Article
Chemistry, Multidisciplinary
Nils Lefringhausen, Victoria Seiffert, Catharina Erbacher, Uwe Karst, Jens Mueller
Summary: It has been discovered that by incorporating ligands capable of forming chiral metal complexes into a DNA double helix, it is possible to selectively form enantiomers of metal-mediated base pairs depending on the number of consecutive pairs. The chirality of the metal complex formed inside the DNA duplex remains the same for up to five neighboring pairs, regardless of the enantiomer used. However, with six pairs, the chirality of the metal complex is inverted for one enantiomer but not the other, suggesting a delicate balance between the metal-centered chirality and the DNA helical chirality in determining the configuration of the metal complex.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Review
Engineering, Biomedical
Qiao Sun, Xiao Xie, Yujie Song, Litao Sun
Summary: The investigation of the interaction between metal ions and DNA has always been a topic of great interest in the fields of bioinorganic chemistry, supramolecular coordination chemistry, and DNA nanotechnology. The interaction can be divided into non-specific electrostatic adsorption and specific covalent binding. This article focuses on the mechanism of action between Ag+ and DNA mismatch pair C-C, and summarizes the characterization methods and applications. It aims to provide a reference for the field of biological devices. The development of cryo-electron microscopy and liquid-cell TEM is expected to further characterize the structure of C-Ag+-C and enhance its application.
BIOMATERIALS RESEARCH
(2022)
Article
Chemistry, Inorganic & Nuclear
Daniela Escher, Jens Mueller
Summary: The study investigated the ability of DNA duplexes containing artificial nucleobases to form silver(I)-mediated base pairs. It was found that the stability of resulting silver(I)-mediated base pairs is strongly sequence-dependent. The most stable silver(I)-mediated base pairs are formed when specific artificial nucleobases are located opposite to certain natural nucleobases in the DNA duplex.
ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE
(2021)
Article
Biochemistry & Molecular Biology
Bernhard Lippert
Summary: This commentary discusses the distinction between nucleobase pairs and pairs of basic ligands, and highlights the potential issues with metal ion cross-linking.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Simon Vecchioni, Brandon Lu, William Livernois, Yoel P. Ohayon, Jesse B. Yoder, Chu-Fan Yang, Karol Woloszyn, William Bernfeld, M. P. Anantram, James W. Canary, Wayne A. Hendrickson, Lynn J. Rothschild, Chengde Mao, Shalom J. Wind, Nadrian C. Seeman, Ruojie Sha
Summary: DNA double helices containing metal-mediated DNA (mmDNA) base pairs are constructed from Ag+ and Hg2+ ions between pyrimidine:pyrimidine pairs with the promise of nanoelectronics. Rational design of mmDNA nanomaterials is impractical without a complete lexical and structural description. The programmability of structural DNA nanotechnology is explored to build a comprehensive structural library of mmDNA pairs and discover generalized design rules for mmDNA construction.
ADVANCED MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Yuan Zhuang, Jiangle Liu, Hao Wu, Qingguo Zhu, Yongchang Yan, Haowei Meng, Peng R. Chen, Chengqi Yi
Summary: The HOPE method utilizes paired pegRNAs encoding the same edits to achieve high editing efficiency in human embryonic kidney and colorectal carcinoma cells, showing improved product purity compared to the original PE3 system. This enhanced tool has the potential to broaden both fundamental research and therapeutic applications of prime editing.
NATURE CHEMICAL BIOLOGY
(2022)
Article
Chemistry, Organic
Xiao-Hui Chen, Hai-Lei Cui
Summary: We developed a mild sulfenylation method for pyrrolo-[2,1-a]-isoquinolines using acetyl bromide and dimethyl sulfoxide. A wide range of functionalized pyrrolo-[2,1-a]-isoquinolines could be efficiently prepared by forming a C-S bond with thiophenols (27 examples, 36-94% yield). This strategy can also be used for functionalization of pyrrolo-[1,2-a]-quinolines and indole.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Isabell Schoenrath, Vladimir B. Tsvetkov, Miquel Barcelo-Oliver, Marian Hebenbrock, Timofei S. Zatsepin, Andrey V. Aralov, Jens Mueller
Summary: The artificial nucleobase X can form different types of base pairs mediated by Ag(I), with the dinuclear homo base pair exhibiting higher thermal stabilization. Molecular dynamics simulations and density functional theory calculations reveal structural changes of the nucleobase upon Ag(I) ion incorporation.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Jinghua Hao, Dong Cao, Qiang Zhao, Dapeng Zhang, Hailin Wang
Summary: It has been discovered that Ag+ can interact with polyT oligonucleotides to form an Ag+-bridged T-Ag+-T structure once the concentration of Ag+ in solution exceeds a certain threshold value. The intramolecular folding of the polyT oligonucleotide has a higher thermal stability than the duplex and can be reversibly modulated by cysteine.
Article
Chemistry, Multidisciplinary
Esha V. Shah, Ulrich Kleinekathoefer, Thomas Frauenheim, Debesh R. Roy
Summary: This study proposes a novel pathway of observing transverse transport through nucleobase-pairs of a DNA molecule and finds that the single base-pair G-C and its parallel circuit exhibit superior transport in DNA wires. In comparison with a short DNA molecule, the parallel base-pair circuits enhance transport through quantum interference.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Yinan Zhang, Zhi-Bei Qu, Chu Jiang, Yingying Liu, Raghu Pradeep Narayanan, Dewight Williams, Xiaolei Zuo, Lihua Wang, Hao Yan, Huajie Liu, Chunhai Fan
Summary: In this research, a new method was developed to fabricate silver nanostructures with three-dimensional chirality using DNA origami-enabled aqueous solution metallization strategy. The study found that the chirality of silver nanostructures can be controlled through synergetic interactions, resulting in the synthesis of helical silver patterns with well-defined chirality and pitches. This method opens up new pathways for synthesizing programmable inorganic materials with arbitrary morphology and chirality.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Cheng-Jie Ma, Lin Li, Wen-Xuan Shao, Jiang-Hui Ding, Xiao-Li Cai, Zhao-Rong Lun, Bi-Feng Yuan, Yu-Qi Feng
Summary: 5-Hydroxymethyluracil (5hmU) is a thymine modification found in various organism genomes. A novel enzyme-mediated bioorthogonal labeling method has been developed to selectively enrich 5hmU in genomes, allowing for a better understanding of its distribution and functional roles.
Article
Biochemistry & Molecular Biology
Daniela Escher, Tim Schaefer, Marian Hebenbrock, Jens Mueller
Summary: The artificial nucleobase 6-pyrazolylpurine (6PP) and its deaza derivatives were investigated for their ability to differentiate between cytosine and thymine in silver(I)-mediated base pairing. The results showed that 6PP can form stable silver(I)-mediated base pairs with cytosine but not with thymine, indicating its potential for detecting single-nucleotide polymorphisms.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Armin Feist, Guanhao Huang, Germaine Arend, Yujia Yang, Jan-Wilke Henke, Arslan Sajid Raja, F. Jasmin Kappert, Rui Ning Wang, Hugo Lourenco-Martins, Zheru Qiu, Junqiu Liu, Ofer Kfir, Tobias J. Kippenberg, Claus Ropers
Summary: In this work, we show the preparation of electron-photon pair states by exploiting the phase-matched interaction between free electrons and the optical microresonator on a photonics chip. This breakthrough provides a foundation for the future development of free-electron quantum optics.
Article
Chemistry, Multidisciplinary
Takahiro Atsugi, Akira Ono, Miho Tasaka, Natsumi Eguchi, Shoji Fujiwara, Jiro Kondo
Summary: DNA/RNA duplexes can contain metal-ion-mediated base pairs, which have potential applications in nanodevices and genetic code expansion. Recently, a crystal structure of an Ag-I-DNA nanowire with a continuous one-dimensional silver array was determined. In addition, a new DNA helical wire called the Ag-I-DNA rod, consisting of an uninterrupted array of 11 Ag-I ions, was presented.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Sunit Kumar Jana, Xiurong Guo, Hui Mei, Frank Seela
CHEMICAL COMMUNICATIONS
(2015)
Article
Chemistry, Multidisciplinary
Haozhe Yang, Hui Mei, Frank Seela
CHEMISTRY-A EUROPEAN JOURNAL
(2015)
Article
Chemistry, Organic
Hui Mei, Sachin A. Ingale, Frank Seela
Article
Chemistry, Organic
Saikat Bala, Jen-Yu Liao, Hui Mei, John C. Chaput
JOURNAL OF ORGANIC CHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Hui Mei, Changhua Shi, Randi M. Jimenez, Yajun Wang, Miramar Kardouh, John C. Chaput
NUCLEIC ACIDS RESEARCH
(2017)
Article
Chemistry, Multidisciplinary
Hui Mei, John C. Chaput
CHEMICAL COMMUNICATIONS
(2018)
Article
Chemistry, Multidisciplinary
Xiurong Guo, Peter Leonard, Sachin A. Ingale, Jiang Liu, Hui Mei, Martha Sieg, Frank Seela
CHEMISTRY-A EUROPEAN JOURNAL
(2018)
Article
Chemistry, Multidisciplinary
Hui Mei, Jen-Yu Liao, Randi M. Jimenez, Yajun Wang, Saikat Bala, Cailen McCloskey, Christopher Switzer, John C. Chaput
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2018)
Article
Chemistry, Multidisciplinary
Hui Mei, Sachin A. Ingale, Frank Seela
CHEMISTRY-A EUROPEAN JOURNAL
(2014)
Article
Chemistry, Organic
Hui Mei, Ingo Roehl, Frank Seela
JOURNAL OF ORGANIC CHEMISTRY
(2013)
Article
Chemistry, Organic
Sachin A. Ingale, Hui Mei, Peter Leonard, Frank Seela
JOURNAL OF ORGANIC CHEMISTRY
(2013)
Article
Chemistry, Organic
Hui Mei, Sachin A. Ingale, Frank Seela
Article
Biochemistry & Molecular Biology
Hui Mei, Yajun Wang, Eric J. Yik, John C. Chaput
Summary: Synthetic genetics is a field of synthetic biology aiming to extend genetic and evolutionary properties to artificial genetic polymers known as XNAs. Researchers are working on building XNAs with expanded chemical functionality, such as TNA, which can resist nuclease digestion and undergo Darwinian evolution. A new TNA nucleotide analog, tC(p)TP, has been synthesized and shown to have efficient polymerase activity with 99.9% overall fidelity, expanding the toolkit for in vitro selection.
Review
Biochemistry & Molecular Biology
Peng Nie, Yanfen Bai, Hui Mei
