Journal
CURRENT OPINION IN VIROLOGY
Volume 3, Issue 3, Pages 251-259Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.coviro.2013.03.004
Keywords
-
Categories
Funding
- NIH [RO1 DE 017336, R01 CA 117830, RO1 CA 093606]
Ask authors/readers for more resources
The gammaherpesviruses are unique for their capacity to establish a variety of gene expression programs during latent and lytic infection. This capacity enables the virus to control host-cell proliferation, prevent programmed cell death, elude immune cell detection, and ultimately adapt to a wide range of environmental and developmental changes in the host cell. This remarkable plasticity of gene expression results from the combined functionalities of viral and host factors that biochemically remodel and epigenetically modify the viral chromosome. These epigenetic modifications range from primary DNA methylations, to chromatin protein post-translational modifications, to higher-order chromosome conformations. In addition, gammaherpesviruses have acquired specialized tools to modulate the epigenetic processes that promote viral genome propagation and host-cell survival.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available