Article
Plant Sciences
Lingge Cheng, Wenyue Liu, Chongjin Zhong, Ping Ni, Suiying Ni, Qizhi Wang, Qixiang Zhang, Jingwei Zhang, Jiali Liu, Meijuan Xu, Xuequan Yao, Xiaobo Cen, Guangji Wang, Chao Jiang, Fang Zhou
Summary: SMI can remodel the balance of pro- and anti-angiogenic factors to promote tumor vessel normalization, enhancing drug delivery and anti-tumor effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tomoko Yamazaki, Kristina H. Young
Summary: Research on the effects of radiation on tumor vasculature demonstrates that changes occur post-radiation, impacting the response to anticancer therapies. However, the findings and implications are complex and sometimes contradictory due to variations in radiation dose, timing, and models used.
MOLECULAR CARCINOGENESIS
(2022)
Review
Chemistry, Multidisciplinary
Chunling Wang, Junchao Xu, Yinlong Zhang, Guangjun Nie
Summary: Abnormal angiogenesis is a significant characteristic of malignant tumors, and nanomedicine provides a precise approach to regulate tumor blood vessels. Nanomedicines have the advantage of reducing systemic toxicity and enhancing therapeutic efficacy, as well as enabling more precise drug delivery and release through specific structural designs.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Engineering, Biomedical
Yiqiong Liu, Dailin Xu, Ying Liu, Xiao Zheng, Jie Zang, Wanli Ye, Yuge Zhao, Ruiqing He, Shuangrong Ruan, Tingting Zhang, Haiqing Dong, Yan Li, Yongyong Li
Summary: This study develops an effective strategy to attenuate tumor hyaluronan accumulation and enhance immune-mediated tumor regression by utilizing a nanosystem that combines photothermal therapy and hyaluronidase enzymatic degradation to relieve immunosuppression in the tumor microenvironment.
Review
Engineering, Biomedical
Ying Zhang, Jingni He
Summary: Targeting tumor vasculature with nanomedicines has shown promising results in cancer therapy, offering advantages over traditional methods by avoiding side effects and potentially improving patient adherence to treatment.
ACTA BIOMATERIALIA
(2021)
Review
Immunology
Hassan Dianat-Moghadam, Reza Nedaeinia, Mohsen Keshavarz, Mehdi Azizi, Mohammad Kazemi, Rasoul Salehi
Summary: Angiogenesis is a characteristic of cancer biology, and current therapies targeting tumor vasculature have limitations. By combining immunotherapy and nanocarriers, the efficacy of antiangiogenic agents could be improved while reducing the dosage of chemotherapy drugs. Furthermore, the combination of immunotherapies and nano-based delivery systems can extend the window of vascular normalization and overcome the challenges of antiangiogenic agents in treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Min D. D. Tang-Schomer, Markus J. J. Bookland, Jack E. E. Sargent, Taylor N. N. Jackvony
Summary: This study used a three-dimensional culture system to mimic the microenvironment of ependymoma and successfully replicated patient tumors in vitro. The addition of VEGF supported the in vitro growth of ependymoma samples, while the effects of extracellular matrix were more significant than media conditions. When co-cultured with endothelial cells, the 3D models developed capillary networks resembling the in vivo vasculature of ependymoma. Transcriptomic analysis showed differences between in vitro cultures from different patients, and the presence of endothelial cells affected gene expression patterns, particularly genes associated with ECM remodeling. These findings contribute to understanding the ependymoma microenvironment and advancing the development of patient-derived in vitro models for personalized medicine.
BIOENGINEERING-BASEL
(2023)
Article
Nanoscience & Nanotechnology
Bingyuan Fei, Zhanhao Mo, Jinghui Yang, Zheng Wang, Shuo Li
Summary: This study demonstrates a promising sequential treatment strategy in which the combination of cancer-associated fibroblast (CAF) regulation and tumor vasculature normalization, followed by photodynamic therapy (PDT), could enhance PDT efficacy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Review
Oncology
Adrian M. Baris, Eugenia Fraile-Bethencourt, Sudarshan Anand
Summary: The ability of cells to recognize DNA or RNA from pathogens can trigger immune responses, recent research showing how this process can be mimicked in cancer to recruit immune cells against tumors. Endothelial cells, especially those lining blood vessels, play a crucial role in this process, acting as conduits for nutrients, oxygen, and immune cells within tumors. Understanding the role of nucleic acid sensors in the tumor vasculature can lead to more effective therapies targeting both the vascular and immune components of the tumor microenvironment.
Review
Oncology
Aukie Hooglugt, Miesje M. van der Stoel, Reinier A. Boon, Stephan Huveneers
Summary: Solid tumors rely on vascularization for growth, with YAP/TAZ activation playing a crucial role in promoting tumor angiogenesis. Understanding the regulation of endothelial YAP/TAZ and its downstream targets is essential for developing effective anti-cancer therapies. Strategies targeting YAP/TAZ in tumor endothelium and exploring vascular normalization may hold promise for improving tumor treatments.
FRONTIERS IN ONCOLOGY
(2021)
Article
Engineering, Biomedical
Xiaotian Wu, David A. Pastel, Rihan Khan, Clifford J. Eskey, Yuan Shi, Michael Sramek, Joseph A. Paydarfar, Ryan J. Halter
Summary: Retractors and scopes used in head and neck surgery can cause deformation of critical structures, reducing the reliability of preoperative imaging. A study on patients with tumors of the larynx and pharynx showed significant tumor and vasculature displacement during surgery, highlighting the limitations of relying solely on preoperative imaging. Using specific landmarks or gathering more intraoperative information could help improve surgical outcomes.
ANNALS OF BIOMEDICAL ENGINEERING
(2022)
Review
Oncology
Jacopo Lidonnici, Massimo M. Santoro, Roxana E. Oberkersch
Summary: Angiogenesis plays an important role in tumor growth and metastasis, and understanding the metabolic characteristics and interactions of tumor endothelial cells (TECs) with tumor cells is crucial. The metabolic differences between normal and tumor vasculature provide a basis for developing targeted therapies with higher specificity and fewer side effects, improving patient outcomes.
Article
Multidisciplinary Sciences
M. Atif, Lothar Lilge, Atif Hanif, Shafiq Ahmad, S. Devanesan
Summary: Photoacoustic imaging is an evolving modality for studying and imaging tumor hypoxia. Experimental results show a short-term increase followed by a strong decrease in the tumor vasculature after Photodynamic Therapy (PDT), but no complete stasis. An alternate method is developed by analyzing the spatial and frequency domain histogram of the tumor vasculature using two-dimensional Fast Fourier Transform (FFT). The variations in acoustic impedance and hemoglobin levels after PDT are studied, and their impact on tumor necrosis is investigated.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Review
Nanoscience & Nanotechnology
Duoyi Zhao, Xu Huang, Zhiyu Zhang, Jianxun Ding, Yan Cui, Xuesi Chen
Summary: Tumor vasculature blockade therapy (TVBT) is a promising treatment modality for solid tumors, but its clinical transformation is limited by low selectivity, drug resistance, and severe side effects. Engineered nanoparticles offer potential solutions for TVBT, including prolonged circulation time, targeted transportation, and controlled release of TVBT agents. Furthermore, engineered nanomedicines provide a promising platform for combining TVBT with other therapies.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Jian Zhong, Chaoxin Xiao, Qin Chen, Xiangyu Pan, Tongtong Xu, Yiyun Wang, Wanting Hou, Lu Liu, Fujun Cao, Yulin Wang, Xiaoying Li, Lin Zhou, Hanshuo Yang, Yu Yang, Chengjian Zhao
Summary: This study established a comprehensive method using the zebrafish functional xenograft vasculature platform (zFXVP) to visualize and quantify tumor vasculature changes. PF-502 was identified as a robust vascular normalization agent, and its mechanism of action was investigated. In murine models, PF-502 exhibited pronounced vascular normalization and improved drug delivery.
Article
Chemistry, Multidisciplinary
Siyi Xu, Yue Han, Cheng Zhou, Jianxi Li, Liguo Shen, Hongjun Lin
Summary: A new biobased flame retardant (MHPA) was synthesized by neutralizing magnesium hydroxide (MH) with phytic acid (PA). Adding MHPA to ethylene vinyl acetate (EVA) significantly improved the fire retardancy, smoke suppression, and mechanical properties of the composites. The combination of MHPA and MH exhibited excellent carbonization and expansion effects, contributing to the improved flame retardancy.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Physical
Mengying Qian, Fangyu Zhuo, Yu Li, Penghui Yi, Yubei Gao, Weilu Zhou, Yanlong Sun, Jianrong Chen
Summary: In this study, a novel electro-Fenton system using Fe-N-C catalyst supported on carbon felt as the cathodic catalyst and air as the oxygen source was developed. The CF/Fe-N-C catalyst exhibited high efficiency in the degradation and mineralization of antibiotics in aqueous solution. It also demonstrated outstanding reusability and stability, and could be used for the in-situ fabrication of reticular nanostructure.
APPLIED SURFACE SCIENCE
(2023)
Review
Engineering, Environmental
Mingzhu Zhou, Junjie Chen, Shuning Yu, Binghong Chen, Cheng Chen, Liguo Shen, Bisheng Li, Hongjun Lin
Summary: This paper introduces a PS-activation catalysis-membrane system (PACMS) for wastewater treatment, including homogeneous and heterogeneous systems. The activation methods and mechanisms of PS in PACMS are discussed, and various preparation strategies of catalytic membrane are summarized. The applications of PACMS in wastewater treatment are highlighted.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Environmental Sciences
Hui Zou, Jiahui Huang, Meijia Zhang, Hongjun Lin, Jiaheng Teng, Zhengyi Huang
Summary: This study demonstrates that the addition of magnesium ions (Mg2+) can significantly reduce protein fouling on membranes, and an optimal concentration of Mg2+ exists for achieving the lowest fouling. This is attributed to the hydration repulsion effect of Mg2+ and the conformational change of protein molecules.
Article
Engineering, Environmental
Mengfei Wu, Meijia Zhang, Liguo Shen, Xinhua Wang, Deng Ying, Hongjun Lin, Renjie Li, Yanchao Xu, Huachang Hong
Summary: This study compared the fouling behaviors of a membrane bioreactor (MBR) operated at normal and sludge bulking stages, and explored the different mechanisms behind these behaviors. The results showed that the MBR could be stably operated for about 60 days without membrane cleaning in the normal stage, while daily membrane cleaning was required in the sludge bulking stage. Further characterizations revealed that the bulking sludge had lower dewaterability, smaller particle size, higher fractal dimension, higher viscosity, abundant filamentous bacteria, and different types of extracellular polymer substances (EPS). It was suggested that microbial community transition was responsible for the occurrence of sludge bulking, which in turn affected membrane fouling. Based on these findings, it was proposed that providing extra force to offset a chemical potential gap caused by foulant layer structure transition during sludge bulking is necessary to sustain filtration and prevent extremely high specific filtration resistance (SFR).
Article
Environmental Sciences
Yansha Zeng, Zhe Wang, Zhenxiang Pan, Liguo Shen, Jiaheng Teng, Hongjun Lin, Jianzhen Zhang
Summary: This study investigated the combined effects of polymeric aluminum chloride (PAC) and polyacrylamide (PAM) on sludge dewatering, aiming to uncover the underlying mechanisms. The co-conditioning of 15 mg g-1 PAC and 1 mg g-1 PAM achieved optimal dewatering performance, significantly reducing the specific filtration resistance (SFR) of the co-conditioned sludge. The findings provide insights into the improved dewatering performance and the thermodynamic mechanisms of sludge dewatering with different chemical conditioning.
ENVIRONMENTAL RESEARCH
(2023)
Review
Green & Sustainable Science & Technology
Qianqian Zeng, Hongjun Lin, Yang Qu, Zhengyi Huang, Ning Kong, Lei Han, Cheng Chen, Bisheng Li, Jiaheng Teng, Yanchao Xu, Liguo Shen
Summary: A low-cost approach using in-situ reduction strategy was developed to prepare PDA@NixCo100-x nanotubes, which contained active NiCo nanoparticles encapsulated in the inner wall. The optimized PDA@Ni25Co75 nanotubes exhibited excellent photocatalytic performance, achieving 99.3% degradation of methyl orange and 95.7% degradation of 4-nitro phenol in 10 and 15 minutes, respectively, outperforming previous materials reported in literature. The self-sustained high-density PDA@Ni100Co0 nanotube arrays obtained by removing the membrane structure were efficient catalysts for pollutant capture. This cost-effective nanocatalyst approach has great potential for large-scale applications in environmental remediation, demonstrating significant innovation and contribution to the field.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Chemistry, Physical
Bowen Li, Liguo Shen, Ying Zhao, Wei Yu, Hongjun Lin, Cheng Chen, Yingbo Li, Qianqian Zeng
Summary: Efficient quantification of the interfacial interaction between foulants and rough membrane surfaces is crucial for mitigating adhesive membrane fouling. This study employed artificial intelligence visualization technology and a simplified thermodynamic calculation method using genetic algorithm back propagation artificial neural network (GABP ANN) to address this issue. The GABP ANN with 5 neurons showed reliable prediction performance in seconds, significantly faster than the advanced extended Derjaguin-Landau-Verwey-Overbeek (XDLVO) theory. The results demonstrated the feasibility of using GABP ANN for quantifying interfacial interaction in adhesive membrane fouling.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Engineering, Environmental
Lei Han, Jing Ma, Hongjun Lin, Cheng Chen, Jiaheng Teng, Bisheng Li, Dieling Zhao, Yanchao Xu, Wei Yu, Liguo Shen
Summary: The recycling of wastewater with multiple pollutants is an urgent issue, and gravity-driven membrane separation with metal-organic frameworks (MOFs) as membrane modifications has shown great potential. In this study, a novel Ni-MOF membrane was prepared by synthesizing flower-like nickel-based MOF particles and assembling them on a nylon membrane. The Ni-MOF membrane exhibited superhydrophilic and underwater superoleophobic properties, and demonstrated significantly improved rejection rates for various dye solutions, oil-water emulsion, and microplastic wastewater, while maintaining long-term stability. These findings highlight the broad application prospects of Ni-MOF membranes in wastewater treatment.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Environmental Sciences
Zhenxiang Pan, Zhongqiang Li, Bizhen Zeng, Liguo Shen, Hongjun Lin
Summary: This study innovatively explored the use of an up-flow anaerobic sludge bed (USB) for the treatment of waste brine from ion exchange resin process, finding optimal operating conditions for efficient nitrate removal. The study achieved over 95% removal of nitrate and over 90% removal of total nitrogen from the waste brine.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Environmental Sciences
Rui Wang, Zijing An, Lu Fan, Yan Zhou, Xiaomei Su, Junjie Zhu, Qian Zhang, Chongjun Chen, Hongjun Lin, Faqian Sun
Summary: Quorum quenching (QQ) is a novel technique for controlling biofouling in membrane bioreactors (MBRs) by disrupting quorum sensing (QS) and inhibiting biofilm formation. This study evaluated the effectiveness of the QQ strain Brucella sp. ZJ1, encapsulated in alginate beads, in mitigating biofouling. The results showed that MBR with QQ beads extended operation time by 2-3 times without affecting pollutant degradation, and these beads maintained approximately 50% QQ activity even after 50 days of operation.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Engineering, Chemical
Ning Kong, Liguo Shen, Qianqian Zeng, Cheng Chen, Jiaheng Teng, Yanchao Xu, Leihong Zhao, Hongjun Lin
Summary: A novel approach involving the synthesis of ultra-thin MXene and ferroferric oxide doped molybdenum disulfide (FM) was developed to improve the performance of MXene membranes for oil separation. The resulting membranes showed enhanced interface hydrophilicity, increased surface roughness, and improved permeability, leading to high water flux and efficient oil separation.
JOURNAL OF MEMBRANE SCIENCE
(2023)
Article
Engineering, Chemical
Die Ling Zhao, Haiyi Jin, Qipeng Zhao, Yanchao Xu, Liguo Shen, Hongjun Lin, Tai-Shung Chung
Summary: The surface chemistry and functionality of metal-organic frameworks (MOFs) can be controlled by integrating them with carbon quantum dots (CQDs). In this study, UiO-66-NH2/CQD heterojunctions were prepared and used as nanofillers in thin-film nanocomposite (TFN) membranes for dye removal. The loaded CQDs enhanced the compatibility of UiO-66-NH2 with the polyamide matrix and promoted photocatalytic oxidation under visible light. The TFN membranes embedded with 0.2 wt% UiO-66-NH2/CQD showed significant improvements in water permeance and selectivity to different dyes. The attached dyes could be efficiently degraded within 10 minutes through photocatalytic degradation. This work provides a new strategy for fabricating defect-free and self-cleaning nanofiltration membranes for dye removal and wastewater reclamation.
JOURNAL OF MEMBRANE SCIENCE
(2023)
Review
Chemistry, Multidisciplinary
Cheng Chen, Lingya Fei, Boya Wang, Jiujing Xu, Bisheng Li, Liguo Shen, Hongjun Lin
Summary: Photocatalytic membranes integrate membrane separation and photocatalytic degradation processes to provide an eco-friendly solution for efficient water purification. Highly efficient photocatalytic membranes driven by visible light, such as metal-organic frameworks (MOFs), have great potential in the construction of high-performance photocatalytic membranes. This review provides a comprehensive analysis of recent advancements in MOF-based photocatalytic membranes, including tailoring strategies, fabrication methods, applications, mechanisms, challenges, and future directions.
Article
Engineering, Environmental
Jing Wang, Hao Wang, Liguo Shen, Renjie Li, Hongjun Lin
Summary: This study proposes a novel approach to synthesizing composite membranes capable of catalytic degradation of organic pollutants, which exhibit high efficiency in treating wastewater and effectively eliminate tetracycline. The mechanism of persulfate activation and tetracycline degradation is revealed through detailed investigations using electron paramagnetic resonance and quenching trials. The study also highlights the remarkable rejection ratio of the composite membranes (90%) for sodium alginate, demonstrating their outstanding performance in an electrofiltration-associated in-situ oxidation system. This research provides a unique perspective on the integration of membrane separation technology and enriches the field of advanced wastewater treatment strategies.
Article
Oncology
Masashi Nishimura, Yoshifumi Kimizuka, Takunori Ogawa, Motohiro Tsuchiya, Yoshiki Kato, Akira Matsukida, Shunya Igarashi, Koki Ito, Yusuke Serizawa, Tomomi Tanigaki, Yuji Fujikura, Yuka Katsurada, Sho Ogata, Akihiko Kawana
Summary: This study reports a case of IgG4-related retroperitoneal fibrosis occurring after chemotherapy. The patient showed improvement after discontinuing immunotherapy and receiving steroid treatment.
Article
Oncology
Yuta Ohishi, Yoko Nakanishi, Yukari Hirotani, Atsuko Suzuki, Tomoyuki Tanino, Haruna Nishimaki-Watanabe, Hiroko Kobayashi, Fumi Nozaki, Sumie Ohni, Xiaoyan Tang, Kentaro Hayashi, Yoshiko Nakagawa, Tetsuo Shimizu, Ichiro Tsujino, Noriaki Takahashi, Yasuhiro Gon, Shinobu Masuda
Summary: This study aimed to investigate the clinicopathological differences and therapeutic response of NSCLC patients with SDC4::ROS1 fusion to crizotinib. The study found that different ROS1 fusion partners may affect the efficacy of crizotinib and patient prognosis. In addition, higher expression levels of ROS1 and pERK1/2 in tumor cells of case 2 may be related to the therapeutic response and prognosis.
Review
Oncology
Zitong Zheng, Juanjuan Liu, Junling Ma, Runting Kang, Zhen Liu, Jiangyong Yu
Summary: Small cell lung cancer (SCLC) is a highly aggressive malignancy with limited treatment options. Over the past decade, immunotherapy has made progress in the treatment of SCLC, but current immune checkpoint inhibitors have limited benefits for patient survival. Therefore, it is important to explore new targets and develop drugs with novel mechanisms for immunotherapy in SCLC.
Article
Oncology
Kazuto Sugai, Kojiro Nakaoka, Rika Tobita, Shinji Kikuchi, Kei Inoue, Midori Enokido, Moriyuki Kiyoshima
Summary: This article presents a case of multilocular mediastinal cyst leading to the development of thymic cancer. Resection of multilocular anterior mediastinal cysts should be considered due to the challenges in preoperative diagnosis, the potential for coexisting tumors with cysts, and the risk of malignant tumor development.
