Article
Ophthalmology
Minji Ha, Jin Soo Kim, Seo-Yeon Hong, Dong-Jin Chang, Woong-Joo Whang, Kyung-Sun Na, Eun Chul Kim, Hyun Seung Kim, Ho Sik Hwang
Summary: The study revealed associations between lid margin abnormalities and meibomian gland loss, particularly irregular lid margins in the upper eyelids were correlated with higher degrees of meibomian gland loss. In the lower eyelids, irregular lid margins and total grading score of lid margin abnormalities were associated with higher meibomian gland dropout.
Review
Ophthalmology
Morten Schjerven Magno, Jonatan Olafsson, Marie Beining, Emily Moschowits, Neil Lagali, James S. Wolffsohn, Jennifer P. Craig, Darlene A. Dartt, Jelle Vehof, Tor P. Utheim
Summary: The literature review highlighted that chambered warm moist air eyelid warming devices are effective in raising eyelid temperature, improving dry eye symptoms, lipid layer thickness, and tear film breakup time. However, it remains unclear whether they provide greater benefits compared to other eyelid warming therapies. Further well-conducted research, especially comparing moist and dry heat devices in patients with different severities of dry eye disease, is necessary.
ACTA OPHTHALMOLOGICA
(2022)
Article
Medicine, General & Internal
Hyunmin Ahn, Bo Yi Kim, Jinyoung Kim, Yong Woo Ji, Ikhyun Jun, Tae-im Kim, Hyung Keun Lee, Kyoung Yul Seo
Summary: Maintaining eyelid hygiene is significantly effective in treating meibomian gland dysfunction, with the efficacy lasting up to 4 months after stopping the treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Xiangjun Chen, Reza A. Badian, Havard Hynne, Behzod Tashbayev, Lene Hystad Hove, Janicke Liaaen Jensen, Tor Paaske Utheim
Summary: In this study, meibography of 65-year-old residents in Oslo, Norway was analyzed, and it was found that moderate meibomian gland atrophy was common and not gender-specific. Meibography alone cannot discriminate between meibomian gland dysfunction (MGD) and non-MGD, thus both morphological and functional tests are necessary for screening MGD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Maria C. Martinez-Hergueta, Jorge L. Alio Del Barrio, Mario Canto-Cerdan, Maria A. Amesty
Summary: This study aimed to evaluate the efficacy and safety of IPL applied directly on the eyelids of patients with MGD. The results showed that symptoms and the percentage of meibomian gland loss improved during the 3 IPL sessions, while tear meniscus measurements remained unchanged. No serious adverse effects were reported.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Yasuhiro Takahashi, Aric Vaidya, Hirohiko Kakizaki
Summary: This study showed that postoperative upper eyelid pressure tends to decrease in patients with thyroid eye disease, leading to potential improvement in superior limbic keratoconjunctivitis. However, parameters related to dry eye and MGD may worsen or remain unchanged after orbital decompression surgery.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Ophthalmology
Ho Sik Hwang, Eric Mikula, Yilu Xie, Donald J. Brown, James V. Jester
Summary: A novel mouse transillumination meibography device was developed and successfully used to detect age-related changes in meibomian glands of young and old mice. Older mice exhibited meibomian gland dropout and irregular shapes.
Article
Multidisciplinary Sciences
Tohru Sakimoto, Takeshi Sugiura
Summary: We retrospectively evaluated the clinical features of postoperative anterior blepharitis following cataract surgery and the efficacy of topical azithromycin. This study included 30 eyes of 30 patients with a clinical diagnosis of anterior blepharitis by 6 months postoperatively among those who underwent cataract surgery. Azithromycin eye drops were prescribed for all patients, and the findings and symptoms before and after the drops were reviewed. The onset of anterior blepharitis after cataract surgery may be related to a gradual decrease in postoperative eye drops, and azithromycin eye drops were effective in alleviating or resolving the symptoms.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Igor Petricek, Martina Tomic, Tomislav Bulum, Dina Lesin Gacina, Sania Vidas Pauk
Summary: This cross-sectional study examined the relationship between meibomian gland excreta quantity and quality, dry eye disease symptoms, and objective signs of dry eye. The study found that subjects with dry eye symptoms had lower meibomian gland quantity scores compared to healthy controls. Meibum quality and quantity scores were associated with gender, dry eye symptoms, and objective signs of dry eye. Adjusted logistic regression analysis showed that dry eye was independently associated with self-reported skin type, lid parallel conjunctival folds, fluorescein corneal staining, tear break-up time, and meibum quantity score. The study established a correlation between dry eye symptoms caused by meibomian gland dysfunction and dry skin, which can help general health practitioners consider dry eye as a potential cause of chronic eye complaints in patients with dry skin.
Article
Medicine, General & Internal
Reiko Arita, Shima Fukuoka, Motoko Kawashima
Summary: Treatment selection for meibomian gland dysfunction (MGD) should be based on a comprehensive stage classification that includes ocular symptoms, lid margin abnormalities, meibum grade, and ocular surface staining. Different treatment modalities have varying efficacy based on the meiboscore determined by noncontact meibography, with intense pulsed light therapy showing improvement even in cases with high meiboscore. Prospective studies are needed to further validate these findings.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Engineering, Biomedical
Jung Yeob Han, So Young Park, Jeong Hye Sunwoo, Jae Yong Kim, Hungwon Tchah, Hun Lee
Summary: This study found that low-level radiofrequency thermal treatment is a safe and effective method for treating obstructive meibomian gland dysfunction (MGD) in a rabbit model. The treatment improved lid margin abnormalities and corneal staining, and also increased the area of secretory acini in the meibomian glands and prevented gland loss.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Shima Fukuoka, Reiko Arita
Summary: This study compared the efficacy of the new AQUA CEL device and the traditional M22 device in treating meibomian gland dysfunction (MGD) with Intense Pulsed Light (IPL) therapy. The results showed that IPL therapy with both devices significantly improved symptoms and eye parameters in patients with MGD, and there were no significant differences in efficacy between the two devices.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Min Li, Yunjie Yu, Ying Yuan, Peng Wang, Xiaojun Hu, Chengcheng Zhu, Bilian Ke
Summary: Meibomian gland dysfunction (MGD) can lead to changes in the morphology and function of eyelid rete ridges, which may be correlated with injury to the ocular surface. Some inflammatory cytokines are associated with changes in the rete ridges morphology, which could impact ocular surface function.
CURRENT EYE RESEARCH
(2021)
Article
Ophthalmology
Igor Kaiserman, Gilad Rabina, Michael Mimouni, Naava. B. Sadi Optom, Nitsan Duvdevan, Shmuel Levartovsky, David Ben David
Summary: Therapeutic Meibomian gland expression improves dry-eye symptoms in subjects with MGD, compared to conventional treatment with artificial tears. The improvement in symptoms was significant in the study group, with better outcomes in OSDI score, blepharitis questionnaire score, burning sensation, and eyelid scales, as well as conjunctival hyperemia.
CURRENT EYE RESEARCH
(2021)
Review
Medicine, General & Internal
Chao Liu, Qi Zhou, Zi-Qing Gao
Summary: This review evaluates the effectiveness and safety of intense pulsed light treatment combined with meibomian gland expression (IPL-MGX) in patients with meibomian gland dysfunction-related dry eye. The meta-analysis of randomized controlled trials shows that IPL-MGX is safer and more effective than MGX alone, with significant improvements in meibomian gland yielding secretion score and tear breakup time.