Article
Clinical Neurology
Victoria Gauthier, Dominique Cottel, Philippe Amouyel, Jean Dallongeville, Aline Meirhaeghe
Summary: The study in northern France found that the 28-day case fatality rates were 48% for hemorrhagic strokes and 15% for ischemic strokes. Age and stroke severity were significantly associated with case fatality, with cardiovascular history and nursing home residence also influencing prognosis. Being treated in a neurology ward was linked to improved survival rates for all stroke subtypes.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Public, Environmental & Occupational Health
Conrad Drescher, Fredrik Buchwald, Teresa Ullberg, Mats Pihlsgard, Bo Norrving, Jesper Petersson
Summary: This study investigated the incidence trends of spontaneous intracerebral hemorrhage (ICH) in Sweden between 2010 and 2019. The results showed a decrease in the overall incidence of first-ever ICH, with a significant decrease in non-OAC-associated ICH and a significant increase in OAC-associated ICH.
Article
Pediatrics
Annika Julihn, Fernanda Cunha Soares, Anders Hjern, Goran Dahllof
Summary: This study shows that the level of development in the parental country of origin and the socioeconomic status of the family in Sweden influence the risk of caries development in their children.
Article
Public, Environmental & Occupational Health
Nina T. Rogers, Joanna M. Blodgett, Samuel D. Searle, Rachel Cooper, Daniel H. J. Davis, Snehal M. Pinto Pereira
Summary: The study found that early-life socioeconomic status is associated with frailty in midlife, and that adult socioeconomic status only partially explains this association.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Oncology
Maneet Kaur, Corinne E. Joshu, Kala Visvanathan, Avonne E. Connor
Summary: Breast cancer incidence rates have been increasing across race/ethnicity and subgroups in the United States, with the highest average annual percent increases observed among non-Hispanic Black women. Non-Hispanic Black women and Hispanic women also showed significant increases in some subgroups.
Article
Public, Environmental & Occupational Health
Ashleigh Craig, Asanda Mtintsilana, Witness Mapanga, Siphiwe N. Dlamini, Shane A. Norris
Summary: This study examined the relationship between overweight perception and multimorbidity and found that individuals who perceived themselves as overweight had a higher likelihood of having multiple chronic conditions. The study also found that overweight perception partially mediated the association between socioeconomic position and multimorbidity. These findings highlight the importance of targeted interventions aimed at raising awareness about weight-related risks, particularly in lower economic developed countries.
Article
Public, Environmental & Occupational Health
Amalie H. Simoni, Kriatian H. Kragholm, Henrik Boggild, Svend E. Jensen, Jan B. Valentin, Soren P. Johnsen
Summary: This study investigated the income-related disparity in the incidence of ACS in Denmark over a period of 20 years and found that although the overall incidence of ACS decreased, the income-related disparity remained unchanged.
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Mohamed Yusuf, Gallin Montgomery, Mark Hamer, Jamie McPhee, Rachel Cooper
Summary: The study suggests that lower childhood and adulthood socioeconomic status is associated with weaker grip strength in women and stronger grip strength in men. Additionally, the relationship between occupational class and grip strength is non-linear, with differences observed between different occupational groups.
Article
Behavioral Sciences
Klara Andersson, Anneli Ozanne, Johan Zelano, Kristina Malmgren, John E. Chaplin
Summary: Perceived stigma is associated with the country of birth and socioeconomic status (SES). It is important to acknowledge the concerns of foreign-born patients and prioritize seizure control and the detection and treatment of comorbidities.
EPILEPSY & BEHAVIOR
(2022)
Article
Public, Environmental & Occupational Health
Mikael Rostila, Agneta Cederstrom, Matthew Wallace, Maria Branden, Bo Malmberg, Gunnar Andersson
Summary: Research in Stockholm, Sweden, found that migrants from the Middle East, Africa, and non-Sweden Nordic countries, as well as individuals born in specific countries (such as Somalia, Lebanon, Syria, Turkey, Iran, and Iraq), have higher mortality risks from COVID-19. Socioeconomic status, household composition, and neighborhood population density play a role in mitigating the increased COVID-19 mortality risks among foreign-born individuals.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Oncology
Kari Hemminki, Kristina Sundquist, Jan Sundquist, Asta Foersti, Vaclav Liska, Akseli Hemminki, Xinjun Li
Summary: Familial risk of liver and gallbladder cancer is relatively high, and it is associated with other cancers. Prevention of these cancers should focus on avoiding risk factors, such as alcohol, smoking, and overweight, and seeking medical care for diabetes and liver infections.
Article
Public, Environmental & Occupational Health
Kimberly D. Martin, Gloria L. Beckles, Chengyi Wu, Leslie A. McClure, April P. Carson, Aleena Bennett, Kai McKeever Bullard, M. Maria Glymour, Fred Unverzagt, Solveig Cunningham, Giuseppina Imperatore, Virginia J. Howard
Summary: This study found that low childhood socioeconomic position was associated with Type 2 diabetes incidence among African Americans but not among white participants. Cumulative socioeconomic position had an impact on T2DM incidence for both racial groups, and social mobility also affected the risk of diabetes.
PREVENTIVE MEDICINE
(2021)
Article
Neurosciences
Emma Lindgren, Josephine Sorenson, Carina Wattmo, Ingemar Kareholt, Katarina Nagga
Summary: This registry-based study found significant differences in dementia diagnostics, treatment, and care between foreign-born and Swedish-born individuals. These differences were more pronounced with lower country level socioeconomic position, indicating a need for further research on equity in dementia care.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Peripheral Vascular Disease
Jose Aparecido Soares Lopes, Luana Giatti, Rosane Harter Griep, Antonio Alberto da Silva Lopes, Sheila Maria Alvim Matos, Dora Chor, Maria de Jesus M. Fonseca, Sandhi Maria Barreto
Summary: Life course epidemiology is a powerful framework to understand the role of socioeconomic position disparities in hypertension. This study found that socioeconomic disparities at all phases of life raise hypertension incidence rates, with individuals who have greater accumulation of exposure to low SEP and more unfavorable intergenerational mobility at greatest risk.
AMERICAN JOURNAL OF HYPERTENSION
(2021)
Article
Public, Environmental & Occupational Health
M. Waller, L. Lissner, D. Hange, V Sundh, A. Blomstrand, C. Bjorkelund
Summary: Women's lives have changed dramatically in recent decades, with higher perceptions of well-being but also higher mental stress regardless of socio-occupational group. While good well-being has increased in 50-year-old women over time, high mental stress has increased for both 38- and 50-year-old women. Belonging to a low socio-occupational group was associated with lower perceived well-being in 1980 but not in 2016.
Article
Medicine, Research & Experimental
Lars Alfredsson, Tomas Olsson
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
(2019)
Article
Nutrition & Dietetics
Josefin E. Lofvenborg, Emma Ahlqvist, Lars Alfredsson, Tomas Andersson, Mozhgan Dorkhan, Leif Groop, Tiinamaija Tuomi, Alicja Wolk, Sofia Carlsson
EUROPEAN JOURNAL OF NUTRITION
(2020)
Article
Anesthesiology
Joern Loetsch, Lars Alfredsson, Jon Lampa
Article
Multidisciplinary Sciences
Katarina Tengvall, Jesse Huang, Cecilia Hellstrom, Patrick Kammer, Martin Bistrom, Burcu Ayoglu, Izaura Lima Bomfim, Pernilla Stridh, Julia Butt, Nicole Brenner, Angelika Michel, Karin Lundberg, Leonid Padyukov, Ingrid E. Lundberg, Elisabet Svenungsson, Ingemar Ernberg, Sigurgeir Olafsson, Alexander T. Dilthey, Jan Hillert, Lars Alfredsson, Peter Sundstrom, Peter Nilsson, Tim Waterboer, Tomas Olsson, Ingrid Kockum
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Clinical Neurology
Anna Karin Hedstrom, Nicole Brenner, Julia Butt, Jan Hillert, Tim Waterboer, Tomas Olsson, Lars Alfredsson
Summary: This study found that overweight/obesity in young adulthood interacts significantly with high EBNA-1 antibody levels, increasing the risk for multiple sclerosis. Furthermore, three-way interactions were present between HLA-DRB1*15:01, overweight/obesity at age 20 years, and each aspect of EBV infection.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2021)
Article
Biochemistry & Molecular Biology
Morten Mattingsdal, S. Sunna Ebenesersdottir, Kristjan H. S. Moore, Ole A. Andreassen, Thomas F. Hansen, Thomas Werge, Ingrid Kockum, Tomas Olsson, Lars Alfredsson, Agnar Helgason, Kari Stefansson, Eivind Hovig
Summary: This study describes the genetic structure of the Norwegian population, revealing distinctive patterns of genetic variation in the far northeast and south regions, with enriched Uralic Sami ancestry in the North. Migration rates are influenced by topography, and higher relatedness is found between the mid- and northern border areas towards Sweden. Despite Norway's maritime history, the region closest to mainland Europe seems to have been isolated, hindered by the open sea as a barrier to gene flow.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2021)
Article
Medicine, General & Internal
Goran Walldius, Ulf de Faire, Lars Alfredsson, Karin Leander, Peter Westerholm, Hakan Malmstrom, Torbjorn Ivert, Niklas Hammar
Summary: Elevated levels of apoB and apoB/apoA-1 ratio are associated with increased risk of MACEs, while decreased levels of apoA-1 potentiate the impact of apoB. MACEs occur earlier with higher apoB/apoA-1 ratio, suggesting the need for early recognition and primary prevention.
Article
Endocrinology & Metabolism
Jessica Edstorp, Yuxia Wei, Emma Ahlqvist, Lars Alfredsson, Valdemar Grill, Leif Groop, Bahareh Rasouli, Elin P. Sorgjerd, Per M. Thorsby, Tiinamaija Tuomi, Bjorn O. Asvold, Sofia Carlsson
Summary: The study reveals that smoking and snus use are associated with a higher risk of LADA and type 2 diabetes, and smoking acts synergistically with HLA high-risk genotypes in the development of LADA.
Article
Multidisciplinary Sciences
Olivia G. Thomas, Mattias Bronge, Katarina Tengvall, Birce Akpinar, Ola B. Nilsson, Erik Holmgren, Tara Hessa, Guro Gafvelin, Mohsen Khademi, Lars Alfredsson, Roland Martin, Andre Ortlieb Guerreiro-Cacais, Hans Groenlund, Tomas Olsson, Ingrid Kockum
Summary: Multiple sclerosis (MS) is an inflammatory disease of the central nervous system, with Epstein-Barr virus (EBV) infection as a likely prerequisite. This study found that antibody reactivity to CRYAB amino acids 7 to 16 was associated with MS, and the combination of high EBNA1 responses with CRYAB positivity greatly increased disease risk. Additionally, evidence of antibody cross-reactivity between EBNA1 and CRYAB, as well as T cell cross-reactivity, was found, further demonstrating the role of EBV immune responses in MS development.
Article
Biochemistry & Molecular Biology
Alexandre Xavier, Vicki E. Maltby, Ewoud Ewing, Maria Pia Campagna, Sean M. Burnard, Jesper N. Tegner, Mark Slee, Helmut Butzkueven, Ingrid Kockum, Lara Kular, Vilija G. Jokubaitis, Trevor Kilpatrick, Lars Alfredsson, Maja Jagodic, Anne-Louise Ponsonby, Bruce V. Taylor, Rodney J. Scott, Rodney A. Lea, Jeannette Lechner-Scott
Summary: This study reveals that DNA methylation differences in multiple sclerosis (MS) occur independently of known genetic risk loci. It shows that these differences more effectively differentiate the disease compared to known genetic risk loci. The study also indicates that the methylation differences in MS predominantly occur in B cells and monocytes, involving cell-specific biological pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Meeting Abstract
Clinical Neurology
J. Wu, A. K. Hedstrom, I. S. Kockum, T. Olsson, L. Alfredsson
MULTIPLE SCLEROSIS JOURNAL
(2019)
Meeting Abstract
Clinical Neurology
V. Rosengren, L. Alfredsson, T. Olsson
MULTIPLE SCLEROSIS JOURNAL
(2019)
Meeting Abstract
Clinical Neurology
M. Pahlevan Kakhki, L. Kular, Y. Liu, T. James, A. Gyllenberg, L. Alfredsson, J. Hillert, T. Olsson, I. Kockum, M. Jagodic
MULTIPLE SCLEROSIS JOURNAL
(2019)
Meeting Abstract
Clinical Neurology
A. Manouchehrinia, K. A. McKay, L. Alfredsson, F. Peihl, T. Olsson, J. Kuhle, I. Kockum
MULTIPLE SCLEROSIS JOURNAL
(2019)
Correction
Anesthesiology
S. Burkill, S. Montgomery, I Kockum, F. Piehl, P. Strid, J. Hillert, L. Alfredsson, T. Olsson, S. Bahmanyar