The fungal UPR

Aspergillosis due to Voriconazole Highly Resistant Aspergillus fumigatus and Recovery of Genetically Related Resistant Isolates From Domiciles

(2013) Jan W. M. van der Linden et al.   CLINICAL INFECTIOUS DISEASES

Undressing the Fungal Cell Wall/Cell Membrane - the Antifungal Drug Targets

(2013) Rui Tada et al.   CURRENT PHARMACEUTICAL DESIGN

Effects of a Defective Endoplasmic Reticulum-Associated Degradation Pathway on the Stress Response, Virulence, and Antifungal Drug Susceptibility of the Mold Pathogen Aspergillus fumigatus

(2013) Karthik Krishnan et al.   EUKARYOTIC CELL

Essential Roles of the Kar2/BiP Molecular Chaperone Downstream of the UPR Pathway in Cryptococcus neoformans

(2013) Kwang-Woo Jung et al.   PLoS One

Dissection of Ire1 Functions Reveals Stress Response Mechanisms Uniquely Evolved in Candida glabrata

(2013) Taiga Miyazaki et al.   PLoS Pathogens

Structural Basis of the Unfolded Protein Response

(2012) Alexei Korennykh et al.   Annual Review of Cell and Developmental Biology

The Unfolded Protein Response in Secretory Cell Function

(2012) Kristin A. Moore et al.   Annual Review of Genetics

Blockade of XBP1 splicing by inhibition of IRE1  is a promising therapeutic option in multiple myeloma

(2012) N. Mimura et al.   BLOOD

Cleaning Up: ER-Associated Degradation to the Rescue

(2012) Jeffrey L. Brodsky   CELL

The PATH (Prospective Antifungal Therapy) Alliance® registry and invasive fungal infections: update 2012

(2012) Nkechi Azie et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Hypoxia and Fungal Pathogenesis: To Air or Not To Air?

(2012) Nora Grahl et al.   EUKARYOTIC CELL

Expression and secretion of Aspergillus fumigatus proteases are regulated in response to different protein substrates

(2012) Edward Farnell et al.   Fungal Biology

Invasive fungal infections in solid organ transplant recipients

(2012) Shmuel Shoham et al.   Future Microbiology

Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors

(2012) Likun Wang et al.   Nature Chemical Biology

Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing

(2012) M Ri et al.   Blood Cancer Journal

Iron homeostasis—Achilles’ heel of Aspergillus fumigatus?

(2011) Markus Schrettl et al.   CURRENT OPINION IN MICROBIOLOGY

Ccr4 Promotes Resolution of the Endoplasmic Reticulum Stress Response during Host Temperature Adaptation in Cryptococcus neoformans

(2011) Virginia E. Havel et al.   EUKARYOTIC CELL

Disruption of the Phospholipase D Gene Attenuates the Virulence of Aspergillus fumigatus

(2011) Xianping Li et al.   INFECTION AND IMMUNITY

Shaping the fungal adaptome – Stress responses of Aspergillus fumigatus

(2011) Thomas Hartmann et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Potent and Selective Inhibitors of the Inositol-requiring Enzyme 1 Endoribonuclease

(2011) Kori Volkmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The unfolded protein response supports cellular robustness as a broad-spectrum compensatory pathway

(2011) G. Thibault et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

InterfERing with endoplasmic reticulum stress

(2011) Honorata Kraskiewicz et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The virulence of the opportunistic fungal pathogenAspergillus fumigatusrequires cooperation between the endoplasmic reticulum-associated degradation pathway (ERAD) and the unfolded protein response (UPR)

(2011) Daryl L. Richie et al.   Virulence

Unique Evolution of the UPR Pathway with a Novel bZIP Transcription Factor, Hxl1, for Controlling Pathogenicity of Cryptococcus neoformans

(2011) Seon Ah Cheon et al.   PLoS Pathogens

HacA-Independent Functions of the ER Stress Sensor IreA Synergize with the Canonical UPR to Influence Virulence Traits in Aspergillus fumigatus

(2011) Xizhi Feng et al.   PLoS Pathogens

Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma

(2010) I. Papandreou et al.   BLOOD

NamingAspergillusspecies: progress towards one name for each species

(2010) David L. Hawksworth   MEDICAL MYCOLOGY

Secretion stress and antifungal resistance: An Achilles’ heel ofAspergillus fumigatus?

(2010) Daryl L. Richie et al.   MEDICAL MYCOLOGY

Hospital costs and outcomes among intravenous antifungal therapies for patients with invasive aspergillosis in the United States

(2010) Aryun Kim et al.   MYCOSES

IRE1α Disruption Causes Histological Abnormality of Exocrine Tissues, Increase of Blood Glucose Level, and Decrease of Serum Immunoglobulin Level

(2010) Takao Iwawaki et al.   PLoS One

HacA-Dependent Transcriptional Switch ReleaseshacAmRNA from a Translational Block upon Endoplasmic Reticulum Stress

(2009) Harm J. Mulder et al.   EUKARYOTIC CELL

Stress-sensing mechanisms in the unfolded protein response: similarities and differences between yeast and mammals

(2009) K. Kohno   JOURNAL OF BIOCHEMISTRY

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

(2009) Julie Hollien et al.   JOURNAL OF CELL BIOLOGY

Cotranslational Targeting of XBP1 Protein to the Membrane Promotes Cytoplasmic Splicing of Its Own mRNA

(2009) Kota Yanagitani et al.   MOLECULAR CELL

Aspergillosis

(2009) Brahm H. Segal   NEW ENGLAND JOURNAL OF MEDICINE

Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability

(2009) T. Iwawaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Role for the Unfolded Protein Response (UPR) in Virulence and Antifungal Susceptibility in Aspergillus fumigatus

(2009) Daryl L. Richie et al.   PLoS Pathogens

Impact of the unfolded protein response upon genome-wide expression patterns, and the role of Hac1 in the polarized growth, of Candida albicans

(2008) Tithira T. Wimalasena et al.   FUNGAL GENETICS AND BIOLOGY

Sub-Telomere Directed Gene Expression during Initiation of Invasive Aspergillosis

(2008) Andrew McDonagh et al.   PLoS Pathogens

A Sterol-Regulatory Element Binding Protein Is Required for Cell Polarity, Hypoxia Adaptation, Azole Drug Resistance, and Virulence in Aspergillus fumigatus

(2008) Sven D. Willger et al.   PLoS Pathogens