Article
Cell Biology
Aikaterini Gatsiou, Kateryna Sopova, Alexandros Tselepis, Konstantinos Stellos
Summary: Platelets are immune cells known for their haemostatic properties and play a key role in vascular regeneration and angiogenesis by releasing growth factors. The IL-17A/IL-17RA axis selectively induces the release of pro-angiogenic factors from platelets, affecting endothelial cells and driving them towards a pro-angiogenic state.
Article
Biochemistry & Molecular Biology
Sofia Oliveira, Sofia S. Pereira, Madalena M. Costa, Mariana P. Monteiro, Duarte Pignatelli
Summary: This study evaluated the expression of angiogenesis-related factors in adrenal cortical tumors and aimed to explore their potential as biomarkers for improving the diagnosis and prognosis prediction of adrenocortical carcinoma. The results showed significantly higher expression of Ang1 and Ang2 in ACC and higher Tie1 expression was associated with venous invasion and shorter overall survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Yanru Duan, Shihan Zhang, Yuanyuan Xing, Ye Wu, Wen Zhao, Pinxue Xie, Huina Zhang, Xinxiao Gao, Yanwen Qin, Yajing Wang, Xinliang Ma, Yunhui Du, Huirong Liu
Summary: This study revealed that adiponectin inhibits diabetic endothelial inflammatory response by activating the Wnt/beta-catenin signaling pathway and promoting the expression of CD44 through APPL1. These findings provide a new avenue for the inhibition of diabetic endothelial inflammation.
Article
Medicine, General & Internal
Tarun Kumar, Jitendra S. Nigam, Shambhwi Sharma, Madhu Kumari, Jagjit Pandey
Summary: Adrenocortical carcinoma is a rare tumor with poor prognosis, commonly metastasizing to the lung, liver, and lymph nodes, while bone metastases are less frequent. This case report describes a 35-year-old male with ACC metastasizing to an uncommon site, the mandible ramus.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Review
Pediatrics
Aniket Ramshekar, M. Elizabeth Hartnett
Summary: ROP is a leading cause of blindness in children worldwide. Concerns exist regarding the optimal doses of anti-VEGF for individual infants and the effect of broad VEGF inhibition on physiologic angiogenesis. Understanding VEGF signaling in both physiologic and pathologic angiogenesis in the retina is crucial.
FRONTIERS IN PEDIATRICS
(2021)
Review
Biochemistry & Molecular Biology
Syeda Mahak Zahra Bokhari, Peter Hamar
Summary: Vascular endothelial growth factors (VEGFs) play a crucial role in regulating blood vessel formation in both normal and cancer development. VEGF-A is the most well-studied angiogenic factor secreted by tumor cells, making it a rational target for anticancer therapy. However, inhibiting VEGF-A can lead to the upregulation of VEGF-D, which has been shown to have comparable blood angiogenic potential and may facilitate tumor growth. This review focuses on summarizing the angiogenic role of VEGF-D in blood vessel formation and its potential as a therapeutic target for antiangiogenic therapy in cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Yijia Mao, Lingkai Meng, Huayi Liu, Yuting Lu, Kuo Yang, Guangze Ouyang, Yanran Ban, Shuang Chen
Summary: This review summarizes recent research on the influence of traditional Chinese medicine (TCM) on vascular endothelial growth factor (VEGF). It is found that many Chinese medicines and recipes have a regulatory effect on VEGF, providing new treatment ideas and theoretical basis for TCM as a complementary and alternative therapy.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2022)
Article
Multidisciplinary Sciences
Zhiyang Li, Heng Zhang, Yujie Sun, Zhuangzhuang Feng, Bijia Cui, Jingxia Han, Yinan Li, Huijuan Liu, Tao Sun
Summary: Angiogenesis plays a crucial role in embryologic development, growth, and tissue repair, but dysregulation of this process is a hallmark of various pathologies, including cancer. Existing methods for evaluating cell vascular formation are often limited to static analysis, leading to bias. Researchers have developed code scripts to study the dynamic angiogenesis process, allowing for the screening of drugs that can affect various parameters of vascular formation. Animal experiments have confirmed the efficacy of these drugs in inhibiting blood vessel formation, providing a new perspective for angiogenesis research and drug development.
Article
Endocrinology & Metabolism
Benjamin M. Dungar, Chad D. Schupbach, Jessie R. Jacobson, Phillip G. Kopf
Summary: The study found that BDE-47 significantly increases adrenal corticosteroid secretion and upregulates gene expression of enzymes involved in corticosteroid synthesis and mitochondrial metabolism. In the rat experiment, adrenal weight and plasma corticosterone levels were significantly increased in the BDE-47 treatment groups, suggesting a potential disruption in corticosteroid regulation and supporting the role of PBDEs as endocrine disruptors.
Article
Endocrinology & Metabolism
Benjamin M. Dungar, Chad D. Schupbach, Jessie R. Jacobson, Phillip G. Kopf
Summary: The study found that BDE-47 significantly increased aldosterone and cortisol secretion in HAC15 cells, as well as gene expression related to corticosteroid synthesis and mitochondrial metabolism. In Sprague Dawley rats, adrenal weight was significantly increased in BDE-47 treatment groups, with a notable rise in plasma corticosterone levels in the 100 μg BDE-47/kg treatment group. These results indicate that BDE-47 disrupts corticosteroid secretion and supports the notion that PBDEs could act as endocrine disruptors.
Article
Surgery
Sean M. Wrenn, Alessandra L. Moore, Hina J. Shah, Justine A. Barletta, Anand Vaidya, Kerry L. Kilbridge, Gerard M. Doherty, Heather A. Jacene, Matthew A. Nehs
Summary: This study focused on adrenocortical carcinoma (ACC) and found that higher maximum standard uptake value (SUVmax) on FDG-PET scan was associated with worse survival. The study concluded that FDG-PET may provide clinically useful information for prognosis and treatment.
AMERICAN JOURNAL OF SURGERY
(2023)
Review
Biochemistry & Molecular Biology
Xi Guo, Hong Yi, Tin Chiu Li, Yu Wang, Huilin Wang, Xiaoyan Chen
Summary: VEGF is a well-known angiogenic factor that plays a critical role in embryo implantation by enhancing embryo development and facilitating interactions between the embryo and endometrium. Changes in VEGF expression are correlated with reproductive failure, including recurrent implantation failure and recurrent miscarriage. This study aimed to clarify the role of VEGF in embryo implantation by reviewing recent literature and exploring its effects and underlying mechanisms.
Article
Oncology
Yanfen Cui, Hui Liu, Zhaosong Wang, He Zhang, Jianfei Tian, Zhiyong Wang, Weijie Song, Hui Guo, Liming Liu, Ruinan Tian, Xiaoyan Zuo, Sixin Ren, Fei Zhang, Ruifang Niu
Summary: High fructose intake is associated with increased risk of multiple cancers. Fructose can enhance the biological function of vascular endothelial cells (VECs) and promote angiogenesis by activating the Akt and Src signaling pathways. It can also upregulate production of reactive oxygen species (ROS) in colorectal cancer cells, indirectly enhancing the function of VECs. These findings have been validated in clinical colorectal cancer tissues and mouse models.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Multidisciplinary Sciences
Ruiting Sun, Qingsheng Peng, Fengyi Zhang, Honglian Gao, Tong Li, Lei Wang, Lei Zhang
Summary: The study found that VEGF165 can elevate the levels of DA in the retina of guinea pigs with myopia, effectively slowing down the progression of the condition.
Review
Pathology
Antonio De Leo, Martina Ruscelli, Thais Maloberti, Sara Coluccelli, Andrea Repaci, Dario de Biase, Giovanni Tallini
Summary: This review discusses the main molecular alterations of tumors in endocrine glands such as the anterior pituitary, thyroid and parathyroid glands, adrenal cortex, and adrenal medulla and paraganglia. It examines the correlation between genotype and phenotype in endocrine gland tumors and how high-throughput molecular analysis can group them into relevant molecular groups for pathologic and clinical purposes. The review also addresses the use of genetic alterations as molecular biomarkers for diagnosis, prognosis, and predicting response to molecular therapy, as well as the role of hereditary conditions in predisposition to endocrine tumors.
Article
Oncology
Otilia Kimpel, Paul Schindler, Laura Schmidt-Pennington, Barbara Altieri, Felix Megerle, Harm Haak, James Pittaway, Ulrich Dischinger, Marcus Quinkler, Knut Mai, Matthias Kroiss, Buelent Polat, Martin Fassnacht
Summary: This study retrospectively analyzed all patients who received radiotherapy for advanced adrenocortical carcinoma in five European centers since 2000. The results showed that radiotherapy is effective in adrenocortical carcinoma, and higher doses of radiotherapy are associated with longer time to progression of the treated lesion. The toxicity of radiotherapy was generally mild, and no clear predictive factors could be established.
BRITISH JOURNAL OF CANCER
(2023)
Article
Medical Laboratory Technology
Masanori Murakami, Na Sun, Fengxia Li, Annette Feuchtinger, Celso Gomez-Sanchez, Martin Fassnacht, Martin Reincke, Irina Bancos, Axel Walch, Matthias Kroiss, Felix Beuschlein
Summary: Recent advances in omics techniques have allowed detailed genetic characterization of cortisol-producing adrenal adenoma (CPA). The current study conducted a comprehensive mass spectrometry imaging (MSI) map of CPAs in relation to clinical phenotypes and immunohistochemical profiles of steroidogenic enzymes. The results revealed novel metabolic links between endocrine function and tumorigenesis, which will further support the understanding of CPA pathophysiology.
CLINICAL CHEMISTRY
(2023)
Review
Endocrinology & Metabolism
Yasir S. Elhassan, Fizzah Iqbal, Wiebke Arlt, Stephanie E. Baldeweg, Miles Levy, Paul M. Stewart, John Wass, Sue Pavord, D. Aled Rees, Cristina L. Ronchi
Summary: Adrenal haemorrhage can occur as a complication of COVID-19 infection and vaccination. Assessment of adrenal function is crucial to prevent fatal consequences of unrecognized adrenal insufficiency.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Oncology
Alessandra Mangone, Barbara Altieri, Mario Detomas, Alessandro Prete, Haider Abbas, Miriam Asia, Yasir S. Elhassan, Giovanna Mantovani, Cristina L. Ronchi
Summary: Inflammation-based scores calculated from routinely measured parameters may help predict response to chemotherapy in advanced adrenocortical carcinoma (ACC).
ENDOCRINE-RELATED CANCER
(2023)
Article
Endocrinology & Metabolism
Konstantin L. Uttinger, Joachim Reibetanz, Johannes Diers, Philip Baum, Sebastian Pietryga, Anne Hendricks, Leon Schuetze, Nikolas Baumann, Verena Wiegering, Johann Lock, Ulrich Dischinger, Florian Seyfried, Martin Fassnacht, Christoph-Thomas Germer, Armin Wiegering
Summary: The annual caseload of adrenal resections varies among German hospitals. Surgery in high-volume centers is associated with better patient outcomes, although fatal complications are rare.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ilja Balonov, Max Kurlbaum, Ann-Cathrin Koschker, Christine Stier, Martin Fassnacht, Ulrich Dischinger
Summary: Although the metabolic changes caused by bariatric surgery are known, it is unclear if these changes are specific to the surgery itself or a result of weight loss. A study using liquid chromatography tandem mass spectrometry found that Roux-en-Y Gastric Bypass (RYGB) surgery resulted in distinct changes in the metabolome, which were different from those observed in non-surgical intervention groups.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Ye Lynn Ko, Vaishnavi Kumar, Juliane Lippert, Salvador Diaz-Cano, Kassiani Skordilis, Otilia Kimpel, Stefan Kircher, Miriam Asia, Yasir S. Elhassan, Barbara Altieri, Cristina L. Ronchi
Summary: This article reports three cases where sporadic ACC was identified in patients with coexistent or previous history of melanoma. The researchers found a higher incidence of ACC in patients with melanoma.
BMC ENDOCRINE DISORDERS
(2023)
Article
Endocrinology & Metabolism
Martin Fassnacht, Stylianos Tsagarakis, Massimo Terzolo, Antoine Tabarin, Anju Sahdev, John Newell-Price, Iris Pelsma, Ljiljana Marina, Kerstin Lorenz, Irina Bancos, Wiebke Arlt, Olaf M. Dekkers
Summary: Adrenal incidentalomas are adrenal masses detected on imaging for non-suspected adrenal disease. A revision of the first international guidelines on incidentalomas has been provided, focusing on assessing risk of malignancy, managing mild autonomous cortisol secretion, deciding surgical treatment, and determining follow-up for nonoperated patients. Key recommendations include dedicated adrenal imaging for each adrenal mass, thorough clinical and endocrine work-up to exclude hormone excess, consideration of surgical treatment for patients with mild autonomous cortisol secretion and relevant comorbidities, and appropriate surgical intervention guided by risk of malignancy and hormone excess.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Health Care Sciences & Services
Zhe Wang, Anthony Stell, Richard O. Sinnott
Summary: Australia has a high prevalence of diabetes, and a national registry called ADDN has been established to collect information about type-1 diabetes patients. The registry currently receives data from various diabetes centers, but there is a demand to use fully identifying data for research purposes. This raises concerns about security, privacy, and patient consent, and the GDPR is an important mechanism to address these concerns.
Review
Endocrinology & Metabolism
Iris C. M. Pelsma, Martin Fassnacht, Stylianos Tsagarakis, Massimo Terzolo, Antoine Tabarin, Anju Sahdev, John Newell-Price, Ljiljana Marina, Kerstin Lorenz, Irina Bancos, Wiebke Arlt, Olaf M. Dekkers
Summary: This systematic review and meta-analysis found that patients with adrenal incidentalomas and mild autonomous cortisol secretion (MACS) have a higher prevalence of comorbidities such as diabetes, hypertension, and dyslipidemia, as well as increased all-cause mortality. Adrenalectomy appears to improve glucometabolic control, hypertension, and dyslipidemia in patients with MACS.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Juliane Lippert, Ulrich Dischinger, Silke Appenzeller, Alessandro Prete, Stefan Kircher, Kassiani Skordilis, Yasir S. Elhassan, Barbara Altieri, Martin Fassnacht, Cristina L. Ronchi
Summary: Recent studies have suggested that combining clinical/histopathological parameters or molecular biomarkers improves prognostication of adrenocortical carcinoma (ACC). This study compared the prognostic value of DNA-based biomarkers with the S-GRAS score, and found that DNA-based biomarkers play an independent prognostic role and can enhance the predictive accuracy of the S-GRAS score in ACC.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Nicole Bechmann, Mats Leif Moskopp, Georgiana Constantinescu, Anthony Stell, Angela Ernst, Frank Berthold, Frank Westermann, Jingjing Jiang, Longfei Lui, Elisabeth Nowak, Stephanie Zopp, Karel Pacak, Mirko Peitzsch, Andreas Schedl, Martin Reincke, Felix Beuschlein, Stefan R. Bornstein, Martin Fassnacht, Graeme Eisenhofer, Int Network Adrenal Tumours
Summary: This study investigated the occurrence of adrenal tumors in relation to sex and adrenal asymmetry. It was found that females were more prone to adrenal cortical carcinoma, aldosterone-producing adenoma, and cortisol-secreting adrenocortical adenomas, while males were more prone to pheochromocytoma. Adrenal tumors were more commonly located on the left side, except for pheochromocytoma which was more commonly on the right. Additionally, females had smaller adrenals compared to males.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
I. Tizianel, M. Detomas, T. Deutschbein, M. Fassnacht, N. Albiger, M. Iacobone, C. Scaroni, F. Ceccato
Summary: Unilateral adrenalectomy is an effective alternative treatment for PBMAH, achieving surgical cure in three out of four patients. Pre-operative hCRH testing can predict long-term remission rates.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Rosa Catalano, Barbara Altieri, Anna Angelousi, Maura Arosio, Francesca Bravi, Letizia Canu, Giorgio A. Croci, Mario Detomas, Emanuela Esposito, Emanuele Ferrante, Stefano Ferrero, Carmina T. Fuss, Gregory Kaltsas, Otilia Kimpel, Laura-Sophie Landwehr, Michaela Luconi, Valentina Morelli, Gabriella Nesi, Emma Nozza, Silviu Sbiera, Andreea L. Serban, Cristina L. Ronchi, Giovanna Mantovani, Erika Peverelli
Summary: In adrenocortical carcinomas, the expression of cytoskeleton protein filamin A (FLNA) is associated with tumor aggressiveness and patient survival. High FLNA expression is linked to lower tumor stage, lower scores, and longer overall survival in adrenal cortical carcinomas.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Vittoria Favero, Alessandro Prete, Alessandra Mangone, Yasir S. Elhassan, Valentina Pucino, Miriam Asia, Rowan Hardy, Iacopo Chiodini, Cristina L. Ronchi
Summary: This study evaluated the hematological alterations in benign adrenocortical tumors with different degrees of cortisol excess. It found that the degree of cortisol excess was correlated with an increase in leukocytes, neutrophils, and monocytes. Additionally, the neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and systemic immune-inflammation index were altered in patients with mild autonomous cortisol secretion (MACS) and adrenal Cushing's syndrome.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)