Relationships between the amyloid precursor protein and its various proteolytic fragments and neuronal systems

APP processing in Alzheimer's disease

(2011) Yun-wu Zhang et al.   Molecular Brain

Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples

(2010) Douglas B. Kell   ARCHIVES OF TOXICOLOGY

Identifying dysfunctional crosstalk of pathways in various regions of Alzheimer's disease brains

(2010) Zhi-Ping Liu et al.   BMC Systems Biology

Interactome mapping suggests new mechanistic details underlying Alzheimer's disease

(2010) M. Soler-Lopez et al.   GENOME RESEARCH

sAPPα antagonizes dendritic degeneration and neuron death triggered by proteasomal stress

(2010) Ekaterini Copanaki et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein

(2010) S. O. Dahms et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Divergence of human and mouse brain transcriptome highlights Alzheimer disease pathways

(2010) Jeremy A. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A domain level interaction network of amyloid precursor protein and Aβ of Alzheimer's disease

(2010) Victoria M. Perreau et al.   PROTEOMICS

Vulnerabilities in the Tau Network and the Role of Ultrasensitive Points in Tau Pathophysiology

(2010) Theresa M. Yuraszeck et al.   PLoS Computational Biology

Interactions between the amyloid precursor protein C-terminal domain and G proteins mediate calcium dysregulation and amyloid β toxicity in Alzheimer’s disease

(2009) Gideon M. Shaked et al.   FEBS Journal

Neuroprotective Secreted Amyloid Precursor Protein Acts by Disrupting Amyloid Precursor Protein Dimers

(2009) Matthias Gralle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-Amyloid Impairs AMPA Receptor Trafficking and Function by Reducing Ca2+/Calmodulin-dependent Protein Kinase II Synaptic Distribution

(2009) Zhenglin Gu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Αβ Hinders Nuclear Targeting of AICD and Fe65 in Primary Neuronal Cultures

(2009) A. G. Henriques et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Interleukin-1β enhances nucleotide-induced and α-secretase-dependent amyloid precursor protein processing in rat primary cortical neurons via up-regulation of the P2Y2receptor

(2009) Qiongman Kong et al.   JOURNAL OF NEUROCHEMISTRY

Interaction of Reelin with Amyloid Precursor Protein Promotes Neurite Outgrowth

(2009) H.-S. Hoe et al.   JOURNAL OF NEUROSCIENCE

NMDA receptor-dependent signaling pathways that underlie amyloid β-protein disruption of LTP in the hippocampus

(2009) Ghiam Yamin   JOURNAL OF NEUROSCIENCE RESEARCH

Alzheimer β-amyloid blocks epileptiform activity in hippocampal neurons

(2009) Fernando J. Sepúlveda et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

CD74 interacts with APP and suppresses the production of Aβ

(2009) Shuji Matsuda et al.   Molecular Neurodegeneration

The interactome of the amyloid β precursor protein family members is shaped by phosphorylation of their intracellular domains

(2009) Robert Tamayev et al.   Molecular Neurodegeneration

Changing perspectives regarding late-life dementia

(2009) Majid Fotuhi et al.   Nature Reviews Neurology

Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain

(2009) J. E. Simpson et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Age, Neuropathology, and Dementia

(2009) George M. Savva et al.   NEW ENGLAND JOURNAL OF MEDICINE

In Vivo Turnover of Tau and APP Metabolites in the Brains of Wild-Type and Tg2576 Mice: Greater Stability of sAPP in the β-Amyloid Depositing Mice

(2009) Jose Morales-Corraliza et al.   PLoS One

Reelin signaling antagonizes  -amyloid at the synapse

(2009) M. S. Durakoglugil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deciphering complex mechanisms in neurodegenerative diseases: the advent of systems biology

(2009) Farshid Noorbakhsh et al.   TRENDS IN NEUROSCIENCES

Interaction with Amyloid β Peptide Compromises the Lipid Binding Function of Apolipoprotein E†

(2008) Shiori Tamamizu-Kato et al.   BIOCHEMISTRY

Structural Studies of the Transmembrane C-Terminal Domain of the Amyloid Precursor Protein (APP): Does APP Function as a Cholesterol Sensor?†‡

(2008) Andrew J. Beel et al.   BIOCHEMISTRY

α4β2 nicotinic acetylcholine receptors are required for the amyloid β protein-induced suppression of long-term potentiation in rat hippocampal CA1 region in vivo

(2008) M.N. Wu et al.   BRAIN RESEARCH BULLETIN

A Novel Sorting Nexin Modulates Endocytic Trafficking and α-Secretase Cleavage of the Amyloid Precursor Protein

(2008) Susanne Schöbel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin-1β up-regulates TACE to enhance α-cleavage of APP in neurons: resulting decrease in Aβ production

(2008) Yuriko Tachida et al.   JOURNAL OF NEUROCHEMISTRY

A novel reciprocal and biphasic relationship between membrane cholesterol and β-secretase activity in SH-SY5Y cells and in human platelets

(2008) Wei Wei Liu et al.   JOURNAL OF NEUROCHEMISTRY

A Systems Level Analysis of Transcriptional Changes in Alzheimer's Disease and Normal Aging

(2008) J. A. Miller et al.   JOURNAL OF NEUROSCIENCE

Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1

(2008) Tracy L Young-Pearse et al.   Neural Development

Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain

(2008) J.E. Simpson et al.   NEUROBIOLOGY OF AGING

Endogenous secreted amyloid precursor protein-α regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory

(2008) Chanel J. Taylor et al.   NEUROBIOLOGY OF DISEASE

M1 Muscarinic Agonists Target Major Hallmarks of Alzheimer’s Disease – The Pivotal Role of Brain M1 Receptors

(2008) Abraham Fisher   Neurodegenerative Diseases

Engineered Heparins: Novel β-Secretase Inhibitors as Potential Alzheimer’s Disease Therapeutics

(2008) S.J. Patey et al.   Neurodegenerative Diseases

Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo

(2008) John R. Cirrito et al.   NEURON

Transthyretin Protects against A-Beta Peptide Toxicity by Proteolytic Cleavage of the Peptide: A Mechanism Sensitive to the Kunitz Protease Inhibitor

(2008) Rita Costa et al.   PLoS One

Variations in the transcriptome of Alzheimer's disease reveal molecular networks involved in cardiovascular diseases

(2008) Monika Ray et al.   GENOME BIOLOGY

αv integrins mediate beta-amyloid induced inhibition of long-term potentiation

(2007) Qinwen Wang et al.   NEUROBIOLOGY OF AGING

Aβ1–42 modulation of Akt phosphorylation via α7 nAChR and NMDA receptors

(2007) Jonathan J. Abbott et al.   NEUROBIOLOGY OF AGING

Calcium dysregulation in Alzheimer's disease

(2007) Lukasz Bojarski et al.   NEUROCHEMISTRY INTERNATIONAL