Review
Oncology
Surendar Aravindhan, Sura Salman Ejam, Methaq Hadi Lafta, Alexander Markov, Alexei Valerievich Yumashev, Majid Ahmadi
Summary: The interaction between the tumor microenvironment and tumor cells plays a crucial role in tumor progression, with mesenchymal stem cells (MSCs) being key players in modulating the tumor microenvironment and influencing the fate of tumor cells. MSCs exhibit dual functions in the tumor microenvironment, either promoting tumorigenicity or inhibiting tumor growth. Their ability to release mediators such as exosomes and migrate to tumor sites facilitates efficient drug delivery and targeting of migrating tumor cells.
CANCER CELL INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Talagavadi Channaiah Anudeep, Madhan Jeyaraman, Sathish Muthu, Ramya Lakshmi Rajendran, Prakash Gangadaran, Prabhu Chandra Mishra, Shilpa Sharma, Saurabh Kumar Jha, Byeong-Cheol Ahn
Summary: Alopecia, including scarring and non-scarring types, is a common diagnosis in clinical practice. The most prevalent type is non-scarring alopecia, with androgenetic alopecia and alopecia areata being the majority of cases. Traditional treatments have significant downsides, leading to the exploration of regenerative therapies. Growth factor-rich and stem cell-rich treatments have shown potential, but standardization is lacking. Further understanding and standardization of regenerative cellular therapies for hair restoration are needed.
Article
Oncology
Quoc Thang Bui, Kuan-Der Lee, Yu-Ching Fan, Branwen S. Lewis, Lih-Wen Deng, Yuan-Chin Tsai
Summary: Cancer cells and MSCs secrete CCL2, which attracts TAMs and promotes malignant progression. Blocking CCL2 expression in MSCs showed anti-tumor effects when injected with prostate cancer cells in mice. The inhibitory effect was associated with an increase of mononuclear myeloid cells in tumors.
Article
Cell & Tissue Engineering
Zahra Jabbarpour, Sajjad Aghayan, Babak Arjmand, Khadijeh Fallahzadeh, Sepideh Alavi-Moghadam, Bagher Larijani, Hamid Reza Aghayan
Summary: The study aimed to establish a xeno-free/GMP-compliant protocol for fetal pancreatic-derived mesenchymal stem cells (FPMSCs) manufacturing, with a focus on replacing fetal bovine serum (FBS) with pooled human serum (HS). The results demonstrated that HS was a better alternative to FBS for in vitro expansion of FPMSCs, as it increased their proliferation rate and decreased their senescence. In conclusion, HS can effectively replace FBS for clinical-grade FPMSCs manufacturing.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Cell Biology
Alireza Goodarzi, Mohsen Valikhani, Fatemeh Amiri, Armita Safari
Summary: Mesenchymal stem/stromal cells (MSCs) are characterized by unpredictable characteristics in their bone marrow niche, which makes them an issue in biology. MSCs are widely used in regenerative medicine due to their unique potentials for trans-differentiation, immunomodulation, and paracrine capacity. However, their pathogenic and pro-survival effects in tumors/cancers are undeniable.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Cell & Tissue Engineering
Haoran Shi, Zhishan Jin, Yan Mao, Ruilin Ma, Jianjian Cui, Zejun Yang, Jianwen Zhu, Hui Gao, Yin Zhao
Summary: Preeclampsia is a common complication of pregnancy that seriously jeopardizes the health of both mother and infant. Previous studies have shown that hypoxic preconditioning can enhance the viability and migration ability of placental mesenchymal stem cells (PMSCs) and this effect is mediated through the DANCR/miR-656-3p/HIF-1α pathway.
Article
Immunology
Yiqing Tian, Jian Fang, Fanpeng Zeng, Yongqiang Chen, Yunfeng Pei, Feng Gu, Chen Ding, Guoping Niu, Bing Gu
Summary: This article describes the role of mesenchymal stem cells in tumors and the impact of hypoxic environments on tumor development. It discusses the mutual influence between hypoxic MSCs and immune cells in the TME, as well as the potential drug resistance and therapeutic effects of hypoxic MSCs.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Cell & Tissue Engineering
Ramana Vaka, Darryl R. Davis
Summary: This article discusses the current state of cellular therapies for cardiac repair and regeneration, outlining the progression of new ideas from preclinical literature to ongoing clinical trials. Recent data supporting the mechanics and mechanisms of myogenic and paracrine therapies are evaluated in the context of long-term cardiac engraftment, informing on promising new approaches for future avenues in the field.
Review
Cell Biology
Qing Zhang, Jialin Wang, Junwen Zhang, Fusheng Liu
Summary: Mesenchymal stem cells (MSCs) play crucial roles in the tumor microenvironment (TME), contributing to tumor progression and therapeutic resistance. Glioma-resident MSCs (GR-MSCs) enhance the tumorigenicity of glioma stem cells (GSCs) through the IL-6/gp130/STAT3 pathway. Higher percentage of GR-MSCs in the TME leads to poor prognosis of glioma patients and their secretion of specific miRNA promotes tumor growth. Novel therapeutic strategies targeting GR-MSCs are urgently needed for GBM patients.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jize Liu, Xiaomin Ma, Chuxuan Liu, Yang Cheng, Bingjun Li, Wenjie Zhang, Runzhi Zeng, Qishuai Chen, Yun Zhang, Sanyuan Hu
Summary: In this study, the therapeutic effect of MSCs and their improvement of sensitivity to alpha PD1 therapy in CRC were investigated. It was found that MSCs recruit and polarize macrophages to inhibit tumor growth through the secretion of CX3CL1. The combination of MSCs and alpha PD1 was more effective than monotherapy in CRC.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Cell & Tissue Engineering
Andrea Amaroli, Claudio Pasquale, Angelina Zekiy, Stefano Benedicenti, Andrea Marchegiani, Maria Giovanna Sabbieti, Dimitrios Agas
Summary: Bone marrow-derived multipotent mesenchymal cells (MSCs) have diverse applications in clinical settings. Photobiomodulation therapy (PBM-t) can enhance the anti-inflammatory and osteogenic properties of MSCs.
JOURNAL OF TISSUE ENGINEERING
(2022)
Review
Biochemistry & Molecular Biology
Insun Song, Jongseop Rim, Jaemin Lee, Inseok Jang, Bosung Jung, Kisoo Kim, Soonchul Lee
Summary: This review examines the biological advantages of human fetal MSCs (hfMSCs) in healing diseases and regeneration, as well as the research evidence for their engraftment and immunomodulation. The potential therapeutic feasibilities of hfMSCs for musculoskeletal disorders are also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell & Tissue Engineering
Jiajia Xu, Yiyun Wang, Mario A. Gomez-Salazar, Ginny Ching-Yun Hsu, Stefano Negri, Zhao Li, Winters Hardy, Lijun Ding, Bruno Peault, Aaron W. James
Summary: Mesenchymal progenitor cells are widely distributed in perivascular niches, particularly in the tunica adventitia of mammalian tissues. Adventitial cells demonstrate strong osteogenic potential and may play a significant role in future tissue repair and bioengineering efforts.
Review
Biochemistry & Molecular Biology
Carl Randall Harrell, Ana Volarevic, Valentin G. Djonov, Nemanja Jovicic, Vladislav Volarevic
Summary: Mesenchymal stem cells (MSCs) play a crucial role in regulating the interactions between immune cells and tumor cells, affecting tumor growth and immune responses. Their plasticity allows them to adapt to the tumor microenvironment and potentially be used as therapeutic agents in cancer immunotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Genetics & Heredity
Tong Yang, Shuai Tang, Shan Peng, Gang Ding
Summary: Mesenchymal stem cells (MSCs) have the potential to be used in the treatment of oral cancers, but they may also enhance the growth and metastasis of oral cancer. By studying the effects and mechanisms of MSCs on oral cancers, new insights and approaches for the treatment of oral cancer can be developed.
FRONTIERS IN GENETICS
(2022)
Review
Biochemistry & Molecular Biology
Silvia Sorce, Roland Stocker, Tamara Seredenina, Rikard Holmdahl, Adriano Aguzzi, Adriano Chio, Antoine Depaulis, Freddy Heitz, Peter Olofsson, Tomas Olsson, Venceslas Duveau, Despina Sanoudou, Sara Skosgater, Antonia Vlahou, Dominique Wasquel, Karl-Heinz Krause, Vincent Jaquet
FREE RADICAL BIOLOGY AND MEDICINE
(2017)
Article
Medicine, General & Internal
Marika Mokou, Julie Klein, Manousos Makridakis, Vasiliki Bitsika, Jean-Loup Bascands, Jean Sebastien Saulnier-Blache, William Mullen, Michael Sacherer, Jerome Zoidakis, Burkert Pieske, Harald Mischak, Maria G. Roubelakis, Joost P. Schanstra, Antonia Vlahou
Article
Hematology
Sfougataki Irene, Grafakos Ioannis, Varela Ioanna, Mitrakos Anastasios, Karagiannidou Angeliki, Tzannoudaki Marianna, Poulou Myrto, Mertzanian Anny, Roubelakis G. Maria, Stefanaki Kalliope, Traeger-Synodinos Joanne, Kanavakis Emmanuel, Kitra Vasiliki, Tzetis Maria, Goussetis Evgenios
BLOOD CELLS MOLECULES AND DISEASES
(2019)
Article
Medicine, General & Internal
Dimitra Zagoura, Ourania Trohatou, Manousos Makridakis, Antonia Kollia, Nikolitsa Kokla, Marika Mokou, Adriana Psaraki, Aristides G. Eliopoulos, Antonia Vlahou, Maria G. Roubelakis
Article
Biochemical Research Methods
Anna Mantsiou, Manousos Makridakis, Konstantinos Fasoulakis, Ioannis Katafigiotis, Constantinos A. Constantinides, Jerome Zoidakis, Maria G. Roubelakis, Antonia Vlahou, Vasiliki Lygirou
JOURNAL OF PROTEOME RESEARCH
(2020)
Article
Cell Biology
Maria G. Roubelakis, Grigorios Tsaknakis, Feng-Juan Lyu, Ourania Trohatou, Andrew C. W. Zannettino, Suzanne M. Watt
Review
Gastroenterology & Hepatology
Adriana Psaraki, Lydia Ntari, Christos Karakostas, Despoina Korrou-Karava, Maria G. Roubelakis
Summary: Liver dysfunctions are often treated with liver transplantation, but a new concept in therapy involves using extracellular vesicles secreted by mesenchymal stem cells to overcome limitations and promote liver repair. Studies have shown that these vesicles have the potential to ameliorate systemic inflammation and positively impact various pathways associated with liver diseases.
Article
Biotechnology & Applied Microbiology
Evangelia Yannaki, Nikoletta Psatha, Anastasia Papadopoulou, Takis Athanasopoulos, Achilleas Gravanis, Maria G. Roubelakis, Panagiotis Tsirigotis, Achilles Anagnostopoulos, Nicholas P. Anagnou, George Vassilopoulos
Summary: Gene therapy, a relatively new field with around four decades of development, has entered the clinical stage with a focus on hemoglobinopathies and hematopoietic stem cells. Research efforts have been made to efficiently implement gene therapy through advancements in HSC biology and gene expression technologies, potentially transforming the therapeutic landscape for genetic diseases in the near future.
HUMAN GENE THERAPY
(2021)
Article
Oncology
Rafael Stroggilos, Maria Frantzi, Jerome Zoidakis, Marika Mokou, Napoleon Moulavasilis, Emmanouil Mavrogeorgis, Anna Melidi, Manousos Makridakis, Konstantinos Stravodimos, Maria G. Roubelakis, Harald Mischak, Antonia Vlahou
Summary: This study leveraged large-scale transcriptomic data of bladder cancer to analyze the monotonic changes in genes and processes related to clinical and pathological stages. The findings revealed tumor dependencies on specific cell-cycle and metabolic processes, and proposed an eight-gene signature that can predict the prognosis of bladder cancer.
Review
Cell Biology
Christina Nikokiraki, Adriana Psaraki, Maria G. Roubelakis
Summary: The liver is the most important metabolic organ in the human body, and an imbalance in liver function can lead to liver failure. Orthotropic liver transplantation is the most effective treatment for end-stage liver diseases and acute liver failure, but stem-cell-based therapies are being developed as alternative solutions due to limitations. Stem cells derived from various sources have the potential to differentiate into liver-like cells and liver progenitor cells, which can be used for research and treatment of liver diseases.
Review
Cell Biology
Elena Konstantina Siapati, Maria G. Roubelakis, George Vassilopoulos
Summary: The liver has high regenerative capacity, but chronic inflammation and fibrosis caused by various insults can lead to irreversible liver dysfunction. Cell therapy and stem cell transplantation have shown promising results in liver disease treatment, but the underlying mechanisms are still under investigation.
Review
Biotechnology & Applied Microbiology
Michela Pozzobon, Stefania D'Agostino, Maria G. G. Roubelakis, Anna Cargnoni, Roberto Gramignoli, Susanne Wolbank, Florelle Gindraux, Sveva Bollini, Halima Kerdjoudj, Mathilde Fenelon, Roberta Di Pietro, Mariangela Basile, Veronika Borutinskaite, Roberta Piva, Andreina Schoeberlein, Guenther Eissner, Bernd Giebel, Peter Ponsaerts
Summary: Perinatal tissues contain various types of stem cells that have the potential for regenerative therapies. This review summarizes the therapeutic approaches using perinatal derivatives (PnD) products and discusses the importance of validating their therapeutic efficacy and the concept of PnD application in tissue regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hector Katifelis, Eirini Filidou, Adriana Psaraki, Farinta Yakoub, Maria G. Roubelakis, Gesthimani Tarapatzi, Stergios Vradelis, Giorgos Bamias, George Kolios, Maria Gazouli
Summary: This study investigates the potential anti-inflammatory effects of secretome and exosomes derived from amniotic fluid mesenchymal stem/stromal cells on LPS-induced inflammation in an in vitro model of IBD. The results demonstrate that both secretome and exosomes derived from these cells can reduce the severity of LPS-induced inflammation by decreasing the expression of pro-inflammatory genes and increasing the expression of anti-inflammatory genes.
Meeting Abstract
Cell & Tissue Engineering
A. Psaraki, M. Makridakis, A. Stamatopoulou, F. Korkida, Z. Dorezi, K. Georgila, R. Gramignoli, S. Sakellariou, M. Xilouri, A. G. Eliopoulos, A. Vlahou, M. G. Roubelakis
Review
Cell & Tissue Engineering
Ourania Trohatou, Maria G. Roubelakis
CELLULAR REPROGRAMMING
(2017)