Review
Medicine, General & Internal
Keisuke Narita, Satoshi Hoshide, Kazuomi Kario
Summary: Although various guidelines for cardiovascular disease prevention have been established, the optimal drug therapy is often not implemented due to poor medication adherence and clinical inertia. Polypill strategies, which include combination tablets of three or more medications, have been proven to be useful in preventing cardiovascular disease.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Federico Rea, Laura Savare, Giovanni Corrao, Giuseppe Mancia
Summary: Patients who were prescribed a single-pill combination of statin/ezetimibe were more likely to exhibit good adherence and less likely to have poor adherence to treatment compared to those prescribed a two-pill combination. This was associated with a decreased risk of cardiovascular events in patients with high adherence.
ADVANCES IN THERAPY
(2021)
Article
Pharmacology & Pharmacy
Corey K. Bradley, Ahmed A. Kolkailah, Nishant P. Shah, Courtney B. Page, Eric D. Peterson, Ann Marie Navar
Summary: Nearly two-thirds of individuals with atherosclerotic cardiovascular disease (ASCVD) fail to reach target low-density lipoprotein cholesterol levels despite statin therapy. Three novel lipid-lowering therapies, including ezetimibe, proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i), and icosapent ethyl, have been proven to further reduce ASCVD. However, the utilization rates of these therapies are low, highlighting the need to address the underutilization of non-statin lipid-lowering therapy.
JOURNAL OF CLINICAL LIPIDOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Andre Rivera, Bruno Campos, Stephanie Ceolin, Amanda Godoi, Everton Castanha, Carlos Alberto Campello Jorge, Rhanderson Cardoso
Summary: This study aimed to determine the impact of a polypill-based strategy (PBS) on therapeutic adherence and cardiovascular outcomes compared with usual care for secondary prevention of cardiovascular diseases (CVDs) through a systematic review and meta-analysis of randomized controlled trials (RCTs). The results showed that PBS significantly improved therapeutic adherence, systolic blood pressure (SBP), and LDL-cholesterol (LDL-C), and reduced cardiovascular mortality. Therefore, PBS may be considered as a preferred option for patients with pre-existing CVD.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Julius L. Katzmann, Francesc Sorio-Vilela, Eugen Dornstauder, Uwe Fraas, Timo Smieszek, Sofia Zappacosta, Ulrich Laufs
Summary: Many patients with high cardiovascular disease risk do not achieve the recommended LDL-C targets. Prescription trends for non-statin lipid-lowering therapies have increased in Germany, but are infrequent among general practitioners. Combination therapy with fixed-dose combinations leads to greater reduction in LDL-C, but a significant proportion of patients still have uncontrolled LDL-C levels.
CLINICAL RESEARCH IN CARDIOLOGY
(2022)
Article
Clinical Neurology
Michael Brainin, Yvonne Teuschl, Sheila Martins
Summary: A polypill-type strategy has been proposed as a potential method for preventing cardiovascular and stroke events, especially when combined with community health workers interventions for modifying risk behavior. Despite some issues with nonadherence or potential side effects, this strategy seems to have a significant overall effect in underserved regions of high-income countries as well as in low- and middle-income countries.
Article
Cardiac & Cardiovascular Systems
Shahin Merat, Elham Jafari, Amir Reza Radmard, Masoud Khoshnia, Maryam Sharafkhah, Alireza Nateghi Baygi, Tom Marshall, Abolfazl Shiravi Khuzani, Kar Keung Cheng, Hossein Poustchi, Reza Malekzadeh
Summary: Fixed-dose combination therapy is effective for preventing major cardiovascular events in individuals with and without presumed non-alcoholic steatohepatitis (pNASH). Among participants with fatty liver and elevated liver enzymes, the use of a polypill can reduce liver enzyme levels.
EUROPEAN HEART JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Lluis Masana, Nuria Plana, Natalia Andreychuk, Daiana Ibarretxe
Summary: Statins have played a significant role in preventing atherosclerotic cardiovascular events and deaths by reducing LDL cholesterol levels. International guidelines recommend low LDL cholesterol goals for patients at high cardiovascular risk. However, these goals may not be attainable with statins alone. Recent trials have shown that nonstatin drugs like PCSK9 inhibitors, ezetimibe, bempedoic acid, and icosapent ethyl can also provide cardiovascular benefits. Physicians should use combination therapies based on a patient's risk and LDL cholesterol levels to achieve LDL cholesterol goals and improve cardiovascular outcomes.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Oncology
Kritika Prasai, Sri Harsha Tella, Siddhartha Yadav, Anuhya Kommalapati, Kristin Mara, Mohamed Mady, Mohamed A. Hassan, Nicha Wongjarupong, Natalia Rodriguez-Payan, Mitesh Borad, Tushar Patel, Lewis R. Roberts, Amit Mahipal
Summary: The study demonstrated that the use of aspirin alone or in combination with statins is strongly associated with a reduced risk of gallbladder cancer (GBC). Further prospective studies are needed to confirm these results and elucidate their mechanisms.
Review
Cardiac & Cardiovascular Systems
Mohamed M. G. Mohamed, Mohammed Osman, Babikir Kheiri, Maryam Saleem, Alexandre Lacasse, Mohamad Alkhouli
Summary: This meta-analysis demonstrates that the use of polypills is significantly associated with reductions in blood pressure and blood lipid levels compared to standard of care, leading to a significant decrease in cardiovascular events.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Clinical Neurology
Jackie Bosch, Eva M. Lonn, Gilles R. Dagenais, Peggy Gao, Patricio Lopez-Jaramillo, Jun Zhu, Prem Pais, Alvaro Avezum, Karen Sliwa, Irina E. Chazova, Ron J. G. Peters, Claes Held, Khalid Yusoff, Basil S. Lewis, William D. Toff, Kamlesh Khunti, Christopher M. Reid, Lawrence A. Leiter, Salim Yusuf, Robert G. Hart
Summary: The HOPE-3 trial showed that rosuvastatin significantly reduced the risk of first stroke among individuals at intermediate cardiovascular risk. The combination of blood pressure lowering therapy with rosuvastatin resulted in a substantial reduction in ischemic strokes. Both treatments were found to be safe and well tolerated in the study participants.
Article
Cardiac & Cardiovascular Systems
Jose R. Gonzalez-Juanatey, Alberto Cordero, Jose Ma Castellano, Luis Masana, Regina Dalmau, Emilio Ruiz, Antonio Sicras-Mainar, Valentin Fuster
Summary: This study suggests that treatment with the CNIC-Polypill in secondary prevention patients is associated with a significant reduction in the incidence of recurrent MACE, improved control rates for blood pressure and LDL cholesterol, and increased medication persistence compared to control groups.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Medicine, General & Internal
S. Yusuf, P. Joseph, A. Dans, P. Gao, K. Teo, D. Xavier, P. Lopez-Jaramillo, K. Yusoff, A. Santoso, H. Gamra, S. Talukder, C. Christou, P. Girish, K. Yeates, F. Xavier, G. Dagenais, C. Rocha, T. McCready, J. Tyrwhitt, J. Bosch, P. Pais
Summary: This study showed that combined treatment with a polypill plus aspirin reduced cardiovascular events among participants without cardiovascular disease but at intermediate cardiovascular risk. However, the polypill alone or aspirin alone did not significantly reduce cardiovascular events. Participants in the polypill group had a higher incidence of hypotension or dizziness compared to the placebo group.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Medicine, General & Internal
Antonio Coca, Jose Maria Castellano, Miguel Camafort, Valentin Fuster
Summary: Triple therapy with lipid-lowering, antihypertensive, and antiplatelet agents can reduce the risk of recurrent cardiovascular events and mortality. However, the implementation of these treatments is low in primary and secondary prevention, mainly due to low adherence. Simplifying the treatment regimen through the use of a polypill has shown to improve adherence and control of multiple risk factors.
POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ
(2023)
Review
Cardiac & Cardiovascular Systems
Stefania Angela Di Fusco, Stefano Aquilani, Antonella Spinelli, Alessandro Alonzo, Andrea Matteucci, Lorenzo Castello, Giuseppe Imperoli, Furio Colivicchi
Summary: The polypill strategy has shown promise in improving treatment adherence for cardiovascular disease. Recently published results from a clinical trial focused on secondary prevention demonstrate a reduction in major adverse cardiovascular events. This finding supports the broader implementation of polypill therapy for cardiovascular disease prevention.
PROGRESS IN CARDIOVASCULAR DISEASES
(2023)
Article
Oncology
Johannes J. M. Kwakman, Rob C. M. van Kruijsdijk, Sjoerd G. Elias, Matthew T. Seymour, Angela M. Meade, Frank L. J. Visseren, Cornelis J. A. Punt, Miriam Koopman
Article
Cardiac & Cardiovascular Systems
Gijs F. N. Berkelmans, Soffia Gudbjornsdottir, Frank L. J. Visseren, Sarah H. Wild, Stefan Franzen, John Chalmers, Barry R. Davis, Neil R. Poulter, Annemieke M. Spijkerman, Mark Woodward, Sara L. Pressel, Ajay K. Gupta, Yvonne T. van der Schouw, Ann-Marie Svensson, Yolanda van der Graaf, Stephanie H. Read, Bjorn Eliasson, Jannick An Dorresteijn
EUROPEAN HEART JOURNAL
(2019)
Article
Endocrinology & Metabolism
S. Sharif, F. L. J. Visseren, W. Spiering, P. A. de Jong, M. L. Bots, J. Westerink, A. Algra, Y. van der Graaf, D. E. Grobbee, G. E. H. M. Rutten, G. J. de Borst, L. J. Kappelle, T. Leiner, H. M. Nathoe
Article
Cardiac & Cardiovascular Systems
Nicole E. M. Jaspers, Michael J. Blaha, Kunihiro Matsushita, Yvonne T. van der Schouw, Nicholas J. Wareham, Kay-Tee Khaw, Marie H. Geisel, Nils Lehmann, Raimund Erbel, Karl-Heinz Joeckel, Yolanda van der Graaf, W. M. Monique Verschuren, Jolanda M. A. Boer, Vijay Nambi, Frank L. J. Visseren, Jannick A. N. Dorresteijn
EUROPEAN HEART JOURNAL
(2020)
Article
Cardiac & Cardiovascular Systems
Louise Bowman, Aris Baras, Rene Bombien, Robert M. Califf, Zhengmin Chen, Chris P. Gale, J. Michael Gaziano, Diederick E. Grobbee, Aldo P. Maggioni, Evan D. Muse, Dan M. Roden, Stefan Schroeder, Lars Wallentin, Barbara Casadei
EUROPEAN HEART JOURNAL
(2020)
Correction
Infectious Diseases
Maren Kummerow, Erica J. Shaddock, Kerstin Klipstein-Grobusch, Roos B. Barth, Diederick E. Grobbee, W. D. Francois Venter, Charles Feldman, Alinda Vos
SOUTHERN AFRICAN JOURNAL OF HIV MEDICINE
(2021)
Article
Infectious Diseases
Sarah E. van Riel, Kerstin Klipstein-Grobusch, Roos E. Barth, Diederick E. Grobbee, Charles Feldman, Erica Shaddock, Sarah L. Stacey, Willem D. F. Venter, Alinda G. Vos
Summary: The study identified a history of TB or pneumonia as an independent predictor of impaired lung function in an HIV-positive population in an urban African setting.
SOUTHERN AFRICAN JOURNAL OF HIV MEDICINE
(2021)
Review
Endocrinology & Metabolism
Roberta Lamptey, Maud P. Robben, Mary Amoakoh-Coleman, Daniel Boateng, Diederick E. Grobbee, Melanie J. Davies, Kerstin Klipstein-Grobusch
Summary: There is a lack of research on the association between structured diabetes self-management education (DSME) and glycemic control in low- and middle-income countries (LMICs). However, existing evidence suggests that structured DSME is associated with reductions in glycated hemoglobin in these countries, particularly in sub-Saharan Africa.
Article
Infectious Diseases
Oda E. van den Berg, Erica J. Shaddock, Sarah L. Stacey, Charles Feldman, Roos E. Barth, Diederick E. Grobbee, Willem D. F. Venter, Kerstin Klipstein-Grobusch, Alinda G. Vos
Summary: The study found that HIV infection and ART use were not associated with reduced pulmonary function in an urban African population in Johannesburg, South Africa. Tuberculosis played a mediating role in the relationship between HIV, ART, and pulmonary function.
SOUTHERN AFRICAN JOURNAL OF HIV MEDICINE
(2021)
Article
Medicine, General & Internal
Victor Williams, Alinda Vos, Kennedy Otwombe, Diederick E. Grobbee, Kerstin Klipstein-Grobusch
Summary: This study aims to describe the epidemiology of diabetes mellitus-tuberculosis comorbidity in Eswatini and identify best practices for integrating care for non-communicable diseases into TB services.
Review
Public, Environmental & Occupational Health
Victor Williams, Chukwuemeka Onwuchekwa, Alinda G. Vos, Diederick E. Grobbee, Kennedy Otwombe, Kerstin Klipstein-Grobusch
Summary: This study compiled evidence of changes in blood glucose during and after tuberculosis treatment in previously normoglycaemic patients. It was found that elevated blood glucose in normoglycaemic patients decreased by the end of treatment. Patients with hyperglycaemia at baseline were more likely to develop cavitary lung lesions and experienced poor treatment outcomes and higher post-treatment mortality.
GLOBAL HEALTH ACTION
(2022)
Article
Cardiac & Cardiovascular Systems
Wouter B. van Dijk, Ewoud Schuit, Rieke van der Graaf, Rolf H. H. Groenwold, Sara Laurijssen, Barbara Casadei, Marco Roffi, Seye Abimbola, Martine C. de Vries, Diederick E. Grobbee
Summary: This study evaluated the feasibility of implementing ESC guidelines on general cardiology in 102 countries and found that compliance varied based on the country's income level. High-income countries had better compliance, while low-income countries had lower compliance, largely due to lack of reimbursement and financial barriers.
EUROPEAN HEART JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Salisu Mohammed Ishaku, Kwame Adu-bonsaffoh, Natasha Housseine, Roberta Lamptey, Arie Franx, Diederick Grobbee, Charlotte E. Warren, Joyce L. Browne
Summary: This article aims to generate consensus-based recommendations for the prevention and screening of cardiometabolic and kidney diseases following hypertensive disorders in pregnancy (HDP) in low- and middle-income countries (LMICs). The recommendations provide practical and scalable approaches for effective screening and prevention of cardiometabolic disease following HDP in LMICs. Monitoring and evaluation of implementation of these recommendations provide opportunities for reducing the escalating burden of noncommunicable diseases in LMICs.
Article
Cardiac & Cardiovascular Systems
Wouter B. van Dijk, Artuur M. Leeuwenberg, Diederick E. Grobbee, Sabrina Siregar, Saskia Houterman, Edgar J. Daeter, Martine C. de Vries, Rolf H. H. Groenwold, Ewoud Schuit
Summary: A study in the Netherlands revealed that the EuroSCORE II model has good discriminative performance but consistently overestimates mortality risks in all types of major cardiothoracic surgical procedures. The values of individual predictors varied widely over time.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Hematology
Farahnaz Waissi, Mirthe Dekker, Ingrid E. M. Bank, Suzanne J. A. Korporaal, Rolf T. Urbanus, Gert J. de Borst, Gerard Pasterkamp, Asbjorn M. Scholtens, Diederick E. Grobbee, Arend Mosterd, Dominique P. de Kleijn, Leo Timmers
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2020)