Article
Oncology
Martijn van Dorp, Constantia Trimbos, Wilhelmina H. Schreurs, Chris Dickhoff, David J. Heineman, Bart Torensma, Geert Kazemier, Frank J. C. van den Broek, Ben J. Slotman, Max Dahele
Summary: In this retrospective cohort study, pulmonary metastasectomy and SABR showed comparable overall survival, local recurrence-free survival, and complication rates in patients with colorectal pulmonary metastases, despite significantly lower progression-free survival and local control rates in the SABR group.
Article
Gastroenterology & Hepatology
Hayley M. Fenton, Paul J. Finan, Richard Milton, Michael Shackcloth, John C. Taylor, Tom Treasure, Eva J. A. Morris
Summary: The study revealed significant variation in the rates of pulmonary metastasectomy for colorectal cancer across the English NHS and a 5-year survival rate of 50.8% following the surgery.
COLORECTAL DISEASE
(2021)
Article
Gastroenterology & Hepatology
Tom Treasure, Vernon Farewell, Fergus Macbeth, Tim Batchelor, Misel Milosevic, Juliet King, Yan Zheng, Pauline Leonard, Norman R. Williams, Chris Brew-Graves, Lesley Fallowfield
Summary: This study examined survival in colorectal cancer patients with or without lung metastasectomy. The research found that survival without surgery was higher than expected, with the difference in survival largely related to patient selection.
COLORECTAL DISEASE
(2021)
Article
Oncology
Martijn van Dorp, Semih uenal, Simone Gooijer, Chris Dickhoff, Frank Jozef Christiaan van den Broek, Geert Kazemier, Wilhelmina Hendrika Schreurs, Famke Lorelei Schneiders, Max Dahele, David Jonathan Heineman
Summary: This study describes the experience with salvage surgery in 17 patients who had local recurrence of colorectal pulmonary metastases following stereotactic ablative radiotherapy (SABR). The results show that salvage resection is a feasible option with acceptable morbidity and good oncological outcome in a highly selected cohort.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Review
Respiratory System
Paul Beckers, Lawek Berzenji, Suresh K. Yogeswaran, Patrick Lauwers, Giada Bilotta, Nikol Shkarpa, Jeroen Hendriks, Paul E. Van Schil
Summary: Colorectal cancer is a leading cause of cancer-related deaths worldwide, with some patients able to undergo pulmonary metastasectomy for treatment. Patients who undergo surgery have a 5-year survival rate of approximately 40%, but there is a lack of prospective data on the surgical outcomes.
JOURNAL OF THORACIC DISEASE
(2021)
Letter
Oncology
Tim Batchelor, Jurjees Hasan, Fergus Macbeth, Michael Shackcloth, Tom Treasure
Summary: Pulmonary metastasectomy for sarcoma lacks proven benefits, and should be questioned in light of a randomized controlled trial in colorectal cancer patients.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Ju Sik Yun, Eunchong Kim, Kook Joo Na, Sang Yun Song, In Seok Jeong, Sang Gi Oh
Summary: This study confirms the effectiveness of thoracoscopic metastasectomy for colorectal cancer (CRC) and identifies several prognostic factors such as age, pathological stage, preoperative carcinoembryonic antigen level. Older age and prior extrathoracic metastasis are independent poor prognostic factors. Overall, VATS for pulmonary metastasectomy for CRC can be performed safely with comparable long-term survival rates to other studies.
Article
Oncology
Gustavo C. L. Gossling, Marcio F. Chedid, Fernando S. Pereira, Rafaela K. da Silva, Leonardo B. Andrade, Nicolas Peruzzo, Mauricio G. Saueressig, Gilberto Schwartsmann, Aparna R. Parikh
Summary: This study aimed to identify clinicopathological and molecular features associated with progression-free survival (PFS) and overall survival (OS) after pulmonary metastasectomy for metastatic colorectal cancer. The findings suggest that disease-free interval, synchronous presentation, and number and size of lesions are significant prognostic factors for OS, while presenting with more than one lesion is predictive for PFS but not for OS.
Review
Oncology
Martijn van Dorp, Jelle Egbert Bousema, Bart Torensma, Christian Dickhoff, Frank Jozef Christiaan van den Broek, Wilhelmina Hendrika Schreurs, Michel Gonzalez, Geert Kazemier, David Jonathan Heineman
Summary: This study conducted a systematic review on the impact of simultaneous lymph node metastases on patient survival during metastasectomy for colorectal pulmonary metastases (CRPM). The results showed that simultaneous lymph node metastases have a detrimental impact on survival, especially for mediastinal lymph node metastases. Therefore, lymphadenectomy during pulmonary metastasectomy for CRPM is advised to obtain important prognostic value.
Article
Cardiac & Cardiovascular Systems
Erin M. Corsini, Kyle G. Mitchell, Arlene Correa, Van K. Morris, Mara B. Antonoff
Summary: Colorectal cancer location may affect survival after pulmonary metastasectomy, with patients with left-sided tumors experiencing a survival benefit. Additional research is needed to confirm these findings and assess the impact of tumor location on prognosis in patients eligible for pulmonary metastasectomy.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Oncology
Woo Sik Yu, Mi Kyung Bae, Jung Kyu Choi, Young Ki Hong, In Kyu Park
Summary: The study aimed to investigate the prognostic factors for overall survival in patients who had undergone pulmonary metastasectomy for colorectal cancer. It found that pulmonary metastasectomy provided long-term survival for patients, with female sex, distally located colorectal cancer, and high-volume hospital centers being positive prognostic factors for survival.
CANCER RESEARCH AND TREATMENT
(2021)
Article
Critical Care Medicine
Jessica B. Badlam, David B. Badesch, Eric D. Austin, Raymond L. Benza, Wendy K. Chung, Harrison W. Farber, Kathy Feldkircher, Adaani E. Frost, Abby D. Poms, Katie A. Lutz, Michael W. Pauciulo, Chang Yu, William C. Nichols, C. Gregory Elliott
Summary: This study investigated genetic information, reproductive histories, and environmental exposure data in a population of PAH patients, revealing a common use of combination PAH medications, pregnancy complications, and exposure to various drugs among female patients.
Article
Public, Environmental & Occupational Health
Robert Hsu, Kai-Ya Tsai, Krithika Chennapan, Katherine Y. Wojcik, Alice W. W. Lee, Jorge J. Nieva, Lihua Liu
Summary: Filipino thyroid cancer patients have a higher incidence of high-risk pathological features and greater mortality risk. Further investigation is needed to understand the connection between these factors.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Oncology
Junfeng Huang, Qing Zang, Yaokai Wen, Zhe Pan, Zhiyuan Yao, Mingkai Huang, Jiongqiang Huang, Jingsong Chen, Rongchang Wang
Summary: This study found that KRAS mutation is associated with worse overall survival and recurrence free survival in colorectal cancer patients undergoing pulmonary metastasectomy, along with 18 other factors showing significant effects. This supports the use of a comprehensive model including clinicopathological and biological factors for optimal patient selection and prognosis in surgical treatment.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Review
Medicine, General & Internal
Kai-Yin Lee, Jerrald Lau, Bei-En Siew, Yong-Kang Chua, Yi-Xuan Lim, Xin-Yi Lim, Choon-Seng Chong, Ker-Kan Tan
Summary: The evidence currently does not support a clear survival benefit in patients with metastatic colorectal cancer who undergo lung metastasectomy compared to those who do not, or compared to those who undergo liver metastasectomy. More prospective studies are needed to fully understand the impact of lung metastasectomy on outcomes in metastatic CRC.
ANNALS ACADEMY OF MEDICINE SINGAPORE
(2021)
Article
Surgery
Maria Teresa Gomez Hernandez, Nuria M. Novoa Valentin, Raul Embun Flor, Gonzalo Varela Simo, Marcelo F. Jimenez Lopez
Summary: This study aims to develop a predictive model for prolonged post-operative length of stay (PLOS) in patients undergoing anatomic lung resection and evaluate its impact on readmission and 90-day mortality. The results indicate that factors such as age, BMI, sex, ppoFEV1%, ppoDLCO%, and thoracotomy contribute to PLOS. Moreover, PLOS is significantly associated with an increased risk of readmission and 90-day mortality.
Article
Respiratory System
David Gomez de Antonio, Silvana Crowley Carrasco, Alejandra Romero Roman, Ana Royuela, Alvaro Sanchez Calle, Carme Obiols Fornell, Sergi Call Caja, Raul Embun, Inigo Royo, Jose Luis Recuero, Alberto Cabanero, Nicolas Moreno, Sergio Bolufer, Miguel Congregado, Marcelo F. Jimenez, Borja Aguinagalde, Sergio Amor-Alonso, Miguel Jesus Arraras, Ana Isabel Blanco Orozco, Marc Boada, Isabel Cal, Angel Cilleruelo Ramos, Elena Fernandez-Martin, Santiago Garcia-Barajas, Maria Dolores Garcia-Jimenez, Jose Maria Garcia-Prim, Jose Alberto Garcia-Salcedo, Juan Jose Gelbenzu-Zazpe, Carlos Fernando Giraldo-Ospina, Maria Teresa Gomez Hernandez, Jorge Hernandez, Jennifer D. Illana Wolf, Alberto Jauregui Abularach, Unai Jimenez, Iker Lopez Sanz, Nestor J. Martinez-Hernandez, Elisabeth Martinez-Tellez, Lucia Milla Collado, Roberto Mongil Poce, Francisco Javier Moradiellos-Diez, Ramon Moreno-Basalobre, Sergio B. Moreno Merino, Florencio Quero-Valenzuela, Maria Elena Ramirez-Gil, Ricard Ramos-Izquierdo, Eduardo Rivo, Alberto Rodriguez-Fuster, Rafael Rojo-Marcos, David Sanchez-Lorente, Laura Sanchez Moreno, Carlos Simon, Juan Carlos Trujillo-Reyes, Cipriano Lopez Garcia, Juan Jose Fibla Alfara, Julio Sesma Romero, Florentino Hernando Trancho
Summary: The aim of this study was to develop a surgical risk prediction model for patients undergoing anatomic lung resections. By analyzing a large dataset, the researchers identified relevant variables and developed a simple and effective model. This model can assist doctors in assessing the risk for patients undergoing surgery.
ARCHIVOS DE BRONCONEUMOLOGIA
(2022)
Article
Surgery
Jorge Hernandez, Laureano Molins, Juan J. Fibla, Angela Guirao, Juan J. Rivas, Laura Casas, Nuria Pajuelo, Raul Embun
Summary: This study evaluated the effectiveness of CT in detecting pulmonary metastases in colorectal cancer patients and compared the differences between video-assisted surgery and thoracotomy. The results showed that the majority of patients had an M1/CT ratio of ≤1, with no difference between surgical approaches. A minority of patients had more M1 nodules than predicted by CT, and these patients had lower disease-specific survival and disease-free survival. There was no difference in DSS and DFS between VATS and thoracotomy.
Article
Cardiac & Cardiovascular Systems
David Gomez de Antonio, Silvana Crowley Carrasco, Alejandra Romero Roman, Ana Royuela, Mariana Gil Barturen, Carme Obiols, Sergi Call, Inigo Royo, Jose Luis Recuero, Alberto Cabanero, Nicolas Moreno, Raul Embun
Summary: The external validation of Eurolung 1 and Eurolung 2 was conducted in a multicentre national database. Eurolung 1 showed suboptimal calibration and lower discrimination, while Eurolung 2 exhibited good calibration and higher discrimination. Therefore, Eurolung 2 seems to be applicable to other anatomic lung-resected patients, while Eurolung 1 lacks generalizability for new patients.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Jose Luis Recuero-Diaz, Inigo Royo-Crespo, David Gomez de-Antonio, Sergi Call, Borja Aguinagalde, Maria Teresa Gomez-Hernandez, Jorge Hernandez-Ferrandez, David Sanchez-Lorente, Julio Sesma-Romero, Eduardo Rivo, Nicolas Moreno-Mata, Raul Embun
Summary: Video-assisted thoracic surgery (VATS) can reduce the risk of 90-day mortality after anatomical lung resection. However, the implications of conversion to thoracotomy and the potential impact of hidden bias should be further investigated.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Oncology
Carme Obiols, Sergi Call, Ramon Rami-Porta, Angeles Jaen, David Gomez de Antonio, Silvana Crowley Carrasco, Inigo Royo-Crespo, Raul Embun
Summary: This study aimed to analyze the differences in intraoperative nodal assessment in lung cancer patients undergoing thoracotomy and video-assisted thoracoscopy (VATS). The results showed that thoracotomy was associated with a more thorough lymphadenectomy, suggesting the need for improved lymph node evaluation during VATS surgery for better prognosis.
Article
Surgery
Iker Lopez, Borja Aguinagalde, Iratxe Urreta, Inigo Royo, Sergio Bolufer, Laura Sanchez, Jon Zabaleta, Arantza Fernandez-Monge, Jose Luis Recuero, Julio Sesma, Sergio Amor, Francisco Javier Moradiellos, Miguel Jesus Arraras, Ana Isabel Blanco, Marc Boada, David Sanchez, Alberto Cabanero, Nicolas Moreno, Isabel Cal, Ramon Moreno, Angel Cilleruelo, Silvana Crowley, David Gomez, Elena Fernandez, Florentino Hernando, Santiago Garcia, Cipriano Lopez, Maria Dolores Garcia, Jose Maria Garcia, Jose Eduardo Rivo, Jose Alberto Garcia, Juan Jose Gelbenzu, Maria Elena Ramirez, Carlos Fernando Giraldo, Roberto Mongil, Maria Teresa Gomez, Marcelo Jimenez, Jorge Henandez, Juan Jose Fibla, Jennifer Illana, Alberto Jauregui, Unai Jimenez, Rafael Rojo, Nestor J. Martinez, Elisabeth Martinez, Juan Carlos Trujillo, Lucia Milla, Sergio B. Moreno, Miguel Congregado, Carme Obiols, Sergi Call, Florencio Quero, Ricard Ramos, Alberto Rodriguez, Carlos Maria Simon, Raul Embun
Summary: The study aimed to assess the diagnostic performance of combined CT and PET in mediastinal staging of surgical lung cancer. The overall success rate of CT and PET was 82.9%, with a high negative predictive value. Tumors larger than 3 cm and higher mediastinal SUVmax were associated with lower success rates, while VATS approach was associated with higher success rates. The risk of unexpected pN2 increased with certain risk factors but did not vary significantly with invasive testing.
Article
Critical Care Medicine
Irene Dot, Purificacion Perez-Teran, Albert Frances, Yolanda Diaz, Clara Vila-Vilardell, Anna Salazar-Degracia, Roberto Chalela, Esther Barreiro, Alberto Rodriguez-Fuster, Joan Ramon Masclans, Judith Marin-Corral
Summary: This study evaluated the ability of diaphragm expiratory thickness (Tdi) measured by ultrasound to predict diaphragm atrophy. The results showed that a lower Tdi is a good tool for diagnosing atrophy, but normal or increased Tdi cannot rule out atrophy.
JOURNAL OF INTENSIVE CARE
(2022)
Article
Respiratory System
Alejandra Romero Roman, Silvana Crowley Carrasco, Mariana Gil Barturen, Ana Royuela, Carme Obiols, Sergi Call, Jose Luis Recuero, Inigo Royo, Raul Embun, David Gomez de Antonio
Summary: This study aims to determine the incidence and risk factors of occult N1/N2 nodal metastases in patients with non-small cell lung cancer (NSCLC) no larger than 3 cm and deemed cN0 by CT and PET-CT. The incidence of occult pN1/N2 disease was 10.70%. Factors associated with occult N1/N2 metastases included degree of differentiation, size, location, SUV of the tumor in PET, surgeon experience, and number of lymph nodes resected.
ARCHIVOS DE BRONCONEUMOLOGIA
(2023)
Article
Surgery
Maria Teresa Gomez-Hernandez, Cristina Rivas, Nuria Novoa, Marcelo F. Jimenez
Summary: A significant number of patients undergoing anatomical lung resections fail to be rescued after major complications. Risk factors associated with rescue failure include ppoDLCO%, cardiac comorbidity, extended resection, pneumonectomy, and hospital volume <120 cases per year. High-risk patients with complex thoracic pathology should be treated in high-volume centers for optimal outcomes.
FRONTIERS IN SURGERY
(2023)
Article
Surgery
Sara Fra-Fernandez, Gemma Maria Munoz-Molina, Alberto Cabanero-Sanchez, Laura del Campo-Albendea, Sergio Bolufer-Nadal, Raull Embun-Flor, Nestor J. Martinez-Hernandez, Nicolas Moreno-Mata
Summary: This study compares postoperative morbidity after open and video-assisted thoracoscopic lung resections. The results show that in the treatment analysis, video-assisted thoracoscopic lung resections are associated with fewer complications, lower readmission rate, and shorter hospital length of stay compared to open surgery. However, the benefits of the video-assisted approach are less prominent in the intention-to-treat analysis.
Article
Cardiac & Cardiovascular Systems
Maria Teresa Gomez-Hernandez, Clara Forcada, Gonzalo Varela, Marcelo F. Jimenez
Summary: This study aimed to investigate the relationship between operating time and postoperative complications in video-thoracoscopic lobectomy surgeries. The results showed that prolonged operating time was associated with increased overall and pulmonary complications.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Respiratory System
Yingchen Xia, Jianhua Zha, Victor Curull, Albert Sanchez-Font, Maria Guitart, Alberto Rodriguez-Fuster, Rafael Aguilo, Esther Barreiro
Summary: Epithelial-mesenchymal transition (EMT) gene expression profile and signaling cascade may differ in lung cancer (LC) patients with and without chronic obstructive pulmonary disease (COPD). Several markers of EMT expression were differentially expressed in lung tumor samples of patients with COPD, suggesting their potential role in regulating EMT in this respiratory disease.