Article
Pharmacology & Pharmacy
Zhen Xing Gao, Ze Long Cui, Min Ran Zhou, Yue Fu, Fen Liu, Lu Zhang, Sai Ma, Chun Yan Chen
Summary: This study identified BAM15 as a novel mitochondrial uncoupling agent that effectively inhibits AML cell activity, while being less cytotoxic to normal cells. BAM15 can also enhance the anti-cancer activity of cytarabine when used in combination. This discovery provides a potential drug candidate for the treatment of AML.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Hui He, Chengqiang Wang, Gen Liu, Haoyue Ma, Mingdong Jiang, Pan Li, Qianwei Lu, Li Li, Hongyi Qi
Summary: The study demonstrates that Isobavachalcone induces apoptosis and differentiation of acute myeloid leukemia cells through multiple pathways, with the ROS-mediated signaling pathway playing a key role.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Xuan Gao, Yong-Yue Gao, Hui-Ying Yan, Guang-Jie Liu, Yan Zhou, Tao Tao, Ting-Ting Yue, Cong Pang, Xiang-Xin Chen, Sen Gao, Ling-Yun Wu, Chun-Hua Hang, Wei Li
Summary: This study showed that PDK4 overexpression post-SAH may mitigate neuronal apoptosis by reducing oxidative stress through the ROS/ASK1/P38 pathway. PDK4 could potentially serve as a new therapeutic target to improve EBI after SAH.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Biochemistry & Molecular Biology
Sicong Wang, Yaoying Lu, Kyra Woods, Giovanna Di Trapani, Kathryn F. Tonissen
Summary: Inhibition of thioredoxin reductase (TrxR) has been found to be an effective therapeutic approach for lymphoma. The combination of thioredoxin (Trx) and glutathione (GSH) systems can induce cell apoptosis and enhance the expression of tumor suppressor genes.
Article
Plant Sciences
Hang Yu, Xi Huang, Hua-He Zhu, Na Wang, Cong Xie, Yao-Long Zhou, Han -Lin Shi, Meng-Meng Chen, Yue-Ren Wu, Zhen-Hui Ruan, Yu-bao Lyu, Qing-Li Luo, Jing-Cheng Dong
Summary: This study found that apigenin, a flavonoid compound, effectively suppressed the complex inflammation in obese asthma, reduced airway hyperresponsiveness, inflammatory cell infiltration, airway epithelial cell apoptosis, airway collagen deposition, and lung oxidative stress via the ROS-ASK1-MAPK pathway. It also clarified the potential therapeutic targets of apigenin in chronic obese asthma and provided new options for its treatment.
Article
Biochemistry & Molecular Biology
Liangwei Duan, Yucong Zhao, Jing Jia, Tianzhu Chao, Hao Wang, Yinming Liang, Yunwei Lou, Qianqian Zheng, Hui Wang
Summary: In atherosclerosis, macrophages play an important role in inflammation. CD68, a specific receptor in macrophages, regulates the occurrence and development of atherosclerosis. CD68 deficiency can reduce atherosclerosis, decrease inflammation and necrotic content, and increase smooth muscle cell content in atherosclerotic plaques.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Oncology
Kun-Chi Chen, I-Hsin Hsiao, Yu-Nan Huang, Yu-Tung Chou, Yi-Chun Lin, Ju-Yi Hsieh, Yung-Lung Chang, Kang-Hsi Wu, Guang-Yaw Liu, Hui-Chih Hung
Summary: Acute myeloid leukemia (AML) is a fast-growing and fatal blood cancer, and targeting the human mitochondrial NAD(P)(+)-dependent malic enzyme (ME2) shows promise in AML treatment. ME2 inhibition through silencing or using its allosteric inhibitor Na(2)EA decreases pyruvate, NADH, and NADPH levels, leading to reduced ATP production, increased reactive oxygen species (ROS), and cellular apoptosis. ME2 inhibition also impairs pyruvate metabolism and the biosynthetic pathway, inhibiting the growth of AML cells. Overall, ME2 plays a crucial role in AML energy metabolism, and its inhibition provides a potential approach for AML treatment.
Review
Oncology
Wonhyoung Seo, Prashanta Silwal, Ik-Chan Song, Eun-Kyeong Jo
Summary: In this review, the multifaceted functions of autophagy in AML were discussed, including its link to genetic alterations, potential prognostic predictors, and drivers of AML tumorigenesis. The crosstalk between autophagy and tumor cell metabolism and its impact on AML progression and treatment were also examined. Additionally, the potential therapeutics for AML, such as autophagy regulators, were described, along with their translation into clinical practice.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Silvia Trombetti, Elena Cesaro, Rosa Catapano, Raffaele Sessa, Alessandra Lo Bianco, Paola Izzo, Michela Grosso
Summary: Myeloid leukemic cells are intrinsically under oxidative stress due to impaired ROS homeostasis, and the redox-dependent signaling pathways play a crucial role in the leukemogenic process. New chemotherapy options that target cellular redox imbalance are discussed as an effective strategy to eradicate chemoresistant cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
You Jiang, Shui-Yan Wu, Yan-Ling Chen, Zi-Mu Zhang, Yan-Fang Tao, Yi Xie, Xin-Mei Liao, Xiao-Lu Li, Gen Li, Di Wu, Hai-Rong Wang, Ran Zuo, Hai-Bo Cao, Jing-Jing Pan, Juan-Juan Yu, Si-Qi Jia, Zheng Zhang, Xin-Ran Chu, Yong-Ping Zhang, Chen-xi Feng, Jian-Wei Wang, Shao-Yan Hu, Zhi-Heng Li, Jian Pan, Fang Fang, Jun Lu
Summary: This study systematically explored the molecular characteristics of CEBPG in AML and identified CEBPG as a potential therapeutic target for AML patients. It was found that CEBPG promotes AML cell proliferation by activating EIF4EBP1, thus contributing to the progression of AML.
CANCER CELL INTERNATIONAL
(2021)
Article
Chemistry, Physical
Wei Guo, Xing Liu, Lianjie Ye, Jie Liu, Kollie Larwubah, Ge Meng, Weiqiang Shen, Xiangxian Ying, Jun Zhu, Shengjie Yang, Jianjun Guo, Yanrong Jia, Meilan Yu
Summary: Hydroxylated fullerene C-60(OH)(n) (n = 18-22) has both growth-promoting and inhibitory effects on leukemia cells, with high concentrations leading to cell death.
Article
Cell Biology
Ju-Fang Liu, Miao-Ching Chi, Chih-Yang Lin, Chiang-Wen Lee, Tsung-Ming Chang, Chien-Kuo Han, Yuan-Li Huang, Yi-Chin Fong, Hsien-Te Chen, Chih-Hsin Tang
Summary: PM2.5 exposure increases IL-6 synthesis in human OASFs through ROS, ASK1, ERK, p38, JNK, and AP-1 signaling pathways, linking PM2.5 with OA progression.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yang Chen, Nanjing Li, Jun Yang, Ke Li, Mei Tang, Xinyu Zhao, Wenhao Guo, Aiping Tong, Chunlai Nie, Yong Peng, Zhu Yuan
Summary: This study reveals a novel mechanism of PUMA in promoting apoptosis in ovarian cancer by activating ASK1 and subsequently activating the ASK1-JNK axis. Additionally, in vivo experiments demonstrate that PUMA combined with chemotherapy can effectively inhibit the growth of cisplatin-resistant ovarian cancer.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Hanyun Zhang, Chunjie Sun, Qi Sun, Ye Li, Chao Zhou, Changgang Sun
Summary: This study summarizes recent studies on ferroptosis in AML cells, highlighting the increased susceptibility of AML cells to ferroptosis due to their metabolic characteristics, gene mutation patterns, and dependence on mitochondria. The study also summarizes the strategies used by AML cells to evade ferroptosis and the drugs targeting the ferroptosis pathway in AML treatment.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Medicine, Research & Experimental
Ana Carolina B. da C. Rodrigues, Larissa M. Bomfim, Sara P. Neves, Milena B. P. Soares, Rosane B. Dias, Ludmila F. Valverde, Clarissa A. Gurgel Rocha, Emmanoel V. Costa, Felipe M. A. da Silva, Waldireny C. Rocha, Hector H. F. Koolen, Daniel P. Bezerra
Summary: Tingenone (TG) and 22-hydroxytingenone (22-HTG) are quinonemethide triterpenes from the Amazonian plant Salacia impressifolia, showing potent cytotoxicity against AML HL-60 cell line through apoptosis pathway mediated by oxidative stress. These compounds are potential candidates for anti-AML therapy targeting thioredoxin.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Crystallography
Qing Tang, Huan-Yong Li, Zhong-Nan Wu, Ming Yan, Yu-Bo Zhang, Yao-Lan Li, Guo-Cai Wang
Summary: The translation provides information about the crystal structure of a compound, including cell parameters, symmetry, and temperature.
ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES
(2021)
Article
Chemistry, Medicinal
Qing Tang, Ding Luo, Ding-Chai Lin, Wen-Zhi Wang, Can-Jie Li, Xue-Fang Zhuo, Zhong-Nan Wu, Yu-Bo Zhang, Guo-Cai Wang, Yao-Lan Li
Summary: Five matrine-type alkaloids, including two new compounds and a new natural product, were isolated from the roots of Sophora tonkinesis. These compounds were evaluated for their activity against inflammatory cytokines, with compound 1 showing the most significant activity.
JOURNAL OF NATURAL MEDICINES
(2021)
Article
Chemistry, Applied
Ding-Chai Lin, Qing Tang, Xue-Fang Zhuo, Wen-Zhi Wang, Can-Jie Li, Guang-Kai Kuang, Zhong-Nan Wu, Yu-Bo Zhang, Guo-Cai Wang, Yao-Lan Li
Summary: In this study, three new sesquiterpene lactones were isolated from Elephantopus scaber, along with four known compounds. These compounds showed effective anti-inflammatory effects on LPS-stimulated cells.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Ding Luo, Neng-Hua Chen, Wen-Zhi Wang, Ji-Hui Zhang, Can-Jie Li, Xue-Fang Zhuo, Zhen-Chao Tu, Zhong-Nan Wu, Chun-Lin Fan, Hai-Peng Zhang, Yao-Lan Li, Guo-Cai Wang, Yu-Bo Zhang
Summary: A study on the seeds of Sophora alopecuroides uncovered fourteen matrine-based alkaloids, with eight being new compounds. Among them, alopecuroide F (1) was identified as the first dimeric matrine-type skeleton assembled via a unique connection. Biological evaluations showed that alopecuroide F (1) could dose-dependently inhibit the production of two pro-inflammatory cytokines.
CHINESE JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Ding Luo, Zhong-Nan Wu, Ji-Hui Zhang, Qiang Lin, Neng-Hua Chen, Si Chen, Qing Tang, Zhao-Chun Zhan, Chun-Lin Fan, Yao-Lan Li, Guo-Cai Wang, Yu-Bo Zhang
Summary: Seven new matrine-based alkaloids, Sophaloseedlines A-G (1-7), along with two known analogues, were isolated from Sophora alopecuroides seeds. The new structures were determined using spectroscopic data, electronic circular dichroism calculations, and X-ray crystallography. Notably, sophaloseedline A (1) features a novel rearranged alkaloid with unprecedented highly constructed tetracyclic fused ring skeleton. Additionally, new alkaloids 1 and 2 exhibited more potent antiviral activities against hepatitis B virus compared to matrine and positive control.
CHINESE JOURNAL OF CHEMISTRY
(2021)
Article
Food Science & Technology
Ziyi An, Peiyan He, Guocai Wang, Gexiu Liu, Jianwei Jiang
Summary: PP-10 suppresses cancer cell growth with low toxicity to normal cells, inducing mitochondrial-related apoptosis in HepG2 and HuH7 cells. GSEA suggests correlation with the MAPK signaling pathway, and western blotting confirms modulation of JNK/SPAK and inhibition of STAT3 signaling pathways in apoptosis induction.
FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Wen Li, Zhongnan Wu, Yiping Xia, Jinlin Tan, Haiyue Zhao, Si Chen, Yaolan Li, Hongfeng Tang, Guocai Wang, Yubo Zhang
Summary: Chinese star anise is a widely used spice in Chinese and Southeast Asian cuisine. This study investigated the chemical compounds and biological activities of the fruit of Chinese star anise. They isolated and identified 20 compounds and evaluated their antiviral and antioxidant activities. Compound 7 demonstrated strong antiviral activity against influenza virus, outperforming commonly used drugs.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Green & Sustainable Science & Technology
Pei-min Zhan, Xiao-xiang Zhang, Zhi-hai He, Jin-yan Shi, Osman Gencel, Nguyen Thi Hai Yen, Guo-cai Wang
Summary: This study investigates the effect of reusing construction and demolition wastes on the performance of recycled aggregate concrete (RAC) and the synergistic effect of steel slag powder (SSP) and waste glass powder (GP) on the compressive strength and microstructure of RAC. The results demonstrate that the incorporation of SSP and GP significantly improves the performance of RAC, enhancing its compressive strength and microstructure.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Chemistry, Applied
Wen-Zhi Wang, Zhao-Chun Zhan, Qing Tang, Ming Yan, Neng-Hua Chen, Hai-Yue Zhao, Hao-Yue Zhu, Huan-Qing Zhang, Zhong-Nan Wu, Hao-Yun Wang, Yu-Bo Zhang, Guo-Cai Wang, Yao-Lan Li
Summary: Three new compounds, along with seven known compounds, were isolated from the whole plant of Salsola collina Pall. Their structures and configurations were determined through extensive spectroscopic analysis. One of the compounds exhibited significant anti-inflammatory activity.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Medicinal
Zhi-Peng Ling, Qing Tang, Can-Jie Li, Jin-Lin Tan, Hai-Yue Zhao, Yi-Kun Hao, Zhao-Chun Zhan, Zhong-Nan Wu, Yu-Bo Zhang, Qing Zheng, Guo-Cai Wang
Summary: Two new compounds and one new derivative, as well as five known compounds, were isolated from Croton crassifolius. Crassifolin X, one of the new compounds, is a novel clerodane diterpenoid with a unique lactone core. The structures and absolute configurations were determined using spectroscopic methods and experiments. Additionally, several compounds exhibited potential anti-neuroinflammatory activity.
JOURNAL OF NATURAL MEDICINES
(2022)
Review
Chemistry, Physical
Weili Wang, Qing Shen, Hao Cai, Leichen Wang, Jinjun Shao, Wenjun Wang, Xiaochen Dong
Summary: The always-on activity of natural enzymes limits their bio-applications. Recent research has shown that light-responsive organic artificial enzymes exhibit prominent absorption and controlled activity under illumination, playing a key role in biosensing and biomedical research.
Article
Agriculture, Multidisciplinary
Zhongnan Wu, Xiaoyong Dai, Wenzhi Wang, Xianfang Zhang, Jiawei Chen, Jing Liu, Laiqiang Huang, Yaolan Li, Shuixing Zhang, Guocai Wang, Yubo Zhang
Summary: The fruits of Garcinia oblongifolia are well-known for their unique taste and high nutritional value. In this study, new compounds with potential health benefits were isolated from the fruits, and one of them showed strong cytotoxicity against nasopharyngeal carcinoma cells.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Physical
Wei Du, Mengli Liu, Guocai Wang, Hua Su, Bo Liu, Hao Meng, Xiaoli Tang
Summary: This research investigates the properties of Pt/CoFeB/MgO (bottom structure) and MgO/CoFeB/Pt (top structure) samples with different compositions. It is found that the bottom structure always exhibits stronger perpendicular magnetic anisotropy (PMA) properties compared to the top structure. Additionally, a higher Co atomic composition in CoFeB leads to a stronger PMA. The results are attributed to the Pt-Co hybridization and the catalytic action of Pt on the Fe-O hybridization at the CoFeB/MgO interface.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Biochemistry & Molecular Biology
Ji-hui Zhang, Jin-lin Chen, Wei-bin Xu, Yi-ping Xia, Hao-yue Zhu, Jing-hao Wang, Yao-lan Li, Guo-cai Wang, Yu-bo Zhang, Neng-hua Chen
Summary: Nine undescribed phloroglucinol derivatives and three known acylphloroglucinol compounds were isolated from the rhizome of Dryopteris atrata. The structures of these compounds were determined through spectroscopic analysis, X-ray diffraction, and electronic circular dichroism calculations. Dryatraol C showed the strongest antiviral activity against respiratory syncytial virus (RSV) and influenza A virus (H1N1), while Dryatraols F-H exhibited significant inhibitory activity against herpes simplex virus type 1 (HSV-1). Dryatraol G may inhibit HSV-1 replication by interfering with the late stage of the viral life cycle.
Article
Business
Dong Liu, Yongchuan Bao, Guocai Wang
Summary: This study conducted research on 225 manufacturers in China and found that formal contracts have a positive impact on relationship learning, which in turn improves alliance innovation performance. The study also revealed that guanxi positively moderates the effect of formal contracts on alliance innovation performance, and also positively moderates the mediating effect.
JOURNAL OF BUSINESS & INDUSTRIAL MARKETING
(2022)