The Structural Determinants behind the Epigenetic Role of Histone Variants

Molecular turnover, the H3.3 dilemma and organismal aging (hypothesis)

(2015) Evelyne Saade et al.   AGING CELL

Nucleosome adaptability conferred by sequence and structural variations in histone H2A–H2B dimers

(2015) Alexey K Shaytan et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

CENP-A K124 Ubiquitylation Is Required for CENP-A Deposition at the Centromere

(2015) Yohei Niikura et al.   DEVELOPMENTAL CELL

Two distinct modes for propagation of histone PTMs across the cell cycle

(2015) Constance Alabert et al.   GENES & DEVELOPMENT

Expression of Non-acetylatable H2A.Z in Myoblast Cells Blocks Myoblast Differentiation through Disruption of MyoD Expression

(2015) Cindy Law et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone exchange, chromatin structure and the regulation of transcription

(2015) Swaminathan Venkatesh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Multiple facets of histone variant H2AX: a DNA double-strand-break marker with several biological functions

(2015) Valentina Turinetto et al.   NUCLEIC ACIDS RESEARCH

Restricted epigenetic inheritance of H3K9 methylation

(2015) P. N. C. B. Audergon et al.   SCIENCE

CENP-C reshapes and stabilizes CENP-A nucleosomes at the centromere

(2015) S. J. Falk et al.   SCIENCE

Histone Variants and Epigenetics

(2015) Steven Henikoff et al.   Cold Spring Harbor Perspectives in Biology

Unbiased chromatin accessibility profiling by RED-seq uncovers unique features of nucleosome variants in vivo

(2015) Poshen B Chen et al.   BMC GENOMICS

Expression and functionality of histone H2A variants in cancer

(2015) Fátima Liliana Monteiro et al.   Oncotarget

The shades of gray of the chromatin fiber

(2014) Juan Ausió   BIOESSAYS

Histone H2A.Z deregulation in prostate cancer. Cause or effect?

(2014) Deanna Dryhurst et al.   CANCER AND METASTASIS REVIEWS

Subnucleosomal Structures and Nucleosome Asymmetry across a Genome

(2014) Ho Sung Rhee et al.   CELL

dBigH1, a second histone H1 inDrosophila, and the consequences for histone fold nomenclature

(2014) Rodrigo González-Romero et al.   Epigenetics

Mice without MacroH2A Histone Variants

(2014) J. R. Pehrson et al.   MOLECULAR AND CELLULAR BIOLOGY

BS69/ZMYND11 Reads and Connects Histone H3.3 Lysine 36 Trimethylation-Decorated Chromatin to Regulated Pre-mRNA Processing

(2014) Rui Guo et al.   MOLECULAR CELL

Genomic and proteomic dissection and characterization of the human sperm chromatin

(2014) J. Castillo et al.   MOLECULAR HUMAN REPRODUCTION

Every amino acid matters: essential contributions of histone variants to mammalian development and disease

(2014) Ian Maze et al.   NATURE REVIEWS GENETICS

A Comprehensive View of the Epigenetic Landscape Part I: DNA Methylation, Passive and Active DNA Demethylation Pathways and Histone Variants

(2014) Anna Sadakierska-Chudy et al.   NEUROTOXICITY RESEARCH

Mapping of six somatic linker histone H1 variants in human breast cancer cells uncovers specific features of H1.2

(2014) Lluís Millán-Ariño et al.   NUCLEIC ACIDS RESEARCH

The histone variant H2A.Bbd is enriched at sites of DNA synthesis

(2014) Viola Sansoni et al.   NUCLEIC ACIDS RESEARCH

Genome-Wide Analysis of the Chromatin Composition of Histone H2A and H3 Variants in Mouse Embryonic Stem Cells

(2014) Masashi Yukawa et al.   PLoS One

Epigenetic inheritance uncoupled from sequence-specific recruitment

(2014) K. Ragunathan et al.   SCIENCE

Cryo-EM Study of the Chromatin Fiber Reveals a Double Helix Twisted by Tetranucleosomal Units

(2014) F. Song et al.   SCIENCE

Mechanisms of epigenetic memory

(2014) Agustina D’Urso et al.   TRENDS IN GENETICS

Histone variants at the transcription start-site

(2014) Tatiana A. Soboleva et al.   TRENDS IN GENETICS

The budding yeast Centromere DNA Element II wraps a stable Cse4 hemisome in either orientation in vivo

(2014) Steven Henikoff et al.   eLife

Structural polymorphism in the L1 loop regions of human H2A.Z.1 and H2A.Z.2

(2013) Naoki Horikoshi et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

MacroH2A – An epigenetic regulator of cancer

(2013) Neus Cantariño et al.   CANCER LETTERS

Dynamic Readers for 5-(Hydroxy)Methylcytosine and Its Oxidized Derivatives

(2013) Cornelia G. Spruijt et al.   CELL

Histone variants: emerging players in cancer biology

(2013) Chiara Vardabasso et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Histone variants in pluripotency and disease

(2013) P. J. Skene et al.   DEVELOPMENT

Faddish Stuff: Epigenetics and the Inheritance of Acquired Characteristics

(2013) Mark Ptashne   FASEB JOURNAL

Chromatin-to-nucleoprotamine transition is controlled by the histone H2B variant TH2B

(2013) E. Montellier et al.   GENES & DEVELOPMENT

Reconstitution of hemisomes on budding yeast centromeric DNA

(2013) Takehito Furuyama et al.   NUCLEIC ACIDS RESEARCH

Epigenetics: Core misconcept

(2013) M. Ptashne   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Developmental roles of histone H3 variants and their chaperones

(2013) Dan Filipescu et al.   TRENDS IN GENETICS

Stepwise histone modifications are mediated by multiple enzymes that rapidly associate with nascent DNA during replication

(2013) Svetlana Petruk et al.   Nature Communications

Structural basis of a nucleosome containing histone H2A.B/H2A.Bbd that transiently associates with reorganized chromatin

(2013) Yasuhiro Arimura et al.   Scientific Reports

Placing the HIRA Histone Chaperone Complex in the Chromatin Landscape

(2013) Nikolay A. Pchelintsev et al.   Cell Reports

The Genomic Landscape of the Somatic Linker Histone Subtypes H1.1 to H1.5 in Human Cells

(2013) Annalisa Izzo et al.   Cell Reports

Histone variant selectivity at the transcription start site: H2A.Z or H2A.Lap1

(2013) Maxim Nekrasov et al.   Nucleus

The CENP-A nucleosome

(2013) Minh Bui et al.   Nucleus

TrxG and PcG Proteins but Not Methylated Histones Remain Associated with DNA through Replication

(2012) Svetlana Petruk et al.   CELL

The unconventional structure of centromeric nucleosomes

(2012) Steven Henikoff et al.   CHROMOSOMA

A Conserved Function for the H2A.Z C Terminus

(2012) Daniel Wratting et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone Variant H2A.Bbd Is Associated with Active Transcription and mRNA Processing in Human Cells

(2012) Michael Y. Tolstorukov et al.   MOLECULAR CELL

The basic linker of macroH2A stabilizes DNA at the entry/exit site of the nucleosome

(2012) Srinivas Chakravarthy et al.   NUCLEIC ACIDS RESEARCH

Histone H2A variants in nucleosomes and chromatin: more or less stable?

(2012) C. Bonisch et al.   NUCLEIC ACIDS RESEARCH

A unified phylogeny-based nomenclature for histone variants

(2012) Paul B Talbert et al.   Epigenetics & Chromatin

The Cell Cycle Timing of Centromeric Chromatin Assembly in Drosophila Meiosis Is Distinct from Mitosis Yet Requires CAL1 and CENP-C

(2012) Elaine M. Dunleavy et al.   PLOS BIOLOGY

Structures of human nucleosomes containing major histone H3 variants

(2011) Hiroaki Tachiwana et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The double face of the histone variant H3.3

(2011) Emmanuelle Szenker et al.   CELL RESEARCH

The Linker Region of MacroH2A Promotes Self-association of Nucleosomal Arrays

(2011) Uma M. Muthurajan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of the human centromeric nucleosome containing CENP-A

(2011) Hiroaki Tachiwana et al.   NATURE

Proteomic characterization of the human sperm nucleus

(2011) Sara de Mateo et al.   PROTEOMICS

Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA

(2011) Y.-F. He et al.   SCIENCE

Stepwise Histone Replacement by SWR1 Requires Dual Activation with Histone H2A.Z and Canonical Nucleosome

(2010) Ed Luk et al.   CELL

Multiple facets of the unique histone variant macroH2A: From genomics to cell biology

(2010) Matthew J. Gamble et al.   CELL CYCLE

The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3

(2010) P. Drane et al.   GENES & DEVELOPMENT

Phosphorylation of Histone H2A.X by DNA-dependent Protein Kinase Is Not Affected by Core Histone Acetylation, but It Alters Nucleosome Stability and Histone H1 Binding

(2010) Andra Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The structure of (CENP-A–H4)2 reveals physical features that mark centromeres

(2010) Nikolina Sekulic et al.   NATURE

Histone variants — ancient wrap artists of the epigenome

(2010) Paul B. Talbert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

H2A.Z nucleosomes enriched over active genes are homotypic

(2010) Christopher M Weber et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The docking domain of histone H2A is required for H1 binding and RSC-mediated nucleosome remodeling

(2010) Manu Shubhdarshan Shukla et al.   NUCLEIC ACIDS RESEARCH

Structural basis of instability of the nucleosome containing a testis-specific histone variant, human H3T

(2010) H. Tachiwana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acetylation of Vertebrate H2A.Z and Its Effect on the Structure of the Nucleosome

(2009) Toyotaka Ishibashi et al.   BIOCHEMISTRY

H2A.Z and H3.3 Histone Variants Affect Nucleosome Structure: Biochemical and Biophysical Studies

(2009) Amit Thakar et al.   BIOCHEMISTRY

Regulation of gene expression and cellular proliferation by histone H2A.ZThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB’s 51st Annual Meeting – Epigenetics and Chromatin Dynamics, and has undergone the Journal’s usual peer review process.

(2009) Amy Svotelis et al.   Biochemistry and Cell Biology

Origin and evolution of chromosomal sperm proteins

(2009) José M. Eirín-López et al.   BIOESSAYS

Characterization of the histone H2A.Z-1 and H2A.Z-2 isoforms in vertebrates

(2009) Deanna Dryhurst et al.   BMC BIOLOGY

Centromeric Nucleosomes Induce Positive DNA Supercoils

(2009) Takehito Furuyama et al.   CELL

Distinctive chromatin in human sperm packages genes for embryo development

(2009) Saher Sue Hammoud et al.   NATURE

H3.3/H2A.Z double variant–containing nucleosomes mark 'nucleosome-free regions' of active promoters and other regulatory regions

(2009) Chunyuan Jin et al.   NATURE GENETICS

H2A.Bbd: an X-chromosome-encoded histone involved in mammalian spermiogenesis

(2009) Toyotaka Ishibashi et al.   NUCLEIC ACIDS RESEARCH

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

(2009) S. Kriaucionis et al.   SCIENCE

Environmental signals and transgenerational epigenetics

(2009) Michael K Skinner et al.   Epigenomics

The histone H1 family: specific members, specific functions?

(2008) Annalisa Izzo et al.   BIOLOGICAL CHEMISTRY

PHD fingers in human diseases: Disorders arising from misinterpreting epigenetic marks

(2008) Lindsey A. Baker et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Metabolism and regulation of canonical histone mRNAs: life without a poly(A) tail

(2008) William F. Marzluff et al.   NATURE REVIEWS GENETICS

H2A.Z: View from the Top

(2008) Jordanka Zlatanova et al.   STRUCTURE

H2A.Bbd: a quickly evolving hypervariable mammalian histone that destabilizes nucleosomes in an acetylation-independent way

(2007) José María Eirín-López et al.   FASEB JOURNAL