Article
Materials Science, Multidisciplinary
Ivana Jarak, Miguel Pereira-Silva, Ana Claudia Santos, Francisco Veiga, Horacio Cabral, Ana Figueiras
Summary: PMs are efficient NA delivery platforms that can manipulate gene expression and have enormous potential for treating life-threatening diseases. The facile manipulation of polymeric building blocks allows for tuning crucial parameters for NA protection and targeted delivery.
APPLIED MATERIALS TODAY
(2021)
Review
Biochemistry & Molecular Biology
Lei Xu, Yuan Cao, Ya Xu, Rong Li, Xiaoding Xu
Summary: Cancer development and progression are closely linked to the activation of oncogenes and loss of tumor suppressor genes. Nucleic acid drugs, such as siRNA, mRNA, and DNA, have been widely used for cancer therapy due to their ability to regulate the expression of cancer-associated genes. However, the negatively charged nature of nucleic acid drugs makes them susceptible to degradation and limits their ability to enter cells. To overcome this, specific delivery tools, such as nanoparticles, have been developed. In this review, the authors summarize the important genes and signaling pathways involved in the abnormal redox status of cancer cells, and discuss the recent development of redox-responsive nanoparticles for nucleic acid delivery and cancer therapy. The challenges and future development of nanoparticle-mediated nucleic acid delivery are also discussed.
MACROMOLECULAR BIOSCIENCE
(2023)
Review
Pharmacology & Pharmacy
Genada Sinani, Meltem Ezgi Durgun, Erdal Cevher, Yildiz Ozsoy
Summary: Nucleic acids can regulate gene expression specifically and have huge potential in disease prevention and treatment. However, their clinical translation is challenging due to rapid clearance, low stability, and limited cellular uptake. Polymeric micelles have emerged as suitable delivery vehicles for nucleic acids, with their versatile structures and ability to overcome barriers and enhance therapeutic efficacy. Various strategies, such as stimuli-sensitive groups and specific ligands, can be used to improve delivery, targeting, and cellular uptake of nucleic acids. Additionally, polymeric micelles can deliver both chemotherapeutic drugs and nucleic acid therapeutics simultaneously, achieving synergistic combination treatment.
Review
Medicine, Research & Experimental
Gang Chen, Bowen Zhao, Elena F. Ruiz, Fuwu Zhang
Summary: Nucleic acid vaccines, especially mRNA vaccines, have unique advantages in the COVID-19 pandemic. The use of polymeric materials as delivery carriers has greatly improved the development of nucleic acid vaccines for prevention and treatment. This review summarizes the different polymers and formulations used for nucleic acid vaccine delivery and discusses existing problems, coping strategies, and future prospects.
Review
Engineering, Biomedical
Chen Xu, Bingran Yu, Yu Qi, Nana Zhao, Fu-Jian Xu
Summary: This review focuses on the construction strategies and biomedical applications of cyclodextrin (CD)-based nucleic acid delivery systems. It covers the synthesis and properties of simple CD-grafted polycations, CD-related supramolecular assemblies, and CD-based organic/inorganic nanohybrids. The review aims to inspire the delicate design of CD-based nucleic acid delivery systems for potential clinical applications.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Chemistry, Analytical
Siying Xie, Zhirun Ji, Tiying Suo, Bingzhi Li, Xing Zhang
Summary: CRISPR/Cas technology, originating from bacteria's adaptive immune system, has been recognized by the Nobel Prize in Chemistry for its achievements in gene editing. It has a wide range of applications, including biosensors detection, with advantages such as high accuracy, specificity, rapid response, and integrity, attracting significant research interest. In addition to nucleic acid monitoring, CRISPR technology also shows promise in detecting various biomarkers, making it valuable to explore and summarize strategies for recognizing a broad range of targets.
ANALYTICA CHIMICA ACTA
(2021)
Review
Chemistry, Multidisciplinary
Fei Ding, Shuangye Zhang, Qian Chen, Hao Feng, Zhilei Ge, Xiaolei Zuo, Chunhai Fan, Qian Li, Qiang Xia
Summary: Programmable nucleic acid nanotechnology allows the customization of synthetic nucleic acid nanodevices with unprecedented precision, showing potential for precise immunoengineering.
Article
Chemistry, Multidisciplinary
Annette I. S. van den Berg, Chae-Ok Yun, Raymond M. Schiffelers, Wim E. Hennink
Summary: This review discusses the clinical applications of gene therapy using nucleic acids and the development of carrier systems, highlighting the drawbacks of viral vectors and the potential of non-viral carrier systems. It focuses on polymer-based nucleic acid formulations, known as polyplexes, summarizing different polymeric systems and addressing cellular barriers encountered by polyplexes. Attention is given to the clinical status of non-viral nucleic acid formulations.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Multidisciplinary
Jianbing Liu, Xuehe Lu, Tiantian Wu, Xiaohui Wu, Lin Han, Baoquan Ding
Summary: This study presents a novel strategy for constructing a nanoplatform that combines branched antisense DNA and siRNA for gene silencing. The multifunctional nucleic acid nanosystem efficiently inhibits tumor growth by targeting the tumor-associated gene PLK1 through combined gene silencing.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemistry & Molecular Biology
Ryohei Yamaji, Osamu Nakagawa, Yuki Kishimoto, Akane Fujii, Tomoki Matsumura, Taisuke Nakayama, Haruhiko Kamada, Takashi Osawa, Takao Yamaguchi, Satoshi Obika
Summary: This study demonstrates that using oligonucleotides (ONs) containing phenoxazine nucleobases can significantly enhance the therapeutic effect on mouse skeletal muscle diseases, which is of great importance for the treatment of skeletal muscle diseases.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Review
Engineering, Biomedical
Fan Rong, Tengjiao Wang, Qian Zhou, Haowei Peng, Jingtian Yang, Quli Fan, Peng Li
Summary: This review focuses on the design, preparation, and therapeutic applications of intelligent polymeric H2S delivery systems in cardiovascular therapy, inflammatory therapy, tissue regenerative therapy, cancer therapy and bacteria-associated therapy. Precise H2S therapies, especially imaging-guided H2S theranostics, are highlighted.
BIOACTIVE MATERIALS
(2023)
Review
Chemistry, Analytical
Siyu Chen, Bo Gong, Cong Zhu, Chunyang Lei, Zhou Nie
Summary: Nucleic acid molecules possess attractive properties for biosensing and bioimaging due to their high designability and structural predictability. CRISPR-Cas systems, with high programmability and flexibility, recognize and cleave nucleic acid targets and have been engineered as multifunctional tools. Integration of nucleic acids with CRISPR-Cas systems has advanced biosensing and bioimaging methodologies, holding great promise in biochemical research and clinical diagnosis.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Wioleta Borzecka, Adrian Dominski, Marek Kowalczuk
Summary: This perspective article summarizes the developments in the field of phthalocyanine-polymeric nanoparticle delivery systems for cancer photodynamic therapy over the past decade, highlighting the potential of these nanomaterials as advanced carriers for PDT while pointing out the need for further research.
Review
Biotechnology & Applied Microbiology
Ying Zhang, Qiqi Liu, Xinmeng Zhang, Haoqiang Huang, Shiqi Tang, Yujuan Chai, Zhourui Xu, Meirong Li, Xin Chen, Jia Liu, Chengbin Yang
Summary: Cancer is a global public health problem with challenging treatments. Gene therapy has emerged as a potential solution, but delivery methods are limiting its effectiveness. Exosomes, as therapeutic carriers and diagnostic markers, have gained extensive attention for their favorable characteristics. This review discusses the characteristics of exosomes, their applications in cancer therapy, and the challenges in exosome-mediated nucleic acid delivery for cancer treatment.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Nanoscience & Nanotechnology
Md. Abu Sufian, Marc A. Ilies
Summary: Lipid-based nucleic acid carriers have shown significant advantages in therapeutic delivery due to their large payload capacity, reduced immunogenicity, and ease of manufacture. This article provides a comprehensive review of the mechanisms, barriers, and properties of lipid-based systems, as well as their formulation parameters and manufacturing techniques. The success and failures of lipid-based nucleic acid delivery systems in clinical applications are also discussed.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)