Does neonatal pain management in intensive care units differ between night and day? An observational study

Objective To determine whether analgesic use for painful procedures performed in neonates in the neonatal intensive care unit (NICU) differs during nights and days and during each of the 6h period of the day. Design Conducted as part of the prospective observational Epidemiology of Painful Procedures in Neonates study which was designed to collect in real time and around-the-clock bedside data on all painful or stressful procedures. Setting 13 NICUs and paediatric intensive care units in the Paris Region, France. Participants All 430 neonates admitted to the participating units during a 6-week period between September 2005 and January 2006. Data collection During the first 14days of admission, data were collected on all painful procedures and analgesic therapy. The five most frequent procedures representing 38012 of all 42413 (90%) painful procedures were analysed. Intervention Observational study. Main outcome assessment We compared the use of specific analgesic for procedures performed during each of the 6h period of a day: morning (7:00 to 12:59), afternoon, early night and late night and during daytime (morning+afternoon) and night-time (early night+late night). Results 7724 of 38012 (20.3%) painful procedures were carried out with a specific analgesic treatment. For morning, afternoon, early night and late night, respectively, the use of analgesic was 25.8%, 18.9%, 18.3% and 18%. The relative reduction of analgesia was 18.3%, p<0.01, between daytime and night-time and 28.8%, p<0.001, between morning and the rest of the day. Parental presence, nurses on 8h shifts and written protocols for analgesia were associated with a decrease in this difference. Conclusions The substantial differences in the use of analgesics around-the-clock may be questioned on quality of care grounds.