Article
Clinical Neurology
Isabel C. Hostettler, Ghil Schwarz, Gareth Ambler, Duncan Wilson, Gargi Banerjee, David J. Seiffge, Clare Shakeshaft, Surabhika Lunawat, Hannah Cohen, Tarek A. Yousry, Rustam Al-Shahi Salman, Gregory Y. H. Lip, Martin M. Brown, Keith W. Muir, Henry Houlden, Hans Rolf Jager, David J. Werring
Summary: CT-based cerebral small vessel disease biomarkers are associated with 6-month functional outcome after intracerebral hemorrhage, but adding them does not significantly improve the performance of the existing ICH prediction score.
Article
Clinical Neurology
G. Schwarz, B. Kanber, F. Prados, S. Browning, R. Simister, H. R. Jager, G. Ambler, C. A. M. Gandini Wheeler-Kingshott, D. J. Werring
Summary: This study found that small vessel disease is the most common cause of spontaneous intracerebral hemorrhage and is associated with widespread microstructural brain tissue disruption, which can be quantified using diffusion tensor imaging metrics. The study found that whole-brain microstructural alterations are associated with functional outcome after intracerebral hemorrhage and have better predictive ability than existing hemorrhage scores.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Sukwoo Hong, Keisuke Maruyama, Akio Noguchi, Teruyuki Hirano, Motoo Nagane, Yoshiaki Shiokawa
Summary: The actual 30-day mortality rate of surgically treated ICH patients was significantly lower than predicted, with anisocoria and preoperative Glasgow Coma Scale < 7 being the only two factors predicting mortality and morbidity. The ICH and SwICH scores were more valid in predicting morbidity rather than mortality after surgical intervention for ICH.
NEUROSURGICAL REVIEW
(2021)
Article
Clinical Neurology
Rui Liu, Changcun Chen, Yutong Zhao, Yuguang Tang, Weiwei Shen, Zongyi Xie
Summary: This study aimed to investigate the relationship between the Osaka Prognostic Score (OPS) and Naples Prognostic Score (NPS) and the short-term outcomes of patients with intracerebral hemorrhage (ICH). The study found that higher OPS and NPS on admission were associated with poor outcomes at six months following ICH, suggesting their potential as markers for predicting the prognosis of ICH patients.
Article
Clinical Neurology
Steven D. Shapiro, Miryam Alkayyali, Alexandra Reynolds, Kaitlin Reilly, Magdy Selim, Neha Dangayach, J. Mocco, Christopher P. Kellner, John W. Liang
Summary: This study suggests that minimally invasive hematoma evacuation with the SCUBA technique for ICH may reduce predicted 30-day mortality, with a number needed to treat of 4 to prevent 1 mortality.
WORLD NEUROSURGERY
(2022)
Article
Immunology
Xianfei Ding, Ran Tong, Heng Song, Guiying Sun, Dong Wang, Huoyan Liang, Junyi Sun, Yuqing Cui, Xiaojuan Zhang, Shaohua Liu, Ming Cheng, Tongwen Sun
Summary: This study found that amino acid metabolism is significantly changed in septic patients, and developed multiple biomarker-based models to predict septic mortality based on metabolites and clinical indicators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Clinical Neurology
I. Putu Eka Widyadharma, Angga Krishna, Andreas Soejitno, A. A. A. Putri Laksmidewi, Kumara Tini, I. B. Kusuma Putra, I. G. N. Budiarsa, I. A. Sri Indrayani
Summary: The modified ICH (mICH) score was found to be more accurate and effective in predicting 30-day mortality and good outcome for non-traumatic ICH patients compared to the original ICH score (oICH).
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Article
Medicine, General & Internal
Laurent Puy, Adrian R. R. Parry-Jones, Else Charlotte Sandset, Dar Dowlatshahi, Wendy Ziai, Charlotte Cordonnier
Summary: Intracerebral haemorrhage (ICH) is a serious condition caused by the rupture of a cerebral vessel and the entry of blood into the brain parenchyma. It is a major cause of stroke-related mortality and dependency, with limited treatment options available. This Primer provides a comprehensive overview of the epidemiology, pathophysiology, diagnosis, and treatment of ICH, highlighting the importance of prevention and management of haematoma expansion and long-term vascular risk.
NATURE REVIEWS DISEASE PRIMERS
(2023)
Article
Medicine, General & Internal
Maria Giulia Mosconi, Maurizio Paciaroni, Giancarlo Agnelli, Martino Marzano, Andrea Alberti, Michele Venti, Monica Acciarresi, Fabrizio Ruffini, Valeria Caso
Summary: In this study, the use of SMASH-U classification system for ICH patients revealed that systemic disease and medication groups were associated with intra-hospital mortality rates, while age and high NIHSS at admission were also significantly associated with mortality. The study suggests that the aetiology-oriented classification system may help predict intra-hospital mortality in acute haemorrhagic stroke patients and support clinicians in management.
INTERNAL AND EMERGENCY MEDICINE
(2021)
Article
Clinical Neurology
Ruijun Ji, Wenjuan Wang, Xinyu Liu, Linlin Wang, Ruixuan Jiang, Runhua Zhang, Dandan Wang, Jiaokun Jia, Hao Feng, Zeyu Ding, Yanfang Liu, Gaifen Liu, Jingjing Lu, Yi Ju, Xingquan Zhao
Summary: A study systematically compared 27 ICH models in terms of mortality and functional outcomes at different time points, revealing that the ICH-FOS model showed superior performance in predicting mortality and poor functional outcomes at 3 months after ICH.
NEUROLOGICAL RESEARCH
(2022)
Article
Clinical Neurology
Girish Menon, Sarah Estar Johnson, Ajay Hegde, Sanjeev Rathod, Raghavendra Nayak, Rajesh Nair
Summary: Elevated levels of admission NLR were found to be independently associated with poor mortality and 90-day outcome after intracerebral haemorrhage. NLR is identified as a novel, easily accessible, and cost-effective prognostic biomarker for outcomes following intracerebral haemorrhage.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Review
Biochemistry & Molecular Biology
Hisham Kashif, Dilan Shah, Sangeetha Sukumari-Ramesh
Summary: Intracerebral hemorrhage (ICH) is a challenging type of stroke with high morbidity and mortality, and currently lacks effective treatment options. Neuroinflammation plays a crucial role in ICH, making microRNAs appealing as potential therapeutic targets for regulating brain inflammation response. Studying the roles of microRNAs in ICH-induced neuroinflammation may provide insights for future research and treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Infectious Diseases
Shahrzad S. Deliran, Matthijs C. Brouwer, Diederik van de Beek
Summary: This study investigated the incidence, clinical course, radiological patterns, and clinical outcome of intracerebral hemorrhage (ICH) complicating bacterial meningitis. The results showed that ICH is a rare but severe complication in patients with bacterial meningitis, occurring in those with endocarditis, cerebral infarction, and anticoagulant use. ICH complicating bacterial meningitis is associated with high rates of death and morbidity.
JOURNAL OF INFECTION
(2022)
Article
Geriatrics & Gerontology
Yan Wan, Hongxiu Guo, Rentang Bi, Shaoli Chen, Jing Shen, Man Li, Yuanpeng Xia, Lei Zhang, Zhou Sun, Xiaolu Chen, Zhuoyuan Cai, Zhaowei Wang, Daokai Gong, Jingwen Xu, Dongya Zhu, Bo Hu, Quanwei He
Summary: This study compared the clinical and prognostic characteristics between recurrent and first-ever intracerebral hemorrhage (ICH). The results showed that recurrent ICH was associated with older age, history of ischemic heart disease, ischemic stroke, hypertension, and hyperlipidemia. Patients with recurrent ICH had previously received more antihypertensive therapy, had lower admission blood pressure, and higher baseline National Institute of Health stroke scale (NIHSS) score. Recurrent ICH was also found to be an independent risk factor for 3-month function dependence.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Zheng-Long Jin, Wen-Ying Gao, Shao-Jun Liao, Tao Yu, Qing Shi, Shang-Zhen Yu, Ye-Feng Cai
Summary: Paeonol inhibits the progression of ICH by mediating the HOTAIR/UPF1/ACSL4 axis, showing potential as a new treatment for ICH.
Article
Critical Care Medicine
M. Chico-Fernandez, M. Sanchez-Casado, J. A. Barea-Mendoza, I Garcia-Saez, M. A. Ballesteros-Sanz, F. Guerrero-Lopez, M. Quintana-Diaz, I Molina-Diaz, L. Martin-Iglesias, J. M. Toboso-Casado, J. Perez-Barcena, J. A. Llompart-Pou
MEDICINA INTENSIVA
(2020)
Article
Cardiac & Cardiovascular Systems
Laura Jordan-Martinez, Ricardo Rivera-Lopez, Francisco Bermudez-Jimenez, Juan Jimenez-Jaimez, Javier Alzueta, Alberto Barrera-Cordero, Ricardo Rivera-Fernandez, Manuel Jimenez-Navarro, Miguel Alvarez, Luis Tercedor
REVISTA ESPANOLA DE CARDIOLOGIA
(2020)
Article
Multidisciplinary Sciences
Mercedes Arrebola-Moreno, Dafina Petrova, Maria-Jose Sanchez, Ricardo Rivera-Lopez, Jose Antonio Ramirez-Hernandez
Article
Clinical Neurology
Miguel Angel Prieto-Palomino, Monica Delange-VanDerKroft, David Rodriguez-Rubio, Jesus Lafuente-Baraza, Eduardo Aguilar-Alonso, Ricardo Rivera-Lopez, Maria Dolores Arias-Verdu, Maria Dolores Pola-GallegoDeGuzman, Alfonso Munoz-Lopez, Juan Francisco Fernandez-Ortega, Emilio Curiel-Balsera, Guillermo Quesada-Garcia, Ricardo Rivera-Fernandez
ACTA NEUROCHIRURGICA
(2020)
Article
Multidisciplinary Sciences
Ricardo Rivera-Lopez, Mercedes Cabrera-Ramos, Laura Jordan-Martinez, Juan Jimenez-Jaimez, Rosa Macias-Ruiz, Eduardo Aguilar-Alonso, Ricardo Rivera-Fernandez, Emilio Sanchez-Cantalejo, Luis Tercedor, Miguel Alvarez
SCIENTIFIC REPORTS
(2020)
Review
Nursing
Mercedes Arrebola-Moreno, Dafina Petrova, Rocio Garcia-Retamero, Ricardo Rivera-Lopez, Laura Jordan-Martinez, Juan Pedro Arrebola, Jose Antonio Ramirez-Hernandez, Andres Catena
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2020)
Article
Medicine, General & Internal
Ricardo Rivera-Lopez, Celia Garcia-Lopez, Jose M. Sanchez-Moreno, Rafael A. Rivera-Lopez, Julio Almansa-Lopez, Ricardo Rivera-Fernandez, Eduardo Molina-Navarro, Miriam Jimenez-Fernandez, Santiago Ortiz-Perez, Jose A. Ramirez-Hernandez
Summary: The study found a higher incidence of cataracts in patients undergoing PCI for chronic total occlusion during follow-up, with cataract development associated with factors such as radiation dose, history of predisposing eye disease, diabetes, and older age.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Ricardo Rivera-Fernandez, Luis Yaguez-Mateos, Maria Guerrero-Marin, Rosa Maria Perez-Manrique, Maria Rojas-Amezcua, Antonio Jesus Pontes-Moreno, Juan Jose Rios-Toro, Rosa Vela-Colmenero, Maria Isabel Ruiz-Garcia, Crispin Colmenero-Aguilar, Ana Castillo-Rivera, Maria Dolores Pola-Gallego De Guzman, Eduardo Aguilar-Alonso
Summary: This multicenter study investigated the elevation of procalcitonin (PCT) and its impact on mortality in COVID-19 patients with respiratory involvement admitted to the ICU. The findings showed a significant association between PCT elevation and mortality, with more than half of the patients who died having elevated PCT levels on their last day. Serial assessment of PCT can help identify high-risk patients and improve treatment and prognosis.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
JesseJ Swen, Cathelijne H. van der Wouden, Lisanne E. N. Manson, Heshu Abdullah-Koolmees, Kathrin Blagec, Tanja Blagus, Stefan Boehringer, Anne Cambon-Thomsen, Erika Cecchin, Ka-Chun Cheung, Vera H. M. Deneer, Mathilde Dupui, Magnus Ingelman-Sundberg, Siv Jonsson, Candace Joefield-Roka, Katja S. Just, Mats O. Karlsson, Lidija Konta, Rudolf Koopmann, Marjolein Kriek, Thorsten Lehr, Christina Mitropoulou, Emmanuelle Rial-Sebbag, Victoria Rollinson, Rossana Roncato, Matthias Samwald, Elke Schaeffeler, Maria Skokou, Matthias Schwab, Daniela Steinberger, Julia C. Stingl, Roman Tremmel, Richard M. Turner, Mandy H. van Rhenen, Cristina L. Davila Fajardo, Vita Dolzan, George P. Patrinos, Munir Pirmohamed, Gere Sunder-Plassmann, Giuseppe Toffoli, Henk-Jan Guchelaar
Summary: This study assessed the clinical utility of pharmacogenetic testing in patients receiving their first prescription drugs. The results showed that using a pharmacogenetic panel significantly reduced the incidence of clinically relevant adverse drug reactions, and this strategy was feasible across diverse European healthcare system organizations and settings.
Article
Cardiac & Cardiovascular Systems
Manuel Molina-Lerma, Eva Cabrera-Borrego, Ricardo Rivera-Lopez, Pablo Sanchez-Millan, Jesus Pena Mellado, Antonio Arriaga Jimenez, Miguel Alvarez
Summary: This study compared the screening results of S-ICD among different cardiac pacing sites and identified electrocardiographic predictors of success.
Article
Medicine, General & Internal
Juan Jesus Rios-Toro, Maria Dolores Pola-Gallego de Guzman, Maria Guerrero-Marin, David Rodriguez-Rubio, Maria Isabel Ruiz-Garcia, Eduardo Aguilar-Alonso, Ricardo Rivera-Fernandez
Summary: This study aimed to evaluate the prognostic value of PCT and CRP changes in ICU septic patients within the first two days of admission, compared to APACHE-II and SOFA scores. Results showed that changes in SOFA and APACHE-II scores were more sensitive predictors of mortality than changes in CRP and PCT levels. Additionally, changes in PCT levels between admission and the fifth day were significantly related to mortality, suggesting its potential use as an additional marker for patient outcome.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)