Article
Immunology
Ziang Zhu, Tong Li, Jinya Chen, Jai Kumar, Princy Kumar, Jing Qin, Colleen Hadigan, Irini Sereti, Jason V. Baker, Marta Catalfamo
Summary: This study examines the impact of HIV infection on endothelial inflammation and repair by evaluating cell phenotypes and subsets in the blood of HIV-infected individuals. The researchers found that infection-induced phenotypic changes were associated with inflammatory biomarkers, suggesting that HIV infection may affect endothelial inflammation and repair.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Osnat Itzhaki Ben Zadok, Dorit Leshem-Lev, Tuvia Ben-Gal, Ashraf Hamdan, Nili Schamroth Pravda, Tali Steinmetz, Irit Kandinov, Ilit Ovadia, Ran Kornowski, Alon Eisen
Summary: The study found that tafamidis has a protective effect on cEPCs in ATTR-CA patients, promoting endothelial repair by increasing levels of CD34((+))/VEGFR-2((+)) and CD133((+))/VEGFR-2((+)), as well as enhancing EPC-CFUs numbers and viability, and increasing VEGF levels.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Review
Biochemistry & Molecular Biology
Klara Komici, Angelica Perna, Germano Guerra
Summary: Frailty is a clinical condition characterized by a decline in biological reserves, physiological mechanism failure, and vulnerability to stressors. This review focuses on the role of endothelial progenitor cells (EPCs) in frailty, highlighting their impaired function, number, and survival in the elderly. It also discusses the modification of EPCs in age-related diseases such as atherosclerosis, hypertension, and diabetes mellitus. The review concludes by exploring interventions that may restore EPCs expression and function in frail individuals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Chien-Yi Hsu, Chun-Yao Huang, Chun-Ming Shih, Yi-Wen Lin, Po-Hsun Huang, Shing-Jong Lin, Chen-Wei Liu, Cheng-Yen Lin, Feng-Yen Lin
Summary: Tumor necrosis factor superfamily 14 (TNFSF14), also known as LIGHT, plays a role in various physiological functions including the synthesis of nitric oxide and cytokines. It stimulates angiogenesis in tumors and induces the expression of certain molecules in endothelial cells. However, its effects on angiogenesis after tissue ischemia are unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Chang-Yu Song, Sunny Li-Yun Chang, Chih-Yang Lin, Chun-Hao Tsai, Shang-Yu Yang, Yi-Chin Fong, Yu-Wen Huang, Shih-Wei Wang, Wei-Cheng Chen, Chih-Hsin Tang
Summary: New treatments for chondrosarcoma are crucial due to its poor prognosis, and factors like PDGF and visfatin play significant roles in tumor development and angiogenesis. Research has shown that visfatin promotes chondrosarcoma angiogenesis by modulating miR-1264 expression, potentially offering a new therapeutic approach for the treatment of chondrosarcoma.
Article
Engineering, Biomedical
Kevin T. Campbell, Matthew B. Curtis, Joshua M. Massey, Kajetan Wysoczynski, Dustin J. Hadley, Steve C. George, Eduardo A. Silva
Summary: Lymphatic dysfunction is associated with the progression of several vascular disorders, and there are limited strategies currently available to promote new lymphatic vasculature. This study isolated lymphatic endothelial progenitor cells from human umbilical cord blood and found that they have the potential to promote lymphatic sprouts, highlighting the therapeutic potential of these cells. Delivery of lymphatic EPCs using alginate hydrogels also showed promise for possible therapeutic applications.
ACTA BIOMATERIALIA
(2021)
Article
Oncology
Heba Abdel Razik Sayed, Helal F. Hetta, Engy A. Shafik, Asmaa M. Zahran
Summary: The study found that pediatric patients with solid tumors have significantly higher levels of CECs and EPCs at diagnosis and even higher levels after chemotherapy; the increase in CECs levels on day 7 after chemotherapy may be an early predictor of treatment response and outcome.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Melissa Garcia-Caballero, Liliana Sokol, Anne Cuypers, Peter Carmeliet
Summary: The dynamic crosstalk between different components of the tumor microenvironment plays a critical role in cancer progression and metastasis. Angiogenesis is crucial for tumor growth, but abnormal blood vessels can lead to hypoxia and acidosis in the tumor microenvironment. Cancer and stromal cells can alter their metabolism to meet high energy demands and promote tumor proliferation. Recent studies have shown that the metabolism of tumor endothelial cells is reprogrammed and targeting these metabolic pathways can affect blood vessel formation. Therefore, metabolic antiangiogenic therapies combined with immunotherapies offer a clinical opportunity for cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Svetlana P. Chumakova, Olga I. Urazova, Vladimir M. Shipulin, Sergey L. Andreev, Olga A. Denisenko, Margarita V. Gladkovskaya, Larisa S. Litvinova, Mikhail A. Bubenchikov
Summary: This study aimed to investigate the angiopoietic endothelial dysfunction in ischemic cardiomyopathy (ICMP) patients. It was found that there was an imbalance in the number of endothelial progenitor cells (EPCs) and desquamated cells (EDCs) in ICMP patients. Additionally, alterations in the levels of HIF-1α, HIF-2α, ADMA, and endothelin-1 were observed in ICMP patients.
Article
Cardiac & Cardiovascular Systems
Cheryl M. J. Tan, Adam J. Lewandowski, Wilby Williamson, Odaro J. Huckstep, Grace Z. Yu, Roman Fischer, Jillian N. Simon, Maryam Alsharqi, Afifah Mohamed, Paul Leeson, Mariane Bertagnolli
Summary: This study aimed to compare the proteomic profiles of functional and dysfunctional ECFCs, revealing distinct protein signatures and changes in cellular mechanisms between the two. Dysfunctional ECFCs have impaired angiogenic capacities and are associated with cardiovascular disease risks in young adults.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Biochemistry & Molecular Biology
Amrilmaen Badawi, Osfred C. Jefferson, Brooke M. Huuskes, Sharon D. Ricardo, Peter G. Kerr, Chrishan S. Samuel, Padma Murthi
Summary: Circulating bone marrow-derived endothelial progenitor cells (EPCs) play an important role in kidney repair but are reduced in end-stage kidney disease (ESKD) patients. This study found that combining human bone marrow-derived mesenchymal stromal cells (BM-MSCs) and recombinant human relaxin (RLX) can enhance EPC proliferation and function, suggesting a potential treatment for ESKD patients.
Article
Oncology
Jie Zhang, Yang Hong, Liang Wang, Weiheng Hu, Guangming Tian, Di Wu, Yang Wang, Ling Dai, Ziran Zhang, Yue Yang, Jian Fang
Summary: This study aimed to detect and describe the distribution characteristics of circulating tumor cells (CTCs) and circulating tumor-derived endothelial cells (CTECs) in patients with advanced lung cancer, and explore the correlation between CTC/CTEC subtypes and novel prognostic biomarkers. CTCs and CTECs derived from 52 patients with advanced lung cancer were identified using the subtraction enrichment-immunofluorescence in situ hybridization (SE-iFISH) system.
FRONTIERS IN ONCOLOGY
(2023)
Article
Clinical Neurology
Qian-Nan Wang, Zheng-Xing Zou, Xiao-Peng Wang, Qian Zhang, Ya-Qun Zhao, Lian Duan, Xiang-Yang Bao
Summary: Encephaloduroarteriosynangiosis (EDAS) is a commonly used method for indirect vascular reconstruction in patients with moyamoya disease (MMD), promoting collateral vessel formation. Endothelial progenitor cells (EPCs) play a crucial role in angiogenesis. A prospective clinical trial found that EPC count may be a critical factor for collateral circulation post-EDAS, with therapeutic benefits more likely for younger or severely ischemic MMD patients.
TRANSLATIONAL STROKE RESEARCH
(2021)
Review
Medicine, Research & Experimental
Alexey Rzhevskiy, Alina Kapitannikova, Polina Malinina, Arthur Volovetsky, Hamidreza Aboulkheyr Es, Arutha Kulasinghe, Jean Paul Thiery, Anna Maslennikova, Andrei V. Zvyagin, Majid Ebrahimi Warkiani
Summary: Immunotherapy, particularly immune checkpoint inhibitor therapy, has revolutionized cancer treatment in recent years. However, slow uptake in clinical oncology is attributed to high treatment costs, associated toxicities, and variability in patient response. Personalized approaches based on predictive biomarkers have emerged as new tools to enhance the effectiveness of immunotherapy.
Article
Endocrinology & Metabolism
Mariana Moraes de Lima Perini, Conner R. Valuch, Ushashi C. Dadwal, Olatundun D. Awosanya, Sarah L. Mostardo, Rachel J. Blosser, Adam M. Knox, Anthony C. McGuire, Hanisha L. Battina, Murad Nazzal, Melissa A. Kacena, Jiliang Li
Summary: Aging negatively affects the activity of endothelial cells, resulting in impaired bone healing. Implantation of neonatal bone marrow-derived endothelial cells (BMECs) has been found to enhance bone healing in aged mice. Compared to BMECs, lung-derived endothelial cells (LECs) are more feasible for clinical application in bone repair.
FRONTIERS IN ENDOCRINOLOGY
(2022)
