An Immune Dysregulation in MPN

Cytokine profiles in polycythemia vera and essential thrombocythemia patients: Clinical implications

(2014) Emmanuel Pourcelot et al.   EXPERIMENTAL HEMATOLOGY

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

Autoimmune Myelofibrosis Accompanied by Sj^|^ouml;gren's Syndrome in a 47, XXX/46, XX Mosaic Woman

(2014) Tohru Takahashi   INTERNAL MEDICINE

The germline sequence variant rs2736100_C in TERT associates with myeloproliferative neoplasms

(2014) A Oddsson et al.   LEUKEMIA

Functional and genetic aberrations of in vitro-cultured marrow-derived mesenchymal stromal cells of patients with classical Philadelphia-negative myeloproliferative neoplasms

(2014) M A Avanzini et al.   LEUKEMIA

TERT rs2736100T/G polymorphism upregulates interleukin 6 expression in non-small cell lung cancer especially in adenocarcinoma

(2014) Fuxia Wang et al.   TUMOR BIOLOGY

Chronic Inflammation and Cytokines in the Tumor Microenvironment

(2014) Glauben Landskron et al.   Journal of Immunology Research

Three-year efficacy, safety, and survival findings from COMFORT-II, a phase 3 study comparing ruxolitinib with best available therapy for myelofibrosis

(2013) F. Cervantes et al.   BLOOD

Subsequent leukaemia in autoimmune disease patients

(2013) Kari Hemminki et al.   BRITISH JOURNAL OF HAEMATOLOGY

Transcription factor nuclear factor erythroid-2 mediates expression of the cytokine interleukin 8, a known predictor of inferior outcome in patients with myeloproliferative neoplasms

(2013) J. Wehrle et al.   HAEMATOLOGICA

Involvement of TGF 1 in autocrine regulation of proplatelet formation in healthy subjects and patients with primary myelofibrosis

(2013) S. Badalucco et al.   HAEMATOLOGICA

Elevated C-reactive protein is associated with shortened leukemia-free survival in patients with myelofibrosis

(2013) T Barbui et al.   LEUKEMIA

Anti-transforming growth factor-β therapy in patients with myelofibrosis

(2013) John Mascarenhas et al.   LEUKEMIA & LYMPHOMA

Whole blood transcriptional profiling reveals significant down-regulation of human leukocyte antigen class I and II genes in essential thrombocythemia, polycythemia vera and myelofibrosis

(2013) Vibe Skov et al.   LEUKEMIA & LYMPHOMA

Increased prevalence of autoimmune phenomena in myelofibrosis: Relationship with clinical and morphological characteristics, and with immunoregulatory cytokine patterns

(2013) Wilma Barcellini et al.   LEUKEMIA RESEARCH

Molecular Profiling of Multiple Human Cancers Defines an Inflammatory Cancer-Associated Molecular Pattern and Uncovers KPNA2 as a Uniform Poor Prognostic Cancer Marker

(2013) Saleh M. Rachidi et al.   PLoS One

Interferon and the treatment of polycythemia vera, essential thrombocythemia and myelofibrosis

(2013) Richard T Silver et al.   Expert Review of Hematology

A3669G polymorphism of glucocorticoid receptor is a susceptibility allele for primary myelofibrosis and contributes to phenotypic diversity and blast transformation

(2012) V. Poletto et al.   BLOOD

Reversal of Transfusion Dependence by Tumor Necrosis Factor Inhibitor Treatment in a Patient With Concurrent Rheumatoid Arthritis and Primary Myelofibrosis

(2012) Anderson Ong et al.   JCR-JOURNAL OF CLINICAL RHEUMATOLOGY

Synergism between fibronectin and transforming growth factor-β1 in the production of substance P in monocytes of patients with myelofibrosis

(2012) Victor T. Chang et al.   LEUKEMIA & LYMPHOMA

Molecular profiling of peripheral blood cells from patients with polycythemia vera and related neoplasms: Identification of deregulated genes of significance for inflammation and immune surveillance

(2012) Vibe Skov et al.   LEUKEMIA RESEARCH

Development of monocytosis in patients with primary myelofibrosis indicates an accelerated phase of the disease

(2012) Leonardo Boiocchi et al.   MODERN PATHOLOGY

JAK/STAT signaling in hematological malignancies

(2012) W Vainchenker et al.   ONCOGENE

Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis

(2012) Alfiya Akhmetshina et al.   Nature Communications

Increased frequency of the glucocorticoid receptor A3669G (rs6198) polymorphism in patients with Diamond-Blackfan anemia

(2011) L. Varricchio et al.   BLOOD

Increase in circulating CD4+CD25+Foxp3+ T cells in patients with Philadelphia-negative chronic myeloproliferative neoplasms during treatment with IFN- 

(2011) C. H. Riley et al.   BLOOD

The dominant negative   isoform of the glucocorticoid receptor is uniquely expressed in erythroid cells expanded from polycythemia vera patients

(2011) L. Varricchio et al.   BLOOD

FLT3-Mediated p38-MAPK Activation Participates in the Control of Megakaryopoiesis in Primary Myelofibrosis

(2011) C. Desterke et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Whole-blood transcriptional profiling of interferon-inducible genes identifies highly upregulated IFI27 in primary myelofibrosis

(2011) Vibe Skov et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Therapeutic approaches in myelofibrosis

(2011) Giovanni Barosi et al.   EXPERT OPINION ON PHARMACOTHERAPY

The JAK2 46/1 haplotype: a marker of inappropriate myelomonocytic response to cytokine stimulation, leading to increased risk of inflammation, myeloid neoplasm, and impaired defense against infection?

(2011) S. Hermouet et al.   HAEMATOLOGICA

Circulating Interleukin (IL)-8, IL-2R, IL-12, and IL-15 Levels Are Independently Prognostic in Primary Myelofibrosis: A Comprehensive Cytokine Profiling Study

(2011) Ayalew Tefferi et al.   JOURNAL OF CLINICAL ONCOLOGY

Thrombocytosis in rheumatoid arthritis: JAK2V617F-positive essential thrombocythemia

(2011) Ozlem Cırpan Ayvaz et al.   RHEUMATOLOGY INTERNATIONAL

The JAK2 46/1 haplotype predisposes to MPL-mutated myeloproliferative neoplasms

(2010) A. V. Jones et al.   BLOOD

Evaluation of the bioactive and total transforming growth factor β1 levels in primary myelofibrosis

(2010) Rita Campanelli et al.   CYTOKINE

Autoimmunity and the risk of myeloproliferative neoplasms

(2010) S. Y. Kristinsson et al.   HAEMATOLOGICA

Inflammation and thrombosis in essential thrombocythemia and polycythemia vera: different role of C-reactive protein and pentraxin 3

(2010) T. Barbui et al.   HAEMATOLOGICA

Myeloproliferative disorders in patients with inflammatory bowel disease on anti-TNF-α therapy

(2010) Monika Fischer et al.   INFLAMMATORY BOWEL DISEASES

Genetic factors in chronic inflammation: Single nucleotide polymorphisms in the STAT-JAK pathway, susceptibility to DNA damage and Crohn's disease in a New Zealand population

(2010) Lynnette R. Ferguson et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Polymorphisms in the glucocorticoid receptor gene that modulate glucocorticoid sensitivity are associated with rheumatoid arthritis

(2010) Manon JM van Oosten et al.   ARTHRITIS RESEARCH & THERAPY

Quantitation of the JAK2V617F Mutation in Microdissected Bone Marrow Trephines: Equal Mutational Load in Myeloid Lineages and Rare Involvement of Lymphoid Cells

(2009) Marcus Kremer et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Risks of myeloid malignancies in patients with autoimmune conditions

(2009) L A Anderson et al.   BRITISH JOURNAL OF CANCER

Multisystem Failure Due to Three Coexisting Autoimmune Diseases

(2009) Arvind Pillai et al.   INTERNAL MEDICINE

Pomalidomide Is Active in the Treatment of Anemia Associated With Myelofibrosis

(2009) Ayalew Tefferi et al.   JOURNAL OF CLINICAL ONCOLOGY

Lytic bone lesions in lupus-associated myelofibrosis

(2009) K. Sacré et al.   LUPUS

A common JAK2 haplotype confers susceptibility to myeloproliferative neoplasms

(2009) Damla Olcaydu et al.   NATURE GENETICS

JAK2 haplotype is a major risk factor for the development of myeloproliferative neoplasms

(2009) Amy V Jones et al.   NATURE GENETICS

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS