Article
Biochemistry & Molecular Biology
Jing Liu, Ke Wang, Xingyang Liu, Lei Pan, Wanlu Zhou, Jingru Huang, Hongli Liu, Zhiying Su, Xiu Qin Xu
Summary: It has been found that RNA binding motif protein 24 (RBM24) is a key regulator of CaMKII delta splicing, playing a crucial role in the heart. Loss of RBM24 leads to abnormal shift of CaMKII delta towards the delta-C isoform, affecting Ca2+ handling and prolonging the ventricular cardiac action potential and QT interval.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Haobo Li, Lena E. Trager, Xiaojun Liu, Margaret H. Hastings, Chunyang Xiao, Justin Guerra, Samantha To, Guoping Li, Ashish Yeri, Rodosthenis Rodosthenous, Michael G. Silverman, Saumya Das, Amrut V. Ambardekar, Michael R. Bristow, Juan Manuel Gonzalez-Rosa, Anthony Rosenzweig
Summary: This study identifies a novel pathway, lncExACT1-DCHS2, that regulates cardiac hypertrophy and cardiomyogenesis. lncExACT1-DCHS2 acts as a master switch toggling the heart between physiological and pathological growth to determine functional outcomes, providing a potentially tractable therapeutic target for harnessing the beneficial effects of exercise.
Article
Medicine, Research & Experimental
R. A. Di Mattia, L. A. Diaz-Zegarra, P. G. Blanco, C. A. Valverde, L. A. Gonano, C. Jaquenod De Giusti, E. L. Portiansky, M. G. Vila-Petroff, E. A. Aiello, A. Orlowski
Summary: There are two alkalinizing mechanisms in cardiac myocytes to maintain intracellular pH: sodium/bicarbonate cotransporter (NBCn1 and NBCe1) and sodium/proton exchanger (NHE1). Dysfunction of these transporters has been linked to cardiovascular diseases. This study aimed to investigate the role of NBCe1 downregulation in cardiac hypertrophy. The researchers used AAV9-shNBCe1 to specifically reduce NBCe1 expression in rat hearts, leading to hypertrophy, altered electrical features, and compensatory upregulation of NBCn1 and NHE1.
Article
Biochemistry & Molecular Biology
Agnieszka A. Gorska, Clara Sandmann, Eva Riechert, Christoph Hofmann, Ellen Malovrh, Eshita Varma, Vivien Kmietczyk, Julie Oelschlaeger, Lonny Juergensen, Verena Kamuf-Schenk, Claudia Stroh, Jennifer Furkel, Mathias H. Konstandin, Carsten Sticht, Etienne Boileau, Christoph Dieterich, Norbert Frey, Hugo A. Katus, Shirin Doroudgar, Mirko Voelkers
Summary: The study reveals the role of mTOR in pathological remodeling of the heart, showing that it protects cardiomyocytes by controlling the translation of specific genes, with Cand2 being a mTOR-regulated protective gene.
Article
Oncology
Samantha Moron-Ros, Albert Blasco-Roset, Artur Navarro-Gascon, Celia Ruperez, Monica Zamora, Fatima Crispi, Iker Uriarte, Maite G. Fernandez-Barrena, Matias Avila, Gemma Ferrer-Curriu, Josep Lupon, Antoni Bayes-Genis, Francesc Villarroya, Aleix Gavalda-Navarro, Anna Planavila
Summary: This study reveals the important role of enterokine FGF15/19 in the development of cardiac hypertrophy and regulation of fatty acid metabolism in the myocardium. The lack of FGF15 prevents the development of cardiac hypertrophy in mice, while experimental increases in FGF15 induce cardiac hypertrophy.
JOURNAL OF PATHOLOGY
(2023)
Article
Multidisciplinary Sciences
Mathilde Bizou, Romain Itier, Mina Majdoubi, Dounia Abbadi, Estelle Pichery, Marianne Dutaur, Dimitri Marsal, Denis Calise, Barbara Garmy-Susini, Victorine Douin-Echinard, Jerome Roncalli, Angelo Parini, Nathalie Pizzinat
Summary: The study revealed that in the process of cardiac hypertrophy and failure, there is remodeling of lymphatic vessels and reduced lymphatic efficiency; the number of lymphatic endothelial cells in failing hearts is positively correlated with cardiac function and a subset of cardiac macrophages; macrophages identified by LYVE-1 play a key role in promoting lymphangiogenesis.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Ekin Su Akdemir, Junsung Woo, Navish A. Bosquez Huerta, Brittney Lozzi, Andrew K. Groves, Akdes Serin Harmanci, Benjamin Deneen
Summary: Astrocytes, the most abundant glial cell in the brain, perform various tasks to support neuronal function and circuit activities. Through the study of astrocytes, a unique subpopulation called Lfng-GFP(+) astrocytes was identified, which occupies a distinct anatomic location in the spinal cord and directly contributes to neuronal function and sensory responses.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
Nanqi Cui, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Ichikawa-Shindo, Hisaka Kawate, Megumu Tanaka, Masaaki Tanaka, Yangxuan Wei, Shinji Kakihara, Yunlu Zhao, Kohsuke Aruga, Hiroyuki Kawagishi, Tsutomu Nakada, Mitsuhiko Yamada, Takayuki Shindo
Summary: The AM-RAMP2 system is crucial for early adaptation to cardiovascular stress in the heart, regulating cardiac mitochondria function. On the other hand, the AM-RAMP3 system plays a critical role in long-term adaptation by regulating lymphatic vessels in the heart. Both systems are essential for maintaining cardiovascular homeostasis against stress.
Article
Microbiology
Yichen Hu, Zhiyuan Pan, Zongyu Huang, Yan Li, Ni Han, Xiaomei Zhuang, Hui Peng, Quansheng Gao, Qing Wang, B. J. Yang Lee, Heping Zhang, Ruifu Yang, Yujing Bi, Zhenjiang Zech Xu
Summary: This study investigated the effects of probiotics, prebiotics, and synbiotics on altitude-related cardiac impairment in a rat model. The treatments alleviated cardiac hypertrophy and restored gut microbiota disruptions caused by hypobaric hypoxia. The study suggests that the gut microbiome may play a causal role in high-altitude-related diseases and could be a target for therapeutic interventions.
MICROBIOLOGY SPECTRUM
(2022)
Article
Pharmacology & Pharmacy
Li-Bo Liu, Si-Hui Huang, Hong-Liang Qiu, Xian-Feng Cen, Ying-Ying Guo, Dan Li, Yu-Lan Ma, Man Xu, Qi-Zhu Tang
Summary: The study demonstrated that limonin significantly improved cardiac function and heart weight in aortic banded mice, reduced the production of cardiac hypertrophy markers, and enhanced SIRT6 protein levels through PPARα activation, thereby inhibiting cardiac hypertrophy.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Pengpeng Li, Dongxia Qin, Tiange Chen, Wei Hou, Xinyu Song, Shumin Yin, Miaomiao Song, W. C. Hewith A. Fernando, Xiaojie Chen, Yu Sun, Juejin Wang
Summary: Diabetic heart exhibits alternative splicing of Ca(V)1.2 channels, especially the Ca(V)1.2(E9*) channel, which is responsible for altered calcium concentration and cardiomyocyte hypertrophy. Glycated serum regulates the expression of Rbfox2, thereby affecting the function of these channels.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Chen Gao, Jianli Gong, Nancy Cao, Yibin Wang, Susan F. Steinberg
Summary: Protein kinase C-alpha (PKCa) is a signaling molecule that plays a major role in various cellular processes. A previously unannotated PKCa variant, PKCa-novel exon (PKCa-NE), was identified through RNA-seq-based transcriptome analysis in mouse and human cardiac tissue. PKCa-NE has distinct biochemical properties and plays a unique role in regulating protein synthesis in cardiomyocytes.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Cell Biology
Michael Mutlak, Izhak Kehat
Summary: Pressure overload and other stress stimuli lead to cardiac hypertrophy and heart failure through signaling cascades, with MAPK pathway and DUSPs playing important roles.
CELLULAR SIGNALLING
(2021)
Article
Cardiac & Cardiovascular Systems
Adrienne R. Guarnieri, Sarah R. Anthony, Anamarie Gozdiff, Lisa C. Green, Salma M. Fleifil, Sam Slone, Michelle L. Nieman, Perwez Alam, Joshua B. Benoit, A. Phillip Owens, Onur Kanisicak, Michael Tranter
Summary: Adipose tissue homeostasis is crucial for cardiovascular health, with the presence of thermogenically active brown adipose tissue (BAT) associated with cardiometabolic health. Deletion of the RNA binding protein HuR in adipose tissue leads to spontaneous development of cardiac hypertrophy and fibrosis, suggesting a direct role of adipose tissue homeostasis in cardiovascular disease. This study demonstrates the intricate relationship between adipose tissue function and cardiovascular pathology, providing insights into potential mechanisms underlying cardiovascular disease.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Drew Theobald, Anand R. Nair, Srinivas Sriramula, Joseph Francis
Summary: Toll-like receptor 4 (TLR4) plays a crucial role in the innate immune response and cardiovascular diseases. This study found that cardiomyocyte-specific deletion of TLR4 provides protection against hypertension, cardiac hypertrophy, and remodeling. The results showed that in mice with cardiomyocyte-specific TLR4 knockdown, angiotensin II-induced hypertension and cardiac hypertrophy were attenuated, myocardial fibrosis was reduced, and cardiac function was improved.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cell Biology
Vikas Kumar, A. Aneesh Kumar, Vinod Joseph, Vipin Mohan Dan, Abdul Jaleel, T. R. Santhosh Kumar, Chandrasekharan C. Kartha
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2020)
Article
Cardiac & Cardiovascular Systems
Chintan Shah, Govindan Vijayaraghavan, Chandrasekharan C. Kartha
Summary: The study reveals that cardiac involvement in patients with dengue infection is not uncommon. ECHO or ECG abnormalities or elevated serum levels of markers of cardiac injury are predictors of risk for adverse outcome. The absence of these abnormalities has a 100% negative predictive value.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cell Biology
C. L. Karthika, S. Ahalya, N. Radhakrishnan, C. C. Kartha, S. Sumi
Summary: This article explores the impact of hemodynamic forces on vascular endothelial cells and the significant role of mechanosensing-related epigenetics in endothelial dysfunction and vascular diseases. It reviews the epigenetic mechanisms leading to endothelial dysfunction in arterial and venous diseases, and discusses the challenges and prospects of using mechanoepigenetic mediators as biomarkers and therapeutic targets for vascular diseases.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Immunology
Jaya Mary Thomas, Dhakshmi Sasankan, Sumi Surendran, Mathew Abraham, Arumugam Rajavelu, Chandrasekharan C. Kartha
Summary: Through high-throughput RNA sequencing analysis and immunostaining, researchers found deregulated expression of genes related to retinoic acid signaling in AVM nidus and its associated astrocytes. This abnormal expression includes ALDH1A2, a key enzyme in retinoic acid signaling, and CYR61, a regulator of angiogenesis. Abnormal astrocytes associated with AVM nidus were also observed, suggesting a potential trigger for the development of cerebral AVM.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Mathematical & Computational Biology
Aparna Rai, Vikas Kumar, Gaurav Jerath, C. C. Kartha, Vibin Ramakrishnan
Summary: Advancements in systems biology have led to the development of network pharmacology, shifting from traditional one-target, one-drug approaches to targeting networks and multi-component therapeutics. This study utilizes a combination of in-vivo assays, gene expression analysis, cheminformatics, and network biology to identify potential pharmacological co-targets for cardiac hypertrophy in a multi-constituent Ayurvedic concoction. The research proposes a novel prospective strategy for the discovery of network pharmacological therapies and repositioning of existing drug molecules for treating pressure-overload cardiac hypertrophy.
NPJ SYSTEMS BIOLOGY AND APPLICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Ganesh R. Koshre, Feba Shaji, Neeraja K. Mohanan, Nimmy Mohan, Jamshaid Ali, Rakesh S. Laishram
Summary: Star-PAP is a non-canonical poly(A) polymerase that selects mRNA targets for polyadenylation. HITS-CLIP technology was used to map the cellular binding landscape of Star-PAP and its global mRNA association mechanism. Star-PAP is highly associated with both the 3'-UTR and CDS regions, with a novel role in mRNA metabolism that requires RBM10-mRNA association.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
R. Dhanya, C. C. Kartha
Summary: Quercetin has a protective effect on pancreatic beta cells against oxidative stress-induced damage and promotes insulin secretion. It also enhances mitochondrial biogenesis, induces hypertrophy in pancreatic beta cells, and activates mTOR signaling.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Genetics & Heredity
A. Aneesh Kumar, G. S. Ajith Kumar, Gopika Satheesh, Arun Surendran, Mahesh Chandran, Chandrasekharan C. Kartha, Abdul Jaleel
Summary: Proteomic analysis revealed differential protein expression and pathway enrichment in aortic-valvular and endocardial endothelial cells, suggesting distinct phenotypes and signaling pathways in these closely related cells. Hemostasis function-related proteins were increased in both endothelial cells, while metabolic process-related proteins and extracellular matrix-related proteins were enriched in valves.
Article
Oncology
Tapas Pradhan, Vikas Kumar, Evangeline Surya H, R. Krishna, Samu John, V. T. Jissa, S. Anjana, K. Chandramohan, S. Asha Nair
Summary: The discovery of the potent gene STIL in colorectal cancer sheds light on its role in tumorigenesis and drug resistance. High expression of STIL is associated with reduced disease-free survival in CRC cases, and its regulation of stemness and drug resistance genes is partially independent of Sonic hedgehog signaling. These findings suggest an important role of STIL in the molecular manifestation and progression of CRC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Vinitha Anandan, Thushara Thulaseedharan, Aishwarya Suresh Kumar, Karthika Chandran Latha, Amjesh Revikumar, Ajit Mullasari, Chandrasekharan C. Kartha, Abdul Jaleel, Surya Ramachandran
Summary: The impairment of efferocytosis in apoptotic macrophages by cyclophilin A is linked to reduced cholesterol efflux and altered expression of CD 47 and calreticulin. These effects can exacerbate other mechanisms of Cyp A in accelerating atherosclerosis progression, as shown in New Zealand white rabbits on a high-fat diet. Further studies are needed to explore the precise mechanisms involved in impaired efferocytosis and the potential therapeutic targets for atherosclerosis.
Article
Cell Biology
Karthika Chandran Latha, Ahalya Sreekumar, Vyshna Beena, S. S. Binil Raj, RaviKumar B. Lakkappa, Ravi Kalyani, Radhakrishnan Nair, Saligrama Ramegowda Kalpana, Chandrasekharan C. Kartha, Sumi Surendran
Summary: The study reveals that endothelial to mesenchymal transition occurs in varicose veins, associated with upregulation of the BMP4-pSMAD5 pathway. Additionally, even minimal disturbances in shear stress can induce phenotype switching in venous endothelial cells, highlighting the importance of shear stress.
Article
Biology
Kirill Tarasov, Khalid Chakir, Daniel R. Riordon, Alexey E. Lyashkov, Ismayil Ahmet, Maria Grazia Perino, Allwin Jennifa Silvester, Jing Zhang, Mingyi Wang, Yevgeniya O. Lukyanenko, Jia-Hua Qu, Miguel Calvo-Rubio Barrera, Magdalena Juhaszova, Yelena S. Tarasova, Bruce Ziman, Richard Telljohann, Vikas Kumar, Mark Ranek, John Lammons, Rostislav Bychkov, Rafael de Cabo, Seungho Jun, Gizem Keceli, Ashish Gupta, Dongmei Yang, Miguel A. Aon, Luigi Adamo, Christopher H. Morrell, Walter Otu, Cameron Carroll, Shane Chambers, Nazareno Paolocci, Thanh Huynh, Karel Pacak, Robert Weiss, Loren Field, Steven J. Sollott, Edward G. Lakatta
Summary: This study found that overexpression of AC8 in mice enables them to adapt to an increased cardiac workload and triggers various adaptive changes. Compared to wild type mice, TG(AC8) mice showed increased number of cardiac myocytes, proliferation of non-cardiac myocytes, enhanced protein synthesis, and metabolic pathway shifts.
Article
Veterinary Sciences
Reshma S. Nair, Praveen K. Sobhan, Sachin J. Shenoy, Mukund A. Prabhu, Vikas Kumar, Surya Ramachandran, Thapasimuthu Anilkumar
Summary: In this study, a porcine cholecystic extracellular matrix was used to treat nonfatal myocardial infarction in rats. The graft-assisted healing reduced fibrosis and promoted regenerative reaction and angiogenesis.
COMPARATIVE MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Vinitha Anandan, Santhosh Kumar Thankayyan Retnabai, Abdul Jaleel, Thushara Thulaseedharan, Ajit Mullasari, M. Radhakrishna Pillai, Cheranellore Chandrasekharan Kartha, Surya Ramachandran
Summary: The study reveals the mechanism by which cyclophilin A induces macrophage apoptosis and accelerates the progression of atherosclerosis. Inhibitors of proinflammatory cytokines like cyclophilin A may prevent macrophage apoptosis and lead to regression of advanced atherosclerotic lesions.
