Article
Biochemistry & Molecular Biology
Gerd Heusch, Ioanna Andreadou, Robert Bell, Edoardo Bertero, Hans-Erik Botker, Sean M. Davidson, James Downey, Philip Eaton, Peter Ferdinandy, Bernard J. Gersh, Mauro Giacca, Derek J. Hausenloy, Borja Ibanez, Thomas Krieg, Christoph Maack, Rainer Schulz, Frank Sellke, Ajay M. Shah, Holger Thiele, Derek M. Yellon, Fabio Di Lisa
Summary: This review summarizes the roles of reactive oxygen species (ROS) in myocardial ischemia/reperfusion injury and cardioprotection. It emphasizes the need for cardioprotection beyond rapid reperfusion in acute myocardial infarction and discusses the pathomechanisms of myocardial ischemia/reperfusion, different modes of cell death in myocardial infarction, and interventions to protect the ischemic/reperfused myocardium. The second part focuses on ROS, providing an overview of molecular and cellular mechanisms involved in ischemia/reperfusion injury.
Article
Cardiac & Cardiovascular Systems
Marios Rossides, Susanna Kullberg, Johan Grunewald, Anders Eklund, Daniela Di Giuseppe, Johan Askling, Elizabeth Arkema
Summary: A small increased risk of acute myocardial infarction was identified in individuals with sarcoidosis, especially those who received immunosuppressant treatment. Early diagnostic or preventive interventions may be beneficial for these patients.
RESPIRATORY MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Jane E. Clougherty, Jamie L. Humphrey, Ellen J. Kinnee, Richard Remigio, Perry E. Sheffield
Summary: This article discusses how to meaningfully define and analyze socioeconomic position in environmental epidemiology. It highlights the differential distribution of SEP, stressors, and pollution by race in US cities, and the challenges this poses, particularly in terms of spatial confounding.
CURRENT ENVIRONMENTAL HEALTH REPORTS
(2022)
Article
Critical Care Medicine
Jorge Ortega-Hernandez, Hector Gonzalez-Pacheco, Rodrigo Gopar-Nieto, Diego Araiza-Garaygordobil, Daniel Sierra Lara-Martinez, Jose Luis Briseno de la Cruz, Salvador Mendoza-Garcia, Alfredo Altamirano-Castillo, Alvaro Montanez-Orozco, Luis Augusto Baeza-Herrera, Jaime Hernandez-Montfort, Klayder Melissa Aguilar-Montano, Luis Alejandro Soliz Uriona, Jesus Angel Freddy Meza Lopez, Carlos Alonso Lizano Loria, Alexandra Arias-Mendoza
Summary: This study compared various prognostic scores for cardiogenic shock (CS) and described their performance in a real-world Latin American country. The results showed that the scores had moderate to good performance overall, with the highest performance in acute myocardial infarction-related CS (AMI-CS). The evaluation time had an impact on the scores' prediction. Conclusion: Understanding the temporal influence on the scores could improve prediction and provide a valuable tool for CS.
Article
Pediatrics
Annika Julihn, Fernanda Cunha Soares, Anders Hjern, Goran Dahllof
Summary: This study shows that the level of development in the parental country of origin and the socioeconomic status of the family in Sweden influence the risk of caries development in their children.
Article
Public, Environmental & Occupational Health
Nina T. Rogers, Joanna M. Blodgett, Samuel D. Searle, Rachel Cooper, Daniel H. J. Davis, Snehal M. Pinto Pereira
Summary: The study found that early-life socioeconomic status is associated with frailty in midlife, and that adult socioeconomic status only partially explains this association.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Ana Catarina Pinho-Gomes, Sanne A. E. Peters, Blake Thomson, Mark Woodward
Summary: The study found that in England, men have higher prevalence of major cardiovascular risk factors such as smoking, hypertension, overweight, and dyslipidaemia compared to women. However, improvements were seen in the treatment and control of hypertension and diabetes in both sexes by 2017. Women were less likely than men to have treated and controlled dyslipidaemia.
Article
Cardiac & Cardiovascular Systems
Medhat Farwati, Anas M. Saad, Vardhmaan Jain, Keerat Rai Ahuja, Agam Bansal, Mohamed M. Gad, Toshiaki Isogai, Omar Abdelfattah, Shashank Shekhar, Nicholas Kassis, Essa Hariri, Lars Svensson, Amar Krishnaswamy, Samir Kapadia
Summary: The study showed an increase in the utilization of TAVI and MC over time, but with lower rates in the lower-income group. While in-hospital mortality, stroke, and 30-day readmissions were generally comparable across groups, lower-income patients may be underrepresented among those undergoing TAVI and MC despite similar outcomes. Further research is needed to understand the reasons behind these disparities and develop targeted strategies for addressing them.
AMERICAN JOURNAL OF CARDIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Ashleigh Craig, Asanda Mtintsilana, Witness Mapanga, Siphiwe N. Dlamini, Shane A. Norris
Summary: This study examined the relationship between overweight perception and multimorbidity and found that individuals who perceived themselves as overweight had a higher likelihood of having multiple chronic conditions. The study also found that overweight perception partially mediated the association between socioeconomic position and multimorbidity. These findings highlight the importance of targeted interventions aimed at raising awareness about weight-related risks, particularly in lower economic developed countries.
Article
Cardiac & Cardiovascular Systems
Abdulla A. Damluji, Behnam Tehrani, Shashank S. Sinha, Marc D. Samsky, Timothy D. Henry, Holger Thiele, Nick E. J. West, Fortunato F. Senatore, Alexander G. Truesdell, George D. Dangas, Nathaniel R. Smilowitz, Amit P. Amin, Adam D. deVore, Nader Moazami, Joaquin E. Cigarroa, Sunil V. Rao, Mitchell W. Krucoff, David A. Morrow, Ian C. Gilchrist
Summary: This article discusses the vascular and bleeding complications in patients with cardiogenic shock treated with percutaneous mechanical circulatory support devices, and proposes improvements in practice.
JACC-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Public, Environmental & Occupational Health
Mohamed Yusuf, Gallin Montgomery, Mark Hamer, Jamie McPhee, Rachel Cooper
Summary: The study suggests that lower childhood and adulthood socioeconomic status is associated with weaker grip strength in women and stronger grip strength in men. Additionally, the relationship between occupational class and grip strength is non-linear, with differences observed between different occupational groups.
Article
Behavioral Sciences
Klara Andersson, Anneli Ozanne, Johan Zelano, Kristina Malmgren, John E. Chaplin
Summary: Perceived stigma is associated with the country of birth and socioeconomic status (SES). It is important to acknowledge the concerns of foreign-born patients and prioritize seizure control and the detection and treatment of comorbidities.
EPILEPSY & BEHAVIOR
(2022)
Article
Public, Environmental & Occupational Health
Mikael Rostila, Agneta Cederstrom, Matthew Wallace, Maria Branden, Bo Malmberg, Gunnar Andersson
Summary: Research in Stockholm, Sweden, found that migrants from the Middle East, Africa, and non-Sweden Nordic countries, as well as individuals born in specific countries (such as Somalia, Lebanon, Syria, Turkey, Iran, and Iraq), have higher mortality risks from COVID-19. Socioeconomic status, household composition, and neighborhood population density play a role in mitigating the increased COVID-19 mortality risks among foreign-born individuals.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Amalie H. Simoni, Kriatian H. Kragholm, Henrik Boggild, Svend E. Jensen, Jan B. Valentin, Soren P. Johnsen
Summary: This study investigated the income-related disparity in the incidence of ACS in Denmark over a period of 20 years and found that although the overall incidence of ACS decreased, the income-related disparity remained unchanged.
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Cardiac & Cardiovascular Systems
Chetan P. Huded, Jarrod E. Dalton, Anirudh Kumar, Nikolas I. Krieger, Nicholas Kassis, Michael Phelan, Kathleen Kravitz, Grant W. Reed, Amar Krishnaswamy, Samir R. Kapadia, Umesh Khot
Summary: The comprehensive ST-segment-elevation myocardial infarction protocol was associated with improved care quality for patients across all levels of socioeconomic deprivation and reduced mortality rates in patients from moderate to high deprivation neighborhoods. Standardized initiatives like this can help mitigate social determinants of health in time-sensitive medical conditions.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Dang Wei, Imre Janszky, Rickard Ljung, Karin Leander, Hua Chen, Fang Fang, Jiong Li, Krisztina D. Laszlo
Summary: The death of a spouse is associated with an increased risk of cardiovascular events, particularly in the months following the loss. This study found that the loss of a spouse/partner in the year before a first acute myocardial infarction (AMI) was linked to a higher risk of non-fatal recurrent AMI and death due to ischemic heart disease.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Article
Psychology, Developmental
Elin E. Kimland, Carola Bardage, Julius Collin, Anders Jarleborg, Rickard Ljung, Anastasia N. Iliadou
Summary: The study characterized the prevalence and incidence of dispensed melatonin prescriptions in children and adolescents aged 0-17 in Sweden from 2006-2017, finding a continuous increase in melatonin use, often concomitant with other psychotropic medications. Further studies are needed to examine the long-term use of sleep disturbances medications, especially in younger children.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2021)
Letter
Medicine, General & Internal
Rickard Ljung, Maria Grunewald, Paulina Tuvendal, Carola Bardage
IRISH JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Cardiac & Cardiovascular Systems
Dang Wei, Tristan Olofsson, Hua Chen, Imre Janszky, Fang Fang, Rickard Ljung, Yongfu Yu, Jiong Li, Krisztina D. Laszlo
Summary: The study found that parents who lost a child had a 15% higher risk of atrial fibrillation compared to parents who had not experienced such loss. The risk of atrial fibrillation increased not only when the child died from cardiovascular causes, but also in cases of other natural or unnatural causes of death. Additionally, the risk of atrial fibrillation was highest in the first week after the loss and remained elevated on the long term.
EUROPEAN HEART JOURNAL
(2021)
Article
Clinical Neurology
Dang Wei, Jiong Li, Hua Chen, Fang Fang, Imre Janszky, Rickard Ljung, Krisztina D. Laszlo
Summary: This study found that parents who lost a child have a slightly increased risk of stroke, especially in the case of unnatural deaths. The risk is higher if the parent has no other live children at the time of the loss, or has three or more children.
Article
Medicine, General & Internal
Rickard Ljung, Anders Sundstrom, Maria Grunewald, Charlotte Backman, Nils Feltelius, Rolf Gedeborg, Bjorn Zethelius
Summary: The Swedish Medical Products Agency has launched a project platform for epidemiological surveillance to detect and characterize suspected adverse effects of COVID-19 vaccines in Sweden, using a nationwide register-based study cohort with individual level linkage of COVID-19 vaccination exposure data to other health data registers for safety signal detection and evaluation.
UPSALA JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Medicine, General & Internal
Rickard Ljung, Maria Grunewald, Anders Sundstrom, Lena Thunander Sundbom, Bjorn Zethelius
Summary: This study compares years of life lost (YLL) to suicide with those lost to COVID-19, finding that suicide generates four times more YLL than COVID-19 deaths. Suicide primarily affects younger age groups, while COVID-19 mainly affects the elderly. The efforts and resources put into tackling the pandemic deserve recognition, but from a public health perspective, other contributors to the burden of disease should not be neglected.
UPSALA JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Oncology
Anna Wikman, Emma Hoven, Anette Alvariza, Malin Lovgren, Ulrika Kreicbergs, Charlotte Skoglund, Emma Fransson, Gustaf Ljungman, Rickard Ljung, Lisa Ljungman
Summary: Parents of adolescent cancer survivors have an increased risk of using anxiolytics and sedatives in the first 6 months after the cancer diagnosis, while only mothers have an increased risk of using antidepressants from 6 months to 2 years after the diagnosis. Risk factors include being divorced/widowed, born in a non-Nordic country, older age, and having had previous mental health problems.
Article
Oncology
Emma Hoven, Lisa Ljungman, Josefin Sveen, Charlotte Skoglund, Gustaf Ljungman, Rickard Ljung, Anna Wikman
Summary: This study investigated the risk of psychotropic medication use in parents who lost a child to cancer during adolescence, both in the short-term and long-term. The results showed that a high proportion of bereaved parents, especially mothers, were prescribed psychotropic medications in the year following their child's death. Bereaved parents had a higher risk of medication use compared to non-bereaved parents. However, the use of medications decreased over time, with mothers still displaying a higher use at 5 years after the child's death, while fathers showed no difference to non-bereaved fathers after 2 years. Overall, the study highlights the mental health challenges faced by bereaved parents and the importance of providing support and interventions to aid their healing process.
Article
Psychiatry
Omid Sadr-Azodi, Rickard Ljung, Mats Lindblad, Viktor Oskarsson
Summary: This large case-control study based on Swedish data examined the association between antipsychotic drug use and the risk of acute pancreatitis. The results showed that there was no clear association between the use of antipsychotic drugs and the risk of acute pancreatitis, after controlling for confounding factors.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Letter
Public, Environmental & Occupational Health
Karl Mikael Kalkner, Anders Sundstrom, Marja-Leena Nurminen, Maria Larsson, Rickard Ljung, Veronica Arthurson
Article
Medicine, General & Internal
Rolf Gedeborg, Lennart Holm, Nils Feltelius, Anders Sundstrom, Kai M. Eggers, Marja-Leena Nurminen, Maria Grunewald, Nicklas Pihlstrom, Bjorn Zethelius, Rickard Ljung
Summary: Validation of register-based myocarditis diagnoses through manual patient record review showed a confirmation rate of 96%. Reclassification had minimal impact on the incidence rate ratios for myocarditis following COVID-19 vaccination.
UPSALA JOURNAL OF MEDICAL SCIENCES
(2023)
Letter
Medicine, General & Internal
Rickard Ljung, YiYi Xu, Anders Sundstrom, Susannah Leach, Ebba Hallberg, Maria Bygdell, Maria Larsson, Veronica Arthurson, Magnus Gisslen, Rolf Gedeborg, Fredrik Nyberg
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Article
Substance Abuse
Carola Bardage, Maria Grunewald, Paulina Tuvendal, Rickard Ljung
Summary: A cohort study in Sweden examined first-time dispensed opioids from 2012 to 2015. The study found a shift in opioid use trends from tramadol to oxycodone, without an overall increase in opioid use.
JOURNAL OF SUBSTANCE USE
(2023)
Letter
Surgery
Rickard Ljung, Nicklas Pihlstrom, Anders Sundstrom
BRITISH JOURNAL OF SURGERY
(2022)
