Journal
CURRENT OPINION IN VIROLOGY
Volume 1, Issue 2, Pages 110-117Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.coviro.2011.05.019
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Funding
- National Institutes of Health [R01AI0175208, P41RR002250, R01GM079429]
- The Robert Welch Foundation [QI242]
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Electron cryo-microscopy (cryo-EM) is a technique in structural biology that is widely used to solve the three-dimensional structures of macromolecular assemblies, close to their biological and solution conditions. Recent improvements in cryo-EM and single-particle reconstruction methodologies have led to the determination of several virus structures at near-atomic resolution (3.3-4.6 A). These cryo-EM structures not only resolve the C alpha backbones and side-chain densities of viral capsid proteins, but also suggest functional roles that the protein domains and some key amino acid residues play. This paper reviews the recent advances in near-atomic-resolution cryo-EM for probing the mechanisms of virus assembly and morphogenesis.
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