Article
Biochemistry & Molecular Biology
Yang Gao, Wolfram Thiele, Omar Saleh, Federico Scossa, Fayezeh Arabi, Hongmou Zhang, Arun Sampathkumar, Kristina Kuehn, Alisdair Fernie, Ralph Bock, Mark A. Schoettler, Reimo Zoschke
Summary: This study reveals the importance of translational regulation of chloroplast genes in plant cold acclimation and identifies a critical role of a small cytochrome b6f complex subunit in chilling tolerance.
Article
Biochemical Research Methods
Xiang Cheng, Md Amanullah, Weigang Liu, Yi Liu, Xiaoqing Pan, Honghe Zhang, Haiming Xu, Pengyuan Liu, Yan Lu
Summary: Researchers proposed a new method to fully control network state transitions by identifying key regulators in the transcriptional co-expression network. They developed a weighted minimum dominating set (WMDS.net) network model to find driver nodes in differential gene co-expression networks. WMDS.net outperformed other top-tier tools in cancer datasets by considering both node degree and the significance of gene co-expression differences between physiological states.
Review
Biotechnology & Applied Microbiology
Alexander Malogolovkin, Alexander D. Egorov, Alexander Karabelsky, Roman A. Ivanov, Vladislav V. Verkhusha
Summary: Optogenetics, a technique that enables precise control of gene and cell activity using light, offers new possibilities for cancer treatment. By activating immune response, inhibiting tumor growth, and modulating cell signaling using specific wavelengths of light, optogenetics has the potential to revolutionize cancer therapy.
BIOTECHNOLOGY ADVANCES
(2022)
Article
Biology
Tharmaraj Jesan, Sitabhra Sinha
Summary: The topological structure of biological networks plays a crucial role in understanding diseases such as cancer. By studying the modular organization and connectivity of cancer disease-gene networks, we can infer relationships between different tumor types and identify potential therapeutic targets.
JOURNAL OF BIOSCIENCES
(2022)
Review
Oncology
Monica Marzagalli, Fabrizio Fontana, Michela Raimondi, Patrizia Limonta
Summary: Cancer stem cells (CSCs) are a subset of cancer cells with tumor-initiating and self-renewal capacity, as well as high adaptive abilities, contributing to treatment failure and tumor progression/relapse. Understanding the molecular mechanisms associated with stemness-driven resistance is crucial for developing more effective drugs and durable responses. Explored mechanisms by CSCs to overcome different therapeutic strategies highlight their plasticity as an insidious trait responsible for their adaptation/escape, with novel CSC-specific approaches showing promising preclinical and clinical applications.
Review
Biochemistry & Molecular Biology
Irene Zamora, Michael R. Freeman, Ignacio J. Encio, Mirja Rotinen
Summary: Neuroendocrine prostate cancer is a highly aggressive subtype of prostate cancer that can evade traditional therapies. Recent molecular research has identified factors driving its development and potential therapeutic targets. Current investigations into treatments show promise in improving patient prognosis for this lethal disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Felix T. Kurz, Heinz -Peter Schlemmer
Summary: This review aims to present recent advancements in translational cancer imaging research, specifically focusing on novel, recently established, or soon to be established cross-sectional imaging techniques such as computed tomography (CT), magnetic resonance imaging (MRI), and positron-emission tomography (PET), as well as computational investigations based on machine-learning techniques.
CANCER BIOLOGY & MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Pietro Gentile
Summary: Mesenchymal stem cells (MSCs) have potential in the treatment of breast cancer by delivering anticancer drugs and gene therapy. The safety of fat grafting and adipose-derived MSCs in breast reconstruction has been confirmed. Extracellular vesicles (EVs), as a cell-free therapy, have also been studied in breast cancer treatment.
Article
Biology
Chaoying Zhan, Kai Liu, Yuxin Zhang, Yingbo Zhang, Mengqiao He, Rongrong Wu, Cheng Bi, Bairong Shen
Summary: This study proposed a novel bioinformatics model based on multivariate biomolecular network analysis to identify putative key miRNAs of myocardial infarction (MI). The model combined TRS, TFP, and AGP features and successfully screened 31 potential MI-related miRNAs, identifying genes associated with key MI pathways. These findings warrant further experimental and clinical validation for translational applications.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Review
Immunology
Yinxi Zhou, Jinghua Xia, Shuonan Xu, Tao She, Yanning Zhang, Ying Sun, Miaomiao Wen, Tao Jiang, Yanlu Xiong, Jie Lei
Summary: The development and growth of tumors pose a significant and ongoing threat to human life globally. Despite the remarkable progress achieved by advanced therapeutic strategies such as immune checkpoint therapy and CAR-T in treating solid and hematological malignancies, the malignant initiation and progression of cancer remains controversial and requires further research. Experimental animal models not only have great advantages in simulating tumor occurrence, development, and malignant transformation mechanisms, but also can be used to evaluate the therapeutic effects of diverse clinical interventions, gradually becoming indispensable in cancer research. This paper reviews recent research progress in mouse and rat models, focusing on spontaneous, induced, transgenic, and transplantable tumor models, aiming to provide guidance for future studies on malignant mechanisms and tumor prevention.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Junjie Zhao, Jiaqi Jin
Summary: This review discusses recent investigations into NETs and their roles in tumor biology, as well as explores their potential as therapeutic targets in cancer treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Geography
Ralph Richter, Gabriela B. Christmann
Summary: Social innovation research often views rural social innovation processes as collective efforts of equally engaged and like-minded individuals. However, recent studies suggest that dedicated key players who face both support and resistance play a crucial role in social innovation projects. This article examines the role of key players in rural social innovation processes and analyzes patterns through empirical cases in two German communities. The findings indicate that assertive key players and strong communities capable of joint action are essential for overcoming opposition and external obstacles in social innovation processes.
JOURNAL OF RURAL STUDIES
(2023)
Review
Cell Biology
Martina Mang Leng Lei, Terence Kin Wah Lee
Summary: Immune cells play a crucial role in driving cancer cells towards stemness and enabling cancer stem cells to evade immune surveillance by affecting various immune cells in the tumor microenvironment. Targeting CSCs with immunotherapy disrupts the interaction between immune cells and CSCs, offering a novel strategy against cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Peng Jiang, Sanju Sinha, Kenneth Aldape, Sridhar Hannenhalli, Cenk Sahinalp, Eytan Ruppin
Summary: Historically, cancer research has focused on a few essential pathways and genes, but recent advances in high-throughput technologies have led to the rapid accumulation of large-scale cancer omics data. The analysis of this "big data" requires significant computational resources and has the potential to bring new insights to cancer research. The combination of big data, bioinformatics, and artificial intelligence has already made notable advances in our understanding of cancer biology and translational research. Future progress will require collaboration among data scientists, clinicians, biologists, and policymakers.
NATURE REVIEWS CANCER
(2022)
Article
Social Sciences, Interdisciplinary
Nestor Armando Nova, Rafael Andres Gonzalez
Summary: This study aims to identify dimensions and barriers to evaluating and leveraging collaboration in a large translational research ecosystem and develops a methodological design for evaluation. The empirical results show that collaboration is closely related to factors and barriers at the socio-technical, management, operational, and institutional levels and provide valuable insights for managing and improving collaborative efforts.
Article
Health Care Sciences & Services
Ann Carrigan, Natalie Roberts, Robyn Clay-Williams, Peter Hibbert, Elizabeth Austin, Diana Fajardo Pulido, Isabelle Meulenbroeks, Hoa Mi Nguyen, Mitchell Sarkies, Sarah Hatem, Katherine Maka, Graeme Loy, Jeffrey Braithwaite
Summary: This study collected consumer and provider views on integrated care and discussed its feasibility in a new hospital. Integrated care was perceived as an accessible and efficient model that enhances staff and patient well-being. Implementation requires supporting consumers, integrating primary care, and centralizing patient electronic medical records.
BMC HEALTH SERVICES RESEARCH
(2023)
Editorial Material
Primary Health Care
Darran Foo, Janani Mahadeva, Francisco Lopez, Louise A. Ellis, Kate Churruca, Genevieve Dammery, Simon Willcock, Jeffrey Braithwaite
BRITISH JOURNAL OF GENERAL PRACTICE
(2023)
Article
Genetics & Heredity
Zornitza Stark, Tiffany Boughtwood, Matilda Haas, Jeffrey Braithwaite, Clara L. Gaff, Ilias Goranitis, Amanda B. Spurdle, David P. Hansen, Oliver Hofmann, Nigel Laing, Sylvia Metcalfe, Ainsley J. Newson, Hamish S. Scott, Natalie Thorne, Robyn L. Ward, Marcel E. Dinger, Stephanie Best, Janet C. Long, Sean M. Grimmond, John Pearson, Nicola Waddell, Christopher P. Barnett, Matthew Cook, Michael Field, David Fielding, Stephen B. Fox, Jozef Gecz, Adam Jaffe, Richard J. Leventer, Paul J. Lockhart, Sebastian Lunke, Andrew J. Mallett, Julie McGaughran, Linda Mileshkin, Katia Nones, Tony Roscioli, Ingrid E. Scheffer, Christopher Semsarian, Cas Simons, David M. Thomas, David R. Thorburn, Richard Tothill, Deborah White, Sally Dunwoodie, Peter T. Simpson, Peta Phillips, Marie-Jo Brion, Keri Finlay, Michael CJ. Quinn, Tessa Mattiske, Emma Tudini, Kirsten Boggs, Sean Murray, Kathy Wells, John Cannings, Andrew H. Sinclair, John Christodoulou, Kathryn N. North
Summary: Australian Genomics is a national collaborative partnership that aims to integrate genomics into healthcare through a whole-of-system approach. It has evaluated genomic testing outcomes in over 5,200 individuals across rare disease and cancer studies and provided evidence-based changes in policy and practice, resulting in government funding and access to genomic tests. It has also developed national skills, infrastructure, policy, and data resources to support data sharing and improve clinical genomic delivery.
AMERICAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Geriatrics & Gerontology
Kate Churruca, Janet C. Long, Louise A. Ellis, Maree Saba, Jeffrey Braithwaite
Summary: This study analysed how cultures of care delivery were considered in the final report of the Royal Commission into Aged Care Quality and Safety in Australia, and explored its subsequent implications. The findings highlighted the importance of care culture and the need for change, but the report provided limited guidance on how to achieve this or conceptualize culture.
AUSTRALASIAN JOURNAL ON AGEING
(2023)
Article
Public, Environmental & Occupational Health
Louise A. Ellis, Yvonne Tran, Chiara Pomare, Janet C. Long, Kate Churruca, Maree Saba, Jeffrey Braithwaite
Summary: This study investigates the impact of teamwork culture on staff attitudes, change readiness, and burnout during hospital organizational change. It also examines different communication channels for organizational change. The results show that a positive teamwork culture and feeling informed are associated with increased change readiness and reduced burnout. Understanding the pathways between culture, communication, and burnout can help facilitate smooth organizational change with minimal disruption to staff and patient care.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Louise A. A. Ellis, Emma Falkland, Peter Hibbert, Siri Wiig, Eline Ree, Timothy J. Schultz, Christy Pirone, Jeffrey Braithwaite
Summary: The concept of safety culture in healthcare, which aims to create a culture that ensures the safety of staff and patients, is complex, multifaceted, and difficult to define. This has led to various definitions and measurement tools, with no consensus on the best way to measure and improve safety culture. Another challenge is achieving sufficient response rates in surveys due to survey fatigue. This paper discusses the challenges and complexities in safety culture assessment, including definition, tools, dimensionality, and response rates, and highlights possible solutions and areas for future research.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Family Studies
Maryam Vizheh, Yvonne Zurynski, Jeffrey Braithwaite, Frances Rapport
Summary: Women's agency is crucial for accessing and utilizing reproductive healthcare services, especially in societies with patriarchal beliefs and cultural norms that hinder women's decision-making ability and resource access. This study conducted a comprehensive systematic review to summarize the determinants of women's agency in accessing and using reproductive healthcare services. Various determinants were identified such as individual characteristics, household structure, reproductive health-related factors, social relations, and economic factors. These determinants were strongly influenced by social norms and cultural beliefs. However, there were gaps in the literature including inconsistent definitions and measurements of women's agency, lack of consideration for cultural sensitivities, and limited focus on services beyond pregnancy and birth. Moreover, the literature primarily focused on developing countries in Africa and Asia, leaving a significant knowledge gap regarding women's agency to access services in other geographic areas or among immigrant and refugee populations in developed countries.
CULTURE HEALTH & SEXUALITY
(2023)
Article
Health Care Sciences & Services
Robyn Clay-Williams, Peter Hibbert, Ann Carrigan, Natalie Roberts, Elizabeth Austin, Diana Fajardo Pulido, Isabelle Meulenbroeks, Hoa Mi Nguyen, Mitchell Sarkies, Sarah Hatem, Katherine Maka, Graeme Loy, Jeffrey Braithwaite
Summary: Virtual care has become increasingly popular in recent years, especially after the COVID-19 pandemic. This study explored the expectations and perspectives of consumers and providers regarding virtual care through workshops and surveys. Virtual care was widely supported but not suitable for all patients. Considering consumer and provider views and expectations can facilitate greater acceptance and uptake of virtual care models.
BMC HEALTH SERVICES RESEARCH
(2023)
Review
Health Care Sciences & Services
Kate Churruca, Emma Falkland, Maree Saba, Louise A. Ellis, Jeffrey Braithwaite
Summary: This review examines the relationship between organizational culture and the quality of care in healthcare organizations, including residential aged care facilities. The study found that there is heterogeneity in research methods and mixed findings regarding the relationship between culture and care quality. Only a small number of studies evaluated interventions. Therefore, further research is needed to explore interventions for culture change and improve care quality.
BMC HEALTH SERVICES RESEARCH
(2023)
Article
Health Care Sciences & Services
Louise A. Ellis, Yvonne Zurynski, Janet C. Long, Robyn Clay-Williams, Eline Ree, Mitchell Sarkies, Kate Churruca, Fiona Shand, Chiara Pomare, Maree Saba, Cecilie Haraldseid-Driftland, Jeffrey Braithwaite
Summary: This study explored resilient characteristics across different system levels (individual, team, management) during the implementation of a large-scale community-based suicide prevention intervention. The study identified numerous impediments to resilient performance and identified indicators and strategies for resilience at multiple system levels. The study emphasizes the importance of considering resilience from a multilevel systems perspective.
BMC HEALTH SERVICES RESEARCH
(2023)
Editorial Material
Medicine, General & Internal
Darran Foo, Samantha Spanos, Genevieve Dammery, Louise A. Ellis, Simon M. Willcock, Jeffrey Braithwaite
MEDICAL JOURNAL OF AUSTRALIA
(2023)
Article
Geriatrics & Gerontology
Seigo Mitsutake, Zhisheng Sa, Janet Long, Jeffrey Braithwaite, Jean-Frederic Levesque, Diane E. Watson, Jacqueline Close, Rebecca Mitchell
Summary: Frailty risk estimated using hospital administrative data can contribute to identifying older hip fracture patients at-risk of fracture-related readmissions and mortality, providing guidance for targeted interventions.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2024)