The changing immune system in sepsis

Recombinant Human Activated Protein C as a Therapy for Severe Sepsis: Lessons Learned?

(2013) Steven M. Opal et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis

(2013) Steven M. Opal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach

(2013) Richard S Hotchkiss et al.   LANCET INFECTIOUS DISEASES

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Historical Perspective on Sepsis

(2012) Peter A. Ward et al.   AMERICAN JOURNAL OF PATHOLOGY

Effects of Recombinant Human Interleukin 7 on T-Cell Recovery and Thymic Output in HIV-Infected Patients Receiving Antiretroviral Therapy: Results of a Phase I/IIa Randomized, Placebo-Controlled, Multicenter Study

(2012) Y. Lévy et al.   CLINICAL INFECTIOUS DISEASES

The immune response to severe bacterial infections: consequences for therapy

(2012) Evangelos J Giamarellos-Bourboulis et al.   Expert Review of Anti-Infective Therapy

IL-7 Restores Lymphocyte Functions in Septic Patients

(2012) F. Venet et al.   JOURNAL OF IMMUNOLOGY

Interleukin-7 Ameliorates Immune Dysfunction and Improves Survival in a 2-Hit Model of Fungal Sepsis

(2012) Jacqueline Unsinger et al.   JOURNAL OF INFECTIOUS DISEASES

BTLA expression contributes to septic morbidity and mortality by inducing innate inflammatory cell dysfunction

(2012) N. J. Shubin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Increased proportion of CD4+CD25+Foxp3+ regulatory T cells during early-stage sepsis in ICU patients

(2012) Feng-Ying Leng et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Sepsis studies need new direction

(2012) Jonathan Cohen et al.   LANCET INFECTIOUS DISEASES

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

(2012) Julie R. Brahmer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

IL-7 in human health and disease

(2012) Wangko Lundström et al.   SEMINARS IN IMMUNOLOGY

Interleukin-7 and immune reconstitution in cancer patients: a new paradigm for dramatically increasing overall survival

(2012) Michel Morre et al.   Targeted Oncology

Peroxisome Proliferator–activated Receptor γ–induced T Cell Apoptosis Reduces Survival during Polymicrobial Sepsis

(2011) Martina Victoria Schmidt et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mechanism of T cell exhaustion in a chronic environment

(2011) Hyun-Tak Jin et al.   BMB Reports

Prospects for TIM3-Targeted Antitumor Immunotherapy

(2011) S. F. Ngiow et al.   CANCER RESEARCH

Anti-TIM3 Antibody Promotes T Cell IFN- -Mediated Antitumor Immunity and Suppresses Established Tumors

(2011) S. F. Ngiow et al.   CANCER RESEARCH

Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases

(2011) Andreas Strasser et al.   EMBO JOURNAL

Immunomodulatory therapy for sepsis: an update

(2011) Eirini Christaki et al.   Expert Review of Anti-Infective Therapy

Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure

(2011) Jonathan S. Boomer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Search for Effective Therapy for Sepsis

(2011) Derek C. Angus   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Immunologic Alterations and the Pathogenesis of Organ Failure in the ICU

(2011) Steven Opal   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

Interleukin-15 biology and its therapeutic implications in cancer

(2011) Jason C. Steel et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Binding of Superantigen Toxins into the CD28 Homodimer Interface Is Essential for Induction of Cytokine Genes That Mediate Lethal Shock

(2011) Gila Arad et al.   PLOS BIOLOGY

Th17 and Regulatory T Cells in Mediating and Restraining Inflammation

(2010) Dan R. Littman et al.   CELL

Phase I Study of Recombinant Human Interleukin-7 Administration in Subjects with Refractory Malignancy

(2010) C. Sportes et al.   CLINICAL CANCER RESEARCH

Prevalence and mortality associated with cytomegalovirus infection in nonimmunosuppressed patients in the intensive care unit*

(2010) Andre C. Kalil et al.   CRITICAL CARE MEDICINE

The CD4-like molecule LAG-3, biology and therapeutic applications

(2010) Sophie Sierro et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

T-cell exhaustion: characteristics, causes and conversion

(2010) John S. Yi et al.   IMMUNOLOGY

Interleukin-7 (IL-7) Treatment Accelerates Neutrophil Recruitment through    T-Cell IL-17 Production in a Murine Model of Sepsis

(2010) K. R. Kasten et al.   INFECTION AND IMMUNITY

Immunoparalysis and nosocomial infection in children with multiple organ dysfunction syndrome

(2010) Mark W. Hall et al.   INTENSIVE CARE MEDICINE

Sepsis-Induced Apoptosis Leads to Active Suppression of Delayed-Type Hypersensitivity by CD8+ Regulatory T Cells through a TRAIL-Dependent Mechanism

(2010) J. Unsinger et al.   JOURNAL OF IMMUNOLOGY

IL-7 Promotes T Cell Viability, Trafficking, and Functionality and Improves Survival in Sepsis

(2010) J. Unsinger et al.   JOURNAL OF IMMUNOLOGY

An early circulating factor in severe sepsis modulates apoptosis of monocytes and lymphocytes

(2010) Ilia Vaki et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis

(2010) P. Brahmamdam et al.   JOURNAL OF LEUKOCYTE BIOLOGY

ICU-acquired immunosuppression and the risk for secondary fungal infections

(2010) Guillaume Monneret et al.   MEDICAL MYCOLOGY

Immunotherapy for Sepsis — A New Approach against an Ancient Foe

(2010) Richard S. Hotchkiss et al.   NEW ENGLAND JOURNAL OF MEDICINE

T-CELL ACTIVATION DIFFERENTIALLY MEDIATES THE HOST RESPONSE TO SEPSIS

(2010) Kevin R. Kasten et al.   SHOCK

An Enigmatic Tail of CD28 Signaling

(2010) J. S. Boomer et al.   Cold Spring Harbor Perspectives in Biology

Granulocyte–Macrophage Colony-stimulating Factor to Reverse Sepsis-associated Immunosuppression

(2009) Christian Meisel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

IL-7 administration drives T cell-cycle entry and expansion in HIV-1 infection

(2009) I. Sereti et al.   BLOOD

Randomized, double-blind, placebo-controlled trial of granulocyte colony-stimulating factor in patients with septic shock

(2009) Dianne P. Stephens et al.   CRITICAL CARE MEDICINE

Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008

(2009) R Phillip Dellinger et al.   CRITICAL CARE MEDICINE

The role of T regulatory cells in human sepsis

(2009) Aharon Kessel et al.   JOURNAL OF AUTOIMMUNITY

IL-15 Prevents Apoptosis, Reverses Innate and Adaptive Immune Dysfunction, and Improves Survival in Sepsis

(2009) S. Inoue et al.   JOURNAL OF IMMUNOLOGY

Sepsis-induced human lymphocyte apoptosis and cytokine production in “humanized” mice

(2009) Jacqueline Unsinger et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The sepsis seesaw: tilting toward immunosuppression

(2009) Richard S Hotchkiss et al.   NATURE MEDICINE

Cell Death

(2009) Richard S. Hotchkiss et al.   NEW ENGLAND JOURNAL OF MEDICINE

PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis

(2009) X. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Treatment with granulocyte–macrophage colony-stimulating factor is associated with reduced indoleamine 2,3-dioxygenase activity and kynurenine pathway catabolites in patients with severe sepsis and septic shock

(2009) Joerg C. Schefold et al.   SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES

The cytokine storm and factors determining the sequence and severity of organ dysfunction in multiple organ dysfunction syndrome

(2008) Houli Wang et al.   AMERICAN JOURNAL OF EMERGENCY MEDICINE

PD-1 and Its Ligands in Tolerance and Immunity

(2008) Mary E. Keir et al.   Annual Review of Immunology

Predictors of 30-Day Mortality and Hospital Costs in Patients With Ventilator-Associated Pneumonia Attributed to Potentially Antibiotic-Resistant Gram-Negative Bacteria

(2008) Katherine E. Kollef et al.   CHEST

Downregulation of CD40 Ligand Response in Monocytes from Sepsis Patients

(2008) A. Sinistro et al.   Clinical and Vaccine Immunology

Increased mortality in long-term intensive care patients with active cytomegalovirus infection*

(2008) Malte Ziemann et al.   CRITICAL CARE MEDICINE

Animal models of sepsis: Why does preclinical efficacy fail to translate to the clinical setting?

(2008) Alex Dyson et al.   CRITICAL CARE MEDICINE

Molecular biology of inflammation and sepsis: A primer*

(2008) Ismail Cinel et al.   CRITICAL CARE MEDICINE

Apoptosis in Sepsis: Mechanisms, Clinical Impact and Potential Therapeutic Targets

(2008) Alfred Ayala et al.   CURRENT PHARMACEUTICAL DESIGN

Twelve immunotherapy drugs that could cure cancers

(2008) Martin A. ‘Mac’ Cheever   IMMUNOLOGICAL REVIEWS

Increased circulating regulatory T cells (CD4+CD25+CD127−) contribute to lymphocyte anergy in septic shock patients

(2008) Fabienne Venet et al.   INTENSIVE CARE MEDICINE

Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets

(2008) Claude Sportès et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Efficacy and Safety of Renal Tubule Cell Therapy for Acute Renal Failure

(2008) J. Tumlin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

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(2008) Stefanie Flohe et al.   MOLECULAR MEDICINE

Immunoparalysis and Adverse Outcomes from Critical Illness

(2008) W. Joshua Frazier et al.   PEDIATRIC CLINICS OF NORTH AMERICA

The PD-1/PD-L costimulatory pathway critically affects host resistance to the pathogenic fungus Histoplasma capsulatum

(2008) E. Lazar-Molnar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology

Role of Toll-like receptor responses for sepsis pathogenesis

(2007) Heike Weighardt et al.   IMMUNOBIOLOGY

Host–pathogen interactions in sepsis

(2007) Tom van der Poll et al.   LANCET INFECTIOUS DISEASES