Article
Medicine, General & Internal
Xiangxiang Zhou, Jingxuan Wan, Xin Gan
Summary: A 73-year-old male patient with pulmonary tuberculosis was eventually diagnosed with malignant eosinophilic pleural effusion. After receiving chemotherapy, the patient achieved partial response and the effusion disappeared. Multiple Thinprep cytology tests showed no evidence of malignancy, highlighting the importance of pleural biopsy for accurate etiology diagnosis.
Article
Engineering, Biomedical
Zhenhuan Song, Weizhan Luo, Haichong Zheng, Yunxiang Zeng, Jinlin Wang, Tianfeng Chen
Summary: A translational selenium nanoparticles coated with immune-modulating macromolecule lentinan are designed to restore dysfunctional immune cells in patient-derived malignant pleural effusion microenvironment, enhancing immune responses and inhibiting tumor growth, thereby providing a potential therapeutic strategy for advanced lung cancer patients with MPE.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Critical Care Medicine
Kamran Mahmood, Parvathi Jampani, Jeffrey M. Clarke, Steven Wolf, Xiaofei Wang, Momen M. Wahidi, Coral X. Giovacchini, Michael Dorry, Scott L. Shofer, Jessica Shier, Greg Jones, Scott J. Antonia, Andrew B. Nixon
Summary: This study investigated the use of pleural cell-free DNA (cfDNA) to assess targetable mutations in lung adenocarcinoma patients with malignant pleural effusions (MPE). The results showed that pleural cfDNA had a higher diagnostic yield for detecting mutations compared to pleural cytology and plasma cfDNA. Pleural cfDNA can be collected longitudinally and easily incorporated into clinical workflow.
Article
Oncology
Nanbin Yu, Huaijun Gong, Wei Chen, Weixing Peng
Summary: Circ-ZKSCAN1 promotes the tumorigenesis and cisplatin resistance in lung adenocarcinoma by regulating the miR-185-5p/TAGLN2 axis.
Article
Oncology
Eiji Takeuchi, Yoshio Okano, Hisanori Machida, Katsuhiro Atagi, Yoshihiro Kondou, Naoki Kadota, Nobuo Hatakeyama, Keishi Naruse, Tsutomu Shinohara
Summary: This study retrospectively analyzed lung cancer patients with malignant pleural effusion (MPE) and found that those with eosinophilic pleural effusion (EPE) had a better prognosis than those without EPE. Factors such as EPE, Eastern Cooperative Oncology Group (ECOG) Performance Status, sex, and the neutrophil-to-lymphocyte ratio in the serum were identified as independent prognostic factors affecting survival.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Oncology
DanHui Huang, JinZhong Zhuo, CuiPing Ye, XiaoFang Su, YueHua Chen, Cui Li, LiSan Lin, LaiYu Liu, Haijin Zhao, Tingyue Luo, QianNan Ren, JianHua Wu, Shaoxi Cai, Hangming Dong
Summary: This study found a strong correlation between pleural microbiota and metabolome in patients with MPE in lung adenocarcinoma. The metabolic profile of MPE was significantly different from that of benign pleural effusion. These findings provide important evidence for further therapeutic explorations.
Article
Oncology
Xu Han, Jixiang Wu, Yajun Zhang, Jianxiang Song, Zhan Shi, Huiwen Chang
Summary: Previous studies have shown that LINC00518 plays a crucial role in cell growth and metastasis in human cancer, while its specific function in lung adenocarcinoma (LUAD) remains unknown. This study focused on investigating the impact of LINC00518 on cell growth in LUAD and found that it promotes cell proliferation by regulating the cell cycle. Additionally, LINC00518 was shown to upregulate MECP2 expression by altering miR-185-3p, indicating its potential as a survival indicator and therapeutic target for LUAD patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Tomohiro Kanayama, Toshiaki Taniguchi, Hiroyuki Tomita, Ayumi Niwa, Kei Noguchi, Mikiko Matsuo, Yuko Imaizumi, Takahiro Kuroda, Yuichiro Hatano, Isao Okazaki, Tatsuo Kato, Akira Hara
Summary: Recent studies suggest that malignant pleural effusion (MPE) may contain a subpopulation of cells with stem-like properties, such as tumorigenicity and self-renewal, and the expression of ALDH1 and SALL4 in MPE cells can impact cluster formation and proliferation.
Article
Oncology
Ke Xu, Xiaodi Wu, Lu Chen, Jingyuan Xie, Xin Hua, Mo Chen, Yuxin Jiang, Hongbing Liu, Fang Zhang, Tangfeng Lv, Yong Song, Ping Zhan
Summary: This retrospective study on 343 patients with metastatic lung adenocarcinoma found that patients with actionable mutations have a lower risk of MPE recurrence and can benefit from targeted therapy and active intrapleural management.
TRANSLATIONAL LUNG CANCER RESEARCH
(2023)
Article
Oncology
Jin Tian, Lin Long, Jianhua Zang, Peng Liu, Lili Zhao, Hongtao Zhang, Jun Xiao
Summary: This article presents a case of advanced lung adenocarcinoma with ROS1 rearrangement, characterized by persistent malignant pleural and peritoneal effusion. The patient received combined therapy of Crizotinib and Anlotinib, resulting in a significant reduction and even disappearance of the malignant effusion. Exploratory use of this treatment approach improved the patient's quality of life and holds potential for extending overall survival, but further validation is needed through multicenter clinical data.
FRONTIERS IN ONCOLOGY
(2023)
Article
Immunology
Lei-lei Lv, Hong-bin Wang, Yao-xin Zhang, Jia-wei Zhai, Yu Shen, Qiu-Xia Qu, Cheng Chen
Summary: This study identifies a subset of CD8 + T cells expressing CD39 in malignant pleural effusion (MPE), which is more prevalent in lung adenocarcinoma (LUAD) with wild-type epidermal growth factor receptor (EGFRwt) and acquired resistance to EGFR-tyrosine kinase inhibitors (AR-EGFR-TKIs). These CD39 + CD8 + T cells display an exhausted phenotype while still retaining cytolytic function and have a higher T cell receptor (TCR) repertoire clonality compared to CD39-CD8 + T cells.
Article
Infectious Diseases
Ling Ai, Jingyuan Li, Ting Ye, Wenjun Wang, Yuying Li
Summary: This article reports a case of exudative pleural effusion caused by lung fluke infection in a young male. It highlights that lung fluke infection is often overlooked as a cause of pleural effusion. Eosinophilia may serve as a marker for infection, and serological tests can aid in confirming the diagnosis.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Oncology
Attila Mokanszki, Emese Sarolta Badon, Aniko Monus, Laszlo Toth, Nora Bittner, Gabor Mehes
Summary: The study revealed that cfDNA isolated from pleural effusion showed significantly higher yield compared to that from PB, and gene mutations could be safely demonstrated from the effusion cfDNA fraction. Pleural effusion appears to be a particularly suitable source for serial genotyping of pulmonary adenocarcinoma.
PATHOLOGY & ONCOLOGY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Meng Huang, Yan Wang, Zhenning Wang, Qiaozhen Qin, Heyang Zhang, Shuirong Liu, Jiantong Cui, Yu Zhang, Xiaoxia Jiang, Lulu Xu
Summary: The study shows that miR-134-5p inhibits osteoclast formation through targeting the Itgb1 gene and regulating the MAPK pathway, suggesting it could be a potential target for osteoporosis therapy.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Environmental Sciences
Kuan-Jen Bai, Shu-Chuan Ho, Shu-Chuan Ho, Cheng-Yu Tsai, Jen-Kun Chen, Chun-Nin Lee, Kang-Yun Lee, Chih-Cheng Chang, Tzu-Tao Chen, Po-Hao Feng, Kuan-Yuan Chen, Chien-Ling Su, Hsiao-Chi Chuang
Summary: The study found that PM2.5 exposure and possible Zn in pleural effusion were associated with the development of malignant pleural effusion in lung cancer patients.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)