HDL/ApoA-1 infusion and ApoA-1 gene therapy in atherosclerosis

Effect of open-label infusion of an apoA-I-containing particle (CER-001) on RCT and artery wall thickness in patients with FHA

(2015) Ruud S. Kootte et al.   JOURNAL OF LIPID RESEARCH

CSL112 Enhances Biomarkers of Reverse Cholesterol Transport After Single and Multiple Infusions in Healthy Subjects

(2014) Andreas Gille et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

High-Density Lipoproteins in the Prevention of Cardiovascular Disease: Changing the Paradigm

(2014) S Tuteja et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

HDL Hypothesis: Where Do We Stand Now?

(2014) Sayed M. Tariq et al.   Current Atherosclerosis Reports

Biosafety of Recombinant Adeno-associated Virus Vectors

(2014) David Dismuke et al.   CURRENT GENE THERAPY

Single injections of apoA-I acutely improve in vivo glucose tolerance in insulin-resistant mice

(2014) Karin G. Stenkula et al.   DIABETOLOGIA

Mendelian randomization of blood lipids for coronary heart disease

(2014) Michael V. Holmes et al.   EUROPEAN HEART JOURNAL

Effects of the high-density lipoprotein mimetic agent CER-001 on coronary atherosclerosis in patients with acute coronary syndromes: a randomized trial

(2014) J.-C. Tardif et al.   EUROPEAN HEART JOURNAL

Current status of haemophilia gene therapy

(2014) K. H. High et al.   HAEMOPHILIA

Comparative Antiatherogenic Effects of Intravenous AAV8- and AAV2-Mediated ApoA-IMilano Gene Transfer in Hypercholesterolemic Mice

(2014) Fang Tian et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

HDL-targeted therapies: progress, failures and future

(2014) Bronwyn A. Kingwell et al.   NATURE REVIEWS DRUG DISCOVERY

Engineering adeno-associated viruses for clinical gene therapy

(2014) Melissa A. Kotterman et al.   NATURE REVIEWS GENETICS

Effects of Extended-Release Niacin with Laropiprant in High-Risk Patients

(2014)   NEW ENGLAND JOURNAL OF MEDICINE

Novel Formulation of a Reconstituted High-Density Lipoprotein (CSL112) Dramatically Enhances ABCA1-Dependent Cholesterol Efflux

(2013) Svetlana Diditchenko et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

CER-001, a HDL-mimetic, stimulates the reverse lipid transport and atherosclerosis regression in high cholesterol diet-fed LDL-receptor deficient mice

(2013) Claudine Tardy et al.   ATHEROSCLEROSIS

Emerging therapies for raising high-density lipoprotein cholesterol (HDL-C) and augmenting HDL particle functionality

(2013) Marcin Barylski et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

HDL particle functionality as a primary pharmacological target for HDL-based therapies

(2013) Kyriakos E. Kypreos et al.   BIOCHEMICAL PHARMACOLOGY

HPS2-THRIVE randomized placebo-controlled trial in 25 673 high-risk patients of ER niacin/laropiprant: trial design, pre-specified muscle and liver outcomes, and reasons for stopping study treatment

(2013) et al.   EUROPEAN HEART JOURNAL

An Emerging Adeno-Associated Viral Vector Pipeline for Cardiac Gene Therapy

(2013) Aravind Asokan et al.   HUMAN GENE THERAPY

Native High Density Lipoproteins (HDL) Interfere with Platelet Activation Induced by Oxidized Low Density Lipoproteins (OxLDL)

(2013) Sigrun Badrnya et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A multiple ascending dose study of CSL112, an infused formulation of ApoA-I

(2013) Rachael Easton et al.   JOURNAL OF CLINICAL PHARMACOLOGY

High density lipoproteins improve insulin sensitivity in high-fat diet-fed mice by suppressing hepatic inflammation

(2013) Kristine C. McGrath et al.   JOURNAL OF LIPID RESEARCH

High-density cholesterol and apolipoprotein AI as modifiers of plasma fibrin clot properties in apparently healthy individuals

(2012) Michał Ząbczyk et al.   BLOOD COAGULATION & FIBRINOLYSIS

HDL-C: Does it matter? An update on novel HDL-directed pharmaco-therapeutic strategies

(2012) Ramprasad Gadi et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

(2012) Benjamin F Voight et al.   LANCET

Effects of Dalcetrapib in Patients with a Recent Acute Coronary Syndrome

(2012) Gregory G. Schwartz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Recombinant HDLMilano exerts greater anti-inflammatory and plaque stabilizing properties than HDLwild-type

(2011) Borja Ibanez et al.   ATHEROSCLEROSIS

Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease

(2011) Christian Besler et al.   JOURNAL OF CLINICAL INVESTIGATION

Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy

(2011)   NEW ENGLAND JOURNAL OF MEDICINE

Effects of High-Density Lipoproteins on Pancreatic β-Cell Insulin Secretion

(2010) Michelle A. Fryirs et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Reconstituted HDL in Acute Coronary Syndromes

(2010) Rémy Chenevard et al.   Cardiovascular Therapeutics

HDL and LDL cholesterol significantly influence β-cell function in type 2 diabetes mellitus

(2010) Janine K Kruit et al.   CURRENT OPINION IN LIPIDOLOGY

Emerging high-density lipoprotein infusion therapies: Fulfilling the promise of epidemiology?

(2010) Jean-Claude Tardif   Journal of Clinical Lipidology

A First-in-Man, Randomized, Placebo-Controlled Study to Evaluate the Safety and Feasibility of Autologous Delipidated High-Density Lipoprotein Plasma Infusions in Patients With Acute Coronary Syndrome

(2010) Ron Waksman et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Effects of Combination Lipid Therapy in Type 2 Diabetes Mellitus

(2010)   NEW ENGLAND JOURNAL OF MEDICINE

Expression and recovery of biologically active recombinant Apolipoprotein AIMilano from transgenic safflower (Carthamus tinctorius) seeds

(2010) Cory L. Nykiforuk et al.   PLANT BIOTECHNOLOGY JOURNAL

Role of HDL, ABCA1, and ABCG1 Transporters in Cholesterol Efflux and Immune Responses

(2009) Laurent Yvan-Charvet et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

HDL biogenesis and functions: Role of HDL quality and quantity in atherosclerosis

(2009) Eirini M. Tsompanidi et al.   ATHEROSCLEROSIS

Reconstituted High-Density Lipoprotein Attenuates Platelet Function in Individuals With Type 2 Diabetes Mellitus by Promoting Cholesterol Efflux

(2009) Anna C. Calkin et al.   CIRCULATION

Cholesterol metabolism and pancreatic β-cell function

(2009) Michelle Fryirs et al.   CURRENT OPINION IN LIPIDOLOGY

Anionic Phospholipids Lose Their Procoagulant Properties When Incorporated into High Density Lipoproteins

(2009) Cecilia Oslakovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholesteryl Ester Transfer Protein Inhibition, High-Density Lipoprotein Raising, and Progression of Coronary Atherosclerosis

(2008) Stephen J. Nicholls et al.   CIRCULATION

Infusion of Reconstituted High-Density Lipoprotein Leads to Acute Changes in Human Atherosclerotic Plaque

(2008) James A. Shaw et al.   CIRCULATION RESEARCH

Wild-type apo A-I and apo A-IMilano gene transfer reduce native and transplant arteriosclerosis to a similar extent

(2008) Yingmei Feng et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Rapid Change in Plaque Size, Composition, and Molecular Footprint After Recombinant Apolipoprotein A-IMilano (ETC-216) Administration

(2008) Borja Ibanez et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Dose-Related Effects of Repeated ETC-216 (Recombinant Apolipoprotein A-IMilano/1-Palmitoyl-2-Oleoyl Phosphatidylcholine Complexes) Administrations on Rabbit Lipid-Rich Soft Plaques

(2008) Cinzia Parolini et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Synthetic HDL as a new treatment for atherosclerosis regression: Has the time come?

(2008) Paola Conca et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

HDL slowing down endothelial progenitor cells senescence: A novel anti-atherogenic property of HDL

(2007) Da-Rong Pu et al.   MEDICAL HYPOTHESES