Article
Biotechnology & Applied Microbiology
Marianna Kulka, Ashley Wagner, Jae-Young Cho, Syed Benazir Alam, Joy Ramielle Santos, Juan Jovel, Leshern Karamchand, Marcelo Marcet-Palacios
Summary: Researchers cultured bone marrow derived mast cells in a matrix containing crystalline nanocellulose (CNC), which had no effect on cell viability but inhibited the production of certain mediators. This study may contribute to understanding the functional expression of cells in specific environments.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Cell Biology
Bo-Gie Yang, A-Ram Kim, Dajeong Lee, Seong Beom An, Yaein Amy Shim, Myoung Ho Jang
Summary: Mast cells are important effectors of inflammation and their degranulation is induced by various cell surface receptors. These receptors have different expression patterns, contributing to varied involvement in inflammatory responses. This review focuses on mast cell receptors involved in allergic inflammation, their role in degranulation induction, tissue-specific expression, and potential new drugs for allergy-related diseases.
Article
Biochemistry & Molecular Biology
Syed Benazir Alam, Ashley Wagner, Steven Willows, Marianna Kulka
Summary: Quercetin and resveratrol have differential inhibitory effects on mast cells, potentially through modulation of FcεRI expression, signaling, and mediator release.
Article
Biochemistry & Molecular Biology
Yuka Nagasaka, Yuki Nakamura, Nguyen Quoc Vuong Tran, Yoshiaki Kobayashi, Nobuhiro Nakano, Atsuhito Nakao
Summary: This study found that Bmal1 plays a regulatory role in the expression of anti-oxidative genes in mast cells, and deficiency of Bmal1 enhances IgE-dependent mast cell degranulation associated with promotion of ROS generation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Immunology
Theres Klewer, Ljubica Bakic, Thomas Mueller-Reichert, Robert Kiewisz, Gregor Jessberger, Nadine Kiessling, Axel Roers, Rolf Jessberger
Summary: The study shows that E-Cadherin plays a role in restricting premature activation of mast cells, with in vitro and in vivo experiments confirming this conclusion. A deficiency of E-Cadherin in mast cells leads to enhanced degranulation and decreased release of newly synthesized inflammatory cytokines, indicating a stronger response to IgE-dependent stimuli and increased risk of anaphylactic shock.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ruijuan Qi, Yuan Kang, Ximeng Li, Xiaoyu Zhang, Yixin Han, Runlan Cai, Yuan Gao, Yun Qi
Summary: The study found that Forsythiae Fructus extract can inhibit the degranulation of mast cells, possibly by reducing intracellular Ca2+ levels. This discovery provides theoretical support for the clinical application of Forsythiae Fructus in allergies and other diseases involving mast cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Peter W. West, Rajia Bahri, Karen M. Garcia-Rodriguez, Georgia Sweetland, Georgia Wileman, Rajesh Shah, Angeles Montero, Laura Rapley, Silvia Bulfone-Paus
Summary: Aberrant mast cell responses and complement activation both contribute to allergic diseases. IL-33 plays a critical role in regulating mast cell responses to complement anaphylatoxins, enhancing mast cell reactivity to C3a and C5a. This cross-regulation may aggravate Th2 immune responses and targeting anti-IL33 therapeutically could provide a rationale in allergic diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Parasitology
Katarzyna Donskow-Lysoniewska, Marta Maruszewska-Cheruiyot, Katarzyna Krawczak-Wojcik, Jorge F. Gonzalez, Julia N. Hernandez, Michael J. Stear
Summary: The nematode's galectin competes with host galectin and inhibits mast cell degranulation, which is an important mechanism for the establishment and survival of gastrointestinal nematodes.
VETERINARY PARASITOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Thomas Buttgereit, Moritz Pfeiffenberger, Stefan Frischbutter, Pierre-Louis Krauss, Yuling Chen, Marcus Maurer, Frank Buttgereit, Timo Gaber
Summary: The role of mitochondrial respiration in immune functions of human skin mast cells is important. Inhibiting mitochondrial respiration may provide potential options for controlling mast cell-driven skin symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Yuejin Wang, Yuanyuan Ding, Chaomei Li, Jiapan Gao, Xiaodong Wang, Hongli An
Summary: The findings suggest that alpha-linolenic acid (ALA) could serve as a therapeutic drug candidate for preventing IgE-mediated anaphylaxis by regulating immune reactions and attenuating inflammation caused by allergies.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Kezia Jack, Graham S. Jackson, Jan Bieschke
Summary: This article reviews a range of experimental approaches for generating PrP amyloid assemblies and discusses the definition of prions, non-protein requirements, and the current state of prion amplification and generation in vitro.
Article
Immunology
Samrat Moitra, Somrita Basu, Mattie Pawlowic, Fong-fu Hsu, Kai Zhang
Summary: This study assessed the function and essentiality of choline ethanolamine phosphotransferase (CEPT) in Leishmania major responsible for PC and PE synthesis. The results showed that targeted deletion of CEPT is only possible in the presence of an episomal CEPT gene, and in vivo infected mice appeared to lose the episomal copy of CEPT while maintaining normal levels of virulence and replication.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Tamuka M. Chidyausiku, Soraia R. Mendes, Jason C. Klima, Marta Nadal, Ulrich Eckhard, Jorge Roel-Touris, Scott Houliston, Tibisay Guevara, Hugh K. Haddox, Adam Moyer, Cheryl H. Arrowsmith, F. Xavier Gomis-Ruth, David Baker, Enrique Marcos
Summary: The researchers develop design rules for tailoring immunoglobulin domains and demonstrate their ability to accurately design these domains de novo with high stability and the ability to scaffold functional loops.
NATURE COMMUNICATIONS
(2022)
Article
Clinical Neurology
Talene A. Yacoubian, Yu-Hua Dean Fang, Adam Gerstenecker, Amy Amara, Natividad Stover, Lauren Ruffrage, Christopher Collette, Richard Kennedy, Yue Zhang, Huixian Hong, Hongwei Qin, Jonathan McConathy, Etty N. Benveniste, David G. Standaert
Summary: This study aimed to evaluate the presence of brain and systemic inflammation in newly diagnosed Parkinson's disease (PD) patients. The results showed increased central inflammation in de novo PD patients and its correlation with cognitive decline. These findings suggest that inflammation may play a significant role in the pathophysiology of PD.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Talene A. Yacoubian, Yu-Hua Dean Fang, Adam Gerstenecker, Amy Amara, Natividad Stover, Lauren Ruffrage, Christopher Collette, Richard Kennedy, Yue Zhang, Huixian Hong, Hongwei Qin, Jonathan McConathy, Etty N. Benveniste, David G. Standaert
Summary: This study aimed to assess the presence of brain and systemic inflammation in subjects newly diagnosed with Parkinson's disease (PD). The results showed increased central inflammation in de novo PD subjects compared to controls, and the presence of inflammation may predict cognitive decline.
MOVEMENT DISORDERS
(2023)
Letter
Allergy
Matthew P. Giannetti, Francesco Olivieri, Grace Godwin, Emma Weller, Jennifer Nicoloro-SantaBarbara, Patrizia Bonadonna, Roberta Zanotti, Giovanna Zanoni, Karin Hartmann, Mariana Castells
Article
Hematology
Vanessa E. Kennedy, Cecelia Perkins, Andreas Reiter, Mohamad Jawhar, Johannes Luebke, Hanneke C. Kluin-Nelemans, William Shomali, Cheryl Langford, Justin Abuel, Olivier Hermine, Marek Niedoszytko, Aleksandra Gorska, Andrzej Mital, Patrizia Bonadonna, Roberta Zanotti, Ilaria Tanasi, Mattias Mattsson, Hans Hagglund, Massimo Triggiani, Akif Selim Yavuz, Jens Panse, Deborah Christen, Marc Heizmann, Khalid Shoumariyeh, Sabine Mueller, Chiara Elena, Luca Malcovati, Nicolas Fiorelli, Friederike Wortmann, Vladan Vucinic, Knut Brockow, Christos Fokoloros, Sotirios G. Papageorgiou, Christine Breynaert, Dominique Bullens, Michael Doubek, Anja Ilerhaus, Irena Angelova-Fischer, Oleksii Solomianyi, Judit Varkonyi, Vito Sabato, Axel Ruefer, Tanja Daniela Schug, Maud A. W. Hermans, Anna Belloni Fortina, Francesca Caroppo, Horia Bumbea, Theo Gulen, Karin Hartmann, Hanneke Oude Elberink, Juliana Schwaab, Michel Arock, Peter Valent, Wolfgang R. Sperr, Jason Gotlib
Summary: This study evaluated 92 patients with mast cell leukemia (MCL) and found that 34% of patients had an associated hematologic neoplasm. Some patients had chronic MCL, while a small percentage had leukemic MCL. The study also identified genetic mutations and treatment strategies that were associated with prognosis.
Editorial Material
Allergy
Cem Akin, Knut Brockow, Karin Hartmann, Gunnar P. P. Nilsson
Article
Biochemistry & Molecular Biology
Christian Schneeweis, Sandra Diersch, Zonera Hassan, Lukas Krauss, Carolin Schneider, Daniele Lucarelli, Chiara Falcomata, Katja Steiger, Rupert Oellinger, Oliver H. Kraemer, Alexander Arlt, Marian Grade, Marc Schmidt-Supprian, Elisabeth Hessmann, Matthias Wirth, Roland Rad, Maximilian Reichert, Dieter Saur, Guenter Schneider
Summary: This study identifies FRA1 as a regulator of sensitivity to RAF-MEK-ERK inhibitors in pancreatic cancer. FRA1 is associated with the adaptive rewiring of oncogenic ERK signaling and its degradation synergizes with MEK inhibitors.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Physiology
Pedro L. Valenzuela, Lidia B. Alejo, Laureano M. Ozcoidi, Alejandro Lucia, Alfredo Santalla, David Barranco-Gil
Summary: The purpose of this study was to assess the durability of professional cyclists and potential associated indicators. Twelve male professional cyclists participated in the study and performed a 20-minute time trial on two different sessions. The study found that performance is significantly impaired after a certain amount of work completed, and this impairment is not related to traditional laboratory-based endurance indicators or training load markers.
INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE
(2023)
Article
Cell Biology
Silke Lambing, Yu Pan Tan, Paraskevi Vasileiadou, Stefan Holdenrieder, Patrick Mueller, Christian Hagen, Stephan Garbe, Rayk Behrendt, Martin Schlee, Jasper G. van den Boorn, Eva Bartok, Marcel Renn, Gunther Hartmann
Summary: Radiotherapy induces DNA damage and activates cell death pathways, but its effectiveness is limited in radioresistant tumors such as melanoma. This study shows that activation of the immune sensing receptor RIG-I can enhance irradiation-induced tumor cell death, leading to improved survival in melanoma models. The results suggest that combining RIG-I ligands with radiotherapy may be a promising approach for treating radioresistant tumors with functional p53 pathways, such as melanoma.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2023)
Review
Medicine, General & Internal
Felicitas Bellutti Enders, Marius Elkuch, Andreas Woerner, Kathrin Scherer Hofmeier, Karin Hartmann
Summary: This case report describes a 7-year-old boy who presented with recurrent wheals and was diagnosed with alpha-gal syndrome. Initial suspicion was chronic spontaneous urticaria, but further investigation revealed a history of tick bites and elevated IgE levels for alpha-gal. The case highlights the importance of recognizing alpha-gal syndrome in children, as it is typically seen in adults and often overlooked in pediatric patients.
JOURNAL OF MEDICAL CASE REPORTS
(2023)
Article
Pediatrics
Hanna Wassmer, Karin Hartmann
Summary: Mastocytosis in children is a rare disease characterized by abnormal accumulation of tissue mast cells, typically presenting with skin alterations and mast cell mediator symptoms. Most cases have a benign and self-limiting course, but systemic mastocytosis with extracutaneous involvement can occasionally occur. Therapeutic options include H1 antihistamines and educating patients about trigger factors. Epinephrine auto-injectors are recommended for emergency treatment in children with severe symptoms and extensive skin alterations.
MONATSSCHRIFT KINDERHEILKUNDE
(2023)
Article
Immunology
Lukas Kaltenbach, Paloma Martzloff, Sarah K. Bambach, Nadim Aizarani, Michael Mihlan, Alina Gavrilov, Katharina M. Glaser, Manuel Stecher, Roland Thuenauer, Aude Thiriot, Klaus Heger, Katrin Kierdorf, Stephan Wienert, Ulrich H. von Andrian, Marc Schmidt-Supprian, Claus Nerlov, Frederick Klauschen, Axel Roers, Marc Bajenoff, Dominic Gruen, Tim Laemmermann
Summary: The movement of mast cells differs from the general concept of interstitial immune cell migration. Integrin-dependent adhesion plays a crucial role in controlling mast cell movement and localization. Substrate-dependent haptokinesis is important for the tissue organization of resident immune cells.
Article
Allergy
Peter Valent, Karin Hartmann, Patrizia Bonadonna, Wolfgang Sperr, Marek Niedoszytko, Hanneke C. Kluin-Nelemans, Olivier Hermine, Karl Sotlar, Gregor Hoermann, Boguslaw Nedoszytko, Sigurd Broesby-Olsen, Roberta Zanotti, Magdalena Lange, Michael Doubek, Knut Brockow, Ivan Alvarez-Twose, Judit Varkonyi, Selim Yavuz, Gunnar Nilsson, Deepti Radia, Clive Grattan, Juliana Schwaab, Theo Gillen, Hanneke N. G. Oude Elberink, Hans Haegglund, Frank Siebenhaar, Emir Hadzijusufovic, Vito Sabato, Jiri Mayer, Andreas Reiter, Alberto Orfao, Hans-Peter Horny, Massimo Triggiani, Michel Arock
Summary: In 2002, the European Competence Network on Mastocytosis (ECNM) was established to improve the diagnosis and management of patients with mast cell disorders. It consists of specialized centers and experts dedicated to MC diseases, aiming to distribute information to patients, doctors, and scientists. Over the past 20 years, the ECNM has made significant contributions to the development of diagnostic concepts and treatments for mastocytosis and MC activation disorders. It has also organized meetings and conferences to support research in this field.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Medicine, General & Internal
Marian Simon Schulz, Cay Bennet Sartorius von Bach, Emilija Marinkovic, Claudia Guenther, Rayk Behrendt, Axel Roers
Summary: As a key enzyme in ribonucleotide excision repair, RNase H2 is crucial for removing single ribonucleotides from DNA to prevent genome damage. Loss of RNase H2 activity is directly linked to the development of autoinflammatory and autoimmune diseases, as well as potential involvement in aging and neurodegeneration. Furthermore, RNase H2 activity can serve as a potential diagnostic and prognostic marker for various types of cancer. However, there is currently no validated method for quantifying RNase H2 activity in clinical settings.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Allergy
Martina Konantz, Margaret Williams, Tamara Merkel, Antonia Reiss, Stefan Dirnhofer, Sara C. Meyer, Peter Valent, Tracy I. George, Alexandar Tzankov, Karin Hartmann
Summary: This study found that serum levels of TIM-3 and galectin-9 are increased in patients with advanced systemic mastocytosis. Additionally, TIM-3 and galectin-9 are expressed in bone marrow infiltrates in mastocytosis. These findings suggest that TIM-3 and galectin-9 could be explored as diagnostic markers and potential therapeutic targets in systemic mastocytosis, particularly in advanced forms.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Oncology
Juliana Schwaab, Hans-Peter Horny, Karin Hartmann
Summary: Systemic mastocytosis (SM) is a clonal stem cell disorder with a wide range of clinical manifestations and a heterogeneous prognosis. This review explores the challenges in diagnosis, prognostic models, and therapeutic options for this rare disease. The elevated serum tryptase levels are a diagnostic criterion of SM and symptomatic therapy may be applied in all patients. Novel KIT inhibitors have significantly improved overall survival and symptoms in advanced phase disease (AdvSM) patients, and allogeneic stem cell transplantation remains the only curative option.
Article
Allergy
Peter Schmid-Grendelmeier, Melinda J. Gooderham, Karin Hartmann, George N. Konstantinou, Marc Fellmann, Christopher Koulias, Claire Clibborn, Pinaki Biswas, Patrick M. Brunner
Summary: This article evaluated the efficacy and safety of abrocitinib in patients with moderate-to-severe atopic dermatitis and allergic comorbidities. The results showed that abrocitinib was effective and safe in managing atopic dermatitis in patients with or without allergic comorbidities.
Article
Cell Biology
Anja Fischer, Robert Lersch, Niklas de Andrade Kraetzig, Alexander Strong, Mathias J. Friedrich, Julia Weber, Thomas Engleitner, Rupert Oellinger, Hsi-Yu Yen, Ursula Kohlhofer, Irene Gonzalez-Menendez, David Sailer, Liz Kogan, Mari Lahnalampi, Saara Laukkanen, Thorsten Kaltenbacher, Christine Klement, Majdaddin Rezaei, Tim Ammon, Juan J. Montero, Guenter Schneider, Julia Mayerle, Mathias Heikenwaelder, Marc Schmidt-Supprian, Leticia Quintanilla-Martinez, Katja Steiger, Pentao Liu, Juan Cadinanos, George S. Vassiliou, Dieter Saur, Olli Lohi, Merja Heinaeniemi, Nathalie Conte, Allan Bradley, Lena Rad, Roland Rad
Summary: Compared to the loss of tumor-suppressor function, the effects of discrete gene dysregulations caused by non-coding genome alterations are poorly understood. In this study, by perturbing the regulatory genome in mice, the researchers reveal the pervasive roles of subtle gene expression variation in cancer evolution. They identified extensive quasi-insufficiency across different tumors and discovered diverse context dependencies. The study provides important insights into tumor evolution and the tissue-specific effects of non-coding mutations.