Article
Neurosciences
Rintaro Fujii, Keita Watanabe, Naomichi Okamoto, Tomoya Natsuyama, Hirofumi Tesen, Ryohei Igata, Yuki Konishi, Atsuko Ikenouchi, Shingo Kakeda, Reiji Yoshimura
Summary: This study aimed to explore the relationship between hippocampal subfield volumes and plasma levels of BDNF in first-episode major depression patients. The results showed that there were no differences in total hippocampal volume between the patient group and the control group. However, specific subfields in the patient group, such as the HATA and several regions on the right side, were significantly smaller compared to the control group. Furthermore, the study found different correlations between hippocampal volume and plasma BDNF concentrations in the patient and control groups. These findings suggest that certain hippocampal subfields may already be atrophic at the onset of major depression, and the sensitivity of certain regions to BDNF may differ between the two groups.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Isabel Gross, Nicola Brandt, Danara Vonk, Franziska Koeper, Lars Woehlbrand, Ralf Rabus, Martin Witt, Axel Heep, Torsten Ploesch, Mark S. Hipp, Anja U. Braeuer
Summary: This study analyzes the expression and localization of PRG5 in the mouse brain, and finds its association with dendritic spine formation and stabilization. PRG5 is highly expressed in areas with regenerative capacity and specifically expressed in the late phase of adult neurogenesis.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Yan-Mei Chen, Hua Fan, Jie Huang, Tian-Shun Shi, Wei-Yu Li, Cheng-Niu Wang, Bo Jiang, Jian-Feng Liu
Summary: Depression is a prevalent psychiatric disorder associated with chronic stress, monoaminergic dysfunction, impaired neurogenesis, and decreased BDNF-CREB signaling. The study suggests that F3/Contactin, a cell-adhesion molecule, may be implicated in depression and could serve as a novel antidepressant target. Over-expression of hippocampal F3/Contactin prevents depressive-like behaviors and dysfunction in neurogenesis and signaling, while administration of vortioxetine, an antidepressant, ameliorates the inhibitory effects on F3/Contactin expression.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Behavioral Sciences
Ling Liu, Chun-Hui Ji, Yuan Wang, Jie Zhao, Yue Liu, Wen-Qian Tang, Jiang-Hong Gu, Bo Jiang
Summary: The study found that L-701,324 has antidepressant effects in mice, possibly by promoting the hippocampal BDNF system, which can prevent stress-induced depressive-like behaviors.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Geriatrics & Gerontology
Golo Kronenberg, Karen Gertz, Johanna Schoener, Lars Bertram, Thomas Liman, Elisabeth Steinhagen-Thiessen, Ilja Demuth, Matthias Endres, Rainer Hellweg
Summary: The study found no significant effect of age, sex, body mass index, self-reported depression, or BDNF Val66Met variant on serum BDNF concentrations, but identified a positive correlation between platelet counts and BDNF levels. There was no significant relationship between Digit Symbol Substitution Test score and Consortium to Establish a Registry for Alzheimer's Disease memory score with BDNF levels.
NEUROBIOLOGY OF AGING
(2021)
Article
Endocrinology & Metabolism
Reza Sardar, Zahra Zandieh, Zeinab Namjoo, Mansoureh Soleimani, Reza Shirazi, Javad Hami
Summary: BDNF shows significant gender differences and left-right asymmetries in the developing rat hippocampus, potentially influencing the gender and laterality differences in the development, structure, and function of the hippocampus.
METABOLIC BRAIN DISEASE
(2021)
Article
Clinical Neurology
Jessica A. Harder, Raina N. Fichorova, Akanksha Srivastava, Aleta Wiley, Katherine E. Burdick, Joseph J. Locascio, Hadine Joffe
Summary: This study found that BDNF levels are positively correlated with the severity of mood symptoms in women with perimenopausal depression symptoms, resembling the pattern seen in hormonally-sensitive PMDD. This suggests the presence of a hormonally-sensitive mood disorder biomarker profile distinct from that of major depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Geriatrics & Gerontology
Lichi Xu, Yanjing Guo, Gongming Wang, Guoqing Sun, Wei Sun, Jingjing Li, Xinlei Li, Jiangnan Wu, Mengyuan Zhang
Summary: Sevoflurane anesthesia can cause cognitive impairment, especially in elderly patients. This study found that exposure to sevoflurane led to cognitive impairment and inhibition of adult hippocampal neurogenesis in aged mice, which could be partially improved by injecting BDNF or NT-3.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Younjung Lee, Kye-Hyun Kim, Bun-Hee Lee, Yong-Ku Kim
Summary: The study found that pregnancy and postpartum depression can affect BDNF concentration, and the BDNF concentration in the postpartum depression-recovery group significantly increased at 6 weeks postpartum.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Review
Psychiatry
Yang Li, Tong Liu, Weifeng Luo
Summary: Research has shown that peripheral facial injection of botulinum neurotoxin type A (BoNT/A) is a rapid, effective, and relatively safe therapy for improving symptoms of depression. However, the specific therapeutic mechanisms of BoNT/A for depression are still unclear.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Agriculture, Dairy & Animal Science
Allison N. Pullin, Victoria S. Farrar, Jason W. Loxterkamp, Claire T. Jones, Rebecca M. Calisi, Kristina Horback, Pamela J. Lein, Maja M. Makagon
Summary: The rearing environment did not affect neural connectivity and performance on spatial cognition tasks in pullets. Hippocampal subregion affected dendritic morphology.
Review
Biology
Massimo Fioranelli, Maria Grazia Roccia, Bianca Przybylek, Maria Luisa Garo
Summary: This systematic review examines the bidirectional relationship between cardiovascular disease (CVD) and depression, with a focus on the potential role of low serum BDNF levels in the development of either disease in the presence of the other. The results suggest a strong association between low serum BDNF levels and the risk of post-stroke depression, but there is limited research on altered serum BDNF levels and other types of CVD, therefore the inverse association between depression and CVD cannot be proven.
Article
Psychiatry
Ya-Xin Sun, Yun-Ai Su, Qi Wang, Jia-Ya Zheng, Chen-Chen Zhang, Ting Wang, Xiao Liu, Yu-Nu Ma, Xue-Xin Li, Xian-Qiang Zhang, Xiao-Meng Xie, Xiao-Dong Wang, Ji-Tao Li, Tian-Mei Si
Summary: Early-life stress can lead to long-lasting deficits of hippocampus-dependent learning and memory in adult mice, which may be associated with the hypofunction of the BDNF-TrkB pathway. In this study, the causal involvement of the BDNF-TrkB pathway in ELS-induced cognitive deficits was examined, and the therapeutic effects of the TrkB agonist (7,8-DHF) were demonstrated.
TRANSLATIONAL PSYCHIATRY
(2023)
Review
Psychiatry
Chunhui Zhang, Xuefang Wang, Qinghua Zhu, Yongxia Mei, Zhenxiang Zhang, Hui Xu
Summary: This study found that serum BDNF levels are lower in poststroke depression (PSD) patients compared to stroke patients without PSD, suggesting that BDNF may serve as a potential biomarker for predicting the risk of PSD among stroke survivors.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Geriatrics & Gerontology
Hamid Arazi, Parvin Babaei, Makan Moghimi, Abbas Asadi
Summary: The study found that both strength and endurance exercise can significantly increase serum BDNF and IGF-1 concentrations and platelets, with no significant differences between them after exercise.
Article
Pharmacology & Pharmacy
Bjoern H. Schott, Golo Kronenberg, Ulrike Schmidt, Henning P. Duesedau, Stefanie Ehrentraut, Olga Geisel, Oliver von Bohlen Und Halbach, Peter Gass, Ildiko Rita Dunay, Rainer Hellweg
Summary: Our study reveals that p75NTR signaling plays a role in regulating hippocampal BDNF levels, particularly under stress conditions. Furthermore, the p75NTR signaling modulates baseline Il6 expression in mice but has a lesser effect on stress-induced Il6 increase.
PHARMACOPSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Marcus W. Meinhardt, Simone Pfarr, Gregory Fouquet, Cathrin Rohleder, Manuela L. Meinhardt, Janet Barroso-Flores, Rebecca Hoffmann, Jerome Jeanblanc, Elisabeth Paul, Konstantin Wagner, Anita C. Hansson, Georg Koehr, Nils Meier, Oliver von Bohlen und Halbach, Richard L. Bell, Heike Endepols, Bernd Neumaier, Kai Schoenig, Dusan Bartsch, Mickael Naassila, Rainer Spanagel, Wolfgang H. Sommer
Summary: The study identified a common molecular pathological mechanism for both executive dysfunction and alcohol craving in alcohol-dependent patients, and proposed a personalized mGluR2 mechanism-based intervention strategy for medication development.
Article
Multidisciplinary Sciences
Javad Hami, Viola von Bohlen Und Halbach, Anja Tetzner, Thomas Walther, Oliver von Bohlen und Halbach
Summary: Numerous studies have shown evidence of a local renin-angiotensin system (RAS) in the central nervous system (CNS), with the identification of a novel receptor known as Mas-related G-protein coupled receptor D (MrgD). The distribution pattern of MrgD receptors in the adult mouse brain reveals its presence in specific areas related to reward and limbic functions, suggesting a potential role in processes such as pain perception/modulation, synaptic plasticity, learning, memory, and cognition.
Article
Biology
Viola von Bohlen Und Halbach, Simone Venz, Simon Nwakor, Christian Hentschker, Elke Hammer, Heike Junker, Andreas W. Kuss, Oliver von Bohlen Und Halbach, Lars R. Jensen
Summary: The study found that FTSJ1 deficiency in mice resulted in altered neuronal plasticity in the hippocampal area, both morphologically and physiologically. These changes may contribute to impaired learning and memory functions.
Editorial Material
Neurosciences
Oliver von Bohlen, Halbach
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Simone Venz, Viola von Bohlen Und Halbach, Christian Hentschker, Heike Junker, Andreas Walter Kuss, Thomas Sura, Elke Krueger, Uwe Voelker, Oliver von Bohlen Und Halbach, Lars Riff Jensen, Elke Hammer
Summary: A workflow for tandem mass spectrometry-based protein profiling of immunohistochemistry specimens was established and applied to tissue sections. The CA1 region of the hippocampus was investigated using protein extraction and digestion methods followed by mass spectrometry measurement and data analysis. Literature searches and Gene Ontology annotation verified the applicability of this method for global protein profiling using formalin-fixed and embedded material and previously used immunohistochemistry slides.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Anatomy & Morphology
Julia Sophie Ehlers, Katharina Bracke, Viola von Bohlen Und Halbach, Florian Siegerist, Nicole Endlich, Olivervon Bohlen Und Halbach
Summary: The SLC35F1 gene mutation in humans is associated with neurodevelopmental disorders. However, Slc35f1-deficient mice do not exhibit obvious deficits in learning and memory, and neuroanatomical parameters of neuronal plasticity are also unaffected. Therefore, they do not display a neurodevelopmental phenotype.
BRAIN STRUCTURE & FUNCTION
(2023)
Review
Cell Biology
Oliver von Bohlen und Halbach
Summary: The brain has its own intrinsic renin-angiotensin system (RAS) and ACE2 system, which play important roles in processes such as neuronal plasticity and learning and memory. Malfunctions in the brain ACE2 system are associated with disturbances in neuronal plasticity, and it is possible that Neuro-Covid may depend on a disturbed balance in the ACE2 system due to the high affinity of SARS-CoV-2 towards ACE2.
HISTOLOGY AND HISTOPATHOLOGY
(2021)