Article
Cardiac & Cardiovascular Systems
Catherina Tjahjadi, Federico Fortuni, Jan Stassen, Philippe Debonnaire, Rodolfo P. Lustosa, Nina Ajmone Marsan, Victoria Delgado, Jeroen J. Bax
Summary: Right ventricular systolic dysfunction is independently associated with poor prognosis in cardiac amyloidosis patients. RV free wall strain serves as an important predictor for outcomes.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Giuseppe Palmiero, Emanuele Monda, Federica Verrillo, Francesca Dongiglio, Martina Caiazza, Marta Rubino, Michele Lioncino, Gaetano Diana, Erica Vetrano, Adelaide Fusco, Annapaola Cirillo, Alfredo Mauriello, Giovanni Ciccarelli, Luigi Ascione, Maria Luisa De Rimini, Michele D'Alto, Giuseppe Cerciello, Antonello D'Andrea, Paolo Golino, Paolo Calabro, Eduardo Bossone, Giuseppe Limongelli
Summary: This study aimed to evaluate the prevalence and clinical significance of right ventricular pulmonary arterial (RV-PA) uncoupling in patients with cardiac amyloidosis (CA). The results showed that RV-PA uncoupling is common in CA patients, indicating advanced disease and worse outcomes. The study also suggested that the TAPSE/PASP ratio may improve risk stratification and guide management strategies in CA patients.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Peter R. Huntjens, Kathleen W. Zhang, Yuko Soyama, Maria Karmpalioti, Daniel J. Lenihan, John Gorcsan
Summary: In patients with cardiac amyloidosis, echocardiographic strain imaging of all four cardiac chambers was found to be significantly associated with survival. Among the strain values, peak longitudinal LA strain showed the strongest association with prognosis. Atrial and ventricular strain have potential clinical utility in predicting outcomes in these patients.
JACC-CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Cristiane C. Singulane, Jeremy A. Slivnick, Karima Addetia, Federico M. Asch, Nitasha Sarswat, Laurie Soulat-Dufour, Victor Mor-Avi, Roberto M. Lang
Summary: Cardiac amyloidosis (CA) has a significant impact on the right atrial (RA) structure and function, with increased RA volume and impaired RA reservoir, conduit, and booster strains. RA reservoir and conduit strains are significantly associated with mortality in CA patients. RA strain may serve as a potentially useful marker for the diagnosis, subtype differentiation, and risk stratification of CA.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2022)
Article
Cardiac & Cardiovascular Systems
Tor Skibsted Clemmensen, Hans Eiskjaer, Bertil Ladefoged, Fabian Mikkelsen, Jens Sorensen, Sven-Olof Granstam, Sara Rosengren, Frank A. Flachskampf, Steen Hvitfeldt Poulsen
Summary: This study suggests that left ventricular myocardial work may have prognostic value in cardiac amyloidosis patients by predicting major adverse cardiac events (MACE) and all-cause mortality. Combining LVMWI and the apical-to-basal segmental work ratio can independently predict all-cause mortality. LVGLS, on the other hand, does not predict all-cause mortality in this patient population.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2021)
Article
Medicine, General & Internal
Jan Eckstein, Negin Moghadasi, Hermann Koerperich, Elena Weise Valdes, Vanessa Sciacca, Lech Paluszkiewicz, Wolfgang Burchert, Misagh Piran
Summary: This study challenges the state-of-the-art diagnostic methods for cardiac amyloidosis (CA) by utilizing machine learning algorithms to analyze multi-chamber strain and cardiac function. The results show that the supervised machine (SVM) with radial basis function (RBF) kernel achieved competitive diagnostic accuracies, providing valuable predictions for CA under supervised conditions.
Article
Cardiac & Cardiovascular Systems
Efstratios Koutroumpakis, Adam Niku, Christopher K. Black, Abdelrahman Ali, Humaira Sadaf, Juhee Song, Nicolas Palaskas, Cezar Iliescu, Jean-Bernard Durand, Syed Wamique Yusuf, Hans C. Lee, L. Maximilian Buja, Anita Deswal, Jose Banchs
Summary: This study investigated the predictive role of echocardiographic and cardiac histomorphology parameters in mortality of patients with cardiac AL amyloidosis. Patients with biopsy-proven cardiac AL amyloidosis were analyzed for myocardial strain and histomorphology. The results showed that lower LA strain and absence of SCT were associated with increased risk of death, and higher LV mass and lower RV tricuspid annular plane systolic excursion were associated with increased odds of interstitial amyloid deposition on biopsy. This study suggests the potential benefits of using LA strain in routine assessment and the positive effect of SCT in cardiac AL amyloidosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Marius Keller, Tim Heller, Marcia-Marleen Duerr, Christian Schlensak, Martina Nowak-Machen, You-Shan Feng, Peter Rosenberger, Harry Magunia
Summary: 3D right ventricular strain analysis can help identify patients at risk for adverse postoperative events in cardiac surgery.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2022)
Article
Biochemistry & Molecular Biology
Jan Eckstein, Vanessa Sciacca, Hermann Korperich, Lech Paluszkiewicz, Elena Weise Valdes, Wolfgang Burchert, Muhammed Gercek, Martin Farr, Philipp Sommer, Christian Sohns, Misagh Piran
Summary: This study assesses the diagnostic differences in the longitudinal right atrial strain and strain rate between cardiac amyloidosis (CA) and hypertrophic cardiomyopathy (HCM) patients, as well as the impact of atrial fibrillation on the right atrial function in CA patients. The study finds that MRI-derived right atrial strain and strain rate are impaired in CA patients and can support noninvasive differentiation between CA, HCM, and control subjects.
Article
Medicine, General & Internal
Silvia Oghina, Wulfran Bougouin, Mounira Kharoubi, Louis Bonnefous, Arnault Galat, Soulef Guendouz, Melanie Bezard, Fabien Le Bras, Jean-Francois Deux, Emmanuel Itti, Anissa Moktefi, Pascale Fanen, Emmanuel Teiger, Dania Mohty, Thibaud Damy, Diane Bodez
Summary: All LVDF patterns can be observed in CA, and one quarter of CA patients have a better prognosis with grade I LVDF.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Maria Chiara Meucci, Rosa Lillo, Federica Mango, Antonella Lombardo, Gaetano A. Lanza, Valentina Parisi, Maria Grandinetti, Massimo Massetti, Nina Ajmone Marsan, Filippo Crea, Francesca Graziani
Summary: Left ventricular hypertrophy is the main feature of cardiac involvement in Anderson-Fabry disease, but the right ventricle is also frequently affected. Previous studies failed to show an independent association between conventional parameters of right ventricular performance and outcomes in Anderson-Fabry disease. However, it is currently unknown whether right ventricular free wall strain assessed by 2D speckle tracking analysis can provide better prognostication.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Veterinary Sciences
Lina Hamabe, Kazumi Shimada, Ahmed S. Mandour, Tomohiko Yoshida, Miki Hirose, Hanan Hendawy, Hussein M. El-Husseiny, Ryou Tanaka
Summary: Standard and advanced echocardiographic techniques are important tools for assessing cardiac performance in animals. Factors such as breed, age, and body weight can affect echocardiographic parameters, but breed does not have a significant association with these parameters. However, left ventricular dimensions increase with body weight, and certain parameters are influenced by age.
VETERINARY SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Vito Di Terlizzi, Roberta Barone, Vincenzo Manuppelli, Michele Correale, Grazia Casavecchia, Giovanni Goffredo, Pierluigi Pellegrino, Alessandra Puteo, Riccardo Ieva, Matteo Di Biase, Natale Daniele Brunetti, Massimo Iacoviello
Summary: This study aimed to analyze the impact of heart rate changes on left and right ventricular longitudinal strain in participants with and without chronic heart failure (CHF). The results showed that as heart rate increased, there was a decrease in left ventricular longitudinal strain and an improvement in right ventricular longitudinal strain and right ventricular free wall longitudinal strain. Some participants exhibited deteriorations in right ventricular strain measures, which were associated with lower baseline right ventricular function and higher pulmonary systolic pressures.
APPLIED SCIENCES-BASEL
(2022)
Review
Biochemistry & Molecular Biology
Dominik Waldmeier, Jan Herzberg, Frank-Peter Stephan, Marcus Seemann, Nisha Arenja
Summary: This review provides an overview of the use of multimodality imaging in cardiac amyloidosis, highlighting its diagnostic possibilities and prognostic values. Echocardiography is the preferred diagnostic tool, while cardiac magnetic resonance and scintigraphy play crucial roles in diagnosis and subtype differentiation.
Article
Cardiac & Cardiovascular Systems
Francesco Bandera, Raffaele Martone, Liza Chacko, Sharmananthan Ganesananthan, Janet A. Gilbertson, Markella Ponticos, Thirusha Lane, Ana Martinez-Naharro, Carol Whelan, Cristina Quarta, Dorota Rowczenio, Rishi Patel, Yousuf Razvi, Helen Lachmann, Ashutosh Wechelakar, James Brown, Daniel Knight, James Moon, Aviva Petrie, Francesco Cappelli, Marco Guazzi, Luciano Potena, Claudio Rapezzi, Ornella Leone, Philip N. Hawkins, Julian D. Gillmore, Marianna Fontana
Summary: This study characterized left atrial pathology in explanted hearts with transthyretin amyloid cardiomyopathy (ATTR-CM); assessed left atrial mechanics using echocardiographic speckle tracking in a large cohort of ATTR-CM patients; and studied the association with mortality. The findings revealed extensive atrial infiltration of ATTR amyloid, loss of atrial function, and increased stiffness, which were strong independent predictors of mortality. A distinctive phenotype named atrial electromechanical dissociation (AEMD) was identified in patients in sinus rhythm with poor prognosis.
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Mandeep S. Sidhu, Karen P. Alexander, Zhen Huang, Roy O. Mathew, Jonathan D. Newman, Sean M. O'Brien, Patricia A. Pellikka, Radmila Lyubarova, Olga Bockeria, Carlo Briguori, Evgeny L. Kretov, Tomasz Mazurek, Francesco Orso, Marek F. Roik, Chakkanalil Sajeev, Evgeny Shutov, Frank W. Rockhold, David Borrego, Stephen Balter, Gregg W. Stone, Bernard R. Chaitman, Shaun G. Goodman, Jerome L. Fleg, Harmony R. Reynolds, David J. Maron, Judith S. Hochman, Sripal Bangalore
Summary: In the ISCHEMIA-CKD study, patients with advanced chronic kidney disease and chronic coronary disease had similar all-cause mortality rates with initial invasive or conservative strategies. This secondary analysis aimed to determine whether an initial invasive strategy reduced the incidence of cardiovascular or non-cardiovascular causes of death. The results showed no significant difference in the cause-specific death rates between the two treatment strategies.
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Patricia A. Pellikka
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Patricia A. Pellikka
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Article
Cardiac & Cardiovascular Systems
Hema Krishna, Kevin Desai, Brody Slostad, Siddharth Bhayani, Joshua H. Arnold, Wouter Ouwerkerk, Yoran Hummel, Carolyn S. P. Lam, Justin Ezekowitz, Matthew Frost, Zhubo Jiang, Cyril Equilbec, Aamir Twing, Patricia A. Pellikka, Leon Frazin, Mayank Kansal
Summary: Aortic stenosis is a common heart valve disease, and the use of artificial intelligence technology can accurately evaluate the severity of the disease, improving the accuracy of diagnosis and treatment.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Biographical-Item
Cardiac & Cardiovascular Systems
Patricia A. Pellikka
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Patricia A. Pellikka
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Article
Cardiac & Cardiovascular Systems
Tomoko Ichiki, Valentina Cannone, Christopher G. Scott, Seethalakshmi R. Iyer, S. Jeson Sangaralingham, Kent R. Bailey, Jens P. Goetze, Yoshihisa Tsuji, Richard J. Rodeheffer, John C. Burnett
Summary: Males have lower levels of ANP and BNP and higher prevalence of cardiometabolic disease. The ANP gene variant rs5068 is associated with better metabolic function in males, while the BNP gene variant rs198389 is not associated with metabolic profile in the general population. ANP may play a more significant role in metabolic homeostasis, especially in males.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jwan A. Naser, Eunjung Lee, Christopher G. Scott, Austin M. Kennedy, Patricia A. Pellikka, Grace Lin, Sorin Pislaru, Barry A. Borlaug
Summary: This study aimed to investigate the prevalence and incidence of DD in patients with new-onset AF compared with SR. The results showed that patients with new-onset AF have high-risk features for HFpEF at diagnosis and accelerated progression in DD over time.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Li-Tan Yang, Zi Ye, Muhammad Wajih Ullah, Joseph J. Maleszewski, Christopher G. Scott, Ratnasari Padang, Sorin Pislaru, Vuyisile T. Nkomo, Sunil Mankad, Patricia A. Pellikka, Jae K. Oh, Veronique L. Roger, Maurice Enriquez-Sarano, Hector Michelena
Summary: This study aimed to assess lifetime morbidity and long-term survival in patients with bicuspid aortic valve (BAV) in the community. The results showed that BAV patients have a high lifetime morbidity burden, with a high incidence of complications such as aortic stenosis or regurgitation, aortic surgery, aortic aneurysm, infective endocarditis, and aortic dissection. Compared to patients with typical valvulo-aortopathy, patients with complex valvulo-aortopathy have lower survival rates.
EUROPEAN HEART JOURNAL
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Brototo Deb, Christopher Scott, Sorin Pislaru, Vuyisile Tlhopane Nkomo, Garvan C. Kane, Mohamad Adnan Alkhouli, Nishant Saran, Juan A. Crestanello, Patricia A. Pellikka, Vidhu Anand
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
S. Michael Gharacholou, David O. Hodge, Goyal Umadat, Carolyn Meyers, Garvan C. Kane, Lawrence J. Sinak, Patricia A. Pellikka, Leslie T. Cooper, Pragnesh Parikh, Abdallah El Sabbagh
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Ashley Akerman, Mihaela Porumb, Arian Beqiri, Agisilaos Chartsias, Christopher Scott, Alexander Ryu, Garvan C. Kane, Sorin Pislaru, Francisco Lopez-Jimenez, Rizwan Sarwar, Paul Leeson, Ross Upton, Gary Woodward, Patricia A. Pellikka
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Vidhu Anand, Hector I. Michelena, Christopher Scott, Alexander Lee, Vera H. Rigolin, Juan A. Crestanello, Sorin Pislaru, Garvan C. Kane, Patricia A. Pellikka
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Li-Tan Yang, Muhammad Wajih Ullah, Zi Ye, Joseph John Maleszewski, Christopher Scott, Ratnasari Padang, Sorin Pislaru, Vuyisile Tlhopane Nkomo, Sunil V. Mankad, Patricia A. Pellikka, Jae K. Oh, Veronique Lee Roger, Maurice Enriquez-Sarano, Hector I. Michelena
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Pamela Pina Santana, Daniel Lorenzatti, Kacie Amacher, Jake T. Gilman, Abdullah Aftab, Patricia A. Pellikka, Min Pu, Amit Jai Verma, Nishi Shah, Carlos A. Gongora, Aldo Schenone, Ulrich P. Jorde, Luigi Di Biase, Mario J. Garcia, Leandro Slipczuk
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)