Article
Oncology
Wei Hong, Ang Li, Yanhong Liu, Xiangjun Xiao, David C. Christiani, Rayjean J. Hung, James McKay, John Field, Christopher Amos, Chao Cheng
Summary: Analysis of whole-exome sequencing data reveals correlations between clonal hematopoiesis and lung cancer risk factors, identifies genetic variants associated with clonal hematopoiesis, and uncovers numerous potential novel clonal hematopoiesis mutations.
Article
Medicine, General & Internal
Alberto Caballero-Vazquez, Jose Luis Romero-Bejar, Luis Albendin-Garcia, Nora Suleiman-Martos, Jose Luis Gomez-Urquiza, Gustavo Raul Canadas, Guillermo Arturo De la Fuente
Summary: This study analyzed two stepwise binary logistic regression models to predict prognosis in patients with lung cancer, identifying important factors related to survival and confirming the significance of treatment in terms of survival.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Jie Ding, Zhenxing Tu, Hongquan Chen, Zhiguang Liu
Summary: The study found a causal relationship between smoking behavior and lung cancer, with quitting smoking reducing the risk. An increase in BMI leads to an increase in daily cigarette consumption, and elevated systolic blood pressure also marginally increases smoking intensity.
Article
Immunology
Seong Mi Moon, Hayoung Choi, Sang Hyuk Kim, Hyung Koo Kang, Dong Won Park, Jin Hyung Jung, Kyungdo Han, Dong Wook Shin, Hyun Lee
Summary: This study comprehensively evaluated the risk of lung cancer in tuberculosis survivors, considering smoking and chronic obstructive pulmonary disease (COPD). The results showed that tuberculosis survivors had a 1.72-fold higher risk of lung cancer compared to the control group. Current smokers with >= 20 pack-years and tuberculosis survivors with COPD had the highest risks. Risk factors for lung cancer in tuberculosis survivors included pulmonary tuberculosis, age >60 years, smoking, and the presence of COPD or asthma.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Psychology, Multidisciplinary
Maria Angelina Pereira, Antonio Araujo, Mario Simoes, Catarina Costa
Summary: This systematic review examined the association between psychological factors and the risk of breast and lung cancer prior to diagnosis. Despite conflicting results, psychological factors may play a significant role in the etiology of both breast and lung cancer. Considering psychological factors as a variable affecting cancer development could be crucial in advancing prevention and intervention strategies.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Maria Teresa Landi, Naoise C. Synnott, Jennifer Rosenbaum, Tongwu Zhang, Bin Zhu, Jianxin Shi, Wei Zhao, Michael Kebede, Jian Sang, Jiyeon Choi, Laura Mendoza, Marwil Pacheco, Belynda Hicks, Neil E. Caporaso, Mustapha Abubakar, Dmitry A. Gordenin, David C. Wedge, Ludmil B. Alexandrov, Nathaniel Rothman, Qing Lan, Montserrat Garcia-Closas, Stephen J. Chanock
Summary: The Sherlock-Lung study investigates cancer etiology by studying somatic mutational signatures imprinted on the cellular genome. By integrating various data sources, the study aims to classify LCINS into subtypes that could reveal distinct risk factors. Challenges and potential for this approach in future epidemiologic studies are discussed.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Oncology
Jiayi Shen, Huaqiang Zhou, Jiaqing Liu, Yaxiong Zhang, Ting Zhou, Yunpeng Yang, Wenfeng Fang, Yan Huang, Li Zhang
Summary: This study constructed a modifiable risk factors atlas of lung cancer using Mendelian randomization framework, finding higher socioeconomic status to be significantly correlated with lower lung cancer risk, while smoking, TV watching time, and certain fatty acids in blood associated with higher risk.
Article
Oncology
Wei Guo, Tao Zhang, Runze Li, Xiaoxi Chen, Jiaohui Pang, Hua Bao, Xue Wu, Yang Shao, Bin Qiu, Shugeng Gao, Jie He
Summary: Locoregional recurrence is a high-risk factor for poor prognosis in NSCLC, and its associated genomic biomarkers have been inadequately studied. This study identified genomic biomarkers from tumor and ctDNA samples that showed promising prognostic value for patients with locoregional recurrence only.
Review
Oncology
Wen Tang, Wan-Qing Zhang, Shi-Qi Hu, Wang-Qin Shen, Hong-Lin Chen
Summary: The scoping review aimed to explore the high-risk period of suicide among lung cancer patients after diagnosis and identify the risk factors behind suicidal behaviors. Results showed that lung cancer patients have a higher incidence of suicidal death in the first years after diagnosis, especially in males and older patients. Risk factors for suicidal death include gender, prognosis, marital status, and age.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Oncology
Amanda Fisher, Seongho Kim, Dina Farhat, Kimberly Belzer, MaryAnn Milczuk, Courtney French, Hirva Mamdani, Ammar Sukari, Frank Baciewicz, Ann G. Schwartz, Antoinette Wozniak, Misako Nagasaka
Summary: The study found that surgical resection for initial primary lung cancer increases the risk of developing second primary lung cancer, highlighting the importance of close monitoring for these patients. Factors such as age and smoking history were not associated with second primary lung cancer risk, indicating the need for further research in this area.
CLINICAL LUNG CANCER
(2021)
Article
Biology
Karsten M. Heil, Matthias Helmschrott, Fabrice F. Darche, Tom Bruckner, Philipp Ehlermann, Michael M. Kreusser, Andreas O. Doesch, Wiebke Sommer, Gregor Warnecke, Norbert Frey, Rasmus Rivinius
Summary: This study examined the risk factors, treatment, and prognosis of post-transplant lung cancer in patients who received heart transplantation. Recipient age, COPD, and history of smoking were identified as risk factors for post-transplant lung cancer. Patients diagnosed in early stages had significantly better survival rates, emphasizing the importance of routine reassessment of smoking status and intensified lung cancer screening for high-risk heart transplant recipients.
Article
Critical Care Medicine
Junjie Huang, Yunyang Deng, Man Sing Tin, Veeleah Lok, Chun Ho Ngai, Lin Zhang, Don Eliseo Lucero-Prisno, Wanghong Xu, Zhi-Jie Zheng, Edmar Elcarte, Mellissa Withers, Martin C. S. Wong
Summary: Lung cancer is the second most common cancer and the leading cause of cancer death worldwide. Its incidence and mortality rates are associated with Human Development Index, Gross Domestic Products, and smoking prevalence. Most countries show increasing trends in lung cancer incidence and mortality among females, but decreasing trends among males. Measures to control the increasing trends among females and early cancer detection should be implemented in these regions.
Article
Oncology
Elvin S. Cheng, Marianne F. Weber, Julia Steinberg, Karen Canfell, Xue Qin Yu
Summary: This study investigated the risk factors for lung cancer among never-smoking individuals in Australia. The findings suggest that individuals born in Asia have a higher risk of developing lung cancer compared to those born elsewhere. This finding is important for assessing lung cancer risk among never-smoking individuals.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Oncology
Emilia Rissanen, Sanna Heikkinen, Karri Seppa, Heidi Ryynanen, Johan G. Eriksson, Tommi Harkanen, Pekka Jousilahti, Paul Knekt, Seppo Koskinen, Satu Mannisto, Ossi Rahkonen, Harri Rissanen, Nea Malila, Maarit A. Laaksonen, Janne Pitkaniemi
Summary: The study found a decreasing trend in lung cancer incidence among never smoking men in Finland, while there was no significant change among never smoking women. Additionally, it was observed that greater height in women was associated with an increased risk of lung cancer.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Multidisciplinary Sciences
Saori Tatsuno, Hiroshi Doi, Wataru Okada, Eri Inoue, Kiyoshi Nakamatsu, Masao Tanooka, Masahiro Tanaka, Yasumasa Nishimura
Summary: The risk factors for severe radiation pneumonitis (RP) in patients with lung cancer who undergo rotating gantry intensity-modulated radiation therapy (IMRT) using volumetric modulated arc therapy (VMAT) or helical tomotherapy (HT) are poorly understood. This retrospective study included 52 patients who received rotating gantry IMRT for locally advanced lung cancer. In multivariate analysis, lung V5 >= 40% was associated with grade >= 2 RP, and past medical history of pneumonectomy and total lung volume <= 3260 cc were independently associated with grade >= 3 RP.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Masashi Nishimura, Yoshifumi Kimizuka, Takunori Ogawa, Motohiro Tsuchiya, Yoshiki Kato, Akira Matsukida, Shunya Igarashi, Koki Ito, Yusuke Serizawa, Tomomi Tanigaki, Yuji Fujikura, Yuka Katsurada, Sho Ogata, Akihiko Kawana
Summary: This study reports a case of IgG4-related retroperitoneal fibrosis occurring after chemotherapy. The patient showed improvement after discontinuing immunotherapy and receiving steroid treatment.
Article
Oncology
Yuta Ohishi, Yoko Nakanishi, Yukari Hirotani, Atsuko Suzuki, Tomoyuki Tanino, Haruna Nishimaki-Watanabe, Hiroko Kobayashi, Fumi Nozaki, Sumie Ohni, Xiaoyan Tang, Kentaro Hayashi, Yoshiko Nakagawa, Tetsuo Shimizu, Ichiro Tsujino, Noriaki Takahashi, Yasuhiro Gon, Shinobu Masuda
Summary: This study aimed to investigate the clinicopathological differences and therapeutic response of NSCLC patients with SDC4::ROS1 fusion to crizotinib. The study found that different ROS1 fusion partners may affect the efficacy of crizotinib and patient prognosis. In addition, higher expression levels of ROS1 and pERK1/2 in tumor cells of case 2 may be related to the therapeutic response and prognosis.
Review
Oncology
Zitong Zheng, Juanjuan Liu, Junling Ma, Runting Kang, Zhen Liu, Jiangyong Yu
Summary: Small cell lung cancer (SCLC) is a highly aggressive malignancy with limited treatment options. Over the past decade, immunotherapy has made progress in the treatment of SCLC, but current immune checkpoint inhibitors have limited benefits for patient survival. Therefore, it is important to explore new targets and develop drugs with novel mechanisms for immunotherapy in SCLC.
Article
Oncology
Kazuto Sugai, Kojiro Nakaoka, Rika Tobita, Shinji Kikuchi, Kei Inoue, Midori Enokido, Moriyuki Kiyoshima
Summary: This article presents a case of multilocular mediastinal cyst leading to the development of thymic cancer. Resection of multilocular anterior mediastinal cysts should be considered due to the challenges in preoperative diagnosis, the potential for coexisting tumors with cysts, and the risk of malignant tumor development.
