Article
Orthopedics
Yueh-Hsiu Lu, Hsi-Hsien Lin, Hsuan-Ying Chen, Po-Hsin Chou, Shih-Tien Wang, Chien-Lin Liu, Ming-Chau Chang
Summary: Calcium pyrophosphate dihydrate deposition disease involving the cervical ligamentum flavum is rare, with specific clinical and imaging characteristics differentiating it from other conditions such as ossification of ligamentum flavum. Different image signs, including acute on chronic phenomenon, can help distinguish this condition from others.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Review
Orthopedics
Alan H. Daniels, Christopher L. McDonald, Bryce A. Basques, Eren O. Kuris
Summary: Ossification of the ligamentum flavum (OLF) is a spinal condition that can potentially cause compression of the spinal canal and neurological damage. The exact cause is debated but is likely related to gene overexpression and signaling pathways. Progressive myelopathy is the most common symptom, and radiographic analysis can show ossification in different areas. Surgical treatment options exist but may result in complications and postoperative neurological deficits.
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
(2022)
Article
Surgery
Qiangqiang Pan, Zhenhui Zhang, Yanyu Zhu, Wentao Jiang, Kai Su, Peilin Liu, Yongsheng Kang, Zhe Shao, Wei Mei, Qingde Wang
Summary: This study proposed a zoning laminectomy to reduce the incidence of nerve injury during spinal surgery for thoracic ossification of the ligamentum flavum (TOLF). Retrospective analysis of 45 TOLF patients who underwent zoning laminectomy showed that it was a safe and effective surgical option.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Genetics & Heredity
Baoliang Zhang, Guanghui Chen, Xiaoxi Yang, Tianqi Fan, Xi Chen, Zhongqiang Chen
Summary: Pathological changes in the ligamentum flavum, including hypertrophy and ossification, have unclear pathogenesis. MicroRNAs play a crucial role in regulating gene expression and revealing the pathological mechanisms of these changes. Studies have shown the importance of miRNAs in regulating ligamentum flavum pathology.
FRONTIERS IN GENETICS
(2021)
Review
Clinical Neurology
Yoshinori Ishikawa, Naohisa Miyakoshi, Michio Hongo, Yuji Kasukawa, Daisuke Kudo, Chiaki Sato, Yoichi Shimada
Summary: This case report presents successful treatment of coexisting cervical OLF and OPLL in a 70-year-old male patient. Surgical intervention led to significant improvement in symptoms and maintenance of cervical alignment. Surgeons should carefully evaluate the severity of adhesion, muscle damage, and necessity of posterior corrective surgery, as well as consider the patient's comorbidities and potential postoperative complications.
WORLD NEUROSURGERY
(2021)
Article
Chemistry, Multidisciplinary
Norihiro Nishida, Muzammil Mumtaz, Sudharshan Tripathi, Amey Kelkar, Takashi Sakai, Vijay K. Goel
Summary: Cervical laminoplasty may cause ligament damage during surgery, leading to increased biomechanical stresses in the cervical spine, especially during flexion motion.
APPLIED SCIENCES-BASEL
(2021)
Article
Clinical Neurology
Qiangqiang Pan, Yanyu Zhu, Zhenhui Zhang, Wei Mei, Qingde Wang
Summary: This study retrospectively analyzed the imaging characteristics of patients with thoracic ossification of ligamentum flavum combined with dural ossification and the clinical efficacy of zoning laminectomy. The symptoms of all patients significantly improved after surgery, and the average mJOA score increased from 5.0 preoperatively to 8.7 postoperatively. The average improvement rate was 62.6%. The conclusion is that zoning laminectomy is safe and effective.
EUROPEAN SPINE JOURNAL
(2023)
Article
Clinical Neurology
Yin Zhao, Bo Yuan, Li Cheng, Shengyuan Zhou, Yifan Tang, Zhichao Zhang, Yanqing Sun, Zheng Xu, Fengning Li, Xinyuan Liao, Xiongsheng Chen
Summary: This study induced ossification of ligamentum flavum (OLF) in rats using cyclic tensile stress, showing that longer duration of stress led to more visible osteogenesis. Western blot and RT-PCR analyses revealed increased expression of seven osteogenesis-related molecules in the experimental groups.
Article
Anatomy & Morphology
Qian Chen, Jue-han Wang, Yong Wang, Qing-yan Zhang, Jun-fei Feng, Ke Jiang, Xing-kuan Wang, Chao Xiang, Yu-ling Li
Summary: This study investigated the role of CX43 in TOLF and found that it promotes TOLF through the p38MAPK-RUNX2 pathway. Furthermore, it was discovered that RUNX2 can bind to the CX43 promoter, forming a positive feedback regulatory loop.
Article
Multidisciplinary Sciences
Jiabao Chen, Qingsong Yu, Haidong Wang, Huangda An, Chenhao Dou, Zhe Lu, Aoran Ding, Lei Ma
Summary: In this retrospective study, 91 patients with thoracic ossification of the ligamentum flavum (OLF) were included. It was found that the non-DO group had significantly higher residual area ratio (RAR) and short shaft ratio (SSR) compared to the DO group. SSR had a higher accuracy in predicting DO and could be a better predictor.
Article
Multidisciplinary Sciences
Kazuha Nakabachi, Tsutomu Endo, Masahiko Takahata, Ryo Fujita, Yoshinao Koike, Ryota Suzuki, Yuichi Hasegawa, Toshifumi Murakami, Katsuhisa Yamada, Hideki Sudo, Mohamad Alaa Terkawi, Ken Kadoya, Norimasa Iwasaki
Summary: Patients with lumbar ossification of the ligamentum flavum (OLF) may have a high risk of developing concomitant ossification of the entire spinal ligament, and the etiology is still unclear. This study investigated the propensity for spinal ligament ossification in asymptomatic individuals with lumbar OLF. The results showed that subjects with more lumbar OLF were more likely to have multilevel thoracic OLF and coexisting ossification of the posterior longitudinal ligament (OPLL).
SCIENTIFIC REPORTS
(2023)
Article
Engineering, Biomedical
Yi-ting Yang, Shi-jie Zhu, Meng-lei Xu, Liang-dong Zheng, Yu-ting Cao, Qing Yuan, Kai Zhang, Rui Zhu
Summary: Ossification of the ligamentum flavum (OLF) is a significant etiology of myelopathy. This study analyzed the effects of cervical OLF on spinal cord compression using a finite element model and found that cervical extension causes higher stress within the spinal cord.
MEDICAL ENGINEERING & PHYSICS
(2023)
Article
Clinical Neurology
Kaiqiang Sun, Xiaofei Sun, Jian Zhu, Fei Huang, Le Huan, Ximing Xu, Peng Zhang, Jingchuan Sun, Jiangang Shi
Summary: This study compared the safety and effectiveness of the bridge crane technique versus laminectomy for treating thoracic myelopathy caused by ossification of the ligamentum flavum. The results showed that the bridge crane technique may be relatively safe and effective in improving the clinical symptoms of patients with symptomatic thoracic OLF, but further high-quality studies are needed to validate these findings.
GLOBAL SPINE JOURNAL
(2023)
Article
Cell Biology
Xiaoxi Yang, Chuiguo Sun, Xiangyu Meng, Guanghui Chen, Tianqi Fan, Chi Zhang, Zhongqiang Chen
Summary: This study revealed the differential gene expression profile associated with LGR and Wnt signaling pathway in thoracic ligamentum flavum cells (TLFCs) during different stages of ossification through RNA sequencing and gene ontology enrichment analysis. The findings suggest that LGR5 enhances osteogenesis by activating the Wnt signaling pathway in thoracic ossification of the ligamentum flavum (TOLF).
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Baoliang Zhang, Lei Yuan, Guanghui Chen, Xi Chen, Xiaoxi Yang, Tianqi Fan, Chuiguo Sun, Dongwei Fan, Zhongqiang Chen
Summary: This study identifies obesity-related genes and explores their functional signatures in ligamentum flavum ossification (OLF). The results show that these genes are mainly involved in metabolism, inflammation, and immune-related processes. A crucial gene cluster associated with inflammatory/immune responses is identified. The core gene SOCS3 is found to be associated with immune infiltrates and methylation modifiers. This study provides insights into the molecular mechanisms and therapeutic targets of obesity-related OLF.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Clinical Neurology
Guilu He, Jianhao Lin, Jing Ye, Fobao Huang, Changzhi Yan, Zesi Liu, Xiuming Zhou, Qiao Li, Liang Zhang
Summary: This article introduces long tunneled external ventricular drain (LTEVD), which effectively avoids multiple surgeries by connecting an external shunt valve. It allows visual control of drainage flow, prolongs catheter indwelling time, and eliminates the need for multiple surgeries.
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Vinay Suresh, H. S. Suresh, Bharath Raju, Himanshu Jindal, Ahmad Ozair
Summary: This study investigated the outcomes of postoperative discitis treated with debridement and a novel technique focused on reducing outpatient antibiotic requirement in a low- and middle-income country (LMIC) setting. The results showed that patients with medically refractory postoperative discitis potentially have good outcomes after debridement plus 2-week local antibiotic instillation in LMICs.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Beatrice C. Bono, Davide Milani, Fabio Ferreli, Simone Olei, Luca Raspagliesi, Maria Pia Tropeano, Giovanni B. Lasio, Federico Pessina
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Avi A. Gajjar, Shrey Patel, Raj Swaroop Lavadi, Rida Mitha, Rohit Prem Kumar, Tavis Taylor, Galal A. Elsayed, D. Kojo Hamilton, Nitin Agarwal
Summary: Art in neurosurgery has played a crucial role in the discipline for centuries. Medical illustrations help visualize anatomy and surgical procedures, contributing to education, surgical planning, and navigation.
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Joaquin Perez Zabala, Yamila Basilotta Marquez, Romina Arganaraz, Beatriz Mantese
Summary: We present a low-cost and easily accessible adaptation system for stereotactic procedures in infants. By using a headband cast technique, a stereotactic biopsy was successfully performed in a 5-month-old patient, achieving precise targeting, histopathological diagnosis, and no associated complications.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Muhammad Kusdiansah, Arnau Benet, Yosuke Suzuki, Kenichi Haraguchi, Nakao Ota, Kosumo Noda, Rokuya Tanikawa
Summary: Fusiform vertebral artery aneurysms are difficult to treat, and endovascular and open microsurgical treatments are used for different situations. This report presents a case with complex anatomy and branch involvement and describes the treatment strategy used.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Victor M. Lu
Summary: This review emphasizes four essential domains that should be considered when interpreting pediatric neurosurgical SRMAs and provides examples to ensure accurate and effective interpretation of findings in this niche.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Lapo Bonosi, Angelo Torrente, Filippo Brighina, Cateno Concetto Tito Petralia, Pietro Merlino, Chiara Avallone, Vincenzo Gulino, Roberta Costanzo, Lara Brunasso, Domenico Gerardo Iacopino, Rosario Maugeri
Summary: Corticocortical evoked potentials (CCEPs) have emerged as a valuable intraoperative monitoring technique in eloquent brain tumor surgery, aiding in preserving critical functional areas. Current research shows the potential of CCEPs in guiding surgical decision making, reducing the risk of postoperative neurological deficits, and mapping functional connectivity, but further research and standardization are needed.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Yuchen Duan, Dagang Feng, Min Zhu, Heng Qiu, Tong Li, Zhen Chen, Leiming Jiang, Yong Huang
Summary: This study aimed to compare the effect of different Modic changes (MC) grades on the cage subsidence rate after spinal interbody fusion surgery. A meta-analysis was conducted on relevant randomized controlled trials and cohort studies. The results showed that MC may be associated with a higher cage subsidence rate. With the increase in MC grades, the incidence of subsidence decreased gradually, but it was always higher than that in the non-Modic changes (NMC). Oblique lumbar interbody fusion may be a better treatment choice for lumbar degenerative disease with MC.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Brian F. Saway, Conor M. Cunningham, Mustafa Ismail, Alejandro M. Spiotta
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Joanna M. Roy, Michael M. Covell, Carmelo Venero Jr, Christian A. Bowers
Summary: Early exposure to neurosurgery during medical school is critical for improving recruitment into the specialty. However, about 30% of medical schools in the U.S. lack a neurosurgery program, limiting students' exposure to the field. Virtual education, facilitated by webinars during the pandemic, has advantages such as global outreach and accessibility for international medical students. This review identifies and describes 16 educational resources, serving as a guide for medical students interested in neurosurgery.
WORLD NEUROSURGERY
(2024)
