Article
Obstetrics & Gynecology
Brian J. Koos, Jeffrey A. Gornbein
Summary: This metabolomics study identified a high-accuracy model for predicting gestational diabetes mellitus in early pregnancy. The research showed that certain metabolites were independently associated with gestational diabetes mellitus and could be used as predictive markers. This finding contributes to future studies on early therapeutic interventions for gestational diabetes mellitus.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Endocrinology & Metabolism
Emilia Huvinen, Anna-Kaisa Tuomaala, Paula H. Bergman, Jelena Meinila, Tuija Tammelin, Janne Kulmala, Elina Engberg, Saila B. Koivusalo
Summary: This study found that growth patterns during high-risk pregnancies were associated with adiposity at age 5, even after adjusting for lifestyle factors. Accelerated early growth was linked to higher adiposity in children, highlighting the importance of reducing cesarean deliveries and promoting breastfeeding for healthier postnatal growth.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Endocrinology & Metabolism
Niharika Sinha, Gretchen Lydia Walker, Aritro Sen
Summary: Exposure to adverse conditions during fetal development can lead to epigenetic changes that predispose offspring to diseases later in life. For example, offspring exposed to gestational diabetes have an increased risk of developing obesity and metabolic disorders in adulthood. Reproductive dysfunction and infertility later in life may be linked to epigenetic reprogramming of genes.
Article
Endocrinology & Metabolism
Maisa Feghali, Jacqueline Atlass, Kaleab Z. Abebe, Diane Comer, Janet Catov, Steve Caritis, Silva Arslanian, Christina Scifres
Summary: A cohort study of over 800 women with GDM and their offspring found that while offspring of women treated with glyburide or insulin had higher birthweight, z-scores, and BMI, there were no significant differences in childhood growth from 6 months to 3 years among treatment groups. This suggests that GDM treatment methods did not have a meaningful impact on childhood growth outcomes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Cardiac & Cardiovascular Systems
Ana Belen Mendez Fernandez, Ander Vergara Arana, Aleix Olivella San Emeterio, Maria Antonieta Azancot Rivero, Toni Soriano Colome, Maria Jose Soler Romeo
Summary: Cardiorenal syndrome refers to the involvement of both the heart and kidney, where the deterioration of one leads to dysfunction of the other. Diabetes mellitus carries a higher risk of heart failure and poor prognosis, and nearly half of diabetic patients develop chronic kidney disease, making diabetes the main cause of kidney failure. The presence of cardiorenal syndrome and diabetes increases the risk of hospitalization and mortality. Cardiorenal units, with a multidisciplinary team and various diagnostic tools, offer holistic management for patients with cardio-renal-metabolic conditions.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Jelena Stevanovic-Silva, Jorge Beleza, Pedro Coxito, Hugo Rocha, Tiago Bordeira Gaspar, Fatima Gartner, Rossana Correia, Rui Fernandes, Paulo J. Oliveira, Antonio Ascensao, Jose Magalhaes
Summary: This study found that gestational exercise can modulate the effects of maternal high-fat high-sucrose diet-induced gestational diabetes mellitus on hepatic metabolism and mitochondrial outcomes in female offspring. Gestational exercise can prevent early weight gain in female offspring of mothers with gestational diabetes mellitus and reduce hepatic lipid accumulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Medicine, General & Internal
Janine Zoellkau, Laura Swiderski, Alexander Schmidt, Friederike Weschenfelder, Tanja Groten, Dirk Hoyer, Uwe Schneider
Summary: This study found that gestational diabetes can alter fetal autonomic control, increase fetal vagal tone, and have a positive correlation with maternal blood glucose levels and birth weight. However, there wasn't a significant correlation between fetal movement index and birth weight, but it did attenuate the positive correlation between maternal blood glucose levels and birth weight.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Jie Fang, Xiafei Wu, Jie He, Hanwen Zhang, Xuyang Chen, Hua Zhang, Boris Novakovic, Hongbo Qi, Xinyang Yu
Summary: This study revealed that offspring of mothers with gestational diabetes mellitus (GDM) are more susceptible to glucose intolerance and insulin resistance. The study also demonstrated significant metabolic changes in the liver of GDM offspring, indicating the involvement of the glucose synthesis pathway. Furthermore, RNA methylation modification, particularly regulated by RBM15, was found to play a crucial role in the development of metabolic syndrome.
MOLECULAR MEDICINE
(2023)
Review
Medicine, General & Internal
Ivana R. Babovic, Jelena Dotlic, Radmila Sparic, Miljana Z. Jovandaric, Mladen Andjic, Mirjana Marjanovic Cvjeticanin, Slavica Aksam, Jovan Bila, Lidija Tulic, Dusica Kocijancic Belovic, Vera Plesinac, Jovana Plesinac
Summary: In this article, the pathogenesis of gestational diabetes mellitus (GDM), its impact on fetal physiology and neonatal outcomes, as well as the usage of antenatal corticosteroid therapy (ACST) in GDM-complicated pregnancies, are reviewed. The study involved a search of MEDLINE and PubMed for relevant articles published from 1990 to 2022. The results indicate that GDM is associated with adverse pregnancy course and outcomes, affecting the fetal cardiovascular and nervous system, particularly in preterm neonates. However, the use of ACST during pregnancy should take into account the characteristics of both the mother and fetus. The conclusion suggests that GDM does not influence neonatal outcomes after the introduction of ACST, and the personalized use of ACST should consider its gestational age-specific effects on the developing fetus.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Zain Awamleh, Darci T. Butcher, Anthony Hanley, Ravi Retnakaran, Larissa Haertle, Thomas Haaf, Jill Hamilton, Rosanna Weksberg
Summary: This study examined genome-wide DNA methylation in GDM-exposed cord blood and placenta, finding differences in CpG sites between control and treatment groups.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Review
Endocrinology & Metabolism
Joon Ho Moon, Hak Chul Jang
Summary: Gestational diabetes mellitus (GDM) is a common complication during pregnancy, associated with adverse pregnancy outcomes and long-term complications. There are two diagnostic approaches with controversial clinical benefits.
DIABETES & METABOLISM JOURNAL
(2022)
Article
Cell Biology
Yuri Karen Sinzato, Veronyca Goncalves Paula, Franciane Quintanilha Gallego, Rafaianne Q. Moraes-Souza, Jose Eduardo Corrente, Gustavo Tadeu Volpato, Debora Cristina Damasceno
Summary: Maternal diabetes and high-fat diet have similar adverse effects on the health of F1 and F2 generations, including infertility, decreased insulin sensitivity, and fetal growth restriction. The combination of both factors also results in increased lipoperoxidation, decreased glucose tolerance, and increased fetal leptin levels.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Endocrinology & Metabolism
Sumudu Nimali Seneviratne, Shaman Rajindrajith
Summary: The prevalence of obesity and type 2 diabetes mellitus has been rapidly increasing, and current prevention efforts are not successful. Fetal programming provides a new concept for lifelong prevention of obesity and type 2 diabetes mellitus. The World Health Organization now advocates a life-course approach to prevent/control obesity, starting with pre-conceptional and antenatal maternal health. This review summarizes current data on fetal programming of obesity and type 2 diabetes mellitus, including potential causative factors, mechanisms, and interventions to reduce its impact.
WORLD JOURNAL OF DIABETES
(2022)
Article
Endocrinology & Metabolism
Rong Huang, Mark Kibschull, Laurent Briollais, Zdenka Pausova, Kellie Murphy, John Kingdom, Stephen Lye, Zhong-Cheng Luo
Summary: The study found that fetal sex affects the concentration of myostatin in cord blood, with higher levels in male fetuses. Gestational diabetes does not affect the concentration of myostatin in cord blood. The study also revealed a strong correlation between myostatin and testosterone levels in male fetuses.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Meng-Nan Yang, Rong Huang, Xin Liu, Ya-Jie Xu, Wen-Juan Wang, Hua He, Guang-Hui Zhang, Tao Zheng, Fang Fang, Jian-Gao Fan, Fei Li, Jun Zhang, Jiong Li, Fengxiu Ouyang, Zhong-Cheng Luo
Summary: This study found that FGF19 is not associated with glucose homeostasis in newborns of GDM mothers. However, cord plasma FGF19 concentrations were positively correlated with birth weight and length in females, suggesting a sex-dimorphic role of FGF19 in fetal growth. Further studies are needed to validate these findings and explore the underlying mechanisms.
FRONTIERS IN ENDOCRINOLOGY
(2022)
