Article
Oncology
Xin-Hao Wang, Jia-Wen Wang, Wei Zhang, Xiao-Dong Liu, Ze-Hao Yan, Ling-Feng Meng, Yao-Guang Zhang
Summary: Neurogenic lower urinary tract dysfunction is caused by nervous system lesions and characterized by impaired micturition and urinary incontinence. The goal of treatment is to manage these symptoms, improve quality of life, prevent urinary tract infections, and maintain urinary function. Pelvic floor muscle training and medication are commonly used for treating it.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Ifrah Masood, Qi Chen, Jiayi Li, Zhihui Xu, Xiaoqian Ying, Yiming Wang, Guoqing Chen, Limin Liao
Summary: This retrospective study investigated the effectiveness of sacral neuromodulation (SNM) for neurogenic lower urinary tract dysfunction (NLUTD) in 152 subjects from four medical centers in China. The results showed that urinary retention symptoms were a significant positive predictor, and SNM had higher success rates for frequency-urgency, urinary incontinence, and neurogenic bowel dysfunction compared to chronic urinary retention. Despite not resolving all symptoms, SNM remains a reliable method for treating NLUTD.
Article
Oncology
Xin-Hao Wang, Jia-Wen Wang, Wei Zhang, Xiao-Dong Liu, Ze-Hao Yan, Ling-Feng Meng, Yao-Guang Zhang
Summary: Neurogenic lower urinary tract dysfunction (NLUTD), caused by nervous system lesions, is characterized by impaired micturition and urinary incontinence. Treatment includes pelvic floor muscle training, medication, and the use of a rechargeable sacral neuromodulation (SNM) system for managing symptoms and improving quality of life.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Mai Ahmed Banakhar
Summary: This study evaluated the effectiveness of sacral neuromodulation therapy (SNM) for lower urinary tract symptoms (LUTS) caused by neurological diseases. The results showed that SNM significantly improved voided volume, leaking episodes, postvoiding residual, and the need for clean intermittent catheterization compared to baseline. Patient satisfaction with the therapy was also high.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2022)
Review
Medicine, Research & Experimental
Arndt van Ophoven, Stefan Engelberg, Helen Lilley, Karl-Dietrich Sievert
Summary: This study conducted a systematic literature review and meta-analysis on the safety and effectiveness of sacral neuromodulation (SNM) in patients with neurogenic lower urinary tract dysfunctions (nLUTD). The results showed that SNM has high overall success rates and is safe for these patients, but more rigorous studies and/or registries are needed for definitive conclusions.
ADVANCES IN THERAPY
(2021)
Article
Medicine, General & Internal
Lingfeng Meng, Huimin Hou, Peng Zhang, Yinjun Gu, Benkang Shi, Yan Li, Qingwei Wang, Yifei Zhang, Lijuan Ren, Qi Chen, Zhen Yuan, Fan Guo, Dianyou Li, Yunfu Ma, Sheng Dong, Zhijun Liu, Aijia Shang, Bo Li, Wei Xu, Jianwei Lv, Yaoguang Zhang
Summary: This study evaluated the feasibility of using remote programming technology for sacral neuromodulation during the COVID-19 pandemic in China. The results showed that remote programming is important for maintaining the therapeutic effects of electronic sacral stimulator devices and can meet the needs of patients by reducing hospital visits, saving time, and reducing costs.
FRONTIERS IN MEDICINE
(2023)
Article
Urology & Nephrology
Stephanie A. Stalder, Oliver Gross, Collene E. Anderson, Lucas M. Bachmann, Sarah Baumann, Veronika Birkhauser, Mirjam Bywater, Giulio del Popolo, Daniel S. Engeler, Enrico Finazzi Agro, Susanne Friedl, Nuno Grilo, Stephan Kiss, Miriam Koschorke, Lorenz Leitner, Martina D. Liechti, Ulrich Mehnert, Stefania Musco, Helen Sadri, Lara Stachele, Jure Tornic, Stephanie van Der Lely, Stephen Wyler, Thomas M. Kessler
Summary: This study protocol describes a randomized controlled trial investigating the efficacy and safety of transcutaneous tibial nerve stimulation (TTNS) for refractory neurogenic lower urinary tract dysfunction (NLUTD). The primary outcome is improvement in bladder diary variables at study end compared to baseline values. Secondary outcomes include urodynamic, neurophysiological, and bowel function measures, as well as safety assessments.
Article
Biochemistry & Molecular Biology
Chiara Pellegrino, Valentina Forlini, Federica Lena, Maria Luisa Capitanucci, Francesca Diomedi Camassei, Enrico Castelli, Giovanni Mosiello
Summary: This study aims to report the long-term effects on the bladder wall in children treated with BTX-A. Evaluation of specimens from 36 children who had received ≥5 treatments showed increased edema and chronic inflammation, but not statistically significant, suggesting that repeated BTX-A injections could be considered safe, regardless of congenital or acquired diseases.
Review
Biochemistry & Molecular Biology
Dafni Planta, Tim Gerwinn, Souzan Salemi, Maya Horst
Summary: Spinal dysraphism, specifically myelomeningocele, is the main cause of neurogenic lower urinary tract dysfunction in children. The changes in the bladder wall structure begin during fetal development, resulting in reduced smooth muscle, increased fibrosis, impaired urothelial barrier function, and decreased nerve density. This leads to significant functional impairment characterized by decreased compliance and increased elastic modulus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Urology & Nephrology
David A. Ginsberg, Timothy B. Boone, Anne P. Cameron, Angelo Gousse, Melissa R. Kaufman, Erick Keays, Michael J. Kennelly, Gary E. Lemack, Eric S. Rovner, Lesley H. Souter, Claire C. Yang, Stephen R. Kraus
Summary: This Guideline provides clinicians with comprehensive information on evaluating and treating patients with neurogenic lower urinary tract dysfunction (NLUTD), emphasizing the importance of considering various factors such as urologic symptoms, cognition, and neurological disease type. It also offers recommendations for risk stratification, monitoring, and adjustment of treatment plans based on patients' risk levels, with a focus on optimizing patient quality of life.
JOURNAL OF UROLOGY
(2021)
Article
Medicine, General & Internal
Yu-Hua Fan, Yuan-Chi Shen, Chih-Chen Hsu, Po-Ming Chow, Po-Chih Chang, Yu-Hua Lin, Shang-Jen Chang, Yuan-Hong Jiang, Chun-Hou Liao, Chung-Cheng Wang, Chun-Te Wu, Hann-Chorng Kuo
Summary: This study presents a comprehensive review of the efforts made by a workgroup in Taiwan to address urologic surgery for patients with chronic spinal cord injury and neurogenic lower urinary tract dysfunction (NLUTD). Surgical procedures, categorized based on purpose, include reducing bladder pressures, reducing urethra resistance, increasing urethra resistance, and urinary diversion. The choice of surgery depends on the type of NLUTD determined through urodynamic tests, as well as factors such as cognitive function, hand motility, comorbidities, surgical efficacy, and related complications.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biology
Periklis Koukourikis, Maria Papaioannou, Petros Georgopoulos, Ioannis Apostolidis, Stavroula Pervana, Apostolos Apostolidis
Summary: Neurogenic bladder patients are at higher risk for advanced-stage bladder cancer, so it's important to develop non-invasive screening methods. A study found that changes in certain tumor-suppressing genes associated with bladder cancer were significantly more frequent in neurogenic bladder patients, especially in males. Biopsies showed a high percentage of chronic inflammation. Larger long-term studies are needed to establish the value of this non-invasive method in screening and diagnosis, as well as possible associations between gene changes, chronic inflammation, and bladder cancer in the neurogenic population.
Article
Cell Biology
Tim Gerwinn, Souzan Salemi, Larissa J. Schori, Dafni Planta, Daniel Eberli, Maya Horst
Summary: This study suggests that bladder detrusor smooth muscle microtissues derived from pediatric ESLUTD patients exhibit improved contractile potential and extracellular matrix composition, which may make them suitable as a cell source for autologous bladder tissue engineering.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Medicine, General & Internal
Periklis Koukourikis, Maria Papaioannou, Dimitrios Papanikolaou, Apostolos Apostolidis
Summary: This systematic review aims to evaluate the clinical utility of urine biomarkers in the management of neurogenic lower urinary tract dysfunction (NLUTD) in adults. Various urine molecules have been investigated for the diagnosis and management of neurogenic overactive bladder, detrusor overactivity, vesicoureteral reflux, urinary tract infection, and bladder cancer screening in neurological patients. Further research is needed to determine the specific utility of each molecule in the management algorithm of adult NLUTD.
Article
Multidisciplinary Sciences
Liqiong Zhou, Surui Liang, Qin Shuai, Chunhua Fan, Linghong Gao, Wenzhi Cai
Summary: This study constructed and validated an early risk warning model for urinary tract infection in patients with neurogenic lower urinary tract dysfunction (NLUTD). The model performed well in internal validation and external validation, demonstrating good discrimination ability and consistency. The model identified several predictors, such as age, gender, diabetes, urinary calculi, indwelling catheterization, and bladder behavior training intervention time. The model can provide targeted guidance for evaluating urinary tract infection in NLUTD patients.
Letter
Urology & Nephrology
Marc A. Furrer, Fiona C. Burkhard, Patrick Y. Wuethrich, Benjamin C. Thomas
WORLD JOURNAL OF UROLOGY
(2022)
Article
Urology & Nephrology
Marc A. Furrer, Janine Abgottspon, Markus Huber, Dominique Engel, Lukas M. Loeffel, Christian M. Beilstein, Fiona C. Burkhard, Patrick Y. Wuethrich
Summary: The study found that uninterrupted administration of anticoagulant agents such as low-dose aspirin, oral anticoagulants, or low-molecular-weight heparin did not affect blood loss and transfusion rate in patients undergoing open radical cystectomy and urinary diversion. Therefore, discontinuation of anticoagulant agents may not be necessary for these patients.
Review
Cardiac & Cardiovascular Systems
Tiago Bilhim, Patrick Betschart, Pavel Lyatoshinsky, Gautier Mullhaupt, Dominik Abt
Summary: This review describes minimally invasive therapies (MITs) available for benign prostatic obstruction (BPO), including prostatic artery embolization, water vapor thermal therapy (Rezum(R)), prostatic urethral lift, iTIND (R) (temporary implantable device), and aquablation (Aquabeam (R)). The focus is on the technique description, level of evidence, and advantages over conventional surgical options.
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2022)
Article
Ophthalmology
Livia Faes, Kathrin Golla, Meriam Islam, Kenny R. Lienhard, Martin K. Schmid, Dawn A. Sim, Lucas M. Bachmann
Summary: This study evaluates the usability and long-term adherence to the mobile hyperacuity app Alleye in patients with retinal pathology. The majority of patients showed satisfaction with the usability and had a positive attitude towards its trustworthiness and usefulness.
Article
Ophthalmology
Frantisek Sanak, Philipp Baenninger, Katja Iselin, Claude Kaufmann, Lucas Bachmann, Daniela Buhl, Michael Thiel
Summary: This study measured the concentration of VEGF-A in SED and PRGF eye drops, and found that the VEGF concentration was significantly higher in SED compared to PRGF. This is an important finding for the potential treatment of dry eye disease in patients with neuropathic eye disease.
KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE
(2022)
Article
Ophthalmology
Frantisek Sanak, Livia Faes, Leila Eppenberger, Philipp Baenninger, Claude Kaufmann, Kathrin Golla, Lucas Bachmann, Daniela Buhl, Martin K. Schmid, Michael Thiel
Summary: This study evaluates the effectiveness of protective measures on the risk of SARS-CoV-2 infection among employees in a large public eye hospital. The results show that these measures are effective in preventing the transmission of SARS-CoV-2 and there is no significantly higher risk of infection for physicians compared to other staff members.
KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE
(2022)
Review
Medicine, General & Internal
Gallus B. Ineichen, Fiona C. Burkhard
Summary: Historically, prostate enlargement was believed to be the sole cause of male bladder problems. However, as our understanding of urine storage and voiding processes has deepened, we have realized that the issue is more complex, with different mechanisms capable of producing similar symptoms. Metabolic syndrome is an umbrella term associated with bladder and prostate issues, as well as other health problems. This review aims to synthesize interactions and evidence to enhance our understanding of the relationship between these two issues and lay the groundwork for personalized treatment.
Article
Clinical Neurology
Collene E. Anderson, Veronika Birkhauser, Martina D. Liechti, Xavier Jordan, Eugenia Luca, Sandra Mohr, Jurgen Pannek, Thomas M. Kessler, Martin W. G. Brinkhof
Summary: This prospective, multicenter, longitudinal cohort study aimed to investigate the female-male differences in first-line urological management during spinal cord injury (SCI) rehabilitation. The study found that females were more likely to use bladder storage medication and suprapubic catheters during SCI rehabilitation. These findings highlight the need for further research on female-specific urological management in SCI.
Review
Ophthalmology
Livia Faes, Peter M. Maloca, Katja Hatz, Thomas J. Wolfensberger, Marion R. Munk, Dawn A. Sim, Lucas M. Bachmann, Martin K. Schmid
Summary: Ophthalmology faces challenges in providing eye care to an increasing group of people. Health systems will be pushed to their limits due to the quantitative patient increase and new treatment availability. Better networking and patient involvement can lead to efficiency gains, and digitalization has shown potential during the pandemic.
Article
Biochemistry & Molecular Biology
Michelle von Siebenthal, Akshay Akshay, Mustafa Besic, Marc P. Schneider, Ali Hashemi Gheinani, Fiona C. Burkhard, Katia Monastyrskaya
Summary: Bladder function following spinal cord injury (SCI) was examined by repeated urodynamic investigation (UDI) in awake restrained mice. Gene expression and morphological changes in the bladder were correlated with micturition parameters. A partial bladder outlet obstruction (pBOO) model was used for comparison. Results showed that SCI mice developed detrusor sphincter dyssynergia (DSD), while pBOO led to increased maximal bladder pressure. Transcriptome analysis revealed activation of Wnt and TGF-beta signaling in both neurogenic and obstructive LUTD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Urology & Nephrology
Stephanie A. Stalder, Oliver Gross, Collene E. Anderson, Lucas M. Bachmann, Sarah Baumann, Veronika Birkhauser, Mirjam Bywater, Giulio del Popolo, Daniel S. Engeler, Enrico Finazzi Agro, Susanne Friedl, Nuno Grilo, Stephan Kiss, Miriam Koschorke, Lorenz Leitner, Martina D. Liechti, Ulrich Mehnert, Stefania Musco, Helen Sadri, Lara Stachele, Jure Tornic, Stephanie van Der Lely, Stephen Wyler, Thomas M. Kessler
Summary: This study protocol describes a randomized controlled trial investigating the efficacy and safety of transcutaneous tibial nerve stimulation (TTNS) for refractory neurogenic lower urinary tract dysfunction (NLUTD). The primary outcome is improvement in bladder diary variables at study end compared to baseline values. Secondary outcomes include urodynamic, neurophysiological, and bowel function measures, as well as safety assessments.
Article
Biochemistry & Molecular Biology
Veronika Birkhauser, Collene E. Anderson, Marko Kozomara, Mirjam Bywater, Oliver Gross, Stephan Kiss, Stephanie C. Knupfer, Miriam Koschorke, Lorenz Leitner, Ulrich Mehnert, Helen Sadri, Ulla Sammer, Lara Stachele, Jure Tornic, Martina D. Liechti, Martin W. G. Brinkhof, Thomas M. Kessler
Summary: We developed a prediction model using clinical parameters to predict the occurrence of urodynamic risk factors for upper urinary tract damage within the first year after acute spinal cord injury. Two models showed fair discrimination and can be useful for clinical trial planning.
Article
Biochemistry & Molecular Biology
Stephanie A. Stalder, Stephanie van der Lely, Collene E. Anderson, Veronika Birkhauser, Armin Curt, Oliver Gross, Lorenz Leitner, Ulrich Mehnert, Martin Schubert, Jure Tornic, Thomas M. Kessler, Martina D. Liechti
Summary: Transcutaneous tibial nerve stimulation (TTNS) is a promising treatment for neurogenic lower urinary tract symptoms, but limited evidence and lack of standardized protocols exist. In this study, the authors aimed to develop a suitable sham-control protocol for TTNS in a clinical setting to maintain blinding and control for nonspecific effects.
Article
Biochemistry & Molecular Biology
Ulrich Mehnert, Matthias Walter, Lorenz Leitner, Thomas M. Kessler, Patrick Freund, Martina D. Liechti, Lars Michels
Summary: Overactive bladder (OAB) is a global problem that affects the quality of life of patients and increases healthcare costs. This study found differences in supraspinal connectivity between OAB patients and healthy controls, particularly in the frontal and prefrontal cortices.