Accelerating drug discovery for Alzheimer's disease: best practices for preclinical animal studies

Alzheimers Disease and Retinal Neurodegeneration

(2010) L. Guo et al.   Current Alzheimer Research

Identification of the oxidative stress proteome in the brain

(2010) Rukhsana Sultana et al.   FREE RADICAL BIOLOGY AND MEDICINE

Magnetic Resonance Imaging Detection and Time Course of Cerebral Microhemorrhages during Passive Immunotherapy in Living Amyloid Precursor Protein Transgenic Mice

(2010) F. Luo et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

‘Too much good news’ – are Alzheimer mouse models trying to tell us how to prevent, not cure, Alzheimer's disease?

(2010) Kathleen R. Zahs et al.   TRENDS IN NEUROSCIENCES

Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy

(2010) Emily S. Sena et al.   PLOS BIOLOGY

A γ-secretase inhibitor decreases amyloid-β production in the central nervous system

(2009) Randall J. Bateman et al.   ANNALS OF NEUROLOGY

Immunotherapy, Vascular Pathology, and Microhemorrhages in Transgenic Mice

(2009) Donna Wilcock et al.   CNS & Neurological Disorders-Drug Targets

Of Mice and Men

(2009) Hugo Geerts   CNS DRUGS

Development of semagacestat (LY450139), a functional γ-secretase inhibitor, for the treatment of Alzheimer's disease

(2009) David B Henley et al.   EXPERT OPINION ON PHARMACOTHERAPY

Progressive neuropathology and cognitive decline in a single Arctic APP transgenic mouse model

(2009) Annica Rönnbäck et al.   NEUROBIOLOGY OF AGING

Novel age-dependent learning deficits in a mouse model of Alzheimer's disease: Implications for translational research

(2009) K.S. Montgomery et al.   NEUROBIOLOGY OF AGING

Neurochemistry, Neuropathology, and Heredity in SAMP8: A Mouse Model of Senescence

(2009) Koji Tomobe et al.   NEUROCHEMICAL RESEARCH

Effects of γ-Secretase Inhibition on the Amyloid β Isoform Pattern in a Mouse Model of Alzheimer’s Disease

(2009) Erik Portelius et al.   Neurodegenerative Diseases

Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer's disease

(2009) D.M. Wilcock et al.   NEUROSCIENCE

Update of the Stroke Therapy Academic Industry Roundtable Preclinical Recommendations

(2009) Marc Fisher et al.   STROKE

Design, power, and interpretation of studies in the standard murine model of ALS

(2008) Sean Scott et al.   Amyotrophic Lateral Sclerosis

Progression of Amyloid Pathology to Alzheimer's Disease Pathology in an Amyloid Precursor Protein Transgenic Mouse Model by Removal of Nitric Oxide Synthase 2

(2008) D. M. Wilcock et al.   JOURNAL OF NEUROSCIENCE

New therapeutic targets in the neurovascular pathway in Alzheimer’s disease

(2008) Berislav V. Zlokovic   Neurotherapeutics

Small Molecule, Non-Peptide p75NTR Ligands Inhibit Aβ-Induced Neurodegeneration and Synaptic Impairment

(2008) Tao Yang et al.   PLoS One

Alcohol-induced retrograde memory impairment in rats: prevention by caffeine

(2008) Michael J. Spinetta et al.   PSYCHOPHARMACOLOGY