Lentiviral vectors as tools to understand central nervous system biology in mammalian model organisms

Chimeric rabies SADB19-VSVg-pseudotyped lentiviral vectors mediate long-range retrograde transduction from the mouse spinal cord

(2015) L Schoderboeck et al.   GENE THERAPY

Patterned, But Not Tonic, Optogenetic Stimulation in Motor Thalamus Improves Reaching in Acute Drug-Induced Parkinsonian Rats

(2015) S. Seeger-Armbruster et al.   JOURNAL OF NEUROSCIENCE

Single-Cell Phenotyping within Transparent Intact Tissue through Whole-Body Clearing

(2014) Bin Yang et al.   CELL

Integrase-Deficient Lentivirus: Opportunities and Challenges for Human Gene Therapy

(2014) Kuan-Can Liu et al.   CURRENT GENE THERAPY

Injection parameters and virus dependent choice of promoters to improve neuron targeting in the nonhuman primate brain

(2014) W Lerchner et al.   GENE THERAPY

Orexin neurons suppress narcolepsy via 2 distinct efferent pathways

(2014) Emi Hasegawa et al.   JOURNAL OF CLINICAL INVESTIGATION

A Major External Source of Cholinergic Innervation of the Striatum and Nucleus Accumbens Originates in the Brainstem

(2014) D. Dautan et al.   JOURNAL OF NEUROSCIENCE

Improved transduction efficiency of a lentiviral vector for neuron-specific retrograde gene transfer by optimizing the junction of fusion envelope glycoprotein

(2014) Shigeki Kato et al.   JOURNAL OF NEUROSCIENCE METHODS

Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial

(2014) Stéphane Palfi et al.   LANCET

Optogenetics: the age of light

(2014) Michael Häusser   NATURE METHODS

Advanced CLARITY for rapid and high-resolution imaging of intact tissues

(2014) Raju Tomer et al.   Nature Protocols

Molecular neuroanatomy: a generation of progress

(2014) Jonathan D. Pollock et al.   TRENDS IN NEUROSCIENCES

Heritable and inducible gene knockdown in astrocytes or neurons in vivo by a combined lentiviral and RNAi approach

(2014) Fabrice Heitz et al.   Frontiers in Cellular Neuroscience

Mind-controlled transgene expression by a wireless-powered optogenetic designer cell implant

(2014) Marc Folcher et al.   Nature Communications

Recent advances in optogenetics and pharmacogenetics

(2013) Gary Aston-Jones et al.   BRAIN RESEARCH

Tracing Inputs to Inhibitory or Excitatory Neurons of Mouse and Cat Visual Cortex with a Targeted Rabies Virus

(2013) Yong-Jun Liu et al.   CURRENT BIOLOGY

Specificity and efficiency of reporter expression in adult neural progenitors vary substantially among nestin-CreERT2lines

(2013) Min-Yu Sun et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Mapping Brain Metabolic Connectivity in Awake Rats with  PET and Optogenetic Stimulation

(2013) P. K. Thanos et al.   JOURNAL OF NEUROSCIENCE

Structural and molecular interrogation of intact biological systems

(2013) Kwanghun Chung et al.   NATURE

Optical control of mammalian endogenous transcription and epigenetic states

(2013) Silvana Konermann et al.   NATURE

Improved tools for the Brainbow toolbox

(2013) Dawen Cai et al.   NATURE METHODS

SeeDB: a simple and morphology-preserving optical clearing agent for neuronal circuit reconstruction

(2013) Meng-Tsen Ke et al.   NATURE NEUROSCIENCE

Targeting neurons and photons for optogenetics

(2013) Adam M Packer et al.   NATURE NEUROSCIENCE

Engineering Approaches to Illuminating Brain Structure and Dynamics

(2013) Karl Deisseroth et al.   NEURON

LDL receptor and its family members serve as the cellular receptors for vesicular stomatitis virus

(2013) D. Finkelshtein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-term channelrhodopsin-2 (ChR2) expression can induce abnormal axonal morphology and targeting in cerebral cortex

(2013) Toshio Miyashita et al.   Frontiers in Neural Circuits

Optogenetic elevation of endogenous glucocorticoid level in larval zebrafish

(2013) Rodrigo J. De Marco et al.   Frontiers in Neural Circuits

Elucidating information processing in primate basal ganglia circuitry: a novel technique for pathway-selective ablation mediated by immunotoxin

(2013) Masahiko Takada et al.   Frontiers in Neural Circuits

Visualization and genetic modification of resident brain microglia using lentiviral vectors regulated by microRNA-9

(2013) Malin Åkerblom et al.   Nature Communications

Characterization of the Properties of Seven Promoters in the Motor Cortex of Rats and Monkeys After Lentiviral Vector-Mediated Gene Transfer

(2013) Masae Yaguchi et al.   Human Gene Therapy Methods

Intraspinal AAV Injections Immediately Rostral to a Thoracic Spinal Cord Injury Site Efficiently Transduces Neurons in Spinal Cord and Brain

(2013) Michelle C Klaw et al.   Molecular Therapy-Nucleic Acids

Optogenetic control of cell function using engineered photoreceptors

(2012) Gopal P. Pathak et al.   BIOLOGY OF THE CELL

Venezuelan equine encephalitis virus glycoprotein pseudotyping confers neurotropism to lentiviral vectors

(2012) A Trabalza et al.   GENE THERAPY

The case for brain imaging technology

(2012) Bernd Weber   NATURE

Deconstruction of a neural circuit for hunger

(2012) Deniz Atasoy et al.   NATURE

Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons

(2012) Dipesh Chaudhury et al.   NATURE

Spatiotemporal control of gene expression by a light-switchable transgene system

(2012) Xue Wang et al.   NATURE METHODS

Optogenetic investigation of neural circuits underlying brain disease in animal models

(2012) Kay M. Tye et al.   NATURE REVIEWS NEUROSCIENCE

Genetically encoded optical indicators for the analysis of neuronal circuits

(2012) Thomas Knöpfel   NATURE REVIEWS NEUROSCIENCE

In Vivo Optogenetic Control of Striatal and Thalamic Neurons in Non-Human Primates

(2012) Adriana Galvan et al.   PLoS One

Restricted Transgene Expression in the Brain with Cell-Type Specific Neuronal Promoters

(2012) Aurélie Delzor et al.   Human Gene Therapy Methods

The Development and Application of Optogenetics

(2011) Lief Fenno et al.   Annual Review of Neuroscience

Enhanced pseudotyping efficiency of HIV-1 lentiviral vectors by a rabies/vesicular stomatitis virus chimeric envelope glycoprotein

(2011) D C J Carpentier et al.   GENE THERAPY

Lentiviral-Mediated Gene Transfer to the Sheep Brain: Implications for Gene Therapy in Batten Disease

(2011) Kathryn S. Linterman et al.   HUMAN GENE THERAPY

Neuron-Specific Gene Transfer Through Retrograde Transport of Lentiviral Vector Pseudotyped with a Novel Type of Fusion Envelope Glycoprotein

(2011) Shigeki Kato et al.   HUMAN GENE THERAPY

Fragile X Mental Retardation Protein Regulates New Neuron Differentiation in the Adult Olfactory Bulb

(2011) S. Scotto-Lomassese et al.   JOURNAL OF NEUROSCIENCE

Subthalamic nucleus high-frequency stimulation generates a concomitant synaptic excitation-inhibition in substantia nigra pars reticulata

(2011) Clémentine Bosch et al.   JOURNAL OF PHYSIOLOGY-LONDON

AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial

(2011) Peter A LeWitt et al.   LANCET NEUROLOGY

Lentiviral Vector Integration Profiles Differ in Rodent Postmitotic Tissues

(2011) Cynthia C Bartholomae et al.   MOLECULAR THERAPY

Perfecting ChR2

(2011) Erika Pastrana   NATURE METHODS

Scale: a chemical approach for fluorescence imaging and reconstruction of transparent mouse brain

(2011) Hiroshi Hama et al.   NATURE NEUROSCIENCE

Two-photon calcium imaging of evoked activity from L5 somatosensory neurons in vivo

(2011) Wolfgang Mittmann et al.   NATURE NEUROSCIENCE

An optogenetic toolbox designed for primates

(2011) Ilka Diester et al.   NATURE NEUROSCIENCE

Remote Control of Neuronal Signaling

(2011) S. C. Rogan et al.   PHARMACOLOGICAL REVIEWS

A Genetically Encoded Tag for Correlated Light and Electron Microscopy of Intact Cells, Tissues, and Organisms

(2011) Xiaokun Shu et al.   PLOS BIOLOGY

A self-inactivating lentiviral vector for SCID-X1 gene therapy that does not activate LMO2 expression in human T cells

(2010) S. Zhou et al.   BLOOD

Immunohistochemical detection of transgene expression in the brain using small epitope tags

(2010) Evy Lobbestael et al.   BMC BIOTECHNOLOGY

Molecular and Cellular Approaches for Diversifying and Extending Optogenetics

(2010) Viviana Gradinaru et al.   CELL

Optogenetic experimentation on astrocytes

(2010) M. Figueiredo et al.   EXPERIMENTAL PHYSIOLOGY

Gene transfer in the nervous system and implications for transsynaptic neuronal tracing

(2010) Youngbuhm Huh et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

A Lentiviral Strategy for Highly Efficient Retrograde Gene Transfer by Pseudotyping with Fusion Envelope Glycoprotein

(2010) Shigeki Kato et al.   HUMAN GENE THERAPY

Social withdrawal and gambling-like profile after lentiviral manipulation of DAT expression in the rat accumbens

(2010) Walter Adriani et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Mapping brain networks in awake mice using combined optical neural control and fMRI

(2010) M. Desai et al.   JOURNAL OF NEUROPHYSIOLOGY

Optimal promoter usage for lentiviral vector-mediated transduction of cultured central nervous system cells

(2010) Mingjie Li et al.   JOURNAL OF NEUROSCIENCE METHODS

Global and local fMRI signals driven by neurons defined optogenetically by type and wiring

(2010) Jin Hyung Lee et al.   NATURE

Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures

(2010) Feng Zhang et al.   Nature Protocols

Oligodendrocyte degeneration and recovery after focal cerebral ischemia

(2010) S.R. McIver et al.   NEUROSCIENCE

Systematic Comparison of Constitutive Promoters and the Doxycycline-Inducible Promoter

(2010) Jane Yuxia Qin et al.   PLoS One

Lentivirus-mediated transgene delivery to the hippocampus reveals sub-field specific differences in expression

(2009) Lenneke WA van Hooijdonk et al.   BMC NEUROSCIENCE

Transneuronal circuit tracing with neurotropic viruses

(2009) Edward M Callaway   CURRENT OPINION IN NEUROBIOLOGY

Targeting central serotonergic neurons with lentiviral vectors based on a transcriptional amplification strategy

(2009) K Benzekhroufa et al.   GENE THERAPY

Inducible site-specific recombination in neural stem/progenitor cells

(2009) Jian Chen et al.   GENESIS

Neuron-specific RNA interference using lentiviral vectors

(2009) Troels Tolstrup Nielsen et al.   JOURNAL OF GENE MEDICINE

Parvalbumin neurons and gamma rhythms enhance cortical circuit performance

(2009) Vikaas S. Sohal et al.   NATURE

Millisecond-Timescale Optical Control of Neural Dynamics in the Nonhuman Primate Brain

(2009) Xue Han et al.   NEURON

Preferential labeling of inhibitory and excitatory cortical neurons by endogenous tropism of adeno-associated virus and lentivirus vectors

(2009) J.L. Nathanson et al.   NEUROSCIENCE

Engineered lentiviral vector targeting astrocytesIn vivo

(2008) Angélique Colin et al.   GLIA

Bimodal Viral Vectors and In Vivo Imaging Reveal the Fate of Human Neural Stem Cells in Experimental Glioma Model

(2008) K. Shah et al.   JOURNAL OF NEUROSCIENCE

A system for Cre-regulated RNA interference in vivo

(2008) P. Stern et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inducible Cre recombinase activity in mouse mature astrocytes and adult neural precursor cells

(2008) Lionel M. L. Chow et al.   TRANSGENIC RESEARCH

Barriers for retinal gene therapy: Separating fact from fiction

(2008) Rajendra Kumar-Singh   VISION RESEARCH

Noninvasive Molecular Neuroimaging Using Reporter Genes: Part I, Principles Revisited

(2007) T.F. Massoud et al.   AMERICAN JOURNAL OF NEURORADIOLOGY