News Item
Biochemistry & Molecular Biology
Jicheng Yu, Yuqi Zhang, Zhen Gu
Summary: Genetic code expansion serves as a promising strategy for precise control of protein expression, as demonstrated by a recent study that engineered cells to regulate blood glucose levels in a diabetic mouse model through noncanonical amino acid-triggered insulin expression.
NATURE CHEMICAL BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Ibiyemi Ilesanmi, George Tharakan, Kleopatra Alexiadou, Preeshila Behary, Haya Alessimii, Candace Bovill-Taylor, Julia Kenkre, Sirazum Choudhury, Chedie Doyle, Sanjay Purkayastha, Alex Miras, Christos Tsironis, Harvinder Chahal, Stephen R. Bloom, Nick S. Oliver, Ahmed R. Ahmed, Bernard Khoo, Tricia M. -M. Tan
Summary: This study showed that after RYGB surgery, patients experienced a decrease in mean glucose levels, an increase in glycemic variability, and an increase in GLP-1 response, which put them at risk for postbariatric hypoglycemia.
Letter
Medicine, General & Internal
Ryan Howard, Jie Yang, Jyothi Thumma, Anne Ehlers, Sean O'Neill, Dana Telem, Justin B. Dimick
Summary: This study examines the healthcare utilization and occurrence of adverse events up to 5 years after bariatric surgery in adolescents with severe obesity insured by Medicaid.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Letter
Surgery
Oliver A. Varban, Kristen P. Hassett, Monica Yost, Arthur M. Carlin, Amir A. Ghaferi, Jonathan F. Finks, Anne P. Ehlers
Summary: This study compares the expenditure on diabetes medications among diabetes patients in Michigan before and after metabolic surgery.
Article
Surgery
Xinqiang Zhu, Gang Zhou, Xingwei Gu, Xuetong Jiang, Hailong Huang, Sainan You, Gong Zhang
Summary: This study aimed to compare the clinical outcomes of bariatric surgery and medical treatment for obese adolescents with type 2 diabetes. The results showed that bariatric surgery was more effective than medical treatment in controlling weight loss and type 2 diabetes, with LRYGB surgery having better effects on weight loss and glycemic control.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Endocrinology & Metabolism
Naomi Holman, Sarah H. Wild, Kamlesh Khunti, Peter Knighton, Jackie O'Keefe, Chirag Bakhai, Bob Young, Naveed Sattar, Jonathan Valabhji, Edward W. Gregg
Summary: The incidence of remission of type 2 diabetes is generally low in routine care settings, but it may be a reasonable goal for patients who lose a significant amount of weight shortly after diagnosis. Factors associated with higher odds of remission include shorter duration of diagnosis, non-prescription of glucose-lowering medication, lower HbA(1c) and BMI levels, White ethnicity, female sex, and lower socioeconomic deprivation.
Article
Surgery
Phillip Yang, Aaron J. Bonham, Amir A. Ghaferi, Oliver A. Varhan
Summary: This study suggests that sleeve gastrectomy may have weight-independent effects on diabetes outcomes, leading to a reduction in medication use.
Article
Endocrinology & Metabolism
Kaisheng Yuan, Bing Wu, Ruiqi Zeng, Fuqing Zhou, Ruixiang Hu, Cunchuan Wang
Summary: This study aimed to investigate factors influencing diabetes remission (DR) in patients with obesity and T2DM after bariatric metabolic surgery (BMS), and develop a predictive model using a nomogram. Glycated haemoglobin, triglycerides, duration of diabetes, insulin requirement, and hypercholesterolaemia were identified as independent factors for DR. The nomogram showed good efficacy in both training and validation cohorts.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Gladys Wojciechowska, Lukasz Szczerbinski, Marek Kretowski, Magdalena Niemira, Hady Razak Hady, Adam Kretowski
Summary: This study suggests that four serum miRNAs may serve as predictive biomarkers for type 2 diabetes remission 12 months after sleeve gastrectomy. Further validation studies are needed to confirm the findings.
Article
Endocrinology & Metabolism
Rinki Murphy, Lindsay D. Plank, Michael G. Clarke, Nicholas J. Evennett, James Tan, David D. W. Kim, Richard Cutfield, Michael W. C. Booth
Summary: SR-LRYGB provided superior diabetes remission and weight loss compared with LSG at 5 years, with similar low risks of complications.
Article
Medicine, General & Internal
Brianna N. Lauren, Francesca Lim, Abraham Krikhely, Elsie M. Taveras, Jennifer A. Woo Baidal, Brandon K. Bellows, Chin Hur
Summary: This study evaluated the cost-effectiveness of medical therapy, sleeve gastrectomy (SG), and Roux-en-Y gastric bypass (RYGB) in patients with severe obesity and type 2 diabetes (T2D). The results showed that RYGB is the most cost-effective treatment strategy, resulting in the highest number of quality-adjusted life-years (QALYs) gained.
Article
Gastroenterology & Hepatology
Pichamol Jirapinyo, Christopher C. Thompson
Summary: This retrospective study found that combination therapy of transoral outlet reduction (TORe) and antiobesity medication (AOM) provides better efficacy and safety for treating weight regain after Roux-en-Y gastric bypass (RYGB). Compared to AOM alone or TORe alone, combination therapy results in greater weight loss with similar rates of serious adverse events. Combination therapy also yields similar weight loss to surgical revision of RYGB, but with a lower rate of serious adverse events.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Surgery
Vance L. Albaugh, Gautam Sharma, Chao Tu, Ali Aminian
Summary: Studies showed that poor preoperative diabetes control is not associated with worse outcomes in patients with obesity and diabetes undergoing metabolic surgery. Metabolic surgery is generally safe and beneficial for improving diabetes control.
SURGERY FOR OBESITY AND RELATED DISEASES
(2021)
Article
Surgery
Mohamed AbdAlla Salman, Ahmed Rabiee, Ahmed Salman, Ahmed Elewa, Mohamed Tourky, Ahmed Abdelrahman Mahmoud, Ahmed Moustafa, Hossam El-Din Shaaban, Ahmed Abdelaziz Ismail, Khaled Noureldin, Mohamed Issa, Mohamed Farah, Hesham Barbary, Mujahid Gasemelseed Fadlallah Elhaj, Haitham S. E. Omar
Summary: This study aimed to identify predictors of diabetes remission after two types of bariatric procedures. The results showed that nearly half of the patients achieved complete remission of T2DM two years after surgery. The duration of diabetes and preoperative BMI and C-peptide levels were independent factors predicting complete remissions.
ASIAN JOURNAL OF SURGERY
(2022)
Article
Surgery
Ritika Chaturvedi, Tadeja Gracner, Bryan Tysinger, Kimberly Narain, Dana Goldman, Roland Sturm
Summary: Diabetes remission through bariatric surgery has significant social value, but current utilization is low. Expanding eligibility criteria to BMI≥30 kg/m(2) would be more beneficial than increasing utilization among currently eligible individuals.
