Article
Agricultural Engineering
Rita Ribeiro, Liliana Fernandes, Raquel Costa, Carlos Cavaleiro, Ligia Salgueiro, Mariana Henriques, Maria Elisa Rodrigues
Summary: This study aimed to compare the effects of several essential oils (EOs) from Thymus spp. on Candida auris biofilm. Results showed different antifungal activities among the EOs, and the differences in their chemical compositions could explain these variations. Thymus vulgaris and Thymus zygis oils demonstrated the greatest antifungal effects and could be promising alternatives for the treatment of C. auris infections.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Chemistry, Analytical
Zsigmond Papp, Sarra Bouchelaghem, Andras Szekeres, Reka Meszena, Zoltan Gyongyi, Gabor Papp
Summary: Propolis contains unidentified antifungal compounds, and gas chromatography-mass spectrometry and an opto-electronic nose were used for sample classification. The study identified potential antifungal molecules in propolis and demonstrated the usefulness of a portable opto-electronic nose for identifying samples with high antifungal activity.
Article
Food Science & Technology
Marwa Ezz El-Din Ibrahim, Randah Miqbil Alqurashi
Summary: This study aimed to identify the phenolic compounds in propolis and investigate their effects on antifungal activity, pH, color, and sensory analysis of thyme labneh. The study found 11 phenolic compounds in propolis extract and revealed that the ethanolic extract had higher phenolic content and antioxidant activity compared to the water extract. The use of propolis powder and extracts effectively inhibited the growth of mold and yeast in thyme labneh. The sensory evaluation showed no significant difference in sensory attributes of thyme labneh treated with propolis extracts.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2022)
Article
Microbiology
Giovanna Ginestra, Teresa Gervasi, Francesca Mancuso, Federica Bucolo, Laura De Luca, Rosaria Gitto, Davide Barreca, Giuseppina Mandalari
Summary: In this study, a series of arylsulfonamide compounds were screened and the structure-activity relationship was established based on a hit compound. The antifungal activity against various Candida species was tested, and cytotoxicity was evaluated. These findings could contribute to the development of novel topical therapeutics for fungal infections.
Article
Biotechnology & Applied Microbiology
Thiago Henrique Lemes, Julyanna Andrade Silva Nascentes, Luis Octavio Regasini, Joao Paulo Zen Siqueira, Taiza Maschio-Lima, Veridianna Camilo Pattini, Mariela Domiciano Ribeiro, Bianca Gottardo de Almeida, Margarete Teresa Gottardo de Almeida
Summary: This study evaluated the combination effect of different cultured extracts of Candida parapsilosis and Trichophyton mentagrophytes and Trichophyton rubrum with fluconazole, itraconazole, and terbinafine against clinical isolates of Trichophyton rubrum. The results showed that the extracts in combination with the drugs exhibited a synergistic action and decreased minimum inhibitory concentration (MIC) values. The extracts were found to predominantly act on the fungal cell membrane rather than the cell wall.
INTERNATIONAL MICROBIOLOGY
(2023)
Article
Agronomy
Weronika Kursa, Agnieszka Jamiolkowska, Jakub Wyrostek, Radoslaw Kowalski
Summary: The study evaluated the antifungal effects of leaf extracts from yarrow, tansy, sage, and wormwood on major cereal pathogens of the Fusarium genus. Sage and tansy extracts showed strong inhibitory effects on fungal growth, while yarrow and wormwood extracts had weaker fungistatic effects and even stimulated growth in some cases. The results indicate potential for the development of biopreparations to protect plants against fusariosis.
Article
Infectious Diseases
Clarice Elvira Saggin Sabadin, Soraia Lima Lopes, Olga Fischmamm Gompertz, Gilglecia Novaes Pereira Santana, Analy Salles de Azevedo Melo, Lilian Rigo, Daniel Archimedes Da Matta, Dulce Aparecida Barbosa
Summary: This study investigated oral colonization of Candida species and their susceptibility to antifungals in liver transplant patients. Results showed stable yeast species colonization in some patients over 6 months, but substitution in others. The study highlights the importance of monitoring antifungal resistant strains.
Article
Integrative & Complementary Medicine
Maria Coronada Fernandez-Calderon, Laura Hernandez-Gonzalez, Carolina Gomez-Navia, Maria Teresa Blanco-Blanco, Rosa Sanchez-Silos, Leopoldo Lucio, Ciro Perez-Giraldo
Summary: The study found that a new Spanish ethanolic extract of propolis exhibited antifungal activity against Candida glabrata, including azole-resistant strains, and reduced biofilm formation. These results suggest the potential use of propolis in controlling fungal infections associated with biofilms.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2021)
Article
Plant Sciences
Marysol Alvear, Estela Santos, Felipe Cabezas, Andres Perez-SanMartin, Monica Lespinasse, Jorge Veloz
Summary: Chilean propolis exhibits antibacterial, antifungal, and antibiofilm activities, with main compounds such as pinocembrin, quercetin, and caffeic acid phenethyl ester (CAPE). Studies on the influence of geographical and floral variables on the chemical composition of propolis are valuable for understanding its biological properties.
Article
Biochemistry & Molecular Biology
Dawrin Pech-Puch, Diana Grilo, Susana Eunice Calva-Perez, Andreia Pedras, Harold Villegas-Hernandez, Sergio Guillen-Hernandez, Raul Diaz-Gamboa, Mateo Forero Tunjano, Jaime Rodriguez, Oscar A. Lenis-Rojas, Carlos Jimenez, Catarina Pimentel
Summary: This study screened 65 extracts from marine organisms of the Yucatan Peninsula, Mexico, for antifungal activity and identified nine crude extracts with potent antifungal activity, including four from sponge species. The chemical composition analysis of one of the most active fractions revealed the presence of mirabilin B and penaresidin B. These findings highlight the marine organisms of the Yucatan Peninsula as important sources of natural products with promising fungicidal activity, which could greatly advance the treatment of invasive fungal infections, particularly in immunosuppressed patients.
Article
Biotechnology & Applied Microbiology
Rabina Kumpakha, Donna M. Gordon
Summary: The study demonstrates that occidiofungin effectively targets hyphae elongation in Candida species by inhibiting the morphological changes associated with yeast-to-hyphae switching. This suggests that occidiofungin could be a promising candidate for the treatment of Candida associated infections, as it may also inhibit the heterogeneous population of cells present in a clinical setting.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lorene Coelho Silva, Amabel Fernandes Correia, Joao Victor Dutra Gomes, Wanderson Romao, Larissa Campos Motta, Christopher William Fagg, Perola Oliveira Magalhaes, Damaris Silveira, Yris Maria Fonseca-Bazzo
Summary: This study evaluated the antifungal effects of two crude extracts of Crinum americanum L. on Candida species and found that these extracts have antifungal activity. The results are important for the development of new antifungal drugs.
Article
Microbiology
Monica Ganan, Silje B. Lorentzen, Peter Gaustad, Morten Sorlie
Summary: C32 demonstrates concentration-dependent inhibition of Candida biofilms, reducing viable cells and metabolic activity, while also inhibiting new biofilm formation. When used in combination with fluconazole or miconazole, a synergistic effect on biofilm reduction is observed, indicating the potential of C32 as an alternative therapeutic agent to combat antifungal resistance.
Article
Microbiology
A. Espinel-Ingroff, M. Sasso, J. Turnidge, M. Arendrup, F. Botterel, N. Bourgeois, B. Bouteille, E. Canton, S. Cassaing, E. Dannaoui, M. Dehais, L. Delhaes, D. Dupont, A. Fekkar, J. Fuller, G. Garcia-Effron, J. Garcia, G. M. Gonzalez, N. P. Govender, H. Guegan, J. Guinea, S. Houze, C. Lass-Florl, T. Pelaez, A. Forastiero, M. Lackner, R. Magobo
Summary: Susceptibility testing for antifungal drugs is crucial in the clinical setting, relying on categorical endpoints and epidemiological cutoff values for different species. Collaborative efforts have led to the development of Etest sensitivity values for various Candida and Aspergillus species, aiding in clinical laboratory testing.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Orfa Ines Contreras Martinez, Alberto Angulo Ortiz, Gilmar Santafe Patino
Summary: This study aims to evaluate the antifungal activity of isoespintanol (ISO) extracted from Oxandra xylopioides Diels against clinical isolates of Candida spp. The results show inhibitory effects against Candida spp., with minimum inhibitory concentration (MIC) values between 450.4-503.3 μg/mL. Moreover, ISO exhibits stronger inhibitory effects on fungal biofilms compared to amphotericin B.
