, Marc-Antoine Belaud-Rotureau, Sylvie Jaillard
Summary: Sexual development is a complex process involving multiple genes. Disruptions in some of these genes can lead to differences of sexual development (DSDs). The discovery of new genes, such as PBX1, through genome sequencing has advanced our understanding of sexual development. In this study, a fetus with a PBX1 variant was found to have severe DSD along with renal and lung malformations. Further experiments suggested that the mutant PBX1 had modest effects compared with the wild-type PBX1 in a cell model. However, the recurrence of the PBX1 variant in patients with similar phenotypes underscores its potential impact on human diseases. Further functional studies are needed to explore its effects on cellular metabolism.
Article
Biochemistry & Molecular Biology
Sarah Meresse, Helene Gateau, Tessa Tirnan, Vanessa Larrigaldie, Nathalie Casse, Pamela Pasetto, Jean-Luc Mouget, Stephane Mortaud, Mostefa Fodil
Summary: Haslea ostrearia, a marine diatom, produces marennine, a blue pigment that causes greening of filter-feeding organisms. Previous studies have shown that marennine has antibacterial, antioxidant, and antiproliferative effects. This study aimed to determine the effects of marennine on neuroinflammatory and cell migratory processes. Marennine interacted with neuroinflammatory processes and exhibited anti-migratory activity. Further research is needed to identify the molecular and cellular targets affected by marennine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Asma Oummadi, Arnaud Menuet, Sarah Meresse, Anthony Laugeray, Gilles Guillemin, Stephane Mortaud
Summary: Prenatal maternal immune activation (MIA) and perinatal exposure to xenobiotics have been identified as risk factors for neurological disorders. This study demonstrated that early multi-exposure to insults can lead to neuropathologies, and prenatal immune sensitization can increase susceptibility to subsequent exposure to neurotoxins.
FRONTIERS IN NEUROSCIENCE
(2023)