Article
Clinical Neurology
Charles M. Morin, Lydi-Anne Vezina-Im, Hans Ivers, Jean-Arthur Micoulaud-Franchi, Pierre Philip, Manon Lamy, Josee Savard
Summary: The study found that there was a significant increase in the prevalence of insomnia and psychological symptoms during the COVID-19 pandemic compared to the pre-pandemic period. The severity of insomnia and psychological symptoms also worsened compared to 2018. Factors such as living alone, confinement, lower social support, increased time using electronic devices, reduced physical exercise, and higher financial stress were significantly associated with sleep and psychological symptoms.
Article
Immunology
Matthew Thomas Ferreira, Rossana Veronica Mendoza Lopez, Milena Giulia Goncalves, Silvaneide Ferreira, Bradley Sirak, Maria Luizai Baggio, Eduardo Lazcano-Ponce, Alan G. Nyitray, Anna R. Giuliano, Luisa L. Villa, Laura Sichero, Huiyi Lin, Jane Messina, Christine Pierce Campbell, Christine Gage, Donna J. Ingles, Kim Isaacs, Kayoko Kennedy, Andrea Bobanic, Shams Rahman, Matthew Schabath, Alan Nyitray, Julie Rathwell, Lenice Galan de Paula, Ricardo Cintra, Filomena Cernicchiaro, Graca Ribeiro, Rosaria Otero, Roberta Bocalon, Juliana Antunes, Fernanda Silva, Rossana Terreri, Aurelio Cruz Valdez, Rene de Jesus Alvear Vasquez, Oscar Rojas Juarez, Rossana del Carmen Gonzalez Sosa, Rosangel Rios Vences, Martha Huerta Segura, Alicia Rodriguez Galvan, Paula Roman Rodriguez, Ana Laura Landa Velez, Griselda Diaz Garcia, Veronica Chavez Abarca, Gisela Flores Quevedo, Maria del Pilar Hernandez Nevarez, Guillermina Sanchez Martinez, Adriana Ortiz Rojas, Carlos Omar Barrera Flores, Flavia Rotea Mangone, Ana Carolina Pavanelli
Summary: This study demonstrates the influence of HPV-16 nucleotide variability on the risk of persistent infection in the male genitalia for the first time. It suggests differences in the natural history of HPV-16 variants between men and women. The prevalence and persistence of HPV-16 variants in male external genitalia indicate unique characteristics compared to female infections.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Oncology
Imran O. Morhason-Bello, Kathy Baisley, Miquel Angel Pavon, Isaac F. Adewole, Rasheed Bakare, Silvia de Sanjose, Suzanna C. Francis, Deborah Watson-Jones
Summary: This study assessed the prevalence and concordance of oro-genital and anal HPV genotype specific infections among sexually active women in Ibadan, Nigeria. Results showed a high prevalence of HPV infections in the cervix, vulva, anus, and oral cavity, with HPV 35 being the most prevalent high-risk genotype. Concordance of HPV types in the four anatomic sites was observed in 10.0% of women. The study highlights the need for large longitudinal studies to better understand HPV epidemiology in the region.
INFECTIOUS AGENTS AND CANCER
(2021)
Article
Immunology
Joske Hoes, Audrey J. King, Tessa M. Schurink-van 't Klooster, Johannes Berkhof, Johannes A. Bogaards, Hester E. de Melker
Summary: The bivalent HPV vaccine administered in a 2-dose schedule has proven to be highly effective in preventing HPV infections among preadolescent girls in the Netherlands, with a 4-year postvaccination effectiveness rate of 84.0% against HPV-16/18 and 86.5% against cross-protective types HPV-31/33/45.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Katie M. O'Brien, Clarice R. Weinberg, Aimee A. D'Aloisio, Kristen R. Moore, Dale P. Sandler
Summary: While douching was positively associated with both pre-baseline and incident cervical cancers, talcum powder use did not show a significant association in this study. The findings suggest a potential link between douching practices and cervical cancer risk, but no clear evidence was found for talcum powder use.
SCIENTIFIC REPORTS
(2021)
Article
Virology
Kevin Sheng-Kai Ma, Ning-Chien Chin, Ting-Yu Tu, Yao-Cheng Wu, Hei-Tung Yip, James Cheng-Chung Wei, Ren-in Chang
Summary: This cohort study investigated the correlation between HPV infections and the risk of osteoporosis. It found that patients with HPV infections had a significantly higher risk of osteoporosis. Subgroup analysis revealed that females, those aged between 60 and 80 years, and patients with long-term use of glucocorticoids were at greater risk. Furthermore, treatments for HPV infections attenuated the risk of HPV-associated osteoporosis.
Article
Medicine, General & Internal
Huanquan Liao, Dong Pan, Zhenhong Deng, Jingru Jiang, Jinhua Cai, Ying Liu, Baixuan He, Ming Lei, Honghong Li, Yi Li, Yongteng Xu, Yamei Tang
Summary: This study found that shift work is associated with an increased risk of dementia, but night shift work is not significantly associated with dementia risk. The increased incidence of dementia in shift workers does not differ between participants with different genetic susceptibility to dementia.
Article
Multidisciplinary Sciences
Anna Stage Vergmann, Lonny Stokholm, Katrine Hass Rubin, Anne Thykjaer, Soren Moller, Caroline Schmidt Laugesen, Steffen Heegaard, Kurt Hojlund, Ryo Kawasaki, Katja Christina Schielke, Jakob Grauslund
Summary: In this national study involving over 1.2 million individuals, diabetic retinopathy (DR) was associated with a lower risk of migraine. However, DR was not found to be a protective marker against incident migraine.
SCIENTIFIC REPORTS
(2022)
Article
Gastroenterology & Hepatology
Ravy K. Vajravelu, Jennifer M. Kolb, Shivani U. Thanawala, Frank Scott, Samuel Han, Amit G. Singal, Gary W. Falk, David A. Katzka, Sachin Wani
Summary: This study used data from large commercial and Medicare Advantage health plans in the United States to assess and improve the effectiveness of Barrett's esophagus (BE) screening and surveillance. The results showed that two-thirds of esophageal adenocarcinomas (EACs) were diagnosed at the time of BE diagnosis and post-endoscopy esophageal adenocarcinoma accounted for 14% of these EACs.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Immunology
Talia Malagon, Aaron MacCosham, Ann N. Burchell, Mariam El-Zein, Pierre-Paul Tellier, Francois Coutlee, Eduardo L. Franco
Summary: This study investigates the reactivation of latent HPV infections and finds that a significant proportion of newly detected HPV infections are actually reactivations of previous infections rather than recent transmissions. This finding is important for cervical cancer screening in women.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Jade Ghosn, Lionel Piroth, Olivier Epaulard, Paul Le Turnier, France Mentre, Delphine Bachelet, Cedric Laouenan
Summary: One fourth of individuals hospitalized for COVID-19 still experienced three or more persistent symptoms at six months after admission. Factors independently associated with the presence of three or more symptoms at month 6 included female gender, having three or more symptoms at admission, and ICU admission/transfer during the acute phase. Further longitudinal follow-up of severe COVID-19 patients is needed for better understanding of the long-term persistence of symptoms.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Immunology
Joseph E. Tota, Anna R. Giuliano, Stephen E. Goldstone, Brady Dubin, Alfred Saah, Alain Luxembourg, Christine Velicer, Joel M. Palefsky
Summary: The incidence of human papillomavirus (HPV)-related cancer is rising in men, and this study found that the prevalence of HPV infection and seropositivity is higher in men who have sex with men (MSM) compared to heterosexual men (HM). However, overall prevalence is still low. Catch-up vaccination after sexual debut may be beneficial.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Biotechnology & Applied Microbiology
Chantal Sauvageau, Vladimir Gilca, Manale Ouakki, Marilou Kiely, Francois Coutlee, Sara Mathieu-Chartier, Fannie Defay, Gilles Lambert
Summary: The study results indicate that young women vaccinated with HPV vaccine have no significant differences in sexual behavior compared to unvaccinated individuals, but vaccinated individuals are more likely to use condoms, have lower rates of sexually transmitted infections and anogenital condylomas. The association between vaccination status and cervical cancer screening disappeared when adjusting for age.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Clinical Neurology
Clement Gouraud, Emmanuel Wiernik, Joane Matta, Maria Melchior, Guillaume Airagnes, Charles Ouazana-Vedrines, Olivier Robineau, Fabrice Carrat, Gianluca Severi, Alexis Descatha, Mathilde Touvier, Marcel Goldberg, Marie Zins, Cedric Lemogne
Summary: This study examined the association between housing conditions, changes in professional activity, and depression during the first COVID-19 outbreak in France. It found that depression was associated with female gender, lower household income, and a history of depression. The likelihood of depression was higher with fewer rooms but had a U-shaped relationship with the number of people living together. Distance working was also associated with depression. These findings can help identify vulnerable individuals and promote mental health.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Immunology
Catharine Chambers, Shelley L. Deeks, Rinku Sutradhar, Joseph Cox, Alexandra de Pokomandy, Troy Grennan, Trevor A. Hart, Gilles Lambert, David M. Moore, Daniel Grace, Ramandip Grewal, Jody Jollimore, Nathan Lachowsky, Rosane Nisenbaum, Gina Ogilvie, Chantal Sauvageau, Darrell H. S. Tan, Francois Coutlee, Ann N. Burchell
Summary: This study compared the 12-month incidence and persistence of anal HPV infection between vaccinated and unvaccinated gay, bisexual, and other men who have sex with men (GBM). The findings showed that the HPV vaccine was significantly protective against 12-month anal HPV cumulative incidence and persistence among sexually active GBM aged 16-30 years, especially when vaccination was initiated at younger ages or soon after sexual debut.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Sarah Kerry-Barnard, Simon Beddows, Fiona Reid, Nicholas Beckley-Hoelscher, Kate Soldan, Kavita Panwar, Cangul Seran, Charlotte Fleming, Agata Lesniewska, Tim Planche, Jonathan Williamson, Phillip Hay, Pippa Oakeshott
Summary: Despite the low prevalence of oropharyngeal HR-HPV in adolescents, there is a low prevalence of HPV vaccination, high prevalence of oral sex, and genitourinary Chlamydia infection.
SEXUALLY TRANSMITTED INFECTIONS
(2021)
Article
Infectious Diseases
Diarmuid Nugent, Oliver Stirrup, Sarah Pett, Kavita Panwar, Marta Checchi, David Mesher, Kate Soldan, Simon Beddows, Richard Gilson
Summary: Testing the residual STI test specimens for HPV prevalence in MSM is effective in evaluating the impact of the targeted vaccination programme, as high concordance was observed between dedicated and residual specimens.
SEXUALLY TRANSMITTED INFECTIONS
(2021)
Editorial Material
Infectious Diseases
Kate Soldan, Gloria E. Anyalechi, Kristen M. Kreisel, Jane S. Hocking, Kyle Bernstein
SEXUALLY TRANSMITTED INFECTIONS
(2021)
Article
Endocrinology & Metabolism
Louise M. Goff, Carol Rivas, Amanda Moore, Nicholas Beckley-Hoelscher, Fiona Reid, Seeromanie Harding
Summary: Black-British communities are disproportionately affected by type 2 diabetes, and culturally tailored diabetes self-management education programs have shown to be highly acceptable and feasible in this population. This study demonstrated high attendance and completion rates in a culturally tailored diabetes education program among black-British adults, indicating the potential for future clinical and cost-effectiveness assessments.
BMJ OPEN DIABETES RESEARCH & CARE
(2021)
Article
Infectious Diseases
Sarah Kerry-Barnard, Liqing Zhou, Laura Phillips, Martina Furegato, Adam A. Witney, S. Tariq Sadiq, Pippa Oakeshott
Summary: This study investigated the vaginal microbiome in women with and without pelvic inflammatory disease (PID). The results showed no clear association between the vaginal microbiome and the subsequent development of PID.
SEXUALLY TRANSMITTED INFECTIONS
(2022)
Article
Immunology
Kavita Panwar, Anna Godi, Clementina E. Cocuzza, Nick Andrews, Jo Southern, Paul Turner, Elizabeth Miller, Simon Beddows
Summary: The study evaluated the antibody response of HPV vaccines against different types of human papillomavirus. The findings showed that the vaccines provided long-lasting protection against vaccine types and maintained high antibody levels against related non-vaccine types. This contributes to the evidence base supporting public health intervention.
Article
Oncology
Matejka Rebolj, Francesca Pesola, Christopher Mathews, David Mesher, Kate Soldan, Henry Kitchener
Summary: In England, a population-based catch-up campaign for bivalent HPV vaccination was carried out for girls aged 14-17, and these women are now undergoing the national cervical screening program. The study showed that catch-up bivalent vaccination significantly reduced the detection of high-grade cervical intraepithelial neoplasia (CIN2+) associated with HPV16/18, as well as the overall detection rate of CIN2+. The positive predictive value of colposcopy for CIN2+ also decreased for both low-grade and high-grade abnormalities on triage cytology. However, the impact on screening outcomes for women aged 26-29 was smaller.
BRITISH JOURNAL OF CANCER
(2022)
Article
Microbiology
Anna Godi, Stuti Vaghadia, Clementina Cocuzza, Elizabeth Miller, Simon Beddows
Summary: The major virus coat protein of human papillomavirus type 16 (HPV16) is targeted by antibodies induced by both natural infection and vaccination. The study investigates the contribution of surface-exposed loops of the major capsid protein to the antigenic domains recognized by these antibodies. The results suggest that vaccine-induced antibodies target a different area compared to natural infection antibodies, providing a better understanding of HPV16-specific immunity.
MICROBIOLOGY SPECTRUM
(2022)
Article
Urology & Nephrology
Sharlene A. Greenwood, Nicholas Beckley-Hoelscher, Elham Asgari, Salma Ayis, Luke A. Baker, Debasish Banerjee, Sunil Bhandari, Kate Bramham, Joseph Chilcot, James Burton, Philip A. Kalra, Courtney J. Lightfoot, Kieran McCafferty, Thomas H. Mercer, Darlington O. Okonko, Benjamin Oliveira, Chante Reid, Alice C. Smith, Pauline A. Swift, Anastasios Mangelis, Emma Watson, David C. Wheeler, Thomas J. Wilkinson, Fiona Reid, Iain C. Macdougall
Summary: The Iron and Muscle study aims to evaluate the effects of iron supplementation on fatigue, muscle metabolism, exercise capacity, and physical function in non-dialysis CKD patients. The study design is a prospective, double-blind multicentre randomized controlled trial with 75 participants. The primary outcome is the six-minute walk test distance, and secondary outcomes include fatigue, muscle strength, quality of life, etc.
Article
Public, Environmental & Occupational Health
Sophie Bright, Francis Moses, Alex Ridout, Betty Sam, Mariama Momoh, Venetia Goodhart, Francis Smart, Margaret Mannah, Sattu Issa, Simren Herm-Singh, Fiona Reid, Paul T. Seed, James Bunn, Andrew Shennan, Katrin Augustin, Jane Sandall
Summary: This study retrospectively evaluated the adoption of CRADLE in Sierra Leone and found that the complexity related to the technology and organizational context influenced its adoption, resulting in inter-district variation. Key strategies mentioned to mitigate these issues included transparent communication, encouraging localized adaptations, and selecting champions with strong soft skills.
REPRODUCTIVE HEALTH
(2023)
Article
Oncology
Sophie Papa, Antonella Adami, Michael Metoudi, Richard Beatson, Molly Sarah George, Daniela Achkova, Evangelia Williams, Sefina Arif, Fiona Reid, Maria Elstad, Nicholas Beckley-Hoelscher, Abdel Douri, Marc Delord, Mike Lyne, Dharshene Shivapatham, Christopher Fisher, Andrew Hope, Sakina Gooljar, Arindam Mitra, Linda Gomm, Cienne Morton, Rhonda Henley-Smith, Selvam Thavaraj, Alice Santambrogio, Cynthia Andoniadou, Sarah Allen, Victoria Gibson, Gary J. R. Cook, Ana C. Parente-Pereira, David M. Davies, Farzin Farzaneh, Anna Schurich, Teresa Guerrero-Urbano, Jean-Pierre Jeannon, James Spicer, John Maher
Summary: This study developed an autologous CD28-based chimeric antigen receptor T-cell (CAR-T) therapy named T4 immunotherapy for locally advanced/recurrent head and neck squamous cell carcinoma (HNSCC). Patient-derived T-cells were engineered to express a panErbB-specific CAR and an IL-4-responsive chimeric cytokine receptor. Intratumoral delivery was used to mitigate off-tumor toxicity. The study demonstrated the safe and effective intratumoral administration of T4 immunotherapy in advanced HNSCC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Urology & Nephrology
Sharlene A. Greenwood, Benjamin A. Oliveira, Elham Asgari, Salma Ayis, Luke A. Baker, Nicholas Beckley-Hoelscher, Aicha Goubar, Debasish Banerjee, Sunil Bhandari, Joseph Chilcot, James O. Burton, Philip A. Kalra, Courtney J. Lightfoot, Iain C. Macdougall, Kieran McCafferty, Thomas H. Mercer, Darlington O. Okonko, Chante Reid, Fiona Reid, Alice C. Smith, Pauline A. Swift, Anastasios Mangelis, Emma Watson, David C. Wheeler, Thomas J. Wilkinson, Kate Bramham
Summary: This trial evaluated the effects of iron supplementation on exercise capacity of nonanemic patients with CKD. The results showed that IV iron therapy did not improve exercise capacity at 4 weeks. A larger study is needed to confirm the benefits of IV iron in iron-deficient non-dialysis CKD patients.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Multidisciplinary Sciences
Kavita Panwar, Anna Godi, Clementina E. Cocuzza, Nick Andrews, Jo Southern, Paul Turner, Elizabeth Miller, Simon Beddows
Summary: In vitro techniques are available to estimate antibody levels in human serum samples. Multiplex serology plays a crucial role in public health programs, allowing evaluation of immune responses to multiple antigens simultaneously. Human papillomavirus (HPV) serology is limited, but utilizing common platforms and virus-like particles enables the detection and quantification of antibody responses against nine vaccine-relevant HPV genotypes.