Review
Oncology
Gildas Gabiache, Charline Zadro, Laura Rozenblum, Delphine Vezzosi, Celine Mouly, Matthieu Thoulouzan, Rosine Guimbaud, Philippe Otal, Lawrence Dierickx, Herve Rousseau, Christopher Trepanier, Laurent Dercle, Fatima-Zohra Mokrane
Summary: Summary Pheochromocytomas and paragangliomas (PPGLs) are rare neural-crest-derived tumors that present challenges in diagnosis and treatment due to their complexity. Medical imaging plays a crucial role in confirming the diagnosis, guiding surgical resection, and selecting appropriate therapies for these tumors. However, the conventional concepts of medical imaging are undergoing a paradigm shift with the development of radiomic and metabolic imaging. The use of artificial intelligence (AI) in PPGLs may provide valuable insights by detecting changes in tumor phenotype. Multicentric collaboration and further research are needed to validate and integrate these new imaging parameters into clinical practice. This review aims to provide a comprehensive tool for physicians dealing with PPGLs, augmented by perspectives of AI and big data.
Article
Oncology
Francesca Torresan, Arianna Beber, Donatella Schiavone, Stefania Zovato, Francesca Galuppini, Filippo Crimi, Filippo Ceccato, Maurizio Iacobone
Summary: The study analyzed the long-term outcomes in 170 patients who underwent surgery for pheochromocytoma and sympathetic paraganglioma (PHEO/sPGL). It was found that even apparently benign and sporadic variants had a risk of long-term recurrence, highlighting the importance of lifelong follow-up.
Review
Oncology
Jan Calissendorff, Carl Christofer Juhlin, Irina Bancos, Henrik Falhammar
Summary: Pheochromocytomas and abdominal paragangliomas (PPGLs) are rare tumors that can be discovered incidentally or during hormonal surveillance. Most cases are asymptomatic or have non-specific symptoms. PPGLs have malignant potential and require close surveillance. Genetic susceptibility is important for predicting the risk of recurrence or metastasis and identifying affected family members. Multidisciplinary management is essential for patients with PPGLs.
Review
Urology & Nephrology
Jose Viana Lima Junior, Claudio Elias Kater
Summary: Pheochromocytomas/paragangliomas (PPGL) are rare, metastatic, and potentially fatal neuroendocrine tumors with symptoms similar to other prevalent conditions, leading to delayed diagnosis and treatment. The diagnosis rate of PPGL is increasing with improved measurements and imaging procedures. Extensive research has been conducted on the genetic basis of PPGL, with more than 20 genes currently associated and potentially more to be discovered. This overview covers the clinical, laboratory, topographical, genetic diagnosis, and management of PPGL.
INTERNATIONAL BRAZ J UROL
(2023)
Article
Endocrinology & Metabolism
Minghao Li, Yazhi He, Yingxian Pang, Jing Zhang, Yu Feng, Yao He, Xiaowen Xu, Yongbao Wei, Dewen Zhong, Wanglong Deng, Long Wang, Bin Yan, Yazhuo Jiang, Ning Xu, Hai Cai, Yanlin Wen, Jinzhuo Ning, Yujun Liu, Xin Gao, Zhongyan Shan, Longfei Liu, Xiaochun Teng, Susan Richter, Jingjing Jiang
Summary: This study investigates the prevalence of IDH1 hotspot variants and associated phenotypes in a Chinese population with PPGL. The results show a low prevalence of IDH1 hotspot variants in Chinese PPGL patients, especially in those with apparently sporadic paragangliomas without mutations in major PPGL driver genes and with a non-adrenergic phenotype.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, General & Internal
Junne Kamihara, Kayla V. Hamilton, Jessica A. Pollard, Catherine M. Clinton, Jill A. Madden, Jasmine Lin, Alma Imamovic, Catherine B. Wall, Ari J. Wassner, Brent R. Weil, Matthew M. Heeney, Sara O. Vargas, William G. Kaelin, Katherine A. Janeway, Rodolfo F. Perini, Naseem J. Zojwalla, Stephan D. Voss, Steven G. DuBois
Summary: Treatment with belzutifan in a patient with Pacak-Zhuang syndrome led to tumor regression, normalized hemoglobin levels, and symptom resolution, demonstrating the effectiveness of targeted therapy for rare tumor predisposition syndromes.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Endocrinology & Metabolism
Hyojung Park, Min-Sun Kim, Jiwon Lee, Jung-Han Kim, Byong Chang Jeong, Sanghoon Lee, Suk-Koo Lee, Sung Yoon Cho, Dong-Kyu Jin
Summary: This study demonstrates that pediatric PPGL tends to be extra-adrenal and bilateral, with a higher potential for genetic mutations. Genetic screening tests are strongly recommended for pediatric PPGL due to their hereditary predisposition, and lifelong follow-up is necessary to detect recurrence and metastasis. Further research with a larger sample size and routine genetic screening is needed to better understand the genetic conditions and long-term prognosis of PPGL.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Stefanie Parisien-La Salle, Mathieu Provencal, Isabelle Bourdeau
Summary: The study found that CgA is a sensitive marker for diagnosing PHEO and thoracoabdominal paragangliomas. Additionally, CgA may have potential in monitoring nonfunctional PGLs as a tumor marker, as well as complementary role in early detection of recurrence in secreting PPGLs.
ENDOCRINE PRACTICE
(2021)
Article
Endocrinology & Metabolism
Roderick J. Clifton-Bligh
Summary: Diagnosis of pheochromocytoma or paraganglioma (PPGL) during pregnancy has historically led to high rates of maternal and fetal morbidity and mortality. Recent evidence suggests that early recognition of PPGL and appropriate medical management can improve outcomes. The need for antepartum surgery and the mode of delivery in PPGL cases are still controversial. It is important to offer genetic counseling and testing to women with PPGL in pregnancy, as they are often associated with heritable syndromes.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Article
Oncology
R. Garcia-Carbonero, F. Matute Teresa, E. Mercader-Cidoncha, M. Mitjavila-Casanovas, M. Robledo, I. Tena, C. Alvarez-Escola, M. Aristegui, M. R. Bella-Cueto, C. Ferrer-Albiach, F. A. Hanzu
Summary: Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors with complex diagnosis and treatment due to heterogeneity in etiology. This article provides practical clinical guidelines from a multidisciplinary perspective, covering various aspects including epidemiology, diagnosis, treatment, and follow-up recommendations.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2021)
Review
Endocrinology & Metabolism
Graeme Eisenhofer, Mirko Peitzsch, Nicole Bechmann, Angela Huebner
Summary: Catecholamine-producing tumors of childhood, including neuroblastoma, pheochromocytoma, and paraganglioma, have different diagnostic methods. While biopsy-dependent histopathology is used for neuroblastoma, biochemical tests for catecholamine excess are crucial for the diagnosis of PPGL. However, there are challenges in using these tests in children, and the true prevalence of childhood PPGL may be underestimated. Early identification and accurate diagnosis are important for improving therapeutic outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Gregory A. Kline, Jessica Boyd, Brenda Polzin, Adrian Harvey, Janice L. Pasieka, Hossein S. M. Sadrzadeh, Alexander A. Leung
Summary: The study found a poor-to-moderate correlation between urine and seated plasma metanephrines in outpatients without PPGL. Approximately 20% of high-risk patients with high urine metanephrines in the absence of PPGL also had high seated plasma metanephrines.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Jing Zhang, Minghao Li, Yingxian Pang, Cikui Wang, Jingjing Wu, Ziyun Cheng, Xiaomu Li, Zhiqiang Lu, Yujun Liu, Jianming Guo, Xiang Chen, Yao He, Xiao Guan, Xiaowen Xu, Yong Wang, Jiahao Liu, Wei Guo, Yingyong Hou, Longfei Liu, Jingjing Jiang, Xin Gao
Summary: More than half of patients with incidental PPGLs had mutations in common susceptibility genes. The search for susceptibility genes should take both the mode of discovery and tumor location into consideration.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Jiyeon Ahn, Ji Yun Park, Gyuri Kim, Sang-Man Jin, Kyu Yeon Hur, Soo-Youn Lee, Jae Hyeon Kim
Summary: Urinary free metanephrines are a reliable method for diagnosing PPGL in Asian populations, with high diagnostic accuracy. Compared to urinary fractionated metanephrines and plasma free metanephrines, urinary free metanephrines have similar AUC.
ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Oncology
Serena Martinelli, Francesca Amore, Tommaso Mello, Massimo Mannelli, Mario Maggi, Elena Rapizzi
Summary: This study demonstrates that metformin has different effects on cancer cells and fibroblasts, suggesting its potential in altering the tumor microenvironment homeostasis. Understanding the properties of the malignant tumor microenvironment could lead to the development of complementary strategies to target tumor spread and progression.
Meeting Abstract
Urology & Nephrology
J. A. Beilan, A. S. Baumgarten, M. Bickell, T. S. Hakky, R. E. Carrion
JOURNAL OF SEXUAL MEDICINE
(2017)
Article
Hematology
Ankush Bhatia, Gary Ulaner, Raajit Rampal, David M. Hyman, Omar Abdel-Wahab, Benjamin H. Durham, Ahmet Dogan, Neval Ozkaya, Mario E. Lacouture, Julio Hajdenberg, Chezi Ganzel, Eli L. Diamond
Article
Hematology
Ankush Bhatia, Gary Ulaner, Raajit Rampal, David M. Hyman, Omar Abdel-Wahab, Benjamin H. Durham, Ahmet Dogan, Neval Ozkaya, Mario E. Lacouture, Julio Hajdenberg, Chezi Ganzel, Eli L. Diamond
Article
Urology & Nephrology
Adam S. Baumgarten, Jonathan A. Beilan, Bhavik B. Shah, Aram Loeb, Michael Bickell, Justin Parker, Gerard D. Henry, Rafael E. Carrion
JOURNAL OF SEXUAL MEDICINE
(2019)
Article
Urology & Nephrology
Martin S. Gross, Lael Reinstatler, Gerard D. Henry, Stanton C. Honig, Peter J. Stahl, Arthur L. Burnett, Pedro P. Maria, Nelson E. Bennett, Bruce R. Kava, Tobias S. Kohler, Jonathan A. Beilan, Rafael E. Carrion, Ricardo M. Munarriz
JOURNAL OF SEXUAL MEDICINE
(2019)
Article
Andrology
Ujval Pathak, Adithya Balasubramanian, Jonathan A. Beilan, Mohit Butaney, Alexander J. Tatem, Nannan Thirumavalavan, Larry Lipshultz
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2019)
Review
Andrology
Alexander J. Tatem, Levi C. Holland, Jason Kovac, Jonathan A. Beilan, Larry I. Lipshultz
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2020)
Article
Urology & Nephrology
Seul Ku, Adithya Balasubramanian, Justin Yu, Ashwin Srivatsav, Jabez Gondokusumo, Alexander J. Tatem, Jonathan A. Beilan, Asad Hasan, James M. Hotaling, Larry I. Lipshultz, Alexander W. Pastuszak
Summary: This study evaluates YouTube videos focused on male infertility to assess information quality and identify high-quality content that can reliably facilitate care. Higher grades were associated with shorter video duration. Most videos were created by healthcare-related organizations and discussed male infertility evaluation methods and interventions.
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
(2021)
Letter
Hematology
Jacob Barish, Julio Hajdenberg
Review
Urology & Nephrology
Kareem Elgendi, Nicholas Zulia, Jonathan Beilan
Summary: This review discusses the clinical applications of penile duplex Doppler ultrasound (PDDU) in sexual medicine practices, including its indications, protocols, advantages, and limitations. It also provides a brief background on outdated diagnostic tests to give readers an understanding of the evolution of diagnostic testing in sexual medicine. Recent findings show that PDDU has become a key diagnostic tool for evaluating erectile dysfunction (ED) and Peyronie's disease (PD). By using intracavernosal injections and ultrasound technology, clinicians can accurately diagnose and develop appropriate treatment plans based on the hemodynamics of the patient's erection cycle. The review aims to improve understanding of PDDU techniques and interpretations related to male sexual function.
CURRENT UROLOGY REPORTS
(2023)
Review
Urology & Nephrology
Nicholas Zulia, Jonathan Beilan
Summary: This review explores minimally invasive BPH therapies, focusing on the sexual side effects of each treatment. Recent findings show that UroLift(R), Rezum(TM), and Aquablation have a lower risk of erectile or ejaculatory dysfunction compared to traditional transurethral resection of the prostate (TURP). Other treatment options may also become standard as more evidence regarding safety and efficacy emerges.
CURRENT SEXUAL HEALTH REPORTS
(2022)
Review
Andrology
Alexander J. Tatem, Jonathan Beilan, Jason R. Kovac, Larry Lipshultz
WORLD JOURNAL OF MENS HEALTH
(2020)
Review
Urology & Nephrology
Kirtishri Mishra, Aram Loeb, Laura Bukavina, Adam Baumgarten, Jonathan Beilan, Melissa Mendez, Lorenzo DiGiorgio, Liying Fu, Rafael Carrion
SEXUAL MEDICINE REVIEWS
(2020)
Review
Andrology
Nanfu Deng, Nannan Thirumavalavan, Jonathan A. Beilan, Alexander J. Tatem, Mark S. Hockenberry, Alexander W. Pastuszak, Larry I. Lipshultz
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2018)
Review
Urology & Nephrology
Jonathan A. Beilan, Jared J. Wallen, Adam S. Baumgarten, Kevin N. Morgan, Justin L. Parker, Rafael E. Carrion
SEXUAL MEDICINE REVIEWS
(2018)