Article
Geriatrics & Gerontology
Egle Tamuleviciute-Prasciene, Aurelija Beigiene, Mark James Thompson, Kristina Balne, Raimondas Kubilius, Birna Bjarnason-Wehrens
Summary: The specially tailored resistance and balance training did not show additional benefit in improving functional and exercise capacity, physical performance, and muscular strength, but exercise-based cardiac rehabilitation was effective in improving these outcomes in older patients after valve surgery/intervention in the short and medium terms. The Short Physical Performance Battery (SPPB) score and 5-meter walk test (5MWT) were found to be useful for assessing physical frailty in a cardiac rehabilitation setting.
Article
Cardiac & Cardiovascular Systems
Darko Boljevic, Milovan Bojic, Mihajlo Farkic, Dragan Sagic, Dragan Topic, Vladimir Kovacevic, Jovana Lakcevic, Stefan Veljkovic, Milan Dobric, Sasa Hinic, Nenad Ilijevski, Marko Nikolic, Aleksandra Kaludjerovic, Matjaz Bunc, Aleksandra Nikolic
Summary: The Dedinje Cardiovascular Institute has successfully established a TAVI program, and the initial results are comparable to previous large randomized trials, setting the foundation for further development.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Ala Abu Dogosh, Ahlam Adawi, Aref El Nasasra, Carlos Cafri, Orit Barrett, Gal Tsaban, Rami Barashi, Edward Koifman
Summary: This study compared various TAVI devices through a network meta-analysis. The findings suggest that newer generation TAVI devices, such as Sapien 3 and Evolut R/Pro, have improved outcomes compared to SAVR and older generation devices.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biology
Matthaios Didagelos, Vlasis Ninios, Charalampos Kakderis, Lampros Lakkas, Antonios Kouparanis, Dimitrios Nikas, Katerina K. Naka, Aidonis Rammos, Thomas Zegkos, Vasileios Kamperidis, Ilias Ninios, Sotirios Evangelou, Dimitrios G. Tsalikakis, Lampros Michalis, Antonios Ziakas
Summary: The study evaluated outcomes at 2 years after TAVI with the Portico valve for patients with severe aortic stenosis. The results showed that TAVI with the Portico valve is an effective and safe solution for high-risk surgical patients with severe aortic stenosis.
Article
Cardiac & Cardiovascular Systems
Yaoyao Zhou, Qifeng Zhu, Xinping Lin, Huajun Li, Zhaoxia Pu, Xianbao Liu, Jian'an Wang
Summary: This study investigates the early evolution of cardiac damage after transcatheter aortic valve implantation (TAVI) and its association with clinical outcomes in TAVI recipients. The results show that within 30 days post-TAVI, the baseline cardiac damage stage changed in 22.2% of patients, accompanied by improvements in dyspnoea and left ventricular ejection fraction. Residual cardiac damage within 30 days post-TAVI is associated with 2-year mortality, and further cardiac damage within 30 days is associated with higher mortality risk. Cardiac deterioration within 30 days post-TAVI is an independent risk factor for 2-year mortality.
Article
Cardiac & Cardiovascular Systems
Kari Feldt, Magnus Dalen, Christopher U. Meduri, Mikael Kastengren, Jessica Bager, Jonas Hornsten, Aninda Omar, Andreas Ruck, Nawzad Saleh, Rickard Linder, Magnus Settergren
Summary: The use of a soft-tip temporary right ventricular pacing lead was associated with a lower risk of pacemaker related cardiac tamponade in transcatheter aortic valve replacement (TAVR).
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Mohamed Salem, Christina Grothusen, Mostafa Salem, Derk Frank, Mohammed Saad, Markus Ernst, Thomas Puehler, Georg Lutter, Assad Haneya, Jochen Cremer, Jan Schoettler
Summary: The number of transcatheter aortic valve implantations (TAVI) has increased significantly in recent decades. This study provides an analysis of the causes of TAVI failure, including degenerative, functional, and infective factors, as well as the outcomes of surgical aortic valve replacement (SAVR) after TAVI. The causes of SAVR after TAVI failure are multifactorial, and the prognosis varies depending on the underlying factors.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Monil Majmundar, Rajkumar Doshi, Ashish Kumar, Douglas Johnston, James Brockett, Anmar Kanaa'N, Joseph A. Lahorra, Lars G. Svensson, Amar Krishnaswamy, Grant W. Reed, Rishi Puri, Samir R. Kapadia, Ankur Kalra
Summary: This study compared the outcomes of valve-in-valve transcatheter aortic valve implantation (ViV TAVI) with repeat surgical aortic valve replacement (SAVR) in patients with a failed aortic bioprosthetic valve. The results showed that ViV TAVI was associated with lower in-hospital mortality but higher rates of 30-day and 6-month all-cause readmission compared with repeat SAVR. However, there were no differences in the risk of in-hospital stroke, post-procedure pacemaker implantation, major adverse cardiac events (MACE), and mortality during readmission between the two groups.
Article
Medicine, General & Internal
Jorge Calderon-Parra, Juan E. de Villarreal-Soto, Juan Francisco Oteo-Dominguez, Maria Mateos-Seirul, Elsa Rios-Rosado, Laura Dorado, Beatriz Vera-Puente, Carlos Arellano-Serrano, Antonio Ramos-Martinez, Alberto Forteza-Gil
Summary: This study compared the risk of infective endocarditis (IE) after surgical aortic valve replacement (SAVR) and transcatheter aortic valve implantation (TAVI). The results showed a higher risk of early IE after TAVI, but the overall risk of IE was similar between the two procedures. Further studies are needed to identify and optimize the risk factors of IE prior to TAVI.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Haruka Kameshima, Masaki Izumo, Tomomi Suzuki, Hiroshi Ohara, Yukio Sato, Mika Watanabe, Shingo Kuwata, Kazuaki Okuyama, Ryo Kamijima, Manabu Takai, Seisyou Kou, Yasuhiro Tanabe, Tomoo Harada, Yoshihiro J. Akashi
Summary: This study investigated the changes in kinematic hemodynamics during exercise in AS patients after TAVI. It found that patients with PPM showed a disproportionate increase in the transvalvular pressure gradient and pulmonary artery systolic pressure during exercise, and PPM was associated with exercise-induced pulmonary hypertension.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Medicine, General & Internal
Simona Sperlongano, Francesca Renon, Maurizio Cappelli Bigazzi, Rossella Sperlongano, Giovanni Cimmino, Antonello D'Andrea, Paolo Golino
Summary: Cardiac rehabilitation (CR) after transcatheter aortic valve implantation (TAVI) can improve exercise tolerance and quality of life in patients, and potentially reduce mortality during follow-up. While major guidelines currently do not recommend CR after TAVI, emerging scientific evidence supports the benefits of such programs.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Vassili Panagides, Dimitri Kalavrouziotis, Eric Dumont, Robert Delarochelliere, Jean-Michel Paradis, Jules Mesnier, Siamak Mohammadi, Josep Rodes-Cabau
Summary: This study evaluated the safety of transcatheter aortic valve replacement (TAVR) via the transcarotid route through pre- and post-procedure carotid artery ultrasound assessment. The results showed that TC-TAVR was associated with a mild but significant increase in carotid flow velocities, without clinical events. Further studies are needed.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Francesco Saverio Mennini, Francesco Meucci, Gabriele Pesarini, Pietro Vandoni, Maddalena Lettino, Archita Sarmah, Judith Shore, Michelle Green, Stefano Giardina
Summary: This cost-utility analysis showed that TAVI with SAPIEN 3 is likely to be cost effective compared with SAVR for the treatment of low-risk sSAS patients.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Uri Landes, Olga Morelli, Haim Danenberg, Janarthanan Sathananthan, Ole De Backer, Lars Sondergaard, Mohamed Abdel-Wahab, Sung-Han Yoon, Raj R. Makkar, Holger Thiele, Won-Keun Kim, Christian Hamm, Mayra Guerrero, Josep Rodes-Cabau, Taishi Okuno, Thomas Pilgrim, Antonio Mangieri, Nicolas M. Van Mieghem, Didier Tchetche, Wolfgang H. Schoels, Marco Barbanti, Jan-Malte Sinning, Alfonso Ielasi, Giuseppe Tarantini, Federico De Marco, Ariel Finkelstein, Horst Sievert, Martin Andreas, Azeem Latib, Rebecca Godfrey, David Hildick-Smith, Lisa Manevich, Ran Kornowski, Tamim M. Nazif, Martin B. Leon, John G. Webb
Summary: The study focused on the efficacy of redo-TAVI in reducing para-valvular regurgitation after transcatheter aortic valve implantation. Results showed that redo-TAVI was effective in reducing regurgitation and improving procedural success rates for PVR patients. Further investigation is needed for patient selection in PVR therapies.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Alessandro Vairo, Lorenzo Zaccaro, Andrea Ballatore, Lorenzo Airale, Fabrizio D'Ascenzo, Gianluca Alunni, Federico Conrotto, Luca Scudeler, Daniela Mascaretti, Davide Miccoli, Michele La Torre, Mauro Rinaldi, Gianni Pedrizzetti, Stefano Salizzoni, Gaetano Maria De Ferrari
Summary: Echocardiographic evaluation of hemodynamic forces (HDFs) can predict improvement in left ventricular (LV) function after transcatheter aortic valve implantation (TAVI) in patients with severe aortic stenosis. HDF parameters significantly improved after the procedure, while global longitudinal strain and LV ejection fraction showed no significant difference. Analysis of HDFs can differentiate patients with LV function recovery from those with persistent hemodynamic dysfunction after TAVI.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Engineering, Biomedical
Vincenzo Tarzia, Chiara Tessari, Assunta Fabozzo, Chiara Cavalli, Chiara Pagnin, Biancarosa Volpe, Tomaso Bottio, Gino Gerosa
Summary: LVAD implantation in APS patients is high-risk, but optimal therapeutic strategy can be achieved through continuous rheologic profile monitoring and multiparametric assessment.
INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
(2022)
Article
Cardiac & Cardiovascular Systems
Antonio Piperata, Masazumi Watanabe, Mathieu Pernot, Alexandre Metras, Gregory Kalscheuer, Martina Avesani, Laurent Barandon, Julien Peltan, Giulia Lorenzoni, Vjola Jorgji, Dario Gregori, Shinya Takahashi, Louis Labrousse, Gino Gerosa, Tomaso Bottio
Summary: This retrospective multicentre study compared the clinical outcomes of unilateral and bilateral antegrade cerebral perfusion (ACP) strategies in surgery for type A aortic dissection. The results showed that the unilateral technique required shorter surgery time, but the bilateral group had a higher incidence of permanent neurological deficits and complications. The study concluded that both unilateral and bilateral ACP are valid brain protection strategies in aortic arch surgery, but the unilateral technique may offer some clinical advantages.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Thomas Senage, Anu Paul, Thierry Le Tourneau, Imen Fellah-Hebia, Marta Vadori, Salam Bashir, Manuel Galinanes, Tomaso Bottio, Gino Gerosa, Arturo Evangelista, Luigi P. Badano, Alberto Nassi, Cristina Costa, Galli Cesare, Rizwan A. Manji, Caroline Cueff de Monchy, Nicolas Piriou, Romain Capoulade, Jean-Michel Serfaty, Guillaume Guimbretiere, Etienne Dantan, Alejandro Ruiz-Majoral, Guenola Coste du Fou, Shani Leviatan Ben-Arye, Liana Govani, Sharon Yehuda, Shirley Bachar Abramovitch, Ron Amon, Eliran Moshe Reuven, Yafit Atiya-Nasagi, Hai Yu, Laura Iop, Kelly Casos, Sebastian G. Kuguel, Arnau Blasco-Lucas, Eduard Permanyer, Fabrizio Sbraga, Roger Llatjos, Gabriel Moreno-Gonzalez, Melchor Sanchez-Martinez, Michael E. Breimer, Jan Holgersson, Susann Teneberg, Marta Pascual-Gilabert, Alfons Nonell-Canals, Yasuhiro Takeuchi, Xi Chen, Rafael Manez, Jean-Christian Roussel, Jean-Paul Soulillou, Emanuele Cozzi, Vered Padler-Karavani
Summary: In a large cohort of patients who underwent aortic valve replacement, antibody responses to glycans present in bioprosthetic heart valves, notably galactose-alpha 1,3-galactose and N-glycolylneuraminic acid, were implicated in valve calcification and deterioration. It was found that antibodies against xenoantigens galactose-alpha 1,3-galactose and N-glycolylneuraminic acid could mediate the deterioration of bioprosthetic heart valves through calcification. Results suggest that BHVs manufactured using donor tissues deficient in these antigens may have improved durability.
Article
Cardiac & Cardiovascular Systems
Astrid C. van Nieuwkerk, Raquel B. Santos, Eduard Fernandez-Nofrerias, Didier Tchetche, Fabio S. de Brito Jr, Marco Barbanti, Ran Kornowski, Azeem Latib, Augusto D'Onofrio, Flavio Ribichini, Vicente Mainar, Nicolas Dumonteil, Jan Baan, Alexandre Abizaid, Samantha Sartori, Paola D'Errigo, Giuseppe Tarantini, Mattia Lunardi, Katia Orvin, Matteo Pagnesi, Garikoitz Lasa Larraya, Angie Ghattas, George Dangas, Roxana Mehran, Ronak Delewi
Summary: The use of valve-in-valve transcatheter aortic valve implantation (ViV-TAVI) is increasing, and this study evaluated clinical outcomes in patients with ViV-TAVI compared to patients with native valve TAVI (NV-TAVI). It was found that ViV-TAVI is a safe and effective treatment for failing bioprosthetic valves with mortality and stroke rates comparable to NV-TAVI for both valve types. The study also compared outcomes in patients with ViV-TAVI treated with self-expandable versus balloon-expandable valves.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
A. D'Onofrio, F. Mastro, M. Nadali, A. Fiocco, D. Pittarello, P. Aruta, G. Evangelista, G. Lorenzoni, D. Gregori, G. Gerosa
Summary: This single-center retrospective study compared the outcomes of transapical neochordae implantation (NC) versus conventional surgical (CS) mitral valve repair. The results showed that freedom from moderate and severe mitral regurgitation (MR) was worse in patients undergoing NC at 5-year follow-up. However, in patients with isolated P2 prolapse, the freedom from MR was similar between the two groups. Reoperation freedom was lower in the NC group, but similar in patients with isolated P2 prolapse.
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2022)
Letter
Cardiac & Cardiovascular Systems
Augusto D'Onofrio, Gino Gerosa
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Astrid C. van Nieuwkerk, Raquel B. Santos, Roberto Blanco Mata, Didier Tchetche, Fabio S. de Brito, Marco Barbanti, Ran Kornowski, Azeem Latib, Augusto D'Onofrio, Flavio Ribichini, Jan Baan, Juan Oteo-Dominguez, Nicolas Dumonteil, Alexandre Abizaid, Samantha Sartori, Paola D'Errigo, Giuseppe Tarantini, Mattia Lunardi, Katia Orvin, Matteo Pagnesi, Angie Ghattas, Ignacio Amat-Santos, George Dangas, Roxana Mehran, Ronak Delewi
Summary: This study evaluated clinical outcomes in diabetic patients undergoing transcatheter aortic valve implantation (TAVI). The results showed that diabetic patients had comparable mortality rates and other adverse clinical outcomes to non-diabetic patients. This indicates the safety of TAVI treatment in diabetic patients.
CARDIOVASCULAR DIABETOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Augusto D'Onofrio, Giorgia Cibin, Giulia Lorenzoni, Chiara Tessari, Olimpia Bifulco, Valentina Lombardi, Emma Bergonzoni, Giuseppe Evangelista, Rita Pesce, Pierpaolo Taffarello, Lorenzo Longinotti, Matteo Ponzoni, Dario Gregori, Gino Gerosa
Summary: This study compared the early clinical and hemodynamic outcomes of Intuity and ME bioprostheses. The results showed that Intuity had better hemodynamic performance, with lower gradients, larger effective orifice area index, and lower incidence of patient-prosthesis mismatch. However, there were no significant differences in terms of postoperative complications between the two groups.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Florinda Mastro, Annalisa Angelini, Augusto D'Onofrio, Gino Gerosa
Summary: The concept of repairing a degenerated mitral valve through a micro-invasive approach, such as Neochord implantation, offers cardiac surgeons the challenge of achieving the best physiological outcome while minimizing invasiveness. This method involves implanting artificial chordae to preserve the dynamic characteristics of the mitral annulus and avoid the disadvantages of cardiopulmonary bypass and cardioplegic arrest.
JOURNAL OF CARDIOVASCULAR MEDICINE
(2023)
Article
Surgery
Lorenzo Giovannico, Antonio D'Errico Ramirez, Domenico Parigino, Giuseppe Fischetti, Concetta Losito, Sergio Lenoci, Giuseppe Fiore, Antonio Civita, Davide F. Bavaro, Annalisa Saracino, Salvatore Grasso, Tomaso Bottio, Aldo Domenico Milano
Summary: The outbreak of SARS-CoV-2 infection in China in late 2019 has become a global pandemic, with COVID-19 being a major ongoing public health issue. Transplant programs had to develop strategies to handle the potential presence of COVID-19-positive donors and recipients. In this case, a heart transplant recipient tested positive for SARS-CoV-2 upon admission but proceeded with the transplant due to the patient's clinical condition and vaccination history.
CLINICAL TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Antonio Piperata, Jef Van Den Eynde, Mathieu Pernot, Olivier Busuttil, Martina Avesani, Tomaso Bottio, Stephane Lafitte, Thomas Modine, Louis Labrousse
Summary: The study investigated the long-term outcomes of concomitant suture bicuspidization to treat mild or moderate tricuspid regurgitation at the time of mitral valve surgery. Data analysis showed that patients undergoing mitral valve surgery with concomitant tricuspid valve repair had similar 30-day and long-term survival, similar permanent pacemaker implantation rate, and reduced progression of tricuspid regurgitation compared to those undergoing mitral valve surgery alone.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Augusto D'Onofrio, Chiara Tessari, Giuseppe Tarantini, Giorgia Cibin, Giulia Lorenzoni, Rita Pesce, Chiara Fraccaro, Massimo Napodano, Dario Gregori, Gino Gerosa
Summary: The aim of this study was to evaluate the early and long-term clinical and hemodynamic outcomes of TA-TAVI, and identify predictors of survival. A total of 234 patients underwent TA-TAVI with a 30-day mortality rate of 5.1%. The device success rate was 95.7%. Median follow-up time was 35.2 months. Overall survival rates at 2, 5, and 8 years were 75%, 44%, and 15% respectively. Age, body mass index, and ejection fraction were identified as the strongest predictors of survival. TA-TAVI showed favorable outcomes and can be a suitable alternative when transfemoral access is not possible.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Emanuela De Cillis, Tommaso Acquaviva, Raffaella Ursi, Nicolo Soldato, Paolo Basile, Paola Siena, Maria Cristina Carella, Andrea Baggiano, Saima Mushtaq, Laura Fusini, Mark G. Rabbat, Gianluca Pontone, Tomaso Bottio, Alessandro Santo Bortone, Marco Matteo Ciccone, Aldo Domenico Milano, Andrea Igoren Guaricci
Summary: This study compared intracardiac echocardiography (ICE) with transesophageal echocardiography (TEE) guidance for transcatheter closure of atrial septal defect (ASD). The results showed that ICE had significantly shorter fluoroscopy and procedure time compared to TEE, without compromising image quality, success rate, or causing additional complications. Therefore, ICE is a safe and effective tool for guiding transcatheter closure of ASD.
ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES
(2023)
Article
Cardiac & Cardiovascular Systems
Augusto D'Onofrio, Mario Lachat, Nicola Mangialardi, Michele Antonello, Hubert Schelzig, Lyubov Chaykovska, Andrew Hill, Andrew Holden, Thomas Lindsay, Kong Ten Tan, Matteo Orrico, Sonia Ronchey, Gabby Elbaz Greener, Paul Hayes, Giulia Lorenzoni, Gino Gerosa, David Planer
Summary: This study evaluated the 3-year outcomes of aortic arch stent grafting with the Nexus Aortic Arch Stent Graft System in high-risk patients. The results showed promising clinical and radiologic results, with high overall survival rate and a low incidence of unplanned reinterventions.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Tomaso Bottio, Antonio Piperata, Alvise Guariento, Giulia Lorenzoni, Andrea Gualtiero Cavicchiolo, Marco Gemelli, Rita Pesce, Giuseppe Evangelista, Sara Michelotti, Elisa Gastino, Dario Gregori, Enrico Ferrari, Gino Gerosa
Summary: This study analyzed the clinical outcomes of two generations of pericardial bioprostheses in concomitant aortic valve replacement and coronary artery revascularization surgery. The rapid-deployment bioprostheses group showed shorter surgical times and lower transvalvular gradients compared to the standard bioprostheses group, but there were no significant differences in 5-year survival rates and combined events incidence between the two groups.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)